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The map label for this gene is cobK [H]

Identifier: 187933316

GI number: 187933316

Start: 3011469

End: 3012242

Strand: Reverse

Name: cobK [H]

Synonym: CLL_A2929

Alternate gene names: 187933316

Gene position: 3012242-3011469 (Counterclockwise)

Preceding gene: 187934491

Following gene: 187932988

Centisome position: 79.26

GC content: 26.61

Gene sequence:

>774_bases
ATGATTGGTTTTATATTAGGAACTTCTGAAGGAAAAAATATTGTATCTTTAATTAATAAGTATACAAATGATATTGCAGT
CAGTACAGCAACAGCATATGGTGGAGAACTTTTAAAGAAATTTGATATTAAGAGTTTAAATACAAAACCATTAAATGAAG
AAGAAATGTTAGATTGGATTAAGGATAATAATATAACTATATTAGTAGATGGATCTCATCCGTATGCACAAGAAGTTACT
AAAACAGCATTAAAATGTTGCAGTAAACTTAAAGTGAAATATATAAGATATGAAAGACTAGGAGCATTAGCAAATATAAA
AGCTAATGAGATAATAAGAGTTAAAGATTATGAAGAGGCTATTGAGGCAATTAGTAATTTAAATGGAAATATATTAAACT
CAACAGGCAGCAATAATTTTTCTAAGTTTTTAAATATAGGCTTTAATCATAGGATAATTCATAGAGTTTTACCATCTTAT
GAAGTGTTAAAAAAAATGATAGATGGCGGAGTTAAGATTAAAGATATAATTGCTATGCAAGGACCAATATCAGAACAATT
AGAGGAAGCATTTATTAAGCAATATGATATTAAAGGTATTATAACAAAAGATAGTGGTGTGCAGGGTGGTGTACTAGAAA
AATTTAAAGCAGTACAGAAATGTAATATAAAATTAATAGTTATAGAAAAACCGAAATTTAAATATGATTTAGAATTTAAT
GATGAAGAAAGTTTAGTTTCTTTTTTAGTACATGAATTGGGGGGGAAGTTATGA

Upstream 100 bases:

>100_bases
TGTCTATTGTTATTATAGGAAATTCAAAGAGTTTTCTTAAAAATGGATGTTTTATAACACCTAGAGGATATTCATCTAAG
AAAAGAGATACAGTAAAGTA

Downstream 100 bases:

>100_bases
AAAGTAAAGAAGAAATTCTTAGAGAAATTATAAGCAATATAGATAGTGTAGATAAAAATGTTATGGAAAAAGCAAAAGAA
AGAATGAATTCTCTTGCAAA

Product: cobalt-precorrin-6x reductase

Products: Precorrin 6A; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MIGFILGTSEGKNIVSLINKYTNDIAVSTATAYGGELLKKFDIKSLNTKPLNEEEMLDWIKDNNITILVDGSHPYAQEVT
KTALKCCSKLKVKYIRYERLGALANIKANEIIRVKDYEEAIEAISNLNGNILNSTGSNNFSKFLNIGFNHRIIHRVLPSY
EVLKKMIDGGVKIKDIIAMQGPISEQLEEAFIKQYDIKGIITKDSGVQGGVLEKFKAVQKCNIKLIVIEKPKFKYDLEFN
DEESLVSFLVHELGGKL

Sequences:

>Translated_257_residues
MIGFILGTSEGKNIVSLINKYTNDIAVSTATAYGGELLKKFDIKSLNTKPLNEEEMLDWIKDNNITILVDGSHPYAQEVT
KTALKCCSKLKVKYIRYERLGALANIKANEIIRVKDYEEAIEAISNLNGNILNSTGSNNFSKFLNIGFNHRIIHRVLPSY
EVLKKMIDGGVKIKDIIAMQGPISEQLEEAFIKQYDIKGIITKDSGVQGGVLEKFKAVQKCNIKLIVIEKPKFKYDLEFN
DEESLVSFLVHELGGKL
>Mature_257_residues
MIGFILGTSEGKNIVSLINKYTNDIAVSTATAYGGELLKKFDIKSLNTKPLNEEEMLDWIKDNNITILVDGSHPYAQEVT
KTALKCCSKLKVKYIRYERLGALANIKANEIIRVKDYEEAIEAISNLNGNILNSTGSNNFSKFLNIGFNHRIIHRVLPSY
EVLKKMIDGGVKIKDIIAMQGPISEQLEEAFIKQYDIKGIITKDSGVQGGVLEKFKAVQKCNIKLIVIEKPKFKYDLEFN
DEESLVSFLVHELGGKL

Specific function: Catalyzes the reduction of the macrocycle of cobalt- precorrin-6X into cobalt-precorrin-6Y [H]

COG id: COG2099

COG function: function code H; Precorrin-6x reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin-6x reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003723 [H]

Pfam domain/function: PF02571 CbiJ [H]

EC number: 1.3.1.54

Molecular weight: Translated: 28818; Mature: 28818

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS51014 COBK_CBIJ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGFILGTSEGKNIVSLINKYTNDIAVSTATAYGGELLKKFDIKSLNTKPLNEEEMLDWI
CEEEEEECCCCHHHHHHHHHHHCHHEEEEHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
KDNNITILVDGSHPYAQEVTKTALKCCSKLKVKYIRYERLGALANIKANEIIRVKDYEEA
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHH
IEAISNLNGNILNSTGSNNFSKFLNIGFNHRIIHRVLPSYEVLKKMIDGGVKIKDIIAMQ
HHHHHCCCCCEEECCCCCCHHHHHHCCCCHHHHHHHCCCHHHHHHHHCCCCEEEHHHCCC
GPISEQLEEAFIKQYDIKGIITKDSGVQGGVLEKFKAVQKCNIKLIVIEKPKFKYDLEFN
CCHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHCCEEEEEEECCCEEEEECCC
DEESLVSFLVHELGGKL
CHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIGFILGTSEGKNIVSLINKYTNDIAVSTATAYGGELLKKFDIKSLNTKPLNEEEMLDWI
CEEEEEECCCCHHHHHHHHHHHCHHEEEEHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
KDNNITILVDGSHPYAQEVTKTALKCCSKLKVKYIRYERLGALANIKANEIIRVKDYEEA
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHH
IEAISNLNGNILNSTGSNNFSKFLNIGFNHRIIHRVLPSYEVLKKMIDGGVKIKDIIAMQ
HHHHHCCCCCEEECCCCCCHHHHHHCCCCHHHHHHHCCCHHHHHHHHCCCCEEEHHHCCC
GPISEQLEEAFIKQYDIKGIITKDSGVQGGVLEKFKAVQKCNIKLIVIEKPKFKYDLEFN
CCHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHCCEEEEEEECCCEEEEECCC
DEESLVSFLVHELGGKL
CHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Precorrin 6B; NADP+

Specific reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]