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The map label for this gene is parE [H]

Identifier: 187927924

GI number: 187927924

Start: 874141

End: 876126

Strand: Direct

Name: parE [H]

Synonym: Rpic_0829

Alternate gene names: 187927924

Gene position: 874141-876126 (Clockwise)

Preceding gene: 187927923

Following gene: 187927925

Centisome position: 22.17

GC content: 64.2

Gene sequence:

>1986_bases
ATGAGCAAAACCTCCCAATACAGCGAATCGTCGATCAAGGTCCTCAAGGGCCTGGAACCGGTCAAGCAACGGCCGGGCAT
GTACACGCGCACCGACAATCCCCTGCACATCGTGCAGGAAGTCATCGACAACTCCGCTGACGAGGCGTTGGGCGGCTACG
GCAAGCTGATTGCCGTGACGCTGCACAAGGACGGCAGCGTGAGCGTGGAAGACGATGCGCGGGGCATCCCTGTCGGCATC
CACCCCGAAGAGGGCGTGCCGGTGGTCGAGATCGTCTACACGCGCCTGCATGCTGGCGGCAAGTTCGACAAGGGCCGCGG
CGGCGCATACGCGTTCTCCGGCGGCTTGCACGGCGTGGGGGTGTCGGTCACGAACGCGCTGTCGACGCGGCTGGAAGTGA
CGGTCTGGCGTGACGGCAACGTGTCGACGCTCGCATTCTCCGGTGGCGACGTGATCGAACCGTTGACCACCCGCAAGGCC
GAACGCGGCGAGAAGAAGAGCGGCACGCGCGTGCGTGCGTGGCCGGACGCCAAGTATTTCGATTCCGAGAACATCCCGCA
GGCCGAGCTGCAGCGCTTGCTGCGCAGCAAGGCCGTGCTGCTGCCGGGCGTGAAGGTCACGCTCACGCTGGAAAGAACCG
GCGAGACGCTCGAATGGCAATACGACCAGGGCCTGCGCGGCTATCTGGTCGAATCGCTTGCGCAGGGCAGCGGTGCCGAG
CCGGTGATCCCGCTGTTTGAAGGCGAACACTTTGCCGACCCTGACAAGCCCGGCGAAGAAGGTTTTGCCTTCGGCGAAGG
CGCATCGTGGGTGGTGGCCTGGACGGAAGAGGGCTCGCCGGTGCGTGAGTCATACGTCAACCTCATCCCGACGCCCGCCG
GCGGCACGCACGAATCCGGTTTGCGCGAAGGCCTGTTTCAGGCCGTGAAGAGCTTTGTCGAGATGCACGCGCTCCTGCCC
AAGGGCGTCAAGCTGATGTCCGAAGACGTGTTTGCGCGCGCTTCGTTCGTGCTGTCGGCCAAGGTGCTCGACCCGCAATT
CCAGGGTCAGATCAAGGAACGCCTGAATAGCCGCGATGCGGTGCGCCTGGTGTCCACCTTCAGCCGCCCGGCGCTGGAAC
TGTGGCTGAACCAGCACGTCGAGCACGGCAAGAAGCTGGCCGAACTCGTCATCAAGCAGGCGCAGGCGCGTACACGTGCC
GCGCAGAAGGTCGAGAAGAAGAAGGGCTCCGGTGTGGCCGTGCTGCCCGGCAAGCTGACCGACTGCGAATCCGACGACGT
CACCCGCAACGAACTCTTCCTGGTGGAAGGCGATTCCGCCGGCGGCTCGGCCAAGATGGGCCGCGACAAGGAATTCCAGG
CCATCCTGCCGTTGCGCGGCAAGGTGCTGAACACCTGGGAAACCGAGCGCGACCGCCTGTTCGCCAATAACGAGGTGCAT
GACATTGCGGTCGCCATCGGCGTGGACCCGCACGGGCCGAACGATACGGTCGACCTCTCCGGCCTGCGCTACGGCAAGAT
CTGCATCCTGTCCGATGCTGACGTGGACGGGGCGCACATCCAGGTGCTGCTGCTCACGTTGTTCTTCAAGCACTTCCCGC
AATTGATCGATCGCGGGAACGTATGCGTGGCCCGTCCGCCGCTGTATCGTGTCGATGCCCCGGCGCGTGGCAAGAAGCCC
GCGCAAAAGCTCTACGCGCTGGATGACGGCGAGTTGGAAGCCATTGAAGACAAACTGCGCAAGGATGGCGTGAAAGAGGG
CGCCTGGCAGATTTCCCGCTTCAAGGGCTTGGGCGAAATGAGCGCCGAGCAGCTCTGGGAAACCACCATGAACCCCGACA
CGCGCCGTCTGCTGCCCGTGGCGCTGGGCGAACTGGGCCAAGACCAGACCATCAACATGATGAACATGCTGATGGGCAAG
GGCGAAGCCGGCGCGCGCCGCACGTGGCTGGAAGCGCGCGGCAACGAAGTCGAAGCCGATATCTGA

Upstream 100 bases:

>100_bases
ATGATCCCTCCGCATTGTTGAGGACGGCTTCCTTTACAATGCGCGCTGCATTCCCGGTGCTTGGGGACAGACCCAGGCCT
GGTCAGTTTTTCCGCCTTCC

Downstream 100 bases:

>100_bases
TCGCAAACCGACAACGATGAAGCTTTTCGTACGTTTCGCATTCGCATTGACGGCGCTGGCCTTGTTGGCCAGCCAGCCGG
CGCGCGCGGACGTCTACGGC

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 661; Mature: 660

Protein sequence:

>661_residues
MSKTSQYSESSIKVLKGLEPVKQRPGMYTRTDNPLHIVQEVIDNSADEALGGYGKLIAVTLHKDGSVSVEDDARGIPVGI
HPEEGVPVVEIVYTRLHAGGKFDKGRGGAYAFSGGLHGVGVSVTNALSTRLEVTVWRDGNVSTLAFSGGDVIEPLTTRKA
ERGEKKSGTRVRAWPDAKYFDSENIPQAELQRLLRSKAVLLPGVKVTLTLERTGETLEWQYDQGLRGYLVESLAQGSGAE
PVIPLFEGEHFADPDKPGEEGFAFGEGASWVVAWTEEGSPVRESYVNLIPTPAGGTHESGLREGLFQAVKSFVEMHALLP
KGVKLMSEDVFARASFVLSAKVLDPQFQGQIKERLNSRDAVRLVSTFSRPALELWLNQHVEHGKKLAELVIKQAQARTRA
AQKVEKKKGSGVAVLPGKLTDCESDDVTRNELFLVEGDSAGGSAKMGRDKEFQAILPLRGKVLNTWETERDRLFANNEVH
DIAVAIGVDPHGPNDTVDLSGLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIDRGNVCVARPPLYRVDAPARGKKP
AQKLYALDDGELEAIEDKLRKDGVKEGAWQISRFKGLGEMSAEQLWETTMNPDTRRLLPVALGELGQDQTINMMNMLMGK
GEAGARRTWLEARGNEVEADI

Sequences:

>Translated_661_residues
MSKTSQYSESSIKVLKGLEPVKQRPGMYTRTDNPLHIVQEVIDNSADEALGGYGKLIAVTLHKDGSVSVEDDARGIPVGI
HPEEGVPVVEIVYTRLHAGGKFDKGRGGAYAFSGGLHGVGVSVTNALSTRLEVTVWRDGNVSTLAFSGGDVIEPLTTRKA
ERGEKKSGTRVRAWPDAKYFDSENIPQAELQRLLRSKAVLLPGVKVTLTLERTGETLEWQYDQGLRGYLVESLAQGSGAE
PVIPLFEGEHFADPDKPGEEGFAFGEGASWVVAWTEEGSPVRESYVNLIPTPAGGTHESGLREGLFQAVKSFVEMHALLP
KGVKLMSEDVFARASFVLSAKVLDPQFQGQIKERLNSRDAVRLVSTFSRPALELWLNQHVEHGKKLAELVIKQAQARTRA
AQKVEKKKGSGVAVLPGKLTDCESDDVTRNELFLVEGDSAGGSAKMGRDKEFQAILPLRGKVLNTWETERDRLFANNEVH
DIAVAIGVDPHGPNDTVDLSGLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIDRGNVCVARPPLYRVDAPARGKKP
AQKLYALDDGELEAIEDKLRKDGVKEGAWQISRFKGLGEMSAEQLWETTMNPDTRRLLPVALGELGQDQTINMMNMLMGK
GEAGARRTWLEARGNEVEADI
>Mature_660_residues
SKTSQYSESSIKVLKGLEPVKQRPGMYTRTDNPLHIVQEVIDNSADEALGGYGKLIAVTLHKDGSVSVEDDARGIPVGIH
PEEGVPVVEIVYTRLHAGGKFDKGRGGAYAFSGGLHGVGVSVTNALSTRLEVTVWRDGNVSTLAFSGGDVIEPLTTRKAE
RGEKKSGTRVRAWPDAKYFDSENIPQAELQRLLRSKAVLLPGVKVTLTLERTGETLEWQYDQGLRGYLVESLAQGSGAEP
VIPLFEGEHFADPDKPGEEGFAFGEGASWVVAWTEEGSPVRESYVNLIPTPAGGTHESGLREGLFQAVKSFVEMHALLPK
GVKLMSEDVFARASFVLSAKVLDPQFQGQIKERLNSRDAVRLVSTFSRPALELWLNQHVEHGKKLAELVIKQAQARTRAA
QKVEKKKGSGVAVLPGKLTDCESDDVTRNELFLVEGDSAGGSAKMGRDKEFQAILPLRGKVLNTWETERDRLFANNEVHD
IAVAIGVDPHGPNDTVDLSGLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIDRGNVCVARPPLYRVDAPARGKKPA
QKLYALDDGELEAIEDKLRKDGVKEGAWQISRFKGLGEMSAEQLWETTMNPDTRRLLPVALGELGQDQTINMMNMLMGKG
EAGARRTWLEARGNEVEADI

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=647, Percent_Identity=23.338485316847, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI19913406, Length=614, Percent_Identity=22.9641693811075, Blast_Score=102, Evalue=1e-21,
Organism=Escherichia coli, GI1789408, Length=660, Percent_Identity=49.6969696969697, Blast_Score=618, Evalue=1e-178,
Organism=Escherichia coli, GI48994957, Length=596, Percent_Identity=38.255033557047, Blast_Score=354, Evalue=1e-98,
Organism=Caenorhabditis elegans, GI212645845, Length=633, Percent_Identity=24.1706161137441, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17535065, Length=642, Percent_Identity=22.7414330218069, Blast_Score=103, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI212645657, Length=259, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=642, Percent_Identity=23.98753894081, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI17136538, Length=658, Percent_Identity=23.4042553191489, Blast_Score=112, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 72298; Mature: 72167

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTSQYSESSIKVLKGLEPVKQRPGMYTRTDNPLHIVQEVIDNSADEALGGYGKLIAVT
CCCCCCCCHHHHHHHHCCCHHHHCCCCEECCCCHHHHHHHHHCCCHHHHHCCCCEEEEEE
LHKDGSVSVEDDARGIPVGIHPEEGVPVVEIVYTRLHAGGKFDKGRGGAYAFSGGLHGVG
EECCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCC
VSVTNALSTRLEVTVWRDGNVSTLAFSGGDVIEPLTTRKAERGEKKSGTRVRAWPDAKYF
HHHHHHHCCEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHCCCCCCCCEEEECCCCCCC
DSENIPQAELQRLLRSKAVLLPGVKVTLTLERTGETLEWQYDQGLRGYLVESLAQGSGAE
CCCCCCHHHHHHHHHHCCEECCCEEEEEEEECCCCEEEEECCCCHHHHHHHHHHCCCCCC
PVIPLFEGEHFADPDKPGEEGFAFGEGASWVVAWTEEGSPVRESYVNLIPTPAGGTHESG
CEEEEECCCCCCCCCCCCCCCCEECCCCCEEEEECCCCCHHHHHHHHEECCCCCCCCHHH
LREGLFQAVKSFVEMHALLPKGVKLMSEDVFARASFVLSAKVLDPQFQGQIKERLNSRDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHCCCHHH
VRLVSTFSRPALELWLNQHVEHGKKLAELVIKQAQARTRAAQKVEKKKGSGVAVLPGKLT
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
DCESDDVTRNELFLVEGDSAGGSAKMGRDKEFQAILPLRGKVLNTWETERDRLFANNEVH
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCHHHEECCCCEE
DIAVAIGVDPHGPNDTVDLSGLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIDRGN
EEEEEEECCCCCCCCCEEECCCEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCC
VCVARPPLYRVDAPARGKKPAQKLYALDDGELEAIEDKLRKDGVKEGAWQISRFKGLGEM
EEEECCCCEECCCCCCCCCHHHHHEECCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCHH
SAEQLWETTMNPDTRRLLPVALGELGQDQTINMMNMLMGKGEAGARRTWLEARGNEVEAD
HHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCC
I
C
>Mature Secondary Structure 
SKTSQYSESSIKVLKGLEPVKQRPGMYTRTDNPLHIVQEVIDNSADEALGGYGKLIAVT
CCCCCCCHHHHHHHHCCCHHHHCCCCEECCCCHHHHHHHHHCCCHHHHHCCCCEEEEEE
LHKDGSVSVEDDARGIPVGIHPEEGVPVVEIVYTRLHAGGKFDKGRGGAYAFSGGLHGVG
EECCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCC
VSVTNALSTRLEVTVWRDGNVSTLAFSGGDVIEPLTTRKAERGEKKSGTRVRAWPDAKYF
HHHHHHHCCEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHCCCCCCCCEEEECCCCCCC
DSENIPQAELQRLLRSKAVLLPGVKVTLTLERTGETLEWQYDQGLRGYLVESLAQGSGAE
CCCCCCHHHHHHHHHHCCEECCCEEEEEEEECCCCEEEEECCCCHHHHHHHHHHCCCCCC
PVIPLFEGEHFADPDKPGEEGFAFGEGASWVVAWTEEGSPVRESYVNLIPTPAGGTHESG
CEEEEECCCCCCCCCCCCCCCCEECCCCCEEEEECCCCCHHHHHHHHEECCCCCCCCHHH
LREGLFQAVKSFVEMHALLPKGVKLMSEDVFARASFVLSAKVLDPQFQGQIKERLNSRDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHCCCHHH
VRLVSTFSRPALELWLNQHVEHGKKLAELVIKQAQARTRAAQKVEKKKGSGVAVLPGKLT
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
DCESDDVTRNELFLVEGDSAGGSAKMGRDKEFQAILPLRGKVLNTWETERDRLFANNEVH
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCHHHEECCCCEE
DIAVAIGVDPHGPNDTVDLSGLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIDRGN
EEEEEEECCCCCCCCCEEECCCEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCC
VCVARPPLYRVDAPARGKKPAQKLYALDDGELEAIEDKLRKDGVKEGAWQISRFKGLGEM
EEEECCCCEECCCCCCCCCHHHHHEECCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCHH
SAEQLWETTMNPDTRRLLPVALGELGQDQTINMMNMLMGKGEAGARRTWLEARGNEVEAD
HHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]