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The map label for this gene is cobD [H]

Identifier: 187934156

GI number: 187934156

Start: 3002333

End: 3003283

Strand: Reverse

Name: cobD [H]

Synonym: CLL_A2919

Alternate gene names: 187934156

Gene position: 3003283-3002333 (Counterclockwise)

Preceding gene: 187932890

Following gene: 187933455

Centisome position: 79.03

GC content: 27.87

Gene sequence:

>951_bases
ATGATAGAATTAACTATTGGATTTTTTTTAGATCTAATAATTGGAGATCCAGAAAATCCAATACATCCAGTTAGAATAAT
TGGAAATTTTGCTAGTAAATTAGAAAAATTAACTAGAAAGTTATTTAAGAAGTGCCTAAAGATAGGTGGTCTTCTTACTT
GGTTAATAGTTATAAGTATTACATTTTTAATTAATTTTTTTATATTAAAGATTGTAAGTGATTTTAATAAGTATTTAGGG
ATATTTTTAGGGGGAGTGGTAATATATTTCTGTATTTCTGCTAAAGGATTAGTGACAGAAGGATATAAAGTTATTTCATT
AGTGAGAAAAGATGATATTAAAGCTGCAAGAAAGCAATTATCATTTATAGTAGGAAGAGATACTGAAAATTTAGATAAAC
AAGATATAATAAGAGCTGTAATAGAGACAATTGCAGAAAATATGTCAGATGGAATTATAGCACCAATTTTTTATGCAGGA
CTTGGAGGTGCACCATTAGCTATGGCATATAAAGCAGTAAATACTTTAGATTCTATGTTTGGATATAAAAATGATAAATA
TATGGAGTTTGGATATTTTTCTGCAAAACTAGATGATGTATTTAATTATATTCCAGCAAGAATCACAGGGGTTTTAATAG
TATTATCAGCTATGATTTTAGGGTATGATTATAAACGTAGCTTTAAAATATATAAAAGAGATAGATATAATCATTCAAGT
CCTAATAGTGCTCATCCAGAAGCTGCAATGGCAGGTATATTAGGAGTTCAGCTTGGAGGAGAAAACTACTATTTTGGAAA
ATTAGTTAAAAAGCAAACTATAGGAGAGAGTATTAAGGAAATAGAGGTTTTGGATGTGGACAAAACGTCAAAAGTACTTT
ACTGTAGTGCTATTTTATCATACATATTATCAATTATATTAATTTTTATTGGAGGACATATCTATGGCTAA

Upstream 100 bases:

>100_bases
GTTTTAAATGTGTGTTGATATATGAATAAGCAAACCTAAATTACACAACTAAACTTAGCCTAAAATTAAAATATAATATA
TATTAAGGGTGGTTTATAGA

Downstream 100 bases:

>100_bases
TACAGGACATGGTGGAAATATAAAAGAGATAGCAAGAAAAAAAGGAATTGATTACAATAATATAATAGATTTTTCATCAA
ATATTAATCCTTTAGGTATG

Product: cobalamin biosynthesis protein

Products: ADP; phosphate; Adenosyl cobinamide phosphate; Adenosyl cobinamide

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MIELTIGFFLDLIIGDPENPIHPVRIIGNFASKLEKLTRKLFKKCLKIGGLLTWLIVISITFLINFFILKIVSDFNKYLG
IFLGGVVIYFCISAKGLVTEGYKVISLVRKDDIKAARKQLSFIVGRDTENLDKQDIIRAVIETIAENMSDGIIAPIFYAG
LGGAPLAMAYKAVNTLDSMFGYKNDKYMEFGYFSAKLDDVFNYIPARITGVLIVLSAMILGYDYKRSFKIYKRDRYNHSS
PNSAHPEAAMAGILGVQLGGENYYFGKLVKKQTIGESIKEIEVLDVDKTSKVLYCSAILSYILSIILIFIGGHIYG

Sequences:

>Translated_316_residues
MIELTIGFFLDLIIGDPENPIHPVRIIGNFASKLEKLTRKLFKKCLKIGGLLTWLIVISITFLINFFILKIVSDFNKYLG
IFLGGVVIYFCISAKGLVTEGYKVISLVRKDDIKAARKQLSFIVGRDTENLDKQDIIRAVIETIAENMSDGIIAPIFYAG
LGGAPLAMAYKAVNTLDSMFGYKNDKYMEFGYFSAKLDDVFNYIPARITGVLIVLSAMILGYDYKRSFKIYKRDRYNHSS
PNSAHPEAAMAGILGVQLGGENYYFGKLVKKQTIGESIKEIEVLDVDKTSKVLYCSAILSYILSIILIFIGGHIYG
>Mature_316_residues
MIELTIGFFLDLIIGDPENPIHPVRIIGNFASKLEKLTRKLFKKCLKIGGLLTWLIVISITFLINFFILKIVSDFNKYLG
IFLGGVVIYFCISAKGLVTEGYKVISLVRKDDIKAARKQLSFIVGRDTENLDKQDIIRAVIETIAENMSDGIIAPIFYAG
LGGAPLAMAYKAVNTLDSMFGYKNDKYMEFGYFSAKLDDVFNYIPARITGVLIVLSAMILGYDYKRSFKIYKRDRYNHSS
PNSAHPEAAMAGILGVQLGGENYYFGKLVKKQTIGESIKEIEVLDVDKTSKVLYCSAILSYILSIILIFIGGHIYG

Specific function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group [H]

COG id: COG1270

COG function: function code H; Cobalamin biosynthesis protein CobD/CbiB

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobD/CbiB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004485 [H]

Pfam domain/function: PF03186 CobD_Cbib [H]

EC number: 6.3.1.10

Molecular weight: Translated: 35300; Mature: 35300

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELTIGFFLDLIIGDPENPIHPVRIIGNFASKLEKLTRKLFKKCLKIGGLLTWLIVISI
CEEEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFLINFFILKIVSDFNKYLGIFLGGVVIYFCISAKGLVTEGYKVISLVRKDDIKAARKQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHH
SFIVGRDTENLDKQDIIRAVIETIAENMSDGIIAPIFYAGLGGAPLAMAYKAVNTLDSMF
HHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHH
GYKNDKYMEFGYFSAKLDDVFNYIPARITGVLIVLSAMILGYDYKRSFKIYKRDRYNHSS
CCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCC
PNSAHPEAAMAGILGVQLGGENYYFGKLVKKQTIGESIKEIEVLDVDKTSKVLYCSAILS
CCCCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHH
YILSIILIFIGGHIYG
HHHHHHHHHHCCCCCC
>Mature Secondary Structure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HHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyric acid; (R)-1-aminopropan-2-yl phosphate; (R)-1-aminopropan-2-ol

Specific reaction: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate; (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11792842 [H]