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The map label for this gene is ispA [C]

Identifier: 187932330

GI number: 187932330

Start: 2494421

End: 2495290

Strand: Reverse

Name: ispA [C]

Synonym: CLL_A2402

Alternate gene names: 187932330

Gene position: 2495290-2494421 (Counterclockwise)

Preceding gene: 187933296

Following gene: 187934347

Centisome position: 65.66

GC content: 27.82

Gene sequence:

>870_bases
ATGGAGATAGATAATTTAAAAAATGTAATAGATGAATATTTAAAAAATTATTTTATAAATAGAAATTCTTATAATAAGGT
TGTTTATGAGTCAGCAGGATATAGTGTAAATATAGGTGGAAAAAGAATACGTCCAATATTACTTATATTAACGTATTCTT
TATATAAAGACAATATAGAAAAAATAATGCCAATGGCAGCTGCAATTGAAATGATACACACTTATTCTTTAATACATGAT
GATCTTCCATGCATGGATGATGATGATTTAAGAAGAGGTAAGCCAACAAATCATAAGGTTTTCGGAGAAAATATTGCAGT
TTTAGCAGGAGATGCATTGTTAAATGAAGCTATGACTTTACTTATGAAAAGTTCATTAGAATTAGGAGAAAGTGCCTTAA
AAGCTTCTTATGAAATTTCAAAAGCAGCAGGTCCAGAAGGAATGATAGGCGGTCAAGTTGTTGATGTATTAAGTGAAGTA
AGCGAAATATCAAAAGAAGAATTAGAATATATGCACGAAAAAAAGACTGGAGAACTTATAAGAGTATCAATAGTAGCTGG
TGGTATTTTAGCAAGAGTTCCAAGTGGTGATATAGAAGCTTTAAATGAGTATGGTAAAAAATTAGGCTTAGCTTTTCAAA
TAAAAGATGATATATTAGATGTAATAGGAACTAAGGAAACATTAGGCAAAGCAACTAACAGAGATAAAGAATTAAATAAA
ACTAATTTTATAACTGTTTATGGATTAGAAAAATGCGAAGAACTTTGCAAAATGTTAACTGATGAATGTATAAAAATTTT
AGATAATTTAAGTGTAGATGCTAGTCTATTAAAAGAATTAACGCATAATCTTTTAAATAGACTAAATTAA

Upstream 100 bases:

>100_bases
GGAGTAAAATTAGTAAATAAACTTTATAAAACTTTAAATTCATATGAAGGAAAAATATCTGTAATTAAGGAAGAAAAAGA
AGTGGAGTTTGAAAATCAAG

Downstream 100 bases:

>100_bases
AAAAGGGAATGGTTATTATGAAGTCATTATTAGATAGTTTAAATTTCCCAAAAGATTTAAATAATTTAAATGATAGTGAT
ACAGAGAGATTAAGTAAAGA

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MEIDNLKNVIDEYLKNYFINRNSYNKVVYESAGYSVNIGGKRIRPILLILTYSLYKDNIEKIMPMAAAIEMIHTYSLIHD
DLPCMDDDDLRRGKPTNHKVFGENIAVLAGDALLNEAMTLLMKSSLELGESALKASYEISKAAGPEGMIGGQVVDVLSEV
SEISKEELEYMHEKKTGELIRVSIVAGGILARVPSGDIEALNEYGKKLGLAFQIKDDILDVIGTKETLGKATNRDKELNK
TNFITVYGLEKCEELCKMLTDECIKILDNLSVDASLLKELTHNLLNRLN

Sequences:

>Translated_289_residues
MEIDNLKNVIDEYLKNYFINRNSYNKVVYESAGYSVNIGGKRIRPILLILTYSLYKDNIEKIMPMAAAIEMIHTYSLIHD
DLPCMDDDDLRRGKPTNHKVFGENIAVLAGDALLNEAMTLLMKSSLELGESALKASYEISKAAGPEGMIGGQVVDVLSEV
SEISKEELEYMHEKKTGELIRVSIVAGGILARVPSGDIEALNEYGKKLGLAFQIKDDILDVIGTKETLGKATNRDKELNK
TNFITVYGLEKCEELCKMLTDECIKILDNLSVDASLLKELTHNLLNRLN
>Mature_289_residues
MEIDNLKNVIDEYLKNYFINRNSYNKVVYESAGYSVNIGGKRIRPILLILTYSLYKDNIEKIMPMAAAIEMIHTYSLIHD
DLPCMDDDDLRRGKPTNHKVFGENIAVLAGDALLNEAMTLLMKSSLELGESALKASYEISKAAGPEGMIGGQVVDVLSEV
SEISKEELEYMHEKKTGELIRVSIVAGGILARVPSGDIEALNEYGKKLGLAFQIKDDILDVIGTKETLGKATNRDKELNK
TNFITVYGLEKCEELCKMLTDECIKILDNLSVDASLLKELTHNLLNRLN

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=239, Percent_Identity=30.9623430962343, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1786623, Length=287, Percent_Identity=38.3275261324042, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1789578, Length=219, Percent_Identity=33.7899543378995, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17505681, Length=199, Percent_Identity=32.6633165829146, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24651612, Length=266, Percent_Identity=27.0676691729323, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17137582, Length=244, Percent_Identity=30.327868852459, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32208; Mature: 32208

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIDNLKNVIDEYLKNYFINRNSYNKVVYESAGYSVNIGGKRIRPILLILTYSLYKDNIE
CCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHH
KIMPMAAAIEMIHTYSLIHDDLPCMDDDDLRRGKPTNHKVFGENIAVLAGDALLNEAMTL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCEECCCCEEEEEHHHHHHHHHHH
LMKSSLELGESALKASYEISKAAGPEGMIGGQVVDVLSEVSEISKEELEYMHEKKTGELI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
RVSIVAGGILARVPSGDIEALNEYGKKLGLAFQIKDDILDVIGTKETLGKATNRDKELNK
EEEEHHCHHHHCCCCCHHHHHHHHHHHHCEEEEEHHHHHHHHCCHHHHHHHCCCCCCCCC
TNFITVYGLEKCEELCKMLTDECIKILDNLSVDASLLKELTHNLLNRLN
CCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEIDNLKNVIDEYLKNYFINRNSYNKVVYESAGYSVNIGGKRIRPILLILTYSLYKDNIE
CCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHH
KIMPMAAAIEMIHTYSLIHDDLPCMDDDDLRRGKPTNHKVFGENIAVLAGDALLNEAMTL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCEECCCCEEEEEHHHHHHHHHHH
LMKSSLELGESALKASYEISKAAGPEGMIGGQVVDVLSEVSEISKEELEYMHEKKTGELI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
RVSIVAGGILARVPSGDIEALNEYGKKLGLAFQIKDDILDVIGTKETLGKATNRDKELNK
EEEEHHCHHHHCCCCCHHHHHHHHHHHHCEEEEEHHHHHHHHCCHHHHHHHCCCCCCCCC
TNFITVYGLEKCEELCKMLTDECIKILDNLSVDASLLKELTHNLLNRLN
CCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]