Click here to switch to the map view.

The map label for this gene is algC [H]

Identifier: 187927737

GI number: 187927737

Start: 680570

End: 681958

Strand: Direct

Name: algC [H]

Synonym: Rpic_0641

Alternate gene names: 187927737

Gene position: 680570-681958 (Clockwise)

Preceding gene: 187927720

Following gene: 187927738

Centisome position: 17.26

GC content: 63.35

Gene sequence:

>1389_bases
ATGACACAACTGAACCCCACCATCTTCAAAGCCTACGACATCCGCGGCATCGTCGAAAAAACCGTCGATGCCGAAACCGC
ACGCTTGATCGGCCGTGCCTTCGGCTCCGCAGCACGCGCCAAGGGCGAATCCGCCGTCGTCATCGGCCGTGATGGTCGCC
TGTCCGGCCCTAATCTGCTCGCAGCGCTGGCAGACGGCCTGCGCGCGAGCGGCGTCGATGTGATCGACCTGGGCCTTGTA
GCCACGCCGATGGTCTACTTCGGCACTAACATCGAATTGGCCGGCCGTCGCGCCACGTCGGGCGTGATGGTCACCGGCAG
CCACAACCCGCCTGACTACAACGGCTTCAAGATGGTCCTGGCGGGCCAGGCCATCTACGGCGAGCAGATCCAGGCGCTGC
GCACGCGCATCGAACAGGGCGACTTCACGGAAGGCGCCGGCGACTACGTCCAGGTGGACATCCGCCAGCAATACATCGAC
CGAATCATCTCGGATGTCAAGGTGAGCCGCCCGATGAAGATTGCCGTGGACTGCGGCAACGGCGTGGCAGGCGCTTTTGC
GCCGGAGTTGTTCCGCGCGATGGGCTGCGAGGTGACGGAGCTGTTCTGCGAGGTGGATGGCCATTTCCCGAACCACCATC
CGGACCCGGCCCACGTCGAGAACCTGCAGGACCTCGTGCGCACGCTGCAGACCACGGATTGCGAACTTGGCCTCGCCTTC
GATGGCGATGGTGACCGCCTGGGCGTGGTGACCAAGGACGGTCAGGTCATTTTCCCTGACCGTCAGTTGATGTTGTTCGC
GCAGGAAGTCCTGTCGCGCAACCCGGGCGGCGAGATCATCTTCGACGTGAAGTGCACAGGCAAGCTGGCGCCGTTCATCC
GTGAGCACGGCGGCAAGGCCACGATGTGGAAGACCGGCCATTCGCTGGTCAAGGCGAAGCTAAAGGAAACGGGTGCGCCA
CTGGCCGGCGAGATGAGCGGCCACATTTTCTTCAAGGACCGCTGGTACGGTTTCGATGACGGTCTGTACACGGGCGCGCG
CCTGCTAGAGATCGTCTCGCGTCTGGCCGACCCGAGCGCTACGCTCAACGCGCTGCCGAACTCGCACTGCACGCCAGAGC
TGCAGCTGAAGTGTGCCGAGGGTGAATCGTTCGAGCTGCTCGACAAGATCAAGGCCAATGCCACGTTTACCGGCGCGAAG
GAAGTCAACCGCATCGATGGCGTGCGCGTGGAATACGAAGATGGCTTCGGCTTGGCGCGTCCGTCCAACACCACGCCGGT
GGTGGTGATGCGCTTCGAGGCTGACAACGATGCTGCGATGGCGCGCATCCAGGGTGAATTCCGCCGCGTGATCCTGGCCG
AAAAGCCGGACGCGCAACTGCCGTTCTGA

Upstream 100 bases:

>100_bases
TCATACAAGCCAGCCAAGTATTATAAAGGGTCAAAGGTTAGAATCCGAAACCACTTGTAACATTCCGCACACTGTATGTC
TTTACAGGTGCTGAGAACTC

Downstream 100 bases:

>100_bases
TCGCACGGTTCGCACTCATGAAGTTGGGGGAAGGGATGACGGCATGCGCGTGCTGATCGTCAAGGTTTCGTCGCTTGGCG
ATGTGGTGCATTGCACGCCG

Product: Phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MTQLNPTIFKAYDIRGIVEKTVDAETARLIGRAFGSAARAKGESAVVIGRDGRLSGPNLLAALADGLRASGVDVIDLGLV
ATPMVYFGTNIELAGRRATSGVMVTGSHNPPDYNGFKMVLAGQAIYGEQIQALRTRIEQGDFTEGAGDYVQVDIRQQYID
RIISDVKVSRPMKIAVDCGNGVAGAFAPELFRAMGCEVTELFCEVDGHFPNHHPDPAHVENLQDLVRTLQTTDCELGLAF
DGDGDRLGVVTKDGQVIFPDRQLMLFAQEVLSRNPGGEIIFDVKCTGKLAPFIREHGGKATMWKTGHSLVKAKLKETGAP
LAGEMSGHIFFKDRWYGFDDGLYTGARLLEIVSRLADPSATLNALPNSHCTPELQLKCAEGESFELLDKIKANATFTGAK
EVNRIDGVRVEYEDGFGLARPSNTTPVVVMRFEADNDAAMARIQGEFRRVILAEKPDAQLPF

Sequences:

>Translated_462_residues
MTQLNPTIFKAYDIRGIVEKTVDAETARLIGRAFGSAARAKGESAVVIGRDGRLSGPNLLAALADGLRASGVDVIDLGLV
ATPMVYFGTNIELAGRRATSGVMVTGSHNPPDYNGFKMVLAGQAIYGEQIQALRTRIEQGDFTEGAGDYVQVDIRQQYID
RIISDVKVSRPMKIAVDCGNGVAGAFAPELFRAMGCEVTELFCEVDGHFPNHHPDPAHVENLQDLVRTLQTTDCELGLAF
DGDGDRLGVVTKDGQVIFPDRQLMLFAQEVLSRNPGGEIIFDVKCTGKLAPFIREHGGKATMWKTGHSLVKAKLKETGAP
LAGEMSGHIFFKDRWYGFDDGLYTGARLLEIVSRLADPSATLNALPNSHCTPELQLKCAEGESFELLDKIKANATFTGAK
EVNRIDGVRVEYEDGFGLARPSNTTPVVVMRFEADNDAAMARIQGEFRRVILAEKPDAQLPF
>Mature_461_residues
TQLNPTIFKAYDIRGIVEKTVDAETARLIGRAFGSAARAKGESAVVIGRDGRLSGPNLLAALADGLRASGVDVIDLGLVA
TPMVYFGTNIELAGRRATSGVMVTGSHNPPDYNGFKMVLAGQAIYGEQIQALRTRIEQGDFTEGAGDYVQVDIRQQYIDR
IISDVKVSRPMKIAVDCGNGVAGAFAPELFRAMGCEVTELFCEVDGHFPNHHPDPAHVENLQDLVRTLQTTDCELGLAFD
GDGDRLGVVTKDGQVIFPDRQLMLFAQEVLSRNPGGEIIFDVKCTGKLAPFIREHGGKATMWKTGHSLVKAKLKETGAPL
AGEMSGHIFFKDRWYGFDDGLYTGARLLEIVSRLADPSATLNALPNSHCTPELQLKCAEGESFELLDKIKANATFTGAKE
VNRIDGVRVEYEDGFGLARPSNTTPVVVMRFEADNDAAMARIQGEFRRVILAEKPDAQLPF

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=453, Percent_Identity=33.112582781457, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI1789566, Length=429, Percent_Identity=27.5058275058275, Blast_Score=99, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 50163; Mature: 50032

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLNPTIFKAYDIRGIVEKTVDAETARLIGRAFGSAARAKGESAVVIGRDGRLSGPNLL
CCCCCCCEEEEECHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHH
AALADGLRASGVDVIDLGLVATPMVYFGTNIELAGRRATSGVMVTGSHNPPDYNGFKMVL
HHHHCCHHCCCCCEEEHHHHHCCHHHCCCCEEECCCCCCCCEEEECCCCCCCCCCEEEEE
AGQAIYGEQIQALRTRIEQGDFTEGAGDYVQVDIRQQYIDRIISDVKVSRPMKIAVDCGN
ECCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEECCC
GVAGAFAPELFRAMGCEVTELFCEVDGHFPNHHPDPAHVENLQDLVRTLQTTDCELGLAF
CCCHHHHHHHHHHHCCHHEEHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEE
DGDGDRLGVVTKDGQVIFPDRQLMLFAQEVLSRNPGGEIIFDVKCTGKLAPFIREHGGKA
CCCCCEEEEEECCCEEECCCHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHCCCCE
TMWKTGHSLVKAKLKETGAPLAGEMSGHIFFKDRWYGFDDGLYTGARLLEIVSRLADPSA
EEECCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCH
TLNALPNSHCTPELQLKCAEGESFELLDKIKANATFTGAKEVNRIDGVRVEYEDGFGLAR
HHHCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCEECCHHHHHHHCCEEEEECCCCCCCC
PSNTTPVVVMRFEADNDAAMARIQGEFRRVILAEKPDAQLPF
CCCCCCEEEEEEECCCCHHHHHHHHHHEEEEEECCCCCCCCC
>Mature Secondary Structure 
TQLNPTIFKAYDIRGIVEKTVDAETARLIGRAFGSAARAKGESAVVIGRDGRLSGPNLL
CCCCCCEEEEECHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHH
AALADGLRASGVDVIDLGLVATPMVYFGTNIELAGRRATSGVMVTGSHNPPDYNGFKMVL
HHHHCCHHCCCCCEEEHHHHHCCHHHCCCCEEECCCCCCCCEEEECCCCCCCCCCEEEEE
AGQAIYGEQIQALRTRIEQGDFTEGAGDYVQVDIRQQYIDRIISDVKVSRPMKIAVDCGN
ECCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEECCC
GVAGAFAPELFRAMGCEVTELFCEVDGHFPNHHPDPAHVENLQDLVRTLQTTDCELGLAF
CCCHHHHHHHHHHHCCHHEEHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEE
DGDGDRLGVVTKDGQVIFPDRQLMLFAQEVLSRNPGGEIIFDVKCTGKLAPFIREHGGKA
CCCCCEEEEEECCCEEECCCHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHCCCCE
TMWKTGHSLVKAKLKETGAPLAGEMSGHIFFKDRWYGFDDGLYTGARLLEIVSRLADPSA
EEECCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCH
TLNALPNSHCTPELQLKCAEGESFELLDKIKANATFTGAKEVNRIDGVRVEYEDGFGLAR
HHHCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCEECCHHHHHHHCCEEEEECCCCCCCC
PSNTTPVVVMRFEADNDAAMARIQGEFRRVILAEKPDAQLPF
CCCCCCEEEEEEECCCCHHHHHHHHHHEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]