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The map label for this gene is cysK [H]

Identifier: 187935069

GI number: 187935069

Start: 3185708

End: 3186619

Strand: Reverse

Name: cysK [H]

Synonym: CLL_A3080

Alternate gene names: 187935069

Gene position: 3186619-3185708 (Counterclockwise)

Preceding gene: 187934094

Following gene: 187932641

Centisome position: 83.85

GC content: 31.36

Gene sequence:

>912_bases
ATGATTTACAATGGAATATTAGAATTAATAGGAAAAACACCAATTTTAAAATTAAATAATTTAGTTAGTGATGACAATAT
GGCAGCGGTTTATGTTAAGCTAGAAAAGTTTAATCCAGGTGGAAGTGTAAAAGATAGAGCAGCACTTGGCATGATAGAAA
AAGCTGAGAAGGAAGGTTTATTAAAAAAAGGATCAATCATAGTTGAACCAACAAGTGGAAATACAGGTATAGGTCTTGCT
TTAATAGGAAAGTTAAAGGGTTATAAAGTTATAATAGTTATGCCTGAAACAATGAGTAAAGAAAGAAGAGATTTAATTAA
GGCATATGGAGCAGAACTAGTATTAACAGATGGAAGTAAAGGTATGAAAGGTGCTATTGAAAAGGCTGTAGAAATAGCTA
TTGGAGATGAATATTTTATTCCACAACAATTTGAAAATTATGCTAATCCAGAAAAGCATTATGAAACAACTGCAGAAGAA
ATTTATAAAGATATACCTGATTTAGATGCAATTGTTGCAGGAGTTGGGACTGGTGGAACATTAGTTGGTATATCAAAAAA
CTTAAAGAATAAAAATGTTCAAATAAAAACAGTGGCAGTAGAGCCATTCTCATCACCAATATTAAGTGGAGGGAAGCCAG
GAGCACATAAAATACAAGGAATAGGTGCAGGCTTTATACCAGGAATATATGATGAAAAATATATAGATGAAGTTTTAAAG
GTAAAAGATGAAGATGCATTAAAAATAACTAAGGATGTTGCACAAATAGAAGGTGTCTTAGTAGGAATATCATCTGGAGC
TGCTATATATGGAGCTATTGAAATAGCAAAAAAACTAGGAAAAGGAAAAAAAGTATTAGCTATTGCTCCAGATGGAGGAG
AAAAATATATATCAATGGGAATATACGATTAA

Upstream 100 bases:

>100_bases
AAAAACTAATAAGATTTCTAAATATAAACTAGTCAAAAGGTTTATATTAAAAATAAGCAATATTTAAAATAATGAAAAAT
TAATTTAAGGGGGAGAAAAG

Downstream 100 bases:

>100_bases
TTTGGATTGTGATTTGATATATGTATAAATAAAGTCTGGTTATTAAATAGATTATCTATTATATATCAAAACTATATTAA
AATTAAATTCTATTGAAAAA

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MIYNGILELIGKTPILKLNNLVSDDNMAAVYVKLEKFNPGGSVKDRAALGMIEKAEKEGLLKKGSIIVEPTSGNTGIGLA
LIGKLKGYKVIIVMPETMSKERRDLIKAYGAELVLTDGSKGMKGAIEKAVEIAIGDEYFIPQQFENYANPEKHYETTAEE
IYKDIPDLDAIVAGVGTGGTLVGISKNLKNKNVQIKTVAVEPFSSPILSGGKPGAHKIQGIGAGFIPGIYDEKYIDEVLK
VKDEDALKITKDVAQIEGVLVGISSGAAIYGAIEIAKKLGKGKKVLAIAPDGGEKYISMGIYD

Sequences:

>Translated_303_residues
MIYNGILELIGKTPILKLNNLVSDDNMAAVYVKLEKFNPGGSVKDRAALGMIEKAEKEGLLKKGSIIVEPTSGNTGIGLA
LIGKLKGYKVIIVMPETMSKERRDLIKAYGAELVLTDGSKGMKGAIEKAVEIAIGDEYFIPQQFENYANPEKHYETTAEE
IYKDIPDLDAIVAGVGTGGTLVGISKNLKNKNVQIKTVAVEPFSSPILSGGKPGAHKIQGIGAGFIPGIYDEKYIDEVLK
VKDEDALKITKDVAQIEGVLVGISSGAAIYGAIEIAKKLGKGKKVLAIAPDGGEKYISMGIYD
>Mature_303_residues
MIYNGILELIGKTPILKLNNLVSDDNMAAVYVKLEKFNPGGSVKDRAALGMIEKAEKEGLLKKGSIIVEPTSGNTGIGLA
LIGKLKGYKVIIVMPETMSKERRDLIKAYGAELVLTDGSKGMKGAIEKAVEIAIGDEYFIPQQFENYANPEKHYETTAEE
IYKDIPDLDAIVAGVGTGGTLVGISKNLKNKNVQIKTVAVEPFSSPILSGGKPGAHKIQGIGAGFIPGIYDEKYIDEVLK
VKDEDALKITKDVAQIEGVLVGISSGAAIYGAIEIAKKLGKGKKVLAIAPDGGEKYISMGIYD

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=314, Percent_Identity=39.171974522293, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI295821200, Length=314, Percent_Identity=39.171974522293, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI4557415, Length=314, Percent_Identity=39.171974522293, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI11345492, Length=201, Percent_Identity=30.8457711442786, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1788754, Length=305, Percent_Identity=46.5573770491803, Blast_Score=233, Evalue=9e-63,
Organism=Escherichia coli, GI2367138, Length=296, Percent_Identity=40.2027027027027, Blast_Score=221, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI17535051, Length=300, Percent_Identity=47, Blast_Score=262, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17562970, Length=300, Percent_Identity=43.3333333333333, Blast_Score=234, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI32566674, Length=295, Percent_Identity=43.728813559322, Blast_Score=232, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI115535073, Length=298, Percent_Identity=44.6308724832215, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17561720, Length=302, Percent_Identity=42.7152317880795, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17534315, Length=320, Percent_Identity=37.5, Blast_Score=182, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25147552, Length=321, Percent_Identity=37.3831775700935, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=40.3755868544601, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17561716, Length=119, Percent_Identity=41.1764705882353, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321594, Length=321, Percent_Identity=38.9408099688474, Blast_Score=201, Evalue=9e-53,
Organism=Saccharomyces cerevisiae, GI6321449, Length=326, Percent_Identity=33.1288343558282, Blast_Score=133, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24643623, Length=314, Percent_Identity=38.5350318471338, Blast_Score=197, Evalue=7e-51,
Organism=Drosophila melanogaster, GI20129101, Length=314, Percent_Identity=38.5350318471338, Blast_Score=197, Evalue=7e-51,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32284; Mature: 32284

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYNGILELIGKTPILKLNNLVSDDNMAAVYVKLEKFNPGGSVKDRAALGMIEKAEKEGL
CCHHHHHHHHCCCCEEEECCCCCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCC
LKKGSIIVEPTSGNTGIGLALIGKLKGYKVIIVMPETMSKERRDLIKAYGAELVLTDGSK
EECCCEEEEECCCCCCEEEEEEECCCCEEEEEEECCHHCHHHHHHHHHCCCEEEEECCCC
GMKGAIEKAVEIAIGDEYFIPQQFENYANPEKHYETTAEEIYKDIPDLDAIVAGVGTGGT
CHHHHHHHHHEEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCCE
LVGISKNLKNKNVQIKTVAVEPFSSPILSGGKPGAHKIQGIGAGFIPGIYDEKYIDEVLK
EEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHH
VKDEDALKITKDVAQIEGVLVGISSGAAIYGAIEIAKKLGKGKKVLAIAPDGGEKYISMG
CCCCCHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEC
IYD
CCC
>Mature Secondary Structure
MIYNGILELIGKTPILKLNNLVSDDNMAAVYVKLEKFNPGGSVKDRAALGMIEKAEKEGL
CCHHHHHHHHCCCCEEEECCCCCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCC
LKKGSIIVEPTSGNTGIGLALIGKLKGYKVIIVMPETMSKERRDLIKAYGAELVLTDGSK
EECCCEEEEECCCCCCEEEEEEECCCCEEEEEEECCHHCHHHHHHHHHCCCEEEEECCCC
GMKGAIEKAVEIAIGDEYFIPQQFENYANPEKHYETTAEEIYKDIPDLDAIVAGVGTGGT
CHHHHHHHHHEEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCCE
LVGISKNLKNKNVQIKTVAVEPFSSPILSGGKPGAHKIQGIGAGFIPGIYDEKYIDEVLK
EEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHH
VKDEDALKITKDVAQIEGVLVGISSGAAIYGAIEIAKKLGKGKKVLAIAPDGGEKYISMG
CCCCCHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEC
IYD
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA