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The map label for this gene is proC [H]

Identifier: 187934225

GI number: 187934225

Start: 3776552

End: 3777352

Strand: Reverse

Name: proC [H]

Synonym: CLL_A3578

Alternate gene names: 187934225

Gene position: 3777352-3776552 (Counterclockwise)

Preceding gene: 187932892

Following gene: 187932377

Centisome position: 99.4

GC content: 30.09

Gene sequence:

>801_bases
ATGGATAAAAAAATTGGTTTTATAGGTTGTGGAAACATGGGAAGTTCTATGGTCGGAGGATTAATTAATTCAGGATCTTT
TGAATCTAAAGACATATTTGTTTCTACAAAAACAGAAAATTCAGCAAGCAATATGAAAGATAAATTTAACATCAATGCTA
GCATTAATAATAAGGATGTAGTTAAAAATTCTAATATAATTATTTTATCTGTTAAACCATATATGTTTAAAGATGTAATT
AACGAAATTAAGGATTATTTAACTGAAGATAAATTAATAATTAGTGTAGCAGCTGGGGTTACAATTGAAAATTTAGAAGA
TTTAATAAGCAAGAAACATAAGATAATTAGAAGTATGCCTAATACTCCAGCCTTAGTTGGAGAAGCAATGTCTGCAATAT
GTCCAAATGCAAATGTATCTAAAGAAGATATGGAAGTATGTAAAAAGGTATTTGAAAGCTTTGGAGAATGTGTTGAAATA
TCAGAAAAAGATTTTCATGCATTTATTGCTTTATGTGGATCATCACCAGCATATATATTTATGTTTATAGAAGCTATGGC
AGATGGTGCGGTAAAATTAGGAATACCTAGAAATAAAGCTTATAAGATGGCAGCTCAGAGTGTATTGGGTTCTGCAAAAA
TGGTTTTAGATACAAGAAAACACCCAGGAGAATTAAAAGATGCAGTTTGTTCACCTGGTGGAACTACAATTGATGCTGTA
GTTGAATTAGAGAAGTTAGGCTTTAGAAGTAGTGTTATTCAAGCTATGGATAAATGTGCAGAGAAGTCTAAAAATATGTA
G

Upstream 100 bases:

>100_bases
ATATGCATAAGTAGGTGTACAGAGTAATTGAATTTAAAAATGTTATTTTAAAACATGGATTTAAAATGTAATAAAAATAA
AAAAATTGGGGGCTTAATTT

Downstream 100 bases:

>100_bases
TGTATCTGAAATAGGTTATGTTTTAAGAGGATATTTATATATACATAAGCGAAGTGGACTGAGTAATTGAACTTAGCAAT
ACTAAAATAAATATAGTTTT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MDKKIGFIGCGNMGSSMVGGLINSGSFESKDIFVSTKTENSASNMKDKFNINASINNKDVVKNSNIIILSVKPYMFKDVI
NEIKDYLTEDKLIISVAAGVTIENLEDLISKKHKIIRSMPNTPALVGEAMSAICPNANVSKEDMEVCKKVFESFGECVEI
SEKDFHAFIALCGSSPAYIFMFIEAMADGAVKLGIPRNKAYKMAAQSVLGSAKMVLDTRKHPGELKDAVCSPGGTTIDAV
VELEKLGFRSSVIQAMDKCAEKSKNM

Sequences:

>Translated_266_residues
MDKKIGFIGCGNMGSSMVGGLINSGSFESKDIFVSTKTENSASNMKDKFNINASINNKDVVKNSNIIILSVKPYMFKDVI
NEIKDYLTEDKLIISVAAGVTIENLEDLISKKHKIIRSMPNTPALVGEAMSAICPNANVSKEDMEVCKKVFESFGECVEI
SEKDFHAFIALCGSSPAYIFMFIEAMADGAVKLGIPRNKAYKMAAQSVLGSAKMVLDTRKHPGELKDAVCSPGGTTIDAV
VELEKLGFRSSVIQAMDKCAEKSKNM
>Mature_266_residues
MDKKIGFIGCGNMGSSMVGGLINSGSFESKDIFVSTKTENSASNMKDKFNINASINNKDVVKNSNIIILSVKPYMFKDVI
NEIKDYLTEDKLIISVAAGVTIENLEDLISKKHKIIRSMPNTPALVGEAMSAICPNANVSKEDMEVCKKVFESFGECVEI
SEKDFHAFIALCGSSPAYIFMFIEAMADGAVKLGIPRNKAYKMAAQSVLGSAKMVLDTRKHPGELKDAVCSPGGTTIDAV
VELEKLGFRSSVIQAMDKCAEKSKNM

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=267, Percent_Identity=36.7041198501873, Blast_Score=191, Evalue=5e-49,
Organism=Homo sapiens, GI198041662, Length=264, Percent_Identity=31.4393939393939, Blast_Score=187, Evalue=6e-48,
Organism=Homo sapiens, GI24797095, Length=266, Percent_Identity=34.9624060150376, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI24797097, Length=266, Percent_Identity=34.9624060150376, Blast_Score=185, Evalue=5e-47,
Organism=Escherichia coli, GI1786585, Length=266, Percent_Identity=51.8796992481203, Blast_Score=285, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17569021, Length=262, Percent_Identity=37.4045801526718, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17540664, Length=276, Percent_Identity=36.231884057971, Blast_Score=163, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6320861, Length=285, Percent_Identity=30.1754385964912, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21358587, Length=264, Percent_Identity=36.7424242424242, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24648116, Length=275, Percent_Identity=37.4545454545455, Blast_Score=185, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24647700, Length=168, Percent_Identity=39.8809523809524, Blast_Score=150, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28832; Mature: 28832

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKKIGFIGCGNMGSSMVGGLINSGSFESKDIFVSTKTENSASNMKDKFNINASINNKDV
CCCCEEEEECCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCHHCCCHHEEEEECCCCCCE
VKNSNIIILSVKPYMFKDVINEIKDYLTEDKLIISVAAGVTIENLEDLISKKHKIIRSMP
EECCCEEEEEECHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCC
NTPALVGEAMSAICPNANVSKEDMEVCKKVFESFGECVEISEKDFHAFIALCGSSPAYIF
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHH
MFIEAMADGAVKLGIPRNKAYKMAAQSVLGSAKMVLDTRKHPGELKDAVCSPGGTTIDAV
HHHHHHHCCCEEECCCCCHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHCCCCCCHHHHH
VELEKLGFRSSVIQAMDKCAEKSKNM
HHHHHHCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDKKIGFIGCGNMGSSMVGGLINSGSFESKDIFVSTKTENSASNMKDKFNINASINNKDV
CCCCEEEEECCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCHHCCCHHEEEEECCCCCCE
VKNSNIIILSVKPYMFKDVINEIKDYLTEDKLIISVAAGVTIENLEDLISKKHKIIRSMP
EECCCEEEEEECHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCC
NTPALVGEAMSAICPNANVSKEDMEVCKKVFESFGECVEISEKDFHAFIALCGSSPAYIF
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHH
MFIEAMADGAVKLGIPRNKAYKMAAQSVLGSAKMVLDTRKHPGELKDAVCSPGGTTIDAV
HHHHHHHCCCEEECCCCCHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHCCCCCCHHHHH
VELEKLGFRSSVIQAMDKCAEKSKNM
HHHHHHCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]