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The map label for this gene is thiM [H]

Identifier: 187935001

GI number: 187935001

Start: 3212822

End: 3213658

Strand: Reverse

Name: thiM [H]

Synonym: CLL_A3105

Alternate gene names: 187935001

Gene position: 3213658-3212822 (Counterclockwise)

Preceding gene: 187934219

Following gene: 187933174

Centisome position: 84.56

GC content: 32.14

Gene sequence:

>837_bases
ATGATTAACGAAATATTAGATAAGGTTGTAAGGTTATTAGAAGAGGTTAGAGCAAAGAAACCATTAGTACATAGTATAAC
TAATTATATTACAGCAACAGATTGTGCAAATGTAATTTTAGCAGTTGGAGGTTCCCCAACTATGGCTGATTATGTTAAGG
AGGTTGAAGAAATCGCAAGTATTTCATCGGCAGTAGTTTTAAATATGGGAGTTATAAGTGATGGTATGGTTGAATCTATG
ATTCTTGCAGGAAAGAGTGCTAATAAAAATAATGTGCCAGTTATTTTTGATCCAGTTGGAGCTGGAGTAGCTAATTTTAG
AAATGAAAGTGCAGAAAAGATATTGAGTGAAGTGAAGATAGATATAATTAGGGGAAACATTTCTGAAATAAAATTTATAT
GTGGATTAAGTTCTGAAACAAAAGGTGTTGATGCTTCAGAAAGTGATATGAATATGGGGAATGATAAAAAAGCAATTGTA
GCGCAAGAACTAGCGAAAAAATTAAATTGTGTTGTGGCAATTACAGGGGTAGATGATATTATTTCAGATGGAAAAAGAAA
TGTAATTTTATCTAATGGACATAAAATGCTTGCAAATGTAACAGGAACAGGATGTATGAGTAGTGCATTATGTGGAGCTT
TTGCTGGAGCTAGTAATGATTATTTTATAGCAGCCATATGTGCAATTTTAACAATGGGTATAAGTGGTGAAATTGCGTAT
GAAAAATCTAAGGGAATAGGAATGGGAACTTTCCATACTTCACTTATTGATGCTATTAGTATGATGAATGAAAATATTAT
AAAGGAAAAGGCGAAGGTAACAACAATTAATAGATAG

Upstream 100 bases:

>100_bases
TTAAGTATATAAAAATATATTCAAAGTAATACTTTATATTAAAAATTAGAAAATAATTTTTACAAATACACTATGATTAA
GAGATGGGGATGTGAAATTA

Downstream 100 bases:

>100_bases
CTATTAATACTTAATTATTCATAAAAATACTTTTAATAATTAGTTAGGGACTAGTATTTATTTTTTGAAAAGAACCATGT
TATATTAAAAATTTAATTAA

Product: hydroxyethylthiazole kinase

Products: NA

Alternate protein names: 4-methyl-5-beta-hydroxyethylthiazole kinase; TH kinase; Thz kinase [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MINEILDKVVRLLEEVRAKKPLVHSITNYITATDCANVILAVGGSPTMADYVKEVEEIASISSAVVLNMGVISDGMVESM
ILAGKSANKNNVPVIFDPVGAGVANFRNESAEKILSEVKIDIIRGNISEIKFICGLSSETKGVDASESDMNMGNDKKAIV
AQELAKKLNCVVAITGVDDIISDGKRNVILSNGHKMLANVTGTGCMSSALCGAFAGASNDYFIAAICAILTMGISGEIAY
EKSKGIGMGTFHTSLIDAISMMNENIIKEKAKVTTINR

Sequences:

>Translated_278_residues
MINEILDKVVRLLEEVRAKKPLVHSITNYITATDCANVILAVGGSPTMADYVKEVEEIASISSAVVLNMGVISDGMVESM
ILAGKSANKNNVPVIFDPVGAGVANFRNESAEKILSEVKIDIIRGNISEIKFICGLSSETKGVDASESDMNMGNDKKAIV
AQELAKKLNCVVAITGVDDIISDGKRNVILSNGHKMLANVTGTGCMSSALCGAFAGASNDYFIAAICAILTMGISGEIAY
EKSKGIGMGTFHTSLIDAISMMNENIIKEKAKVTTINR
>Mature_278_residues
MINEILDKVVRLLEEVRAKKPLVHSITNYITATDCANVILAVGGSPTMADYVKEVEEIASISSAVVLNMGVISDGMVESM
ILAGKSANKNNVPVIFDPVGAGVANFRNESAEKILSEVKIDIIRGNISEIKFICGLSSETKGVDASESDMNMGNDKKAIV
AQELAKKLNCVVAITGVDDIISDGKRNVILSNGHKMLANVTGTGCMSSALCGAFAGASNDYFIAAICAILTMGISGEIAY
EKSKGIGMGTFHTSLIDAISMMNENIIKEKAKVTTINR

Specific function: Thiamine biosynthesis. [C]

COG id: COG2145

COG function: function code H; Hydroxyethylthiazole kinase, sugar kinase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Thz kinase family [H]

Homologues:

Organism=Escherichia coli, GI1788421, Length=254, Percent_Identity=30.7086614173228, Blast_Score=128, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6325042, Length=280, Percent_Identity=29.6428571428571, Blast_Score=98, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000417 [H]

Pfam domain/function: PF02110 HK [H]

EC number: =2.7.1.50 [H]

Molecular weight: Translated: 29382; Mature: 29382

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINEILDKVVRLLEEVRAKKPLVHSITNYITATDCANVILAVGGSPTMADYVKEVEEIAS
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHH
ISSAVVLNMGVISDGMVESMILAGKSANKNNVPVIFDPVGAGVANFRNESAEKILSEVKI
HHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHCCHHHHHHHHHHHH
DIIRGNISEIKFICGLSSETKGVDASESDMNMGNDKKAIVAQELAKKLNCVVAITGVDDI
HHEECCHHHEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECHHHH
ISDGKRNVILSNGHKMLANVTGTGCMSSALCGAFAGASNDYFIAAICAILTMGISGEIAY
HCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEE
EKSKGIGMGTFHTSLIDAISMMNENIIKEKAKVTTINR
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MINEILDKVVRLLEEVRAKKPLVHSITNYITATDCANVILAVGGSPTMADYVKEVEEIAS
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHH
ISSAVVLNMGVISDGMVESMILAGKSANKNNVPVIFDPVGAGVANFRNESAEKILSEVKI
HHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHCCHHHHHHHHHHHH
DIIRGNISEIKFICGLSSETKGVDASESDMNMGNDKKAIVAQELAKKLNCVVAITGVDDI
HHEECCHHHEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECHHHH
ISDGKRNVILSNGHKMLANVTGTGCMSSALCGAFAGASNDYFIAAICAILTMGISGEIAY
HCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEE
EKSKGIGMGTFHTSLIDAISMMNENIIKEKAKVTTINR
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA