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The map label for this gene is nagB

Identifier: 187918028

GI number: 187918028

Start: 152569

End: 153372

Strand: Direct

Name: nagB

Synonym: BH0152

Alternate gene names: 187918028

Gene position: 152569-153372 (Clockwise)

Preceding gene: 187918027

Following gene: 187918031

Centisome position: 16.54

GC content: 30.6

Gene sequence:

>804_bases
ATGAGATTAATCATTAGAACTAACTATAATGACATTTCAAAATGGGCTGCTAATCATGTTGCCATGAGAATAAAAGAATT
CTCACCAACAAAAGAAAAACCATTTATCTTAGGACTTCCAACAGGTAGCTCACCAATTGGGATGTATAAAAATTTAATCG
AAATGAATAAAATTGGAAAAATCTCATTTGAAAATGTAGTCACATTTAATATGGATGAATACGTAGGATTAGATAAAAAT
CATCCTGAAAGCTATAACTCATTTATGTGGAACAATTTTTTCTCACATATAGATATCAAAAAAGAAAATGTACATATGTT
AAATGGCAATGCTATTAATCTTACAAATGAATGCACAGAATACGAGAATAAAATTAAATCTTACGGTGGCATCATGCTCT
TTGTGGGGGGAATTGGACCTGATGGTCATATTGCCTTTAATGAACCTGGGTCATCACTGAAATCAAGAACAAGACTTAAA
ACTCTAACTCAAGATACAATTATTGCAAATTCAAGATTTTTTGAAAATGATATTAATAAAGTTCCCAAAAGTGCCCTAAC
AGTAGGAGTAGGAACAATTATGGATTCAAAAGAAGTGATGATTATAGTAAATGGACACAATAAAGCAAGAGCACTAAGAC
ACGCTATTGAAAAAGGAGTGAATCATATGTGGACAATTAGCACGCTGCAGTTACATAAAAATGCAATTATAGTATCAGAT
GAAGCTGCAACATATGAACTAAAAGTCGGAACAGTAAAGTATTTCAATGATATTGAAAAAGATAATTTTAATAACGATAT
ATAA

Upstream 100 bases:

>100_bases
ATGTCCTTGATAAGGATTTAAATTTAAAATTAACAATGATAGAATCAAAAATAATTTTTAACAGACTTTGATTTTATTTA
TAAATATAAGGAGAGAATAA

Downstream 100 bases:

>100_bases
ACATATATTATAATTTCCTAAGGCAGTAAATACAATATAAACTAAACACAAGAAAAATATCTTTAAGTTTAGTTCATGCA
ATGATTAAAAATAATATTAT

Product: glucosamine-6-phosphate deaminase

Products: NA

Alternate protein names: GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomerase

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MRLIIRTNYNDISKWAANHVAMRIKEFSPTKEKPFILGLPTGSSPIGMYKNLIEMNKIGKISFENVVTFNMDEYVGLDKN
HPESYNSFMWNNFFSHIDIKKENVHMLNGNAINLTNECTEYENKIKSYGGIMLFVGGIGPDGHIAFNEPGSSLKSRTRLK
TLTQDTIIANSRFFENDINKVPKSALTVGVGTIMDSKEVMIIVNGHNKARALRHAIEKGVNHMWTISTLQLHKNAIIVSD
EAATYELKVGTVKYFNDIEKDNFNNDI

Sequences:

>Translated_267_residues
MRLIIRTNYNDISKWAANHVAMRIKEFSPTKEKPFILGLPTGSSPIGMYKNLIEMNKIGKISFENVVTFNMDEYVGLDKN
HPESYNSFMWNNFFSHIDIKKENVHMLNGNAINLTNECTEYENKIKSYGGIMLFVGGIGPDGHIAFNEPGSSLKSRTRLK
TLTQDTIIANSRFFENDINKVPKSALTVGVGTIMDSKEVMIIVNGHNKARALRHAIEKGVNHMWTISTLQLHKNAIIVSD
EAATYELKVGTVKYFNDIEKDNFNNDI
>Mature_267_residues
MRLIIRTNYNDISKWAANHVAMRIKEFSPTKEKPFILGLPTGSSPIGMYKNLIEMNKIGKISFENVVTFNMDEYVGLDKN
HPESYNSFMWNNFFSHIDIKKENVHMLNGNAINLTNECTEYENKIKSYGGIMLFVGGIGPDGHIAFNEPGSSLKSRTRLK
TLTQDTIIANSRFFENDINKVPKSALTVGVGTIMDSKEVMIIVNGHNKARALRHAIEKGVNHMWTISTLQLHKNAIIVSD
EAATYELKVGTVKYFNDIEKDNFNNDI

Specific function: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily

Homologues:

Organism=Homo sapiens, GI13027378, Length=258, Percent_Identity=63.5658914728682, Blast_Score=350, Evalue=5e-97,
Organism=Homo sapiens, GI19923881, Length=258, Percent_Identity=63.1782945736434, Blast_Score=349, Evalue=2e-96,
Organism=Escherichia coli, GI1786893, Length=262, Percent_Identity=62.9770992366412, Blast_Score=360, Evalue=1e-101,
Organism=Escherichia coli, GI48994958, Length=241, Percent_Identity=30.2904564315353, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1789530, Length=232, Percent_Identity=25.8620689655172, Blast_Score=88, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17554876, Length=258, Percent_Identity=59.6899224806201, Blast_Score=320, Evalue=5e-88,
Organism=Drosophila melanogaster, GI24581960, Length=261, Percent_Identity=62.8352490421456, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI19920764, Length=261, Percent_Identity=62.8352490421456, Blast_Score=361, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NAGB_BORHD (B2RZL5)

Other databases:

- EMBL:   CP000048
- RefSeq:   YP_001883591.1
- ProteinModelPortal:   B2RZL5
- EnsemblBacteria:   EBBORT00000006584
- GeneID:   6276912
- GenomeReviews:   CP000048_GR
- KEGG:   bhr:BH0152
- GeneTree:   EBGT00050000007325
- HOGENOM:   HBG725991
- OMA:   HLSITMG
- ProtClustDB:   PRK00443
- BioCyc:   BHER314723:BH0152-MONOMER
- HAMAP:   MF_01241
- InterPro:   IPR006148
- InterPro:   IPR004547
- InterPro:   IPR018321
- PANTHER:   PTHR11280
- TIGRFAMs:   TIGR00502

Pfam domain/function: PF01182 Glucosamine_iso

EC number: =3.5.99.6

Molecular weight: Translated: 30207; Mature: 30207

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS01161 GLC_GALNAC_ISOMERASE

Important sites: ACT_SITE 72-72 ACT_SITE 141-141 ACT_SITE 143-143 ACT_SITE 148-148

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLIIRTNYNDISKWAANHVAMRIKEFSPTKEKPFILGLPTGSSPIGMYKNLIEMNKIGK
CEEEEECCCCHHHHHHHHHHEEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCC
ISFENVVTFNMDEYVGLDKNHPESYNSFMWNNFFSHIDIKKENVHMLNGNAINLTNECTE
EEECCEEEECHHHHCCCCCCCCCHHHHHHHHHHHHHEEEECCCEEEECCCEEECCHHHHH
YENKIKSYGGIMLFVGGIGPDGHIAFNEPGSSLKSRTRLKTLTQDTIIANSRFFENDINK
HHHHHHHCCCEEEEEECCCCCCCEEECCCCHHHHHHHHHHHHHHHHEEECCHHHHHHHHH
VPKSALTVGVGTIMDSKEVMIIVNGHNKARALRHAIEKGVNHMWTISTLQLHKNAIIVSD
CCHHHHEEEHHEEECCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEEEEEECCEEEEEC
EAATYELKVGTVKYFNDIEKDNFNNDI
CCEEEEEEECEEHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRLIIRTNYNDISKWAANHVAMRIKEFSPTKEKPFILGLPTGSSPIGMYKNLIEMNKIGK
CEEEEECCCCHHHHHHHHHHEEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCC
ISFENVVTFNMDEYVGLDKNHPESYNSFMWNNFFSHIDIKKENVHMLNGNAINLTNECTE
EEECCEEEECHHHHCCCCCCCCCHHHHHHHHHHHHHEEEECCCEEEECCCEEECCHHHHH
YENKIKSYGGIMLFVGGIGPDGHIAFNEPGSSLKSRTRLKTLTQDTIIANSRFFENDINK
HHHHHHHCCCEEEEEECCCCCCCEEECCCCHHHHHHHHHHHHHHHHEEECCHHHHHHHHH
VPKSALTVGVGTIMDSKEVMIIVNGHNKARALRHAIEKGVNHMWTISTLQLHKNAIIVSD
CCHHHHEEEHHEEECCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEEEEEECCEEEEEC
EAATYELKVGTVKYFNDIEKDNFNNDI
CCEEEEEEECEEHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA