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The map label for this gene is purC [H]

Identifier: 187927594

GI number: 187927594

Start: 526789

End: 527712

Strand: Direct

Name: purC [H]

Synonym: Rpic_0494

Alternate gene names: 187927594

Gene position: 526789-527712 (Clockwise)

Preceding gene: 187927593

Following gene: 187927595

Centisome position: 13.36

GC content: 65.48

Gene sequence:

>924_bases
GTGTCCGCCACCCCTGCATCCTCCGCCCTTTACGAATCGTCGATCACCAGCCTGCCGTTGCTCGGCCGTGGCAAGGTGCG
CGAGAACTACGCTGTCGGCGACGACAAGCTGCTGATGGTCACCACCGACCGCCTCTCGGCGTTTGACGTGATTCTTGGCC
AGCCGATTCCGGACAAGGGCCGTGTGCTCGCGCAGATGTCGGATTTCTGGTTCAACAAGCTGCGCCACATCGTGCCGACA
CACGAGACGGGCATCGCGCCGGAAACCGTGGTGGCCCCGAACGAAGTCGACCAGGTGCGCGGCCGCGCCATTGTGGTCAA
GCGTCTGAAGCCGATCCTGGTGGAAGCCGTGGTGCGCGGTTACCTGGCCGGCAGCGGCTGGAAGGATTACCAGGCCACCG
GCGCCGTGTGCGGTGTGCATCTGGCCCCCGGCCTGCAGAACGCGCAGAAGCTGCCCGAGCCGATCTTCACCCCCGCCGCC
AAGGCCGAGATGGGCGAGCACGACGAGAACATCTCGTTCGATGAAGTCGAGCGCCGCATCGGCCCGGACCTCGCCGCGCA
GATCCGCGACGTGAGCATCCGCCTGTACAAGGAAGCCTCGGACTTTGCCGCCACGCGCGGCATCATCATTGCCGACACCA
AGTTCGAGTTTGGCCTGGACGAAAACGGCACGCTTACGCTGATGGACGAGGCGCTCACCGCAGACTCGTCGCGCTTCTGG
CCGGCCGATTCGTACCAGGTCGGTACGAACCCGCCGTCGTTCGACAAGCAGTTCGTGCGCGACTGGCTCGAAGCCGTGCG
CATCGATGGCAAGCCGTGGCCGAAGACCGCGCCGGCGCCGCAACTGCCTGCCGACGTGATCGAAAAGACCGCTGACAAAT
ACCGCGAGGCGCTGACCCGCCTGACCGGCGAGTCCCTGCGATAA

Upstream 100 bases:

>100_bases
CGCCAGCCGTTTTGCATTGCATGGGCCATCTTATGGGCCACCCATGGGCCACGTATAATGCTGGCCTTCCACGTTTTCTT
ATCTCCTCCCGGGTTCCGCC

Downstream 100 bases:

>100_bases
ACCGGAGCGATGACAATGACCGCACAGCAATCTGCTCCGCTCGTTGGCGTGGTGATGGGCTCCAGCTCCGACTGGGAAGT
GATGCGCCACGCCGTCGATA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MSATPASSALYESSITSLPLLGRGKVRENYAVGDDKLLMVTTDRLSAFDVILGQPIPDKGRVLAQMSDFWFNKLRHIVPT
HETGIAPETVVAPNEVDQVRGRAIVVKRLKPILVEAVVRGYLAGSGWKDYQATGAVCGVHLAPGLQNAQKLPEPIFTPAA
KAEMGEHDENISFDEVERRIGPDLAAQIRDVSIRLYKEASDFAATRGIIIADTKFEFGLDENGTLTLMDEALTADSSRFW
PADSYQVGTNPPSFDKQFVRDWLEAVRIDGKPWPKTAPAPQLPADVIEKTADKYREALTRLTGESLR

Sequences:

>Translated_307_residues
MSATPASSALYESSITSLPLLGRGKVRENYAVGDDKLLMVTTDRLSAFDVILGQPIPDKGRVLAQMSDFWFNKLRHIVPT
HETGIAPETVVAPNEVDQVRGRAIVVKRLKPILVEAVVRGYLAGSGWKDYQATGAVCGVHLAPGLQNAQKLPEPIFTPAA
KAEMGEHDENISFDEVERRIGPDLAAQIRDVSIRLYKEASDFAATRGIIIADTKFEFGLDENGTLTLMDEALTADSSRFW
PADSYQVGTNPPSFDKQFVRDWLEAVRIDGKPWPKTAPAPQLPADVIEKTADKYREALTRLTGESLR
>Mature_306_residues
SATPASSALYESSITSLPLLGRGKVRENYAVGDDKLLMVTTDRLSAFDVILGQPIPDKGRVLAQMSDFWFNKLRHIVPTH
ETGIAPETVVAPNEVDQVRGRAIVVKRLKPILVEAVVRGYLAGSGWKDYQATGAVCGVHLAPGLQNAQKLPEPIFTPAAK
AEMGEHDENISFDEVERRIGPDLAAQIRDVSIRLYKEASDFAATRGIIIADTKFEFGLDENGTLTLMDEALTADSSRFWP
ADSYQVGTNPPSFDKQFVRDWLEAVRIDGKPWPKTAPAPQLPADVIEKTADKYREALTRLTGESLR

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=296, Percent_Identity=45.2702702702703, Blast_Score=265, Evalue=7e-72,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 33746; Mature: 33614

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATPASSALYESSITSLPLLGRGKVRENYAVGDDKLLMVTTDRLSAFDVILGQPIPDKG
CCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCCC
RVLAQMSDFWFNKLRHIVPTHETGIAPETVVAPNEVDQVRGRAIVVKRLKPILVEAVVRG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHCCHHHHHHHHHHHHHHHHHHH
YLAGSGWKDYQATGAVCGVHLAPGLQNAQKLPEPIFTPAAKAEMGEHDENISFDEVERRI
HHCCCCCCCHHHCCCEEEEECCCCCHHHHHCCCCCCCCCHHHHCCCCCCCCCHHHHHHHH
GPDLAAQIRDVSIRLYKEASDFAATRGIIIADTKFEFGLDENGTLTLMDEALTADSSRFW
CCHHHHHHHHHHHEEEHHHHHHHHHCCEEEEECCEEECCCCCCEEEEEEHHHCCCCCCCC
PADSYQVGTNPPSFDKQFVRDWLEAVRIDGKPWPKTAPAPQLPADVIEKTADKYREALTR
CCCCEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LTGESLR
HCCCCCC
>Mature Secondary Structure 
SATPASSALYESSITSLPLLGRGKVRENYAVGDDKLLMVTTDRLSAFDVILGQPIPDKG
CCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCCC
RVLAQMSDFWFNKLRHIVPTHETGIAPETVVAPNEVDQVRGRAIVVKRLKPILVEAVVRG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHCCHHHHHHHHHHHHHHHHHHH
YLAGSGWKDYQATGAVCGVHLAPGLQNAQKLPEPIFTPAAKAEMGEHDENISFDEVERRI
HHCCCCCCCHHHCCCEEEEECCCCCHHHHHCCCCCCCCCHHHHCCCCCCCCCHHHHHHHH
GPDLAAQIRDVSIRLYKEASDFAATRGIIIADTKFEFGLDENGTLTLMDEALTADSSRFW
CCHHHHHHHHHHHEEEHHHHHHHHHCCEEEEECCEEECCCCCCEEEEEEHHHCCCCCCCC
PADSYQVGTNPPSFDKQFVRDWLEAVRIDGKPWPKTAPAPQLPADVIEKTADKYREALTR
CCCCEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LTGESLR
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]