Click here to switch to the map view.

The map label for this gene is clpP [H]

Identifier: 187935559

GI number: 187935559

Start: 2969527

End: 2970126

Strand: Reverse

Name: clpP [H]

Synonym: CLL_A2889

Alternate gene names: 187935559

Gene position: 2970126-2969527 (Counterclockwise)

Preceding gene: 187934599

Following gene: 187933551

Centisome position: 78.15

GC content: 30.33

Gene sequence:

>600_bases
ATGAGTTTAGTTCCAATGGTTGTAGAACAAACAAGTAGAGGAGAGCGTTCTTACGATATATTTTCTAGATTGTTAAAAGA
AAGAATAATTATGTTAAGTGGTGAAGTAAATGACGATTCTTCTAATTTAATAGTTTCACAATTATTATTTTTAGAGAGTG
AAGATCCAGATAAGGATATAAGTATATATATAAATAGCCCTGGAGGTTCAATCACTGCTGGTATGGCTATATATGATACT
ATGCAATATATAAAGCCAGATGTTTCTACTATATGTGTAGGTATGGCTGCTTCTATGGGAGCATTTTTACTATCAAGTGG
TGCTAATGGCAAAAGATATGCTTTACCAAATGCAGAAATAATGATTCATCAACCACTTGGTGGATTTCAAGGTCAAGCAA
CAGATATTCAAATACATGCTAATAGAATATTAAAGATTAAAGAATCTTTAAACAAGATTTTAAGTGAAAACACAAATCAA
CCTTTAGAAGTAATTGAAGCAGATGTTGAAAGAGATAATTTTATGACTGCAGATGAAGCTAAGACATATGGGTTAGTAGA
TAAAGTAATAACTAAGAATGAAACTGGAAAAGATAAATAA

Upstream 100 bases:

>100_bases
GGCAATTATTTCAAATTATGATTAACATTTTGGGTATTTTTTTATATAATTTATATAAGAATCAATTTCAAATGTTGTTA
TATGAAAAGGAGGGAATTAT

Downstream 100 bases:

>100_bases
GATTGCAATTTAATTTATTGTACTAAGTGAGGTGAATATATGGCTAAATATGATGAAAAGAAACAGTTGAAATGTTCATT
TTGTGGTAAAACTCAAGACC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MSLVPMVVEQTSRGERSYDIFSRLLKERIIMLSGEVNDDSSNLIVSQLLFLESEDPDKDISIYINSPGGSITAGMAIYDT
MQYIKPDVSTICVGMAASMGAFLLSSGANGKRYALPNAEIMIHQPLGGFQGQATDIQIHANRILKIKESLNKILSENTNQ
PLEVIEADVERDNFMTADEAKTYGLVDKVITKNETGKDK

Sequences:

>Translated_199_residues
MSLVPMVVEQTSRGERSYDIFSRLLKERIIMLSGEVNDDSSNLIVSQLLFLESEDPDKDISIYINSPGGSITAGMAIYDT
MQYIKPDVSTICVGMAASMGAFLLSSGANGKRYALPNAEIMIHQPLGGFQGQATDIQIHANRILKIKESLNKILSENTNQ
PLEVIEADVERDNFMTADEAKTYGLVDKVITKNETGKDK
>Mature_198_residues
SLVPMVVEQTSRGERSYDIFSRLLKERIIMLSGEVNDDSSNLIVSQLLFLESEDPDKDISIYINSPGGSITAGMAIYDTM
QYIKPDVSTICVGMAASMGAFLLSSGANGKRYALPNAEIMIHQPLGGFQGQATDIQIHANRILKIKESLNKILSENTNQP
LEVIEADVERDNFMTADEAKTYGLVDKVITKNETGKDK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=200, Percent_Identity=54, Blast_Score=235, Evalue=2e-62,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=67.8756476683938, Blast_Score=291, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI17538017, Length=190, Percent_Identity=50, Blast_Score=200, Evalue=4e-52,
Organism=Drosophila melanogaster, GI20129427, Length=201, Percent_Identity=59.7014925373134, Blast_Score=252, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21880; Mature: 21749

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVPMVVEQTSRGERSYDIFSRLLKERIIMLSGEVNDDSSNLIVSQLLFLESEDPDKDI
CCCCHHHHHHCCCCCCCHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCCCCCCCCE
SIYINSPGGSITAGMAIYDTMQYIKPDVSTICVGMAASMGAFLLSSGANGKRYALPNAEI
EEEEECCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEE
MIHQPLGGFQGQATDIQIHANRILKIKESLNKILSENTNQPLEVIEADVERDNFMTADEA
EEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHH
KTYGLVDKVITKNETGKDK
HHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SLVPMVVEQTSRGERSYDIFSRLLKERIIMLSGEVNDDSSNLIVSQLLFLESEDPDKDI
CCCHHHHHHCCCCCCCHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCCCCCCCCE
SIYINSPGGSITAGMAIYDTMQYIKPDVSTICVGMAASMGAFLLSSGANGKRYALPNAEI
EEEEECCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEE
MIHQPLGGFQGQATDIQIHANRILKIKESLNKILSENTNQPLEVIEADVERDNFMTADEA
EEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHH
KTYGLVDKVITKNETGKDK
HHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA