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The map label for this gene is thiD [H]

Identifier: 187934219

GI number: 187934219

Start: 3213852

End: 3214637

Strand: Reverse

Name: thiD [H]

Synonym: CLL_A3106

Alternate gene names: 187934219

Gene position: 3214637-3213852 (Counterclockwise)

Preceding gene: 187933416

Following gene: 187935001

Centisome position: 84.59

GC content: 30.79

Gene sequence:

>786_bases
ATGTTTAAAGCATTAACTATAGCAGGATCAGATAGTTGTGGAGGGGCAGGCATTCAAGCAGATTTAAAATCTTTTTCAGC
TAATGGAGTATATGGAATGAGTGTTATTACAGCAATAACAGCACAAAATACAATGGGAGTCTTTGGAATACAAGATATAA
ATCCAGAAATTATTGAATCACAAATAAATGTTATTTTTGATGACATTATTGTTGATGCAGTAAAGATAGGTATGGTTTCA
AAAATTGAATCTATAAAAGCTATATCAGAAGGATTAAAAAAAGTTAAGAACTTACCAAAGGTAGTTTTAGATCCAGTTAT
GATTTCTAAAAGTGGATTTAATTTATTATCTCCAGATGCGAAGGAAACATTAATTGAAGAATTGTTTCCGTTAGCAACTT
TAATAACTCCAAATCTTCCTGAAGCAGAAGAGATATTAGGAATGAAAATAAGCAATTTAGACGAAATGAAAGAAGCAGCT
AAAAAATTACAAGAATTAGGACCCAAATATGTATTGGTTAAAGGTGGGCACTTGGAAGATGATGCAACTGATTTATTACT
TTATGGAGATGAATTTGTTTTCCTTCCACAAAGAAGAATAAATACAGTTCATACTCATGGGACAGGCTGTACATTATCAT
CAGCAATTGCAGCAAATTTAGCTAAAGGATTAGATGTTAAAGAGTCTGTCATAAATGCAAAGGAATATATAACAGGTGCA
ATAGAAAATGGATTTTCAATTGGAAATGGTGTAGGACCAACTCATCATTTTTATAAATTTTATTAA

Upstream 100 bases:

>100_bases
TTTTAGTAAAAAATCAAGTAAATTTAAATCAATCAAAAGGCACTGAATAGGTGCAATTTATTTAATTATAAAGACGTGAT
AAAAGAGAGGATGAATAAAA

Downstream 100 bases:

>100_bases
AAATACAATGTCCATATATTCAAAAGAGAAGTTGCTTGTGTAATTGAGATTAGAAATACTAAAATAGTTCAATTACAATG
CAACGTTACTTATTTAAGTA

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MFKALTIAGSDSCGGAGIQADLKSFSANGVYGMSVITAITAQNTMGVFGIQDINPEIIESQINVIFDDIIVDAVKIGMVS
KIESIKAISEGLKKVKNLPKVVLDPVMISKSGFNLLSPDAKETLIEELFPLATLITPNLPEAEEILGMKISNLDEMKEAA
KKLQELGPKYVLVKGGHLEDDATDLLLYGDEFVFLPQRRINTVHTHGTGCTLSSAIAANLAKGLDVKESVINAKEYITGA
IENGFSIGNGVGPTHHFYKFY

Sequences:

>Translated_261_residues
MFKALTIAGSDSCGGAGIQADLKSFSANGVYGMSVITAITAQNTMGVFGIQDINPEIIESQINVIFDDIIVDAVKIGMVS
KIESIKAISEGLKKVKNLPKVVLDPVMISKSGFNLLSPDAKETLIEELFPLATLITPNLPEAEEILGMKISNLDEMKEAA
KKLQELGPKYVLVKGGHLEDDATDLLLYGDEFVFLPQRRINTVHTHGTGCTLSSAIAANLAKGLDVKESVINAKEYITGA
IENGFSIGNGVGPTHHFYKFY
>Mature_261_residues
MFKALTIAGSDSCGGAGIQADLKSFSANGVYGMSVITAITAQNTMGVFGIQDINPEIIESQINVIFDDIIVDAVKIGMVS
KIESIKAISEGLKKVKNLPKVVLDPVMISKSGFNLLSPDAKETLIEELFPLATLITPNLPEAEEILGMKISNLDEMKEAA
KKLQELGPKYVLVKGGHLEDDATDLLLYGDEFVFLPQRRINTVHTHGTGCTLSSAIAANLAKGLDVKESVINAKEYITGA
IENGFSIGNGVGPTHHFYKFY

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=264, Percent_Identity=44.3181818181818, Blast_Score=223, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6325378, Length=269, Percent_Identity=35.6877323420074, Blast_Score=165, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6324997, Length=270, Percent_Identity=37.037037037037, Blast_Score=145, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6324517, Length=270, Percent_Identity=36.6666666666667, Blast_Score=142, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28016; Mature: 28016

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKALTIAGSDSCGGAGIQADLKSFSANGVYGMSVITAITAQNTMGVFGIQDINPEIIES
CCEEEEEECCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHH
QINVIFDDIIVDAVKIGMVSKIESIKAISEGLKKVKNLPKVVLDPVMISKSGFNLLSPDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCHHHCCCCCCCCCCCCH
KETLIEELFPLATLITPNLPEAEEILGMKISNLDEMKEAAKKLQELGPKYVLVKGGHLED
HHHHHHHHHHHHHHHCCCCCCHHHHHCCHHCCHHHHHHHHHHHHHCCCCEEEEECCCCCC
DATDLLLYGDEFVFLPQRRINTVHTHGTGCTLSSAIAANLAKGLDVKESVINAKEYITGA
CCCEEEEECCCEEEECHHHCCEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IENGFSIGNGVGPTHHFYKFY
HHCCCCCCCCCCCCCCCEECC
>Mature Secondary Structure
MFKALTIAGSDSCGGAGIQADLKSFSANGVYGMSVITAITAQNTMGVFGIQDINPEIIES
CCEEEEEECCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHH
QINVIFDDIIVDAVKIGMVSKIESIKAISEGLKKVKNLPKVVLDPVMISKSGFNLLSPDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCHHHCCCCCCCCCCCCH
KETLIEELFPLATLITPNLPEAEEILGMKISNLDEMKEAAKKLQELGPKYVLVKGGHLED
HHHHHHHHHHHHHHHCCCCCCHHHHHCCHHCCHHHHHHHHHHHHHCCCCEEEEECCCCCC
DATDLLLYGDEFVFLPQRRINTVHTHGTGCTLSSAIAANLAKGLDVKESVINAKEYITGA
CCCEEEEECCCEEEECHHHCCEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IENGFSIGNGVGPTHHFYKFY
HHCCCCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481431; 8246891 [H]