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The map label for this gene is cbbA [H]

Identifier: 187927593

GI number: 187927593

Start: 525588

End: 526652

Strand: Direct

Name: cbbA [H]

Synonym: Rpic_0493

Alternate gene names: 187927593

Gene position: 525588-526652 (Clockwise)

Preceding gene: 187927592

Following gene: 187927594

Centisome position: 13.33

GC content: 62.54

Gene sequence:

>1065_bases
ATGCCACTCGTCTCGATGCGCCAACTGCTGGACCACGCCGCTGAAAACGGCTACGGCCTGCCGGCATTCAACGTGAACAA
CCTGGAGCAAGTCCAGGCTGTGATGGAAGCTGCCAAGGAAGCCGGCGCACCGGTCATCCTGCAGGCCAGCGCAGGCGCCC
GCAAATACGCCGGCGAATCGTTCATCAAGCACCTGATCCAGGCTGCTGTCGAGGCTTATCCGGAGATCCCGCTGGTCATG
CACCAGGATCACGGCCAAAGCCCCGCGATCTGCCAGGGCGCCATCGACCTGGGCTTCGGCTCGGTCATGATGGACGGCTC
GTTGCGCGAAGATGGCAAGACGCCGGCTGATTTCGACTACAACGTCGACGTCACCCGCCGCGTGGTCGAGATGGCGCACA
AGGTTGGTGTGACCGTTGAAGGCGAACTCGGCTGCCTGGGCTCGCTGGAGACCGGTATGGCCGGCGAGGAAGATGGCCAC
GGCGCGGAAGGCAAGCTCGACCACTCATCCCTGCTGACCGACCCGGAAGAGGCTGCCCAGTTCGTCAAGGCGACCCAACT
GGACGCGCTGGCGATCGCCATCGGCACCAGCCACGGCGCCTACAAGTTCACGCGCAAGCCTACCGGCGACATCCTGGCGA
TCAGCCGCGTGAAGGAAATCCATGCACGCATCCCGAACACCCACTTGGTGATGCATGGCTCGTCGAGCGTGCCGCAAGAA
CTGCTGGCCATCATCAACCAGTACGGCGGCAAGATGAAGGAAACCTACGGCGTGCCCGTCGAGGAAATCCAGGAAGCCAT
CAAGTACGGCGTGCGCAAGATCAACATCGATACCGACATCCGGCTGGCCATGACGGGCGCGGTGCGCAAGTTCCTGGCCG
AAAACCCGGACAAGTTCGACGCCCGCGAATGGCTTAAGCCGGCGCGCGAAGCCGCCAAGCAAATCTGCAAGGCGCGCTAT
ATCCAGTTCGGCTGCGAAGGTCAGGCGGGCAAGATCAAGCCGATCGGCCTGTCAGTGATGGCGCAGAAGTACCAAAGCGG
CGATCTGGCGCAAGTGGTGCAATAA

Upstream 100 bases:

>100_bases
CGGCATGCACTGACGCCCACGACGGAACGCCGTTTGCTACGTCTACCAGACGTCCACGCGTTCCTGAGACCGAATACAGA
TCGATCCATAGGAGAAAACC

Downstream 100 bases:

>100_bases
GCATTTTGCGTCACATTTAGCAAACGGCTGGCACTGCGCCAGCCGTTTTGCATTGCATGGGCCATCTTATGGGCCACCCA
TGGGCCACGTATAATGCTGG

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MPLVSMRQLLDHAAENGYGLPAFNVNNLEQVQAVMEAAKEAGAPVILQASAGARKYAGESFIKHLIQAAVEAYPEIPLVM
HQDHGQSPAICQGAIDLGFGSVMMDGSLREDGKTPADFDYNVDVTRRVVEMAHKVGVTVEGELGCLGSLETGMAGEEDGH
GAEGKLDHSSLLTDPEEAAQFVKATQLDALAIAIGTSHGAYKFTRKPTGDILAISRVKEIHARIPNTHLVMHGSSSVPQE
LLAIINQYGGKMKETYGVPVEEIQEAIKYGVRKINIDTDIRLAMTGAVRKFLAENPDKFDAREWLKPAREAAKQICKARY
IQFGCEGQAGKIKPIGLSVMAQKYQSGDLAQVVQ

Sequences:

>Translated_354_residues
MPLVSMRQLLDHAAENGYGLPAFNVNNLEQVQAVMEAAKEAGAPVILQASAGARKYAGESFIKHLIQAAVEAYPEIPLVM
HQDHGQSPAICQGAIDLGFGSVMMDGSLREDGKTPADFDYNVDVTRRVVEMAHKVGVTVEGELGCLGSLETGMAGEEDGH
GAEGKLDHSSLLTDPEEAAQFVKATQLDALAIAIGTSHGAYKFTRKPTGDILAISRVKEIHARIPNTHLVMHGSSSVPQE
LLAIINQYGGKMKETYGVPVEEIQEAIKYGVRKINIDTDIRLAMTGAVRKFLAENPDKFDAREWLKPAREAAKQICKARY
IQFGCEGQAGKIKPIGLSVMAQKYQSGDLAQVVQ
>Mature_353_residues
PLVSMRQLLDHAAENGYGLPAFNVNNLEQVQAVMEAAKEAGAPVILQASAGARKYAGESFIKHLIQAAVEAYPEIPLVMH
QDHGQSPAICQGAIDLGFGSVMMDGSLREDGKTPADFDYNVDVTRRVVEMAHKVGVTVEGELGCLGSLETGMAGEEDGHG
AEGKLDHSSLLTDPEEAAQFVKATQLDALAIAIGTSHGAYKFTRKPTGDILAISRVKEIHARIPNTHLVMHGSSSVPQEL
LAIINQYGGKMKETYGVPVEEIQEAIKYGVRKINIDTDIRLAMTGAVRKFLAENPDKFDAREWLKPAREAAKQICKARYI
QFGCEGQAGKIKPIGLSVMAQKYQSGDLAQVVQ

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=319, Percent_Identity=33.2288401253918, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=33.1306990881459, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1788072, Length=332, Percent_Identity=31.0240963855422, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789293, Length=357, Percent_Identity=25.4901960784314, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6322790, Length=351, Percent_Identity=25.6410256410256, Blast_Score=76, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38206; Mature: 38075

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLVSMRQLLDHAAENGYGLPAFNVNNLEQVQAVMEAAKEAGAPVILQASAGARKYAGES
CCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
FIKHLIQAAVEAYPEIPLVMHQDHGQSPAICQGAIDLGFGSVMMDGSLREDGKTPADFDY
HHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHCCCCCEEECCCCCCCCCCCCCCCC
NVDVTRRVVEMAHKVGVTVEGELGCLGSLETGMAGEEDGHGAEGKLDHSSLLTDPEEAAQ
CCHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHHHH
FVKATQLDALAIAIGTSHGAYKFTRKPTGDILAISRVKEIHARIPNTHLVMHGSSSVPQE
HHHHHHHCEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHH
LLAIINQYGGKMKETYGVPVEEIQEAIKYGVRKINIDTDIRLAMTGAVRKFLAENPDKFD
HHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHCCCCCCC
AREWLKPAREAAKQICKARYIQFGCEGQAGKIKPIGLSVMAQKYQSGDLAQVVQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure 
PLVSMRQLLDHAAENGYGLPAFNVNNLEQVQAVMEAAKEAGAPVILQASAGARKYAGES
CHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
FIKHLIQAAVEAYPEIPLVMHQDHGQSPAICQGAIDLGFGSVMMDGSLREDGKTPADFDY
HHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHCCCCCEEECCCCCCCCCCCCCCCC
NVDVTRRVVEMAHKVGVTVEGELGCLGSLETGMAGEEDGHGAEGKLDHSSLLTDPEEAAQ
CCHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHHHH
FVKATQLDALAIAIGTSHGAYKFTRKPTGDILAISRVKEIHARIPNTHLVMHGSSSVPQE
HHHHHHHCEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHH
LLAIINQYGGKMKETYGVPVEEIQEAIKYGVRKINIDTDIRLAMTGAVRKFLAENPDKFD
HHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHCCCCCCC
AREWLKPAREAAKQICKARYIQFGCEGQAGKIKPIGLSVMAQKYQSGDLAQVVQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550527 [H]