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The map label for this gene is nhaA [H]

Identifier: 187928004

GI number: 187928004

Start: 964515

End: 965609

Strand: Direct

Name: nhaA [H]

Synonym: Rpic_0909

Alternate gene names: 187928004

Gene position: 964515-965609 (Clockwise)

Preceding gene: 187928003

Following gene: 187928007

Centisome position: 24.46

GC content: 61.92

Gene sequence:

>1095_bases
ATGACTGACTCGATTCCGCCGAAAGGGCCCGACGACGCCCCCAACGAGGGTGCAGGCAAACCAGAAGCGCTGGAAGTCAC
ACAGCATGCGGATCATCCGCTTGAAGCTGAATTGCGTAACCCGCCCGCATCGGCATCGGCAGCTTCTGCGCCGGCCGGCG
GCTGGGAGCGTGAGGTACTCGAAAAAGTACTGATGGCAACGGTCCGTGAGCAGCGCGCCGCGCGCCGCTGGCGCATCTTT
TTCCGCTTCGTGGCTCTGGGCCTGATCGGAGTGCTTATTTATGCGTTCGCCAGCTTGGAGGGCGAAACCGTCAGCACGGG
CCGCCACACAGCGATTGTCACGCTGGAGGGCGAAATTGCGGCGAACACAAACGCCAGCGCCGAAAACATCAACGCATCCT
TGCAGGCCGCGTTTGCAGATGACAACACCGTCGGTGTGATCCTGAAGATCAATTCGCCGGGCGGCTCGCCGGTGCAGGCG
GGCATGATCAACGATGAAATCCGCCGTCTTCGCGCCAAATACAAGAAGATTCCGCTGTACGTCGTCGTGGAAGAAATGTG
CGCGTCAGGCGGTTACTACGTGGCTGCCGCTGCTGACAGGATTTACGTCGACAAGGCCAGCATCGTCGGTTCCATCGGCG
TGCTGATGGACGGCTTCGGCTTTACTGGTCTGATGGACAAAGTGGGCGTGGAGCGCCGCCTGCTCACCGCCGGTTCGAAC
AAGGGAATGCTCGATCCGTTCTCACCCGTGTCGCCCCAGCAGAAACAGTATGCGCAGGAGATGCTGGACCAGGTGCATCA
GCAGTTCATCGACGTGGTCAAGCAGGGCCGCGGCAACCGTCTGAAGGACGATCCCACGCTGTTCACTGGTTTGTTCTGGA
CGGGCGCCAAGGCGGTGGATCTGGGCCTGGCCGACGCGATCGGCAGTTCGGACCTTGTCGCGCGCAGCGTCATCAAGGCG
CCGGACGTGGTGGACTACACCGTCAAGGAAAACTTCGCCTCGCGCGTGGCACGCAAGCTCGGCACGGCGATGGGCGCGGG
CGCAGTCAAGGCGCTGGCCACTACGGGCCAGCTCAAGCTGCTGATGAAGGAGTAG

Upstream 100 bases:

>100_bases
GGCAGCCGGATACGCTATTCCGGGCGCCCGTGTCCGCGCCCGAACCAACTCCTTCTGCCTAGTAGCGCAGTTTTTCTTCT
CGATCGTTTTCTCCTTGTCT

Downstream 100 bases:

>100_bases
AAGGGGCGGAGGCGCGCTATCGCGCTAGCAGCGAGAAAATCGCCGGCCGCTTGTGCAGGTTCATGCGGTCGGCGCGCCAG
TCGCTCACGGGCAACGTGAC

Product: peptidase S49

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MTDSIPPKGPDDAPNEGAGKPEALEVTQHADHPLEAELRNPPASASAASAPAGGWEREVLEKVLMATVREQRAARRWRIF
FRFVALGLIGVLIYAFASLEGETVSTGRHTAIVTLEGEIAANTNASAENINASLQAAFADDNTVGVILKINSPGGSPVQA
GMINDEIRRLRAKYKKIPLYVVVEEMCASGGYYVAAAADRIYVDKASIVGSIGVLMDGFGFTGLMDKVGVERRLLTAGSN
KGMLDPFSPVSPQQKQYAQEMLDQVHQQFIDVVKQGRGNRLKDDPTLFTGLFWTGAKAVDLGLADAIGSSDLVARSVIKA
PDVVDYTVKENFASRVARKLGTAMGAGAVKALATTGQLKLLMKE

Sequences:

>Translated_364_residues
MTDSIPPKGPDDAPNEGAGKPEALEVTQHADHPLEAELRNPPASASAASAPAGGWEREVLEKVLMATVREQRAARRWRIF
FRFVALGLIGVLIYAFASLEGETVSTGRHTAIVTLEGEIAANTNASAENINASLQAAFADDNTVGVILKINSPGGSPVQA
GMINDEIRRLRAKYKKIPLYVVVEEMCASGGYYVAAAADRIYVDKASIVGSIGVLMDGFGFTGLMDKVGVERRLLTAGSN
KGMLDPFSPVSPQQKQYAQEMLDQVHQQFIDVVKQGRGNRLKDDPTLFTGLFWTGAKAVDLGLADAIGSSDLVARSVIKA
PDVVDYTVKENFASRVARKLGTAMGAGAVKALATTGQLKLLMKE
>Mature_363_residues
TDSIPPKGPDDAPNEGAGKPEALEVTQHADHPLEAELRNPPASASAASAPAGGWEREVLEKVLMATVREQRAARRWRIFF
RFVALGLIGVLIYAFASLEGETVSTGRHTAIVTLEGEIAANTNASAENINASLQAAFADDNTVGVILKINSPGGSPVQAG
MINDEIRRLRAKYKKIPLYVVVEEMCASGGYYVAAAADRIYVDKASIVGSIGVLMDGFGFTGLMDKVGVERRLLTAGSNK
GMLDPFSPVSPQQKQYAQEMLDQVHQQFIDVVKQGRGNRLKDDPTLFTGLFWTGAKAVDLGLADAIGSSDLVARSVIKAP
DVVDYTVKENFASRVARKLGTAMGAGAVKALATTGQLKLLMKE

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=206, Percent_Identity=35.9223300970874, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1788064, Length=213, Percent_Identity=27.2300469483568, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 38815; Mature: 38684

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSIPPKGPDDAPNEGAGKPEALEVTQHADHPLEAELRNPPASASAASAPAGGWEREVL
CCCCCCCCCCCCCCCCCCCCCCCEEHHHHCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHH
EKVLMATVREQRAARRWRIFFRFVALGLIGVLIYAFASLEGETVSTGRHTAIVTLEGEIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEEEECCEE
ANTNASAENINASLQAAFADDNTVGVILKINSPGGSPVQAGMINDEIRRLRAKYKKIPLY
CCCCCCHHHCCCEEEEEECCCCEEEEEEEEECCCCCCEECCCHHHHHHHHHHHHHHCCHH
VVVEEMCASGGYYVAAAADRIYVDKASIVGSIGVLMDGFGFTGLMDKVGVERRLLTAGSN
EEHHHHHHCCCEEEEEECCEEEEEHHHHHHHHHHHHCCCCHHHHHHHHCHHHHEEECCCC
KGMLDPFSPVSPQQKQYAQEMLDQVHQQFIDVVKQGRGNRLKDDPTLFTGLFWTGAKAVD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHCCCHHHH
LGLADAIGSSDLVARSVIKAPDVVDYTVKENFASRVARKLGTAMGAGAVKALATTGQLKL
CCHHHHCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEE
LMKE
EECC
>Mature Secondary Structure 
TDSIPPKGPDDAPNEGAGKPEALEVTQHADHPLEAELRNPPASASAASAPAGGWEREVL
CCCCCCCCCCCCCCCCCCCCCCEEHHHHCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHH
EKVLMATVREQRAARRWRIFFRFVALGLIGVLIYAFASLEGETVSTGRHTAIVTLEGEIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEEEECCEE
ANTNASAENINASLQAAFADDNTVGVILKINSPGGSPVQAGMINDEIRRLRAKYKKIPLY
CCCCCCHHHCCCEEEEEECCCCEEEEEEEEECCCCCCEECCCHHHHHHHHHHHHHHCCHH
VVVEEMCASGGYYVAAAADRIYVDKASIVGSIGVLMDGFGFTGLMDKVGVERRLLTAGSN
EEHHHHHHCCCEEEEEECCEEEEEHHHHHHHHHHHHCCCCHHHHHHHHCHHHHEEECCCC
KGMLDPFSPVSPQQKQYAQEMLDQVHQQFIDVVKQGRGNRLKDDPTLFTGLFWTGAKAVD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHCCCHHHH
LGLADAIGSSDLVARSVIKAPDVVDYTVKENFASRVARKLGTAMGAGAVKALATTGQLKL
CCHHHHCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEE
LMKE
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA