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The map label for this gene is trx [H]

Identifier: 187932876

GI number: 187932876

Start: 2887167

End: 2887484

Strand: Reverse

Name: trx [H]

Synonym: CLL_A2807

Alternate gene names: 187932876

Gene position: 2887484-2887167 (Counterclockwise)

Preceding gene: 187932467

Following gene: 187935626

Centisome position: 75.98

GC content: 26.73

Gene sequence:

>318_bases
ATGGCTAAAATTATAAATAGTAGAGAGTTTATGGAAAAGGTAGAAAATACTAAAGGCGTAGTTATGGTTGATTTTTTTGC
AGATTGGTGTGGTCCATGTAAGATGTTAGCTCCAATATTTGAAGACCTTAGTAATGAATTTAATGATAAAGCTAAATTAT
TTAAATTAAATGTAGATCAAAGTGGAGAAATAGCACAAAAATATGGTGTATTTTCTATTCCTACAATGATAATATTCAAA
GATGGAAAAGCAGTAGAAAATTTAACTGGATTTATGCCAAAAGAAAATATAACAAATAAATTAAAGGCTCATTTATAA

Upstream 100 bases:

>100_bases
ATTTAATGTGATTAAGTCACTTAAGTATTATAGAAATACAAGTATAATAAAATTAACAAATATATTATTATATATTTTAA
TTATGATAGGAGGCTTTATT

Downstream 100 bases:

>100_bases
AGTGTTTGAAGGAATAACCTCTGTAAGTAATGTAAGTTATTTATTAGTATTTTTTGAGGGGATAGTTTCATTTCTATCCC
CTTGTGTATTACCTTTAATA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 105; Mature: 104

Protein sequence:

>105_residues
MAKIINSREFMEKVENTKGVVMVDFFADWCGPCKMLAPIFEDLSNEFNDKAKLFKLNVDQSGEIAQKYGVFSIPTMIIFK
DGKAVENLTGFMPKENITNKLKAHL

Sequences:

>Translated_105_residues
MAKIINSREFMEKVENTKGVVMVDFFADWCGPCKMLAPIFEDLSNEFNDKAKLFKLNVDQSGEIAQKYGVFSIPTMIIFK
DGKAVENLTGFMPKENITNKLKAHL
>Mature_104_residues
AKIINSREFMEKVENTKGVVMVDFFADWCGPCKMLAPIFEDLSNEFNDKAKLFKLNVDQSGEIAQKYGVFSIPTMIIFKD
GKAVENLTGFMPKENITNKLKAHL

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=99, Percent_Identity=32.3232323232323, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082331, Length=101, Percent_Identity=38.6138613861386, Blast_Score=91, Evalue=1e-20,
Organism=Escherichia coli, GI1788936, Length=105, Percent_Identity=38.0952380952381, Blast_Score=87, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI212646193, Length=96, Percent_Identity=37.5, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17507705, Length=85, Percent_Identity=37.6470588235294, Blast_Score=78, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71980565, Length=92, Percent_Identity=34.7826086956522, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71980562, Length=92, Percent_Identity=34.7826086956522, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=71, Percent_Identity=43.6619718309859, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=70, Percent_Identity=45.7142857142857, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=70, Percent_Identity=34.2857142857143, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=88, Percent_Identity=42.0454545454545, Blast_Score=85, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323072, Length=88, Percent_Identity=43.1818181818182, Blast_Score=83, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319925, Length=93, Percent_Identity=34.4086021505376, Blast_Score=66, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573567, Length=88, Percent_Identity=36.3636363636364, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24639826, Length=71, Percent_Identity=40.8450704225352, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17648013, Length=71, Percent_Identity=43.6619718309859, Blast_Score=75, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24583090, Length=71, Percent_Identity=43.6619718309859, Blast_Score=75, Evalue=7e-15,
Organism=Drosophila melanogaster, GI21358065, Length=95, Percent_Identity=35.7894736842105, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24664269, Length=81, Percent_Identity=35.8024691358025, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17530795, Length=91, Percent_Identity=27.4725274725275, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24658597, Length=90, Percent_Identity=34.4444444444444, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11910; Mature: 11779

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIINSREFMEKVENTKGVVMVDFFADWCGPCKMLAPIFEDLSNEFNDKAKLFKLNVDQ
CCCCCCHHHHHHHHHCCCCEEEEEEHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCC
SGEIAQKYGVFSIPTMIIFKDGKAVENLTGFMPKENITNKLKAHL
CCCHHHHCCCEECCEEEEEECCCHHHHHHCCCCCCHHHHHHHCCC
>Mature Secondary Structure 
AKIINSREFMEKVENTKGVVMVDFFADWCGPCKMLAPIFEDLSNEFNDKAKLFKLNVDQ
CCCCCHHHHHHHHHCCCCEEEEEEHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCC
SGEIAQKYGVFSIPTMIIFKDGKAVENLTGFMPKENITNKLKAHL
CCCHHHHCCCEECCEEEEEECCCHHHHHHCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA