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The map label for this gene is flp [H]

Identifier: 187934626

GI number: 187934626

Start: 2131990

End: 2132703

Strand: Reverse

Name: flp [H]

Synonym: CLL_A2037

Alternate gene names: 187934626

Gene position: 2132703-2131990 (Counterclockwise)

Preceding gene: 187933531

Following gene: 187935483

Centisome position: 56.12

GC content: 24.79

Gene sequence:

>714_bases
ATGAATAATCATTGTGGTAATTGCTGTAATAATTGCAGAGGAGAACTTTGTGCAAGCAAGGTTTCAATATTTGAAAATTT
AAATAATGAGGAATTAATAGAGATTGTAAAAACTATTAATCATAAGGAATATAATAAAGGAGACATTATTTTTACTGAAG
GAAGTACAGCTAATACACTTTATTTTATAAATAAAGGAAAGATAAAATTATATAAGTATACTAAAGATGGTAAAGAACAG
ATATTGCATATACTTTCAGAAGGAGATCTTTTTGGAGAATTAAATTTAATAAAACCTTCTGAGTATGGATTTAATTCAAA
ATCAATAGTAAATTCTAAGATATGTACTCTTACTAAAGATGAAATGAAAGATATAATTATGAGAAATCCGGAAATTGGAA
TAAAGGTATTAGAAACTGTAGGAGAAAGATTAGGAAAAGTAGAAAGCCTTGTACAAAATCTAGCAACTAATGATGTGGAT
TCAAGAATGGCGTATTTATTAATAGATTTAATGGAAAGGTATGGAGAGACAATAGAAAATAATATATCTATAAAATTATC
ATTGTCAAGAGAAGATATGGCTAATTATATTGGAGTAACAAGAGAAACTATAAGTAGAAAATTAAAAAAATTTGAAGATG
AGAAATTAATAAAAATAGTAGGAACAAAGAATATTATAATTCTAGATGAAAAAGGCTTAAAAGATTATATTTAA

Upstream 100 bases:

>100_bases
TGTAAGATTAAGTGCCACAAATAAAGTTGCAACATAAAACATACATGTGGTATCTTACGTAAATTGATAAACTATCATAA
ATAAAATGGAAGGTGAGATT

Downstream 100 bases:

>100_bases
AAAAAGCTTATTATTACATTGATCGGTAATAATGAGCTTTTTTTAATGATTTTCACAGCTAAGCTGCAATGATTCTAACA
TAATAAATGTGAAAATAAAT

Product: Crp family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MNNHCGNCCNNCRGELCASKVSIFENLNNEELIEIVKTINHKEYNKGDIIFTEGSTANTLYFINKGKIKLYKYTKDGKEQ
ILHILSEGDLFGELNLIKPSEYGFNSKSIVNSKICTLTKDEMKDIIMRNPEIGIKVLETVGERLGKVESLVQNLATNDVD
SRMAYLLIDLMERYGETIENNISIKLSLSREDMANYIGVTRETISRKLKKFEDEKLIKIVGTKNIIILDEKGLKDYI

Sequences:

>Translated_237_residues
MNNHCGNCCNNCRGELCASKVSIFENLNNEELIEIVKTINHKEYNKGDIIFTEGSTANTLYFINKGKIKLYKYTKDGKEQ
ILHILSEGDLFGELNLIKPSEYGFNSKSIVNSKICTLTKDEMKDIIMRNPEIGIKVLETVGERLGKVESLVQNLATNDVD
SRMAYLLIDLMERYGETIENNISIKLSLSREDMANYIGVTRETISRKLKKFEDEKLIKIVGTKNIIILDEKGLKDYI
>Mature_237_residues
MNNHCGNCCNNCRGELCASKVSIFENLNNEELIEIVKTINHKEYNKGDIIFTEGSTANTLYFINKGKIKLYKYTKDGKEQ
ILHILSEGDLFGELNLIKPSEYGFNSKSIVNSKICTLTKDEMKDIIMRNPEIGIKVLETVGERLGKVESLVQNLATNDVD
SRMAYLLIDLMERYGETIENNISIKLSLSREDMANYIGVTRETISRKLKKFEDEKLIKIVGTKNIIILDEKGLKDYI

Specific function: Global Transcription Factor That Controls The Expression Of Over 100 Target Genes In Response To Anoxia. It Facilitates The Adaptation To Anaerobic Growth Conditions By Regulating The Expression Of Gene Products That Are Involved In Anaerobic Energy Metab

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=217, Percent_Identity=25.8064516129032, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1789756, Length=191, Percent_Identity=30.8900523560209, Blast_Score=88, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 27001; Mature: 27001

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS50042 CNMP_BINDING_3 ; PS00042 HTH_CRP_1 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNHCGNCCNNCRGELCASKVSIFENLNNEELIEIVKTINHKEYNKGDIIFTEGSTANTL
CCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEE
YFINKGKIKLYKYTKDGKEQILHILSEGDLFGELNLIKPSEYGFNSKSIVNSKICTLTKD
EEEECCEEEEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHCCHHHCCCHH
EMKDIIMRNPEIGIKVLETVGERLGKVESLVQNLATNDVDSRMAYLLIDLMERYGETIEN
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
NISIKLSLSREDMANYIGVTRETISRKLKKFEDEKLIKIVGTKNIIILDEKGLKDYI
CEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCCCCC
>Mature Secondary Structure
MNNHCGNCCNNCRGELCASKVSIFENLNNEELIEIVKTINHKEYNKGDIIFTEGSTANTL
CCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEE
YFINKGKIKLYKYTKDGKEQILHILSEGDLFGELNLIKPSEYGFNSKSIVNSKICTLTKD
EEEECCEEEEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHCCHHHCCCHH
EMKDIIMRNPEIGIKVLETVGERLGKVESLVQNLATNDVDSRMAYLLIDLMERYGETIEN
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
NISIKLSLSREDMANYIGVTRETISRKLKKFEDEKLIKIVGTKNIIILDEKGLKDYI
CEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2113923; 8441692 [H]