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The map label for this gene is csd [H]

Identifier: 187917962

GI number: 187917962

Start: 79170

End: 80438

Strand: Direct

Name: csd [H]

Synonym: BH0084

Alternate gene names: 187917962

Gene position: 79170-80438 (Clockwise)

Preceding gene: 187917959

Following gene: 187917963

Centisome position: 8.58

GC content: 27.97

Gene sequence:

>1269_bases
ATGGATCTTAAGCTCGCAAAAGACAAAAATGAAAAATTAAAAATCATAAGGAAAGATTTTCCTATTCTAAATAAAACTAT
AAATGATAAAAAAATCATTTATTTTGATAATGCCGCAACTTCTCAAAAACCACAAAGCGTGATTTCATCTGTAGTTGAAT
ACTACGCAAACTATAATGCGAATGTTCACAGAAGCGGGCATGGACTTGCAATACAATCCAGCCTAAAAGTAGAAGAAACA
AGAAAAATTATCAAAAAATTTATCAATGCAAAGTCTTTTAAAAACATAATATTTAATTCTGGAACTACAGATGGAACAAA
TACAATAGCAAATTCATTGCTCTTTTCAAAACTTTTAAAAGAAAATGATGAAATCATTACAACAACACTTGAACATAATA
GTAATTTGCTTCCTTGGATCAATATTGCTAAATATTTAAACTTAAAAATCAAACTTGCCAAATTTAATAAAATGGGAATC
ATTCAACCTGATGAAATAAAAAACTTAATTACAGATAAAACAAAAATTATTACTATATCTGGCATAAATAACATATTAGG
AACTATACAGGATTTAGAAACGATTGGAAAGATTGCTAGAGATAACAAAATTATTCTGTTCATTGATGCAGCTCAAATGG
CACCACACATGAATATAGATGTAGAGAAAATAAACTGTGACTTTTTAGTATTCTCGGGACACAAAATGCTTGCTCCAACA
GGAATTGGGGTTCTATACATATCAGATAAAATTATAGATAAACTCAACAGTTCTAAACTAGGAGGCAATGCCATAGAAAA
TATTTTCATAGAAAATGGAGAGCCTAACTTTAAAACTCTTGAATCTCCAAATAAATTTGAATCAGGTACACCAAACATTG
CAGGAATTATTGGTCTTGGCAAAGCAATAGAATATATTAATAATATATCAATGGACTTTATTCAAGAACATGATAGAGAA
CTGATTGAATATTGTGTTGCAAAATTAAAAGAAATTGATGAAGTTGAATTTATTTTAAATAAAGATATCAAACGAAAATC
AATAATATCATTTACAGTAAAAAATATCCACTCACATGATGTTGAGACATATCTTGATACGATGGGCATTGCAACTAGAT
CTGGAAAAACCTGTGCTTACCTTGCATTTCTCTCAGAAAATATTAAAAAAGACCATCTACTAAGAATAAGCTTTTACTTA
TATAATACAAAAAAAGAAATTGATATCTTCATATCCTGCCTAAAGAAAACAATAAAAGAATTTTATTAA

Upstream 100 bases:

>100_bases
ATCAAAATGCAAGAAATTCTATATGTAAAAATAAAATAGAAAATAATGGTATAATTCTTAAAATAAAAGTTCTTACATAA
AAATAAAGAGTACTAAATAA

Downstream 100 bases:

>100_bases
ATCTATCTTTCAAAAAGATTATAAGAGCTATTAATCATTAATTTATATATTATAATATTAAATAATATAAAAGATAATGG
GTAAAAATTTACTTAATTAC

Product: cysteine desulfhydrase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MDLKLAKDKNEKLKIIRKDFPILNKTINDKKIIYFDNAATSQKPQSVISSVVEYYANYNANVHRSGHGLAIQSSLKVEET
RKIIKKFINAKSFKNIIFNSGTTDGTNTIANSLLFSKLLKENDEIITTTLEHNSNLLPWINIAKYLNLKIKLAKFNKMGI
IQPDEIKNLITDKTKIITISGINNILGTIQDLETIGKIARDNKIILFIDAAQMAPHMNIDVEKINCDFLVFSGHKMLAPT
GIGVLYISDKIIDKLNSSKLGGNAIENIFIENGEPNFKTLESPNKFESGTPNIAGIIGLGKAIEYINNISMDFIQEHDRE
LIEYCVAKLKEIDEVEFILNKDIKRKSIISFTVKNIHSHDVETYLDTMGIATRSGKTCAYLAFLSENIKKDHLLRISFYL
YNTKKEIDIFISCLKKTIKEFY

Sequences:

>Translated_422_residues
MDLKLAKDKNEKLKIIRKDFPILNKTINDKKIIYFDNAATSQKPQSVISSVVEYYANYNANVHRSGHGLAIQSSLKVEET
RKIIKKFINAKSFKNIIFNSGTTDGTNTIANSLLFSKLLKENDEIITTTLEHNSNLLPWINIAKYLNLKIKLAKFNKMGI
IQPDEIKNLITDKTKIITISGINNILGTIQDLETIGKIARDNKIILFIDAAQMAPHMNIDVEKINCDFLVFSGHKMLAPT
GIGVLYISDKIIDKLNSSKLGGNAIENIFIENGEPNFKTLESPNKFESGTPNIAGIIGLGKAIEYINNISMDFIQEHDRE
LIEYCVAKLKEIDEVEFILNKDIKRKSIISFTVKNIHSHDVETYLDTMGIATRSGKTCAYLAFLSENIKKDHLLRISFYL
YNTKKEIDIFISCLKKTIKEFY
>Mature_422_residues
MDLKLAKDKNEKLKIIRKDFPILNKTINDKKIIYFDNAATSQKPQSVISSVVEYYANYNANVHRSGHGLAIQSSLKVEET
RKIIKKFINAKSFKNIIFNSGTTDGTNTIANSLLFSKLLKENDEIITTTLEHNSNLLPWINIAKYLNLKIKLAKFNKMGI
IQPDEIKNLITDKTKIITISGINNILGTIQDLETIGKIARDNKIILFIDAAQMAPHMNIDVEKINCDFLVFSGHKMLAPT
GIGVLYISDKIIDKLNSSKLGGNAIENIFIENGEPNFKTLESPNKFESGTPNIAGIIGLGKAIEYINNISMDFIQEHDRE
LIEYCVAKLKEIDEVEFILNKDIKRKSIISFTVKNIHSHDVETYLDTMGIATRSGKTCAYLAFLSENIKKDHLLRISFYL
YNTKKEIDIFISCLKKTIKEFY

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=405, Percent_Identity=24.4444444444444, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI156713448, Length=442, Percent_Identity=23.0769230769231, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1787970, Length=401, Percent_Identity=34.1645885286783, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1789175, Length=403, Percent_Identity=30.272952853598, Blast_Score=231, Evalue=8e-62,
Organism=Escherichia coli, GI48994898, Length=402, Percent_Identity=26.3681592039801, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25143064, Length=402, Percent_Identity=25.1243781094527, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI193211090, Length=379, Percent_Identity=25.8575197889182, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17533177, Length=296, Percent_Identity=26.6891891891892, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319831, Length=397, Percent_Identity=25.6926952141058, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI20129463, Length=301, Percent_Identity=26.578073089701, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 47807; Mature: 47807

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKLAKDKNEKLKIIRKDFPILNKTINDKKIIYFDNAATSQKPQSVISSVVEYYANYNA
CCCCCCCCCCCHHHHHHHCCCHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCC
NVHRSGHGLAIQSSLKVEETRKIIKKFINAKSFKNIIFNSGTTDGTNTIANSLLFSKLLK
EEEECCCCEEEECCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
ENDEIITTTLEHNSNLLPWINIAKYLNLKIKLAKFNKMGIIQPDEIKNLITDKTKIITIS
CCCCEEEEEECCCCCCCHHHHHHHHHEEEEEEEEECCCCCCCHHHHHHHHCCCEEEEEEE
GINNILGTIQDLETIGKIARDNKIILFIDAAQMAPHMNIDVEKINCDFLVFSGHKMLAPT
CCHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHCCCCCCEEEEEEEEEEEEECCEEECCC
GIGVLYISDKIIDKLNSSKLGGNAIENIFIENGEPNFKTLESPNKFESGTPNIAGIIGLG
CCEEEEECHHHHHHHCCCCCCCCHHHEEEEECCCCCCCCCCCCCCCCCCCCCCEEHHHHH
KAIEYINNISMDFIQEHDRELIEYCVAKLKEIDEVEFILNKDIKRKSIISFTVKNIHSHD
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VETYLDTMGIATRSGKTCAYLAFLSENIKKDHLLRISFYLYNTKKEIDIFISCLKKTIKE
HHHHHHHHCCEECCCCCEEEHHHHHHCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHH
FY
CC
>Mature Secondary Structure
MDLKLAKDKNEKLKIIRKDFPILNKTINDKKIIYFDNAATSQKPQSVISSVVEYYANYNA
CCCCCCCCCCCHHHHHHHCCCHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCC
NVHRSGHGLAIQSSLKVEETRKIIKKFINAKSFKNIIFNSGTTDGTNTIANSLLFSKLLK
EEEECCCCEEEECCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
ENDEIITTTLEHNSNLLPWINIAKYLNLKIKLAKFNKMGIIQPDEIKNLITDKTKIITIS
CCCCEEEEEECCCCCCCHHHHHHHHHEEEEEEEEECCCCCCCHHHHHHHHCCCEEEEEEE
GINNILGTIQDLETIGKIARDNKIILFIDAAQMAPHMNIDVEKINCDFLVFSGHKMLAPT
CCHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHCCCCCCEEEEEEEEEEEEECCEEECCC
GIGVLYISDKIIDKLNSSKLGGNAIENIFIENGEPNFKTLESPNKFESGTPNIAGIIGLG
CCEEEEECHHHHHHHCCCCCCCCHHHEEEEECCCCCCCCCCCCCCCCCCCCCCEEHHHHH
KAIEYINNISMDFIQEHDRELIEYCVAKLKEIDEVEFILNKDIKRKSIISFTVKNIHSHD
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VETYLDTMGIATRSGKTCAYLAFLSENIKKDHLLRISFYLYNTKKEIDIFISCLKKTIKE
HHHHHHHHCCEECCCCCEEEHHHHHHCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHH
FY
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]