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The map label for this gene is gltA [H]

Identifier: 187932828

GI number: 187932828

Start: 3147957

End: 3149348

Strand: Reverse

Name: gltA [H]

Synonym: CLL_A3048

Alternate gene names: 187932828

Gene position: 3149348-3147957 (Counterclockwise)

Preceding gene: 187935507

Following gene: 187935080

Centisome position: 82.87

GC content: 33.48

Gene sequence:

>1392_bases
ATGGATATGAAAGATAGAATGGTTAAGGTTCCTGTAAGAGAACAGGATGCAAAAGTTAGAGCAACAAACTTTGAAGAAGT
ATGTTTAGGATATAATGAAGAAGAAGCTAAAAAAGAAGCTTCAAGATGTTTAAATTGTAAGAATCCTAAATGTATAGAGG
GGTGTCCAGTAGCTATCAATATTCCAGGTTTTATATCACACATAAAAGATAATAAATTTGAAGATGCAGCAAAGGAAATT
GCAAAATATAGTGCCCTTCCTGCTGTATGTGGTAGGGTGTGTCCACAAGAAAGTCAATGTGAAGGTAAATGTGTATTAGG
CATAAAAGGTGAACCAGTATCAATAGGTAAATTAGAAAGATTTACAGCTGATTGGTCTGCAGAACACAATGTTGATTTAA
GTGAAACAGCTCCTTCAAATGGTAAAAAAATTGCAGTAATAGGAAGTGGTCCTTCTGGACTAACTTGTGCTGGAGATTTA
GCTAAAAAGGGATATGATGTTACTATATTTGAAGCTTTACATAAAGCTGGTGGAGTTTTAGAATATGGTATACCTGAATT
CAGACTTCCAAAAGAAAAGGTAGTTAAAAATGAAATTGAAAATATTAAAAAGTTAGGTGTTAAAATTGAAACTAATGTTA
TAATAGGAAAAACTATAACTGTAGATGAACTTTTTGAAGATGAAAAGTTTGAAGCTGTATTTATAGGATCGGGAGCAGGT
CTTCCTAAATTCATGGGTATAAATGGAGAAAATGCAAATGGAGTATTCTCTGCAAATGAATTTTTAACAAGAGTTAACTT
AATGAAAGCATATTTAGATGAATATGATACTCCTGTTAAAAATGGTAAAAAAGTTGCAGTAGTTGGTGGCGGAAATGTTG
CTATGGATGCTGCAAGAACTGCATTAAGACTTGGAGCTGAAAGTCATATAGTATATAGAAGAAGTGAATCAGAACTTCCA
GCAAGAGTTGAAGAAGTTCATCATGCTAAGCAAGAAGGAATAATTTTTGATTTATTAACTAATCCAAAAGAAATATTAAC
AGATGAAAATGGATGGGTTAATGGTATGAGGTGCGTTAAGATGGAACTTGGAGAACCTGATGCATCTGGAAGAAGAAGAC
CAGTTGAAATTGAAGGATCAGAATTTATTATGGATGTAGATACTGTAATAATGTCACTTGGAACTTCACCAAATCCATTA
ATTTCTTCAACAACTGAGGGATTAGAAGTTAATAAGTGGAAGTGTTTAGTTGCAGATGAAAATGGATTAACTACTAAAGA
AGGTGTTTATGCAGGTGGAGATGCTGTTACAGGTGCTGCAACAGTAATACTTGCAATGGGTGCTGGTAAGAAAGCAGCAG
AAGCTATAGATGAATATTTACAAAGTAAATAG

Upstream 100 bases:

>100_bases
GACAAGCTATGTATAAGAGTGAAGAAGGTAGAGCTCAATTAAAGGTTGAAGAAGGAAACACTCATAGTCATGGTGGCTGT
GGCTGTGGAGGTGATAAATA

Downstream 100 bases:

>100_bases
ATACTTAGTAAAATAAAAGAGGTTGTATCAAATTACATTTATTTTAACTTATGGCTGTGTTTTGGTGGCATGTTAATATA
TACACATATTTAAAATAGAG

Product: oxidoreductase

Products: L-glutamine; 2-oxoglutarate; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MDMKDRMVKVPVREQDAKVRATNFEEVCLGYNEEEAKKEASRCLNCKNPKCIEGCPVAINIPGFISHIKDNKFEDAAKEI
AKYSALPAVCGRVCPQESQCEGKCVLGIKGEPVSIGKLERFTADWSAEHNVDLSETAPSNGKKIAVIGSGPSGLTCAGDL
AKKGYDVTIFEALHKAGGVLEYGIPEFRLPKEKVVKNEIENIKKLGVKIETNVIIGKTITVDELFEDEKFEAVFIGSGAG
LPKFMGINGENANGVFSANEFLTRVNLMKAYLDEYDTPVKNGKKVAVVGGGNVAMDAARTALRLGAESHIVYRRSESELP
ARVEEVHHAKQEGIIFDLLTNPKEILTDENGWVNGMRCVKMELGEPDASGRRRPVEIEGSEFIMDVDTVIMSLGTSPNPL
ISSTTEGLEVNKWKCLVADENGLTTKEGVYAGGDAVTGAATVILAMGAGKKAAEAIDEYLQSK

Sequences:

>Translated_463_residues
MDMKDRMVKVPVREQDAKVRATNFEEVCLGYNEEEAKKEASRCLNCKNPKCIEGCPVAINIPGFISHIKDNKFEDAAKEI
AKYSALPAVCGRVCPQESQCEGKCVLGIKGEPVSIGKLERFTADWSAEHNVDLSETAPSNGKKIAVIGSGPSGLTCAGDL
AKKGYDVTIFEALHKAGGVLEYGIPEFRLPKEKVVKNEIENIKKLGVKIETNVIIGKTITVDELFEDEKFEAVFIGSGAG
LPKFMGINGENANGVFSANEFLTRVNLMKAYLDEYDTPVKNGKKVAVVGGGNVAMDAARTALRLGAESHIVYRRSESELP
ARVEEVHHAKQEGIIFDLLTNPKEILTDENGWVNGMRCVKMELGEPDASGRRRPVEIEGSEFIMDVDTVIMSLGTSPNPL
ISSTTEGLEVNKWKCLVADENGLTTKEGVYAGGDAVTGAATVILAMGAGKKAAEAIDEYLQSK
>Mature_463_residues
MDMKDRMVKVPVREQDAKVRATNFEEVCLGYNEEEAKKEASRCLNCKNPKCIEGCPVAINIPGFISHIKDNKFEDAAKEI
AKYSALPAVCGRVCPQESQCEGKCVLGIKGEPVSIGKLERFTADWSAEHNVDLSETAPSNGKKIAVIGSGPSGLTCAGDL
AKKGYDVTIFEALHKAGGVLEYGIPEFRLPKEKVVKNEIENIKKLGVKIETNVIIGKTITVDELFEDEKFEAVFIGSGAG
LPKFMGINGENANGVFSANEFLTRVNLMKAYLDEYDTPVKNGKKVAVVGGGNVAMDAARTALRLGAESHIVYRRSESELP
ARVEEVHHAKQEGIIFDLLTNPKEILTDENGWVNGMRCVKMELGEPDASGRRRPVEIEGSEFIMDVDTVIMSLGTSPNPL
ISSTTEGLEVNKWKCLVADENGLTTKEGVYAGGDAVTGAATVILAMGAGKKAAEAIDEYLQSK

Specific function: Unknown

COG id: COG0493

COG function: function code ER; NADPH-dependent glutamate synthase beta chain and related oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=470, Percent_Identity=33.1914893617021, Blast_Score=195, Evalue=1e-49,
Organism=Escherichia coli, GI1788811, Length=478, Percent_Identity=37.2384937238494, Blast_Score=302, Evalue=3e-83,
Organism=Escherichia coli, GI1789606, Length=455, Percent_Identity=36.4835164835165, Blast_Score=285, Evalue=5e-78,
Organism=Escherichia coli, GI87082180, Length=458, Percent_Identity=36.2445414847162, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1788468, Length=444, Percent_Identity=32.4324324324324, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI1789243, Length=418, Percent_Identity=33.4928229665072, Blast_Score=181, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI71984108, Length=450, Percent_Identity=31.7777777777778, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17570289, Length=482, Percent_Identity=29.253112033195, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17543860, Length=177, Percent_Identity=32.2033898305085, Blast_Score=79, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320030, Length=475, Percent_Identity=30.5263157894737, Blast_Score=190, Evalue=5e-49,
Organism=Drosophila melanogaster, GI24665547, Length=477, Percent_Identity=29.769392033543, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24665543, Length=477, Percent_Identity=29.769392033543, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI28574881, Length=477, Percent_Identity=29.769392033543, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24665539, Length=477, Percent_Identity=29.769392033543, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24640763, Length=448, Percent_Identity=31.25, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI18858217, Length=448, Percent_Identity=31.25, Blast_Score=166, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013027
- InterPro:   IPR012285
- InterPro:   IPR006006 [H]

Pfam domain/function: PF00037 Fer4; PF07992 Pyr_redox_2 [H]

EC number: 1.4.1.13

Molecular weight: Translated: 50063; Mature: 50063

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMKDRMVKVPVREQDAKVRATNFEEVCLGYNEEEAKKEASRCLNCKNPKCIEGCPVAIN
CCCCCCEEECCCCCCCCEEEECCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEE
IPGFISHIKDNKFEDAAKEIAKYSALPAVCGRVCPQESQCEGKCVLGIKGEPVSIGKLER
CCHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCHHH
FTADWSAEHNVDLSETAPSNGKKIAVIGSGPSGLTCAGDLAKKGYDVTIFEALHKAGGVL
HCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEECHHHHHCCCCCHHHHHHHHHCCEE
EYGIPEFRLPKEKVVKNEIENIKKLGVKIETNVIIGKTITVDELFEDEKFEAVFIGSGAG
ECCCCCCCCCHHHHHHHHHHHHHHCCEEEECCEEEECEEEHHHHHCCCCCCEEEEECCCC
LPKFMGINGENANGVFSANEFLTRVNLMKAYLDEYDTPVKNGKKVAVVGGGNVAMDAART
CCCEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHH
ALRLGAESHIVYRRSESELPARVEEVHHAKQEGIIFDLLTNPKEILTDENGWVNGMRCVK
HHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHCCCCCCCCCEEEEE
MELGEPDASGRRRPVEIEGSEFIMDVDTVIMSLGTSPNPLISSTTEGLEVNKWKCLVADE
EECCCCCCCCCCCCEEECCCEEEEEHHHHHHHCCCCCCCCCCCCCCCCEECCEEEEEECC
NGLTTKEGVYAGGDAVTGAATVILAMGAGKKAAEAIDEYLQSK
CCCCCCCCEEECCCCHHHHEEEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MDMKDRMVKVPVREQDAKVRATNFEEVCLGYNEEEAKKEASRCLNCKNPKCIEGCPVAIN
CCCCCCEEECCCCCCCCEEEECCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEE
IPGFISHIKDNKFEDAAKEIAKYSALPAVCGRVCPQESQCEGKCVLGIKGEPVSIGKLER
CCHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCHHH
FTADWSAEHNVDLSETAPSNGKKIAVIGSGPSGLTCAGDLAKKGYDVTIFEALHKAGGVL
HCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEECHHHHHCCCCCHHHHHHHHHCCEE
EYGIPEFRLPKEKVVKNEIENIKKLGVKIETNVIIGKTITVDELFEDEKFEAVFIGSGAG
ECCCCCCCCCHHHHHHHHHHHHHHCCEEEECCEEEECEEEHHHHHCCCCCCEEEEECCCC
LPKFMGINGENANGVFSANEFLTRVNLMKAYLDEYDTPVKNGKKVAVVGGGNVAMDAART
CCCEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHH
ALRLGAESHIVYRRSESELPARVEEVHHAKQEGIIFDLLTNPKEILTDENGWVNGMRCVK
HHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHCCCCCCCCCEEEEE
MELGEPDASGRRRPVEIEGSEFIMDVDTVIMSLGTSPNPLISSTTEGLEVNKWKCLVADE
EECCCCCCCCCCCCEEECCCEEEEEHHHHHHHCCCCCCCCCCCCCCCCEECCEEEEEECC
NGLTTKEGVYAGGDAVTGAATVILAMGAGKKAAEAIDEYLQSK
CCCCCCCCEEECCCCHHHHEEEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-glutamate; NADP+

Specific reaction: 2 L-glutamate + NADP+ = L-glutamine + 2-oxoglutarate + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8955321; 9205837; 9278503 [H]