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The map label for this gene is thrS [H]

Identifier: 187933922

GI number: 187933922

Start: 3217495

End: 3219141

Strand: Reverse

Name: thrS [H]

Synonym: CLL_A3110

Alternate gene names: 187933922

Gene position: 3219141-3217495 (Counterclockwise)

Preceding gene: 187932797

Following gene: 187934314

Centisome position: 84.71

GC content: 25.56

Gene sequence:

>1647_bases
ATGAATTCAATAATTTATAATATTAAAAATAAAGAACAAAATTCTACTGATACTTTTTATGATATATTATCTAAAGATAT
AGTAGAAGTTAAGAATATAGCATTATGTAAATTGAATGGAAAATATAATGAATTAAGAGATATTGTTAATGAAAGTGGAA
AAATTGAAACAATAACATTTAACACAGAAATGGGCTTAAATATATATACAAGAACTTTACAATTCATATTTATTAAAGCG
ACGTTAGATTTATTTCCAAATTCAAAAATAAAAATAGAACATTCAATTAGTAAGGGGTTATTTGGAGAGATAATCAAAGA
AAAGCCTTTAAGTGAGGAAGATATAAAATTAATTAAAGAAAAAATGAAAGAAATTATTTCAAAAGATGTACCTATAAATA
GTATAAGAATTTCTAAAAATGAAGCTATTAATATATTTAAAAAATATGGAATGGAAGATAAAATTTCACTTTTACAATAT
TCTAATCTTAATCAAGTAAAATTATATGAATTAGAAGGTAGATACGATTATTTTTATGGTCATATGGCATATTCAACAGG
TGTTATAAGAGCTTTTGATTTAATTTACTATGAATCAGGGTTTATATTAAGAAGCCCTGAAAAAGAAAATTTAAATGAAC
TTCCACAATATAAAGAAGAAAGAAAGTTAAGAAGTATATTTTTTGAAACAGAAAAATGGCTTAGTATATTAGATATTGGA
GAAGTAGGAACTTTAAATGAAAAACTTTCCAGTAATGAAGCACAAAGTTTAATATTAACTTCAGAAGCACTACATGAAAA
GAAGATAGCTAATATAGCGGATCAAATAGCTAATAAAAAGGATTCAAAAATAGTTCTTATTGCAGGTCCATCATCTTCAG
GAAAAACTACTTTTGCAAATAGGCTTTCAATACAACTCAAGGTTAATGGATTAATTCCTCAGTCATTATCATTAGATGAT
TATTTTGTGGAAAGAGTGAATACACCTAGAGATGAAAATGGAGATTATGATTATGAATCTATTTATGCGTTAGATCTAGA
ATTGATTAATAAATCACTTACAGCTTTAATGAATGGTGAGGTTGTTGATATTCCTACTTATAATTTTTTCACAGGTAAGA
GAGAGTGGAATGGAAATAAGATAAAATTACATGAAAATGGTGTATTGATATTAGAAGGAATTCATGGATTAAATCCTATA
TTAACATCAGGTGTTGATCAAAACAAAATTTTTAAAGTATATATTTCAGCATTGACTCAATTAAATTTAGATAATCATAA
TAGGATATCTACAACAGACGTTAGAAAAGTTAGAAGGATAGTTAGAGATTCATTAAGTAGAGGACATGATGCAGAAGCAA
CTCTTAAAATGTGGCCTTCAATAAAAAAAGGTGAAAAGAATAATATATTTGTTTATCAAGATCAAGCTGATGCAATGTTT
AATTCAACATTAGTGTATGAACTAGGATTGTTAAAACCACATGCGTTAAAAGAATTAAATAAAGTCAAAGAAGAAAGTCC
AGTATATGCAGAAGCAGCAAGGCTAAAATCAATATTAAATTTTTTTAAAGAAGTAGATTCATCTTATATACCTATGAATT
CAATACTTAGAGAATTTATAGGTGGAAGTTGCTTCTATGAATATTAA

Upstream 100 bases:

>100_bases
TTCATTGGAATATGCAAAATAAAAAATAAATTTATCTTTTTATGGGAAATTAGATATAATATAATATAGGGCAACTAGAG
TTTTTGGGAGGATATAGTTA

Downstream 100 bases:

>100_bases
ATATAATAGGCATATGAAAATAGATAACAAGTTAAAGATACGATGGATATTTTGTGAAATACAATGAATTTGGTTCTACT
AGTATTTGTATTATTAGTAG

Product: uridine kinase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MNSIIYNIKNKEQNSTDTFYDILSKDIVEVKNIALCKLNGKYNELRDIVNESGKIETITFNTEMGLNIYTRTLQFIFIKA
TLDLFPNSKIKIEHSISKGLFGEIIKEKPLSEEDIKLIKEKMKEIISKDVPINSIRISKNEAINIFKKYGMEDKISLLQY
SNLNQVKLYELEGRYDYFYGHMAYSTGVIRAFDLIYYESGFILRSPEKENLNELPQYKEERKLRSIFFETEKWLSILDIG
EVGTLNEKLSSNEAQSLILTSEALHEKKIANIADQIANKKDSKIVLIAGPSSSGKTTFANRLSIQLKVNGLIPQSLSLDD
YFVERVNTPRDENGDYDYESIYALDLELINKSLTALMNGEVVDIPTYNFFTGKREWNGNKIKLHENGVLILEGIHGLNPI
LTSGVDQNKIFKVYISALTQLNLDNHNRISTTDVRKVRRIVRDSLSRGHDAEATLKMWPSIKKGEKNNIFVYQDQADAMF
NSTLVYELGLLKPHALKELNKVKEESPVYAEAARLKSILNFFKEVDSSYIPMNSILREFIGGSCFYEY

Sequences:

>Translated_548_residues
MNSIIYNIKNKEQNSTDTFYDILSKDIVEVKNIALCKLNGKYNELRDIVNESGKIETITFNTEMGLNIYTRTLQFIFIKA
TLDLFPNSKIKIEHSISKGLFGEIIKEKPLSEEDIKLIKEKMKEIISKDVPINSIRISKNEAINIFKKYGMEDKISLLQY
SNLNQVKLYELEGRYDYFYGHMAYSTGVIRAFDLIYYESGFILRSPEKENLNELPQYKEERKLRSIFFETEKWLSILDIG
EVGTLNEKLSSNEAQSLILTSEALHEKKIANIADQIANKKDSKIVLIAGPSSSGKTTFANRLSIQLKVNGLIPQSLSLDD
YFVERVNTPRDENGDYDYESIYALDLELINKSLTALMNGEVVDIPTYNFFTGKREWNGNKIKLHENGVLILEGIHGLNPI
LTSGVDQNKIFKVYISALTQLNLDNHNRISTTDVRKVRRIVRDSLSRGHDAEATLKMWPSIKKGEKNNIFVYQDQADAMF
NSTLVYELGLLKPHALKELNKVKEESPVYAEAARLKSILNFFKEVDSSYIPMNSILREFIGGSCFYEY
>Mature_548_residues
MNSIIYNIKNKEQNSTDTFYDILSKDIVEVKNIALCKLNGKYNELRDIVNESGKIETITFNTEMGLNIYTRTLQFIFIKA
TLDLFPNSKIKIEHSISKGLFGEIIKEKPLSEEDIKLIKEKMKEIISKDVPINSIRISKNEAINIFKKYGMEDKISLLQY
SNLNQVKLYELEGRYDYFYGHMAYSTGVIRAFDLIYYESGFILRSPEKENLNELPQYKEERKLRSIFFETEKWLSILDIG
EVGTLNEKLSSNEAQSLILTSEALHEKKIANIADQIANKKDSKIVLIAGPSSSGKTTFANRLSIQLKVNGLIPQSLSLDD
YFVERVNTPRDENGDYDYESIYALDLELINKSLTALMNGEVVDIPTYNFFTGKREWNGNKIKLHENGVLILEGIHGLNPI
LTSGVDQNKIFKVYISALTQLNLDNHNRISTTDVRKVRRIVRDSLSRGHDAEATLKMWPSIKKGEKNNIFVYQDQADAMF
NSTLVYELGLLKPHALKELNKVKEESPVYAEAARLKSILNFFKEVDSSYIPMNSILREFIGGSCFYEY

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0572

COG function: function code F; Uridine kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

None

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 62826; Mature: 62826

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSIIYNIKNKEQNSTDTFYDILSKDIVEVKNIALCKLNGKYNELRDIVNESGKIETITF
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHCCCCCEEEEEE
NTEMGLNIYTRTLQFIFIKATLDLFPNSKIKIEHSISKGLFGEIIKEKPLSEEDIKLIKE
ECCCCCHHHHHEEEEEEEEEEHHHCCCCEEEEEECHHHHHHHHHHHCCCCCHHHHHHHHH
KMKEIISKDVPINSIRISKNEAINIFKKYGMEDKISLLQYSNLNQVKLYELEGRYDYFYG
HHHHHHHCCCCCCEEEECCCHHHHHHHHCCCCHHHHHHCCCCCCEEEEEEECCCEEEEEE
HMAYSTGVIRAFDLIYYESGFILRSPEKENLNELPQYKEERKLRSIFFETEKWLSILDIG
EHHHHCCHHHHHEEEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
EVGTLNEKLSSNEAQSLILTSEALHEKKIANIADQIANKKDSKIVLIAGPSSSGKTTFAN
CCCCCHHHHCCCCHHEEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEE
RLSIQLKVNGLIPQSLSLDDYFVERVNTPRDENGDYDYESIYALDLELINKSLTALMNGE
EEEEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHEEEHHHHHHHHHHHHHHCCC
VVDIPTYNFFTGKREWNGNKIKLHENGVLILEGIHGLNPILTSGVDQNKIFKVYISALTQ
EEEECCCCEECCCEECCCCEEEEECCCEEEEECCCCCCHHHHCCCCCCHHHHHHHHHHHH
LNLDNHNRISTTDVRKVRRIVRDSLSRGHDAEATLKMWPSIKKGEKNNIFVYQDQADAMF
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCEEEEECCCCHHH
NSTLVYELGLLKPHALKELNKVKEESPVYAEAARLKSILNFFKEVDSSYIPMNSILREFI
CCCCEEHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
GGSCFYEY
CCCEEECC
>Mature Secondary Structure
MNSIIYNIKNKEQNSTDTFYDILSKDIVEVKNIALCKLNGKYNELRDIVNESGKIETITF
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHCCCCCEEEEEE
NTEMGLNIYTRTLQFIFIKATLDLFPNSKIKIEHSISKGLFGEIIKEKPLSEEDIKLIKE
ECCCCCHHHHHEEEEEEEEEEHHHCCCCEEEEEECHHHHHHHHHHHCCCCCHHHHHHHHH
KMKEIISKDVPINSIRISKNEAINIFKKYGMEDKISLLQYSNLNQVKLYELEGRYDYFYG
HHHHHHHCCCCCCEEEECCCHHHHHHHHCCCCHHHHHHCCCCCCEEEEEEECCCEEEEEE
HMAYSTGVIRAFDLIYYESGFILRSPEKENLNELPQYKEERKLRSIFFETEKWLSILDIG
EHHHHCCHHHHHEEEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
EVGTLNEKLSSNEAQSLILTSEALHEKKIANIADQIANKKDSKIVLIAGPSSSGKTTFAN
CCCCCHHHHCCCCHHEEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEE
RLSIQLKVNGLIPQSLSLDDYFVERVNTPRDENGDYDYESIYALDLELINKSLTALMNGE
EEEEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHEEEHHHHHHHHHHHHHHCCC
VVDIPTYNFFTGKREWNGNKIKLHENGVLILEGIHGLNPILTSGVDQNKIFKVYISALTQ
EEEECCCCEECCCEECCCCEEEEECCCEEEEECCCCCCHHHHCCCCCCHHHHHHHHHHHH
LNLDNHNRISTTDVRKVRRIVRDSLSRGHDAEATLKMWPSIKKGEKNNIFVYQDQADAMF
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCEEEEECCCCHHH
NSTLVYELGLLKPHALKELNKVKEESPVYAEAARLKSILNFFKEVDSSYIPMNSILREFI
CCCCEEHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
GGSCFYEY
CCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA