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The map label for this gene is mscS [H]

Identifier: 187935293

GI number: 187935293

Start: 2559675

End: 2560490

Strand: Reverse

Name: mscS [H]

Synonym: CLL_A2469

Alternate gene names: 187935293

Gene position: 2560490-2559675 (Counterclockwise)

Preceding gene: 187934289

Following gene: 187935501

Centisome position: 67.38

GC content: 28.06

Gene sequence:

>816_bases
ATGAATATATTGTCAGTGATATTAGATAAAGTATATAGTTGGCTAGCTTTAAGTGGATTAAAAATAGTAATTGGATTATT
AGCCCTATGGATAGGATGGAAAATAGTAAATAAAATTATTAAAACTATGGATAGGATTCTTAAAAGAAAAGAATTTGATG
TCACATTGACAATGTTTTTAAATGCTTTTATAAATATATCATTAAAAGTGTTACTTATAATGATTATAATGGATTATGTT
GGAATGAAAACTACTGGACTTGTAACTTTAATAGGTTCAGCTGGTCTTGCAGTGGGACTTGCTCTTCAAGGTAGTTTATC
TAATTTTGCTGGCGGGGTTGTTATTTTATTGATAAGACCTTTTAATATAGGCGATTTTATTGACGCAGTAGGACATTCTG
GGAATGTTGAAAAAATAGGGATATTTTATACTTATATACTTACTACAGATAATAAACAGATACTTATACCAAATGGTAAA
TTGGCAAATGATAGTATAATAAATTATACAGCTAAGGACAAAAGAAGAGTTGATCTACAATTTTCTGTTGGATATGATGA
AGATGTTATTACGGTTAAGAACATTATAGAAGAAGTTGTTTTAAGTAACGATAAAATATTAAAAGATCCAGAGTATTTTA
TAGGATTATCTGAACATGGGGATAGTTCAGTGAACTTTGCTTTAAGAATATGGACAAAAACAGAGGATTATTGGGATGTA
TATTATGATTTATTAGAAAGAGTTAAAATTAAGTTCGAGGATGAAAGAATAAGTATACCATATCCTCAAATGGATGTTCA
CATTAAAAATGACTAA

Upstream 100 bases:

>100_bases
AATAGACTATATTTTCCTTGGTATAACTTACTTATGGAATTGGAAAATATAAATTTGTATAATTATAAGTAAACTAATAA
ACAAATTAAGGGGAAAAAAG

Downstream 100 bases:

>100_bases
AAATATGGACATGTTTTAGTAATGTGTTGATATATGCAGTGACACTTTAATTATTGCATATATCAGTACATATTTAGTAA
AATATCTTTATTTAAAAGCA

Product: mechanosensitive ion channel family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MNILSVILDKVYSWLALSGLKIVIGLLALWIGWKIVNKIIKTMDRILKRKEFDVTLTMFLNAFINISLKVLLIMIIMDYV
GMKTTGLVTLIGSAGLAVGLALQGSLSNFAGGVVILLIRPFNIGDFIDAVGHSGNVEKIGIFYTYILTTDNKQILIPNGK
LANDSIINYTAKDKRRVDLQFSVGYDEDVITVKNIIEEVVLSNDKILKDPEYFIGLSEHGDSSVNFALRIWTKTEDYWDV
YYDLLERVKIKFEDERISIPYPQMDVHIKND

Sequences:

>Translated_271_residues
MNILSVILDKVYSWLALSGLKIVIGLLALWIGWKIVNKIIKTMDRILKRKEFDVTLTMFLNAFINISLKVLLIMIIMDYV
GMKTTGLVTLIGSAGLAVGLALQGSLSNFAGGVVILLIRPFNIGDFIDAVGHSGNVEKIGIFYTYILTTDNKQILIPNGK
LANDSIINYTAKDKRRVDLQFSVGYDEDVITVKNIIEEVVLSNDKILKDPEYFIGLSEHGDSSVNFALRIWTKTEDYWDV
YYDLLERVKIKFEDERISIPYPQMDVHIKND
>Mature_271_residues
MNILSVILDKVYSWLALSGLKIVIGLLALWIGWKIVNKIIKTMDRILKRKEFDVTLTMFLNAFINISLKVLLIMIIMDYV
GMKTTGLVTLIGSAGLAVGLALQGSLSNFAGGVVILLIRPFNIGDFIDAVGHSGNVEKIGIFYTYILTTDNKQILIPNGK
LANDSIINYTAKDKRRVDLQFSVGYDEDVITVKNIIEEVVLSNDKILKDPEYFIGLSEHGDSSVNFALRIWTKTEDYWDV
YYDLLERVKIKFEDERISIPYPQMDVHIKND

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=251, Percent_Identity=40.2390438247012, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI1787591, Length=234, Percent_Identity=29.4871794871795, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1786670, Length=257, Percent_Identity=23.7354085603113, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI2367355, Length=206, Percent_Identity=24.7572815533981, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 30642; Mature: 30642

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILSVILDKVYSWLALSGLKIVIGLLALWIGWKIVNKIIKTMDRILKRKEFDVTLTMFL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
NAFINISLKVLLIMIIMDYVGMKTTGLVTLIGSAGLAVGLALQGSLSNFAGGVVILLIRP
HHHHHHHHHHHHHHHHHHHHCCCCCHHEEEECCCCCEEEEEEECCHHHCCCCEEEEEEEC
FNIGDFIDAVGHSGNVEKIGIFYTYILTTDNKQILIPNGKLANDSIINYTAKDKRRVDLQ
CCCHHHHHHCCCCCCCEEEEEEEEEEEEECCCEEEECCCCCCCCCEEEEECCCCEEEEEE
FSVGYDEDVITVKNIIEEVVLSNDKILKDPEYFIGLSEHGDSSVNFALRIWTKTEDYWDV
EECCCCCCHHHHHHHHHHHHHCCCCEECCCHHEEEECCCCCCCEEEEEEEEECCCHHHHH
YYDLLERVKIKFEDERISIPYPQMDVHIKND
HHHHHHHHEEEECCCEEECCCCCEEEEECCC
>Mature Secondary Structure
MNILSVILDKVYSWLALSGLKIVIGLLALWIGWKIVNKIIKTMDRILKRKEFDVTLTMFL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
NAFINISLKVLLIMIIMDYVGMKTTGLVTLIGSAGLAVGLALQGSLSNFAGGVVILLIRP
HHHHHHHHHHHHHHHHHHHHCCCCCHHEEEECCCCCEEEEEEECCHHHCCCCEEEEEEEC
FNIGDFIDAVGHSGNVEKIGIFYTYILTTDNKQILIPNGKLANDSIINYTAKDKRRVDLQ
CCCHHHHHHCCCCCCCEEEEEEEEEEEEECCCEEEECCCCCCCCCEEEEECCCCEEEEEE
FSVGYDEDVITVKNIIEEVVLSNDKILKDPEYFIGLSEHGDSSVNFALRIWTKTEDYWDV
EECCCCCCHHHHHHHHHHHHHCCCCEECCCHHEEEECCCCCCCEEEEEEEEECCCHHHHH
YYDLLERVKIKFEDERISIPYPQMDVHIKND
HHHHHHHHEEEECCCEEECCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]