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The map label for this gene is comEC [H]

Identifier: 187935501

GI number: 187935501

Start: 2558576

End: 2559523

Strand: Reverse

Name: comEC [H]

Synonym: CLL_A2468

Alternate gene names: 187935501

Gene position: 2559523-2558576 (Counterclockwise)

Preceding gene: 187935293

Following gene: 187933975

Centisome position: 67.35

GC content: 29.11

Gene sequence:

>948_bases
TTGAATAATAATAATGATGAATTAAAAAAAGCTTTTAAAAAAAGTATGAAAAAAAATAAGGGGAATAAAAAAGCTCAATT
TATAACAATAGTACTTTTTGCTCTTATAGGACTTATGAGTTTTGTTTTTGGAAATGACTTTAATTCCAACAAGGCAGATA
ATGTAGGTAATTTAACCAATGTAAGTGGAAATTTAGAAGTTTCGTATCTGGATGTTGGACAAGGGGATGCTGTATATATA
AGGGTTAATGATTTTGATATATTAATAGATGCAGGTCCAAGAAGTGAAGCGGATCATTTATTAAAGCAATTAGAACAAAA
AAATATAGATGATTTTGAAATGGTAATTGCGACTCACCCACATGAAGATCACATAGGTGGAATGAGCAAAGTATTTGAAA
ACTATAAGGTAGAAAATTTCTATATGCCAAAAGTTACTCATACAACAAAGACATTTGAAAATATGTTGACTTCAGTTTCA
AAACAAGGATTAAAAGTGCAACAAATAAAAGAAGGAATGAAATTTGATTTAGGTTCTGATGCTAAAATAGATGTATACTC
ACCAATGAAAGAAAGCTATGAGGAGTTTAATGATTATTCACCTATAATGAAGTTAACATTTGGGGATAAAAAGTTAATGT
TTACTGGAGATGCAGAAACACTTGTAGAAAAAGAAGTTTTATCTAAATATTCAAAAGATCTTAAAGCAGATGTATTAAAG
TTTGGTCATCATGGCTCAAGCACATCTTCAAGCAATGAATTTATACAAGCTGTTTCGCCACAGTATGGTATAATAAGCTG
TGGAACAGACAATAGTTATGGTCATCCTCATAAAGAAACTATGAAGAAGATTTCTAAAAATAAAATAGAAACTTATAGAA
CAGATTTGCAAGGAGAGATAACCTTATCATCTGATGGAAAGACTATATCAATTAAAACGAAAAAATAA

Upstream 100 bases:

>100_bases
TATTGCATATATCAGTACATATTTAGTAAAATATCTTTATTTAAAAGCAATTTAACAAAGTGATGAAAAGAACTTAAATT
CTTAAGATGGAGGAAATAAT

Downstream 100 bases:

>100_bases
TTATTGATTTTATAATTTATTAATTGTTTATAATATATTTGGAGCTATTTTATAATAATTTGTTTTTAGACAGCCCATTA
TAAAAAATTAAGAAGTAATA

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MNNNNDELKKAFKKSMKKNKGNKKAQFITIVLFALIGLMSFVFGNDFNSNKADNVGNLTNVSGNLEVSYLDVGQGDAVYI
RVNDFDILIDAGPRSEADHLLKQLEQKNIDDFEMVIATHPHEDHIGGMSKVFENYKVENFYMPKVTHTTKTFENMLTSVS
KQGLKVQQIKEGMKFDLGSDAKIDVYSPMKESYEEFNDYSPIMKLTFGDKKLMFTGDAETLVEKEVLSKYSKDLKADVLK
FGHHGSSTSSSNEFIQAVSPQYGIISCGTDNSYGHPHKETMKKISKNKIETYRTDLQGEITLSSDGKTISIKTKK

Sequences:

>Translated_315_residues
MNNNNDELKKAFKKSMKKNKGNKKAQFITIVLFALIGLMSFVFGNDFNSNKADNVGNLTNVSGNLEVSYLDVGQGDAVYI
RVNDFDILIDAGPRSEADHLLKQLEQKNIDDFEMVIATHPHEDHIGGMSKVFENYKVENFYMPKVTHTTKTFENMLTSVS
KQGLKVQQIKEGMKFDLGSDAKIDVYSPMKESYEEFNDYSPIMKLTFGDKKLMFTGDAETLVEKEVLSKYSKDLKADVLK
FGHHGSSTSSSNEFIQAVSPQYGIISCGTDNSYGHPHKETMKKISKNKIETYRTDLQGEITLSSDGKTISIKTKK
>Mature_315_residues
MNNNNDELKKAFKKSMKKNKGNKKAQFITIVLFALIGLMSFVFGNDFNSNKADNVGNLTNVSGNLEVSYLDVGQGDAVYI
RVNDFDILIDAGPRSEADHLLKQLEQKNIDDFEMVIATHPHEDHIGGMSKVFENYKVENFYMPKVTHTTKTFENMLTSVS
KQGLKVQQIKEGMKFDLGSDAKIDVYSPMKESYEEFNDYSPIMKLTFGDKKLMFTGDAETLVEKEVLSKYSKDLKADVLK
FGHHGSSTSSSNEFIQAVSPQYGIISCGTDNSYGHPHKETMKKISKNKIETYRTDLQGEITLSSDGKTISIKTKK

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=252, Percent_Identity=27.3809523809524, Blast_Score=89, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 35412; Mature: 35412

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNNNDELKKAFKKSMKKNKGNKKAQFITIVLFALIGLMSFVFGNDFNSNKADNVGNLTN
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
VSGNLEVSYLDVGQGDAVYIRVNDFDILIDAGPRSEADHLLKQLEQKNIDDFEMVIATHP
CCCCEEEEEEECCCCCEEEEEEECEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEEECC
HEDHIGGMSKVFENYKVENFYMPKVTHTTKTFENMLTSVSKQGLKVQQIKEGMKFDLGSD
CHHHCCCHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCC
AKIDVYSPMKESYEEFNDYSPIMKLTFGDKKLMFTGDAETLVEKEVLSKYSKDLKADVLK
CEEEECCHHHHHHHHHCCCCCEEEEEECCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
FGHHGSSTSSSNEFIQAVSPQYGIISCGTDNSYGHPHKETMKKISKNKIETYRTDLQGEI
HCCCCCCCCCCHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEE
TLSSDGKTISIKTKK
EECCCCCEEEEEECC
>Mature Secondary Structure
MNNNNDELKKAFKKSMKKNKGNKKAQFITIVLFALIGLMSFVFGNDFNSNKADNVGNLTN
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
VSGNLEVSYLDVGQGDAVYIRVNDFDILIDAGPRSEADHLLKQLEQKNIDDFEMVIATHP
CCCCEEEEEEECCCCCEEEEEEECEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEEECC
HEDHIGGMSKVFENYKVENFYMPKVTHTTKTFENMLTSVSKQGLKVQQIKEGMKFDLGSD
CHHHCCCHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCC
AKIDVYSPMKESYEEFNDYSPIMKLTFGDKKLMFTGDAETLVEKEVLSKYSKDLKADVLK
CEEEECCHHHHHHHHHCCCCCEEEEEECCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
FGHHGSSTSSSNEFIQAVSPQYGIISCGTDNSYGHPHKETMKKISKNKIETYRTDLQGEI
HCCCCCCCCCCHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEE
TLSSDGKTISIKTKK
EECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]