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The map label for this gene is iscS [H]

Identifier: 187927979

GI number: 187927979

Start: 938768

End: 939985

Strand: Direct

Name: iscS [H]

Synonym: Rpic_0884

Alternate gene names: 187927979

Gene position: 938768-939985 (Clockwise)

Preceding gene: 187927978

Following gene: 187927980

Centisome position: 23.81

GC content: 61.41

Gene sequence:

>1218_bases
ATGAGCACCCCGCAACTTCCCATCTACATGGACTATTCCGCGACGACGCCGGTGGACCCGCGCGTCGTCGACAAGATGAT
TCCGTATCTGCGCGAGAGCTTCGGCAACCCGGCTTCGCGCAGCCACCCGTTTGGCTGGGAAGCCGAGAAGGCCGTCGAGA
CCGCGCGCGAGCAGGTCGCCGCGCTGGTGAATGCCGACCCGCGCGAAATCGTCTGGACGTCGGGCGCCACGGAGTCCGAC
AACCTAGCCATCAAGGGCGCTGCCAACTTTTACAGCAGCAAGGGCAAGCACATCATCACCGTGAAGACCGAGCACAAGGC
TGTGCTGGACACGACGCGTGAGCTGGAGCGCCAGGGCTTCGAGGTGACCTACCTGGACGTGAAGGACAACGGCCTGATCG
ATATCGACGTCTTCAAGCAAGCCATCCGCCCTGACACCATTCTTGCGTCGGTGATGATGGTGAACAACGAAATCGGCGTC
ATTCAGGACATCGAGCAACTCGGCGAAATCTGCCGCGAAAAAGGCGTGATTTTTCACGTCGATGCCGCGCAGGCTACGGG
CAAGGTGGAAATCGACCTGCAGAAGCTGAAGGTTGACCTAATGTCGTTCTCGGCGCATAAGACGTATGGGCCGAAGGGCA
TCGGCGCGCTGTACGTGCGCCGCAAGCCGCGTATCCGTATCGAAGCGCAGATGCACGGCGGTGGACATGAGCGCGGCATG
CGCTCGGGTACGCTGGCCACGCACCAGATCGTCGGCATGGGTGAGGCCTTCCGCATCGCCAAGGAAGAAATGGCGACCGA
GAACGAGCGCATCCGCATGCTGCGCGACCGCCTGTATCGCGGCCTGAACACGATGGAAGAGGTGTACGTGAACGGCGACA
TGGAAGCCCGTGTGCCGCACAACCTGAACATCAGCTTCAACTTTGTGGAAGGCGAGTCGCTGATCATGGCGATCAAGGAC
GTCGCCGTGTCGTCGGGGTCGGCCTGCACGTCGGCCTCGCTGGAGCCTTCGTACGTGCTGCGTGCGCTGGGCCGCAACGA
TGAACTCGCGCACAGCTCGATCCGCTTCACGGTGGGCCGCTTCACGACGGAAGAAGAAGTCGACTACGTGGTCGAGCTGC
TCAAGAGCAAGATCGGCAAGCTGCGCGACCTGTCTCCGCTGTGGGAGATGTATAAGGACGGCGTGGATCTGAACAGCATT
CAATGGGCGGCGCACTGA

Upstream 100 bases:

>100_bases
TCCGTTTTCAGTCTGGCGCAGTCGTGATTGCGCTAGCGTGAGACTGGCCGCGACGCCAGTCCACACAAGAACATCGCCCC
CCACACAAGGCAGACAAGAT

Downstream 100 bases:

>100_bases
GCGCGGCGTTTGAGAACAACGGCGCCCCCGCGCCAGCCAACGATTGAAAGAGGTGTGAAATGTCTTACAGCAACCAAGTT
CTGGACCATTACGAAAACCC

Product: cysteine desulfurase IscS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MSTPQLPIYMDYSATTPVDPRVVDKMIPYLRESFGNPASRSHPFGWEAEKAVETAREQVAALVNADPREIVWTSGATESD
NLAIKGAANFYSSKGKHIITVKTEHKAVLDTTRELERQGFEVTYLDVKDNGLIDIDVFKQAIRPDTILASVMMVNNEIGV
IQDIEQLGEICREKGVIFHVDAAQATGKVEIDLQKLKVDLMSFSAHKTYGPKGIGALYVRRKPRIRIEAQMHGGGHERGM
RSGTLATHQIVGMGEAFRIAKEEMATENERIRMLRDRLYRGLNTMEEVYVNGDMEARVPHNLNISFNFVEGESLIMAIKD
VAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTVGRFTTEEEVDYVVELLKSKIGKLRDLSPLWEMYKDGVDLNSI
QWAAH

Sequences:

>Translated_405_residues
MSTPQLPIYMDYSATTPVDPRVVDKMIPYLRESFGNPASRSHPFGWEAEKAVETAREQVAALVNADPREIVWTSGATESD
NLAIKGAANFYSSKGKHIITVKTEHKAVLDTTRELERQGFEVTYLDVKDNGLIDIDVFKQAIRPDTILASVMMVNNEIGV
IQDIEQLGEICREKGVIFHVDAAQATGKVEIDLQKLKVDLMSFSAHKTYGPKGIGALYVRRKPRIRIEAQMHGGGHERGM
RSGTLATHQIVGMGEAFRIAKEEMATENERIRMLRDRLYRGLNTMEEVYVNGDMEARVPHNLNISFNFVEGESLIMAIKD
VAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTVGRFTTEEEVDYVVELLKSKIGKLRDLSPLWEMYKDGVDLNSI
QWAAH
>Mature_404_residues
STPQLPIYMDYSATTPVDPRVVDKMIPYLRESFGNPASRSHPFGWEAEKAVETAREQVAALVNADPREIVWTSGATESDN
LAIKGAANFYSSKGKHIITVKTEHKAVLDTTRELERQGFEVTYLDVKDNGLIDIDVFKQAIRPDTILASVMMVNNEIGVI
QDIEQLGEICREKGVIFHVDAAQATGKVEIDLQKLKVDLMSFSAHKTYGPKGIGALYVRRKPRIRIEAQMHGGGHERGMR
SGTLATHQIVGMGEAFRIAKEEMATENERIRMLRDRLYRGLNTMEEVYVNGDMEARVPHNLNISFNFVEGESLIMAIKDV
AVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTVGRFTTEEEVDYVVELLKSKIGKLRDLSPLWEMYKDGVDLNSIQ
WAAH

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=400, Percent_Identity=59.25, Blast_Score=520, Evalue=1e-148,
Organism=Homo sapiens, GI156713448, Length=420, Percent_Identity=32.1428571428571, Blast_Score=206, Evalue=2e-53,
Organism=Escherichia coli, GI48994898, Length=403, Percent_Identity=74.6898263027295, Blast_Score=640, Evalue=0.0,
Organism=Escherichia coli, GI1789175, Length=216, Percent_Identity=34.2592592592593, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787970, Length=395, Percent_Identity=24.3037974683544, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI25143064, Length=405, Percent_Identity=59.7530864197531, Blast_Score=515, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17533177, Length=327, Percent_Identity=32.4159021406728, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319831, Length=399, Percent_Identity=57.3934837092732, Blast_Score=507, Evalue=1e-144,
Organism=Drosophila melanogaster, GI20129463, Length=400, Percent_Identity=56.5, Blast_Score=489, Evalue=1e-138,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 45248; Mature: 45117

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPQLPIYMDYSATTPVDPRVVDKMIPYLRESFGNPASRSHPFGWEAEKAVETAREQVA
CCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
ALVNADPREIVWTSGATESDNLAIKGAANFYSSKGKHIITVKTEHKAVLDTTRELERQGF
HHHCCCCCCEEEECCCCCCCCEEEEECHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCC
EVTYLDVKDNGLIDIDVFKQAIRPDTILASVMMVNNEIGVIQDIEQLGEICREKGVIFHV
EEEEEEECCCCEEEHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEE
DAAQATGKVEIDLQKLKVDLMSFSAHKTYGPKGIGALYVRRKPRIRIEAQMHGGGHERGM
ECCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHCCC
RSGTLATHQIVGMGEAFRIAKEEMATENERIRMLRDRLYRGLNTMEEVYVNGDMEARVPH
CCCCCHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHEEECCCEEEECCC
NLNISFNFVEGESLIMAIKDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTVGR
CCCEEEEEECCCEEEEEEHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEEC
FTTEEEVDYVVELLKSKIGKLRDLSPLWEMYKDGVDLNSIQWAAH
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEECC
>Mature Secondary Structure 
STPQLPIYMDYSATTPVDPRVVDKMIPYLRESFGNPASRSHPFGWEAEKAVETAREQVA
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
ALVNADPREIVWTSGATESDNLAIKGAANFYSSKGKHIITVKTEHKAVLDTTRELERQGF
HHHCCCCCCEEEECCCCCCCCEEEEECHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCC
EVTYLDVKDNGLIDIDVFKQAIRPDTILASVMMVNNEIGVIQDIEQLGEICREKGVIFHV
EEEEEEECCCCEEEHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEE
DAAQATGKVEIDLQKLKVDLMSFSAHKTYGPKGIGALYVRRKPRIRIEAQMHGGGHERGM
ECCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHCCC
RSGTLATHQIVGMGEAFRIAKEEMATENERIRMLRDRLYRGLNTMEEVYVNGDMEARVPH
CCCCCHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHEEECCCEEEECCC
NLNISFNFVEGESLIMAIKDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTVGR
CCCEEEEEECCCEEEEEEHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEEC
FTTEEEVDYVVELLKSKIGKLRDLSPLWEMYKDGVDLNSIQWAAH
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA