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The map label for this gene is tkt [H]

Identifier: 187735037

GI number: 187735037

Start: 622491

End: 624524

Strand: Direct

Name: tkt [H]

Synonym: Amuc_0530

Alternate gene names: 187735037

Gene position: 622491-624524 (Clockwise)

Preceding gene: 187735034

Following gene: 187735039

Centisome position: 23.37

GC content: 60.32

Gene sequence:

>2034_bases
ATGAAGCTGATCCGCTCATATTGCCCGGGCATGAATCTTGACCTTCTCCAAAAAGCCGCCAACCAGGCGCGGGGACTCGC
CATGGATGCCGTTCACGACTGCGCATCCGGCCACCTGGGCCTGCCGCTGGGGTGCGCCGAAATCGGGGCCGTCCTGTTCG
GCGATTTGCTCAACATCTGCCCTTCGCAGCCCCGCTGGCTCAACCGTGACCGCTTCATTCTTTCCGCCGGACACGGCTCC
ATGTTTCTTTACGGCTGGCTCCACCTGTCAGGATTCAACATCGGCATTGAAGATATCAAGAATTTCCGCCGCAAAGGTTC
CATCACGCCCGGCCACCCGGAATTCCGGGATACGGAGGGTGTAGAATGCACCACGGGACCGTTGGGCCAGGGCATTGCGA
ACGCCGTAGGCTTCGCCCTCTCCGCCAGGCGCGCGGCTGCCCGGTTCAACAGGCCCGGCATGGATATCTTCACCCAGCAC
GTCTTCTGCCTCACGGGAGACGGCTGCCTGCAGGAAGGCGTCGCCCGGGAATCCCTCGCCCTGGCCGCCGTGCTCAAGCT
GGATAACCTTATTCTCATTTACGATTCCAACGACATCACGCTGGACGCTCCCGCGGAACGCACCCAGCTCACAGATCCGC
GCGCCGTATACGAAGCCCTGGGCTGGGATGTGCGCCAGATTGACGGGCACGATATCAGGGCCATTGAGTCAGCGGTTGAA
GCCGCCAAAAACGCCAAAAACGGGAAACCCCAGCTCATCATTGCCAAAACGGTCATCGGCAAGGGCATTCCCGGCATTGA
AGGCACCACAAAAGGCCATGGGGAAGGCGGAGCCAAGCTTCAGGAAGAAGCGCACGCCAACTGGGGAATTCCCGCCGGAG
AACGCTATTACGTCTCCGAAGACGTCCGTACCGCTTTCGCAAACCTGAAAGCCCAACGGGAAAAAGATTTCAATGCCTGG
AACGCCATGTATGAACAATGGCGCCGGGCTTATCCGGAACTGGCAGAGGAACTGGACGCAGGCATCAACGCCTGCTCCTG
CGGCGTCAATCCGGCAGACTCGGACAAGGCAATACCGCCCTTCCCGCAGGACTATGGCGATGCTACCCGTTCGGCCGGAG
CCGTTGCCATCAACGCCATCGCTAAAGCGAATCCCTGCTTCCTGACCACCAGCGCAGACCTTTACAGCTCCAATAAAAAC
TACCTTTCCGGCGCAGGAGACTTCTCTGCGGAAACCCCGGAAGGGCGCAACTTCTGGTTCGGCATCCGCGAACACGCCAT
GGCCGCCATCTGCAACGGCATTGCCTACGACGGCCTGTTCCGCGTAAGCGCCGCCACTTTCTGCGTCTTCGTAGACTACA
TGCGCGCCTCCATCCGTGTAGCCGCCCTCAGCGGACTCCCCGTCACCTATATTCTGACGCATGACTCCGTAGCCGTGGGA
GAAGACGGCCCCACCCACCAGCCGGTGGAAACAATTTCCGGCCTCCGTGTCATTCCGAACCTGGATGTCATCCGCCCGGC
GGACCCGGAAGAAACCGCAGGAGCCTGGATGGCCGCCATGCAGCGTGCCGACGGCCCTACCGCCCTCATCCTGACCCGTC
AGAAAGTGGCTACGCTGAACGGAATCCCCGTTGAAACGCGCCGGGAAGGCGTGCTGAAAGGCGCCTACATCGCCCGGAAA
GAACAGGGAGCCTTGAAAGCCATTATTCTTGCCAGCGGTTCCGAACTGGAACTGGCTCTGAAAGCGGCGGAAAAAACAGG
GGAAGGAATCCGGGTCGTCTCCATGCCAAGCTTCTGCCGCTTTGACGCGCAGCCTGCCGAATACCGGGAAAGCGTGCTTC
CCTCCTCCTGCATGAGGAGAGTTTCCGTAGAAGCCGGAGTCACGGACCTCTGGTGGAAATATCTGGGCTGCCAGGGGGAA
GCCGTGGGCATCAACCGTTTCGGCTTCTCCGCTCCCGGAACACAGGTGCTGGAAGAACTCGGCATGAATGTGGACAACGT
CGTTGCCGCCGTCCACAAGGTTCTGGCCAAATAA

Upstream 100 bases:

>100_bases
AGCGTGCCGCAAAACCGGGAACGGCATGCGCGGCGCTTCCATCTTCAATGCTTTTCCCCGGTCCGGAACTGGTGCCGGAG
ACGCATTTTAGGCTTCCAAT

Downstream 100 bases:

>100_bases
ACAGGGAATATTTCCCCTCATCTCCTTTCAGGGGCTGTTCCGCATCCGCCGGGACAGCCCCTTTTTCATGCCTCCCCGGT
TGCCAGGAAAAAGGCAAGGC

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 677; Mature: 677

Protein sequence:

>677_residues
MKLIRSYCPGMNLDLLQKAANQARGLAMDAVHDCASGHLGLPLGCAEIGAVLFGDLLNICPSQPRWLNRDRFILSAGHGS
MFLYGWLHLSGFNIGIEDIKNFRRKGSITPGHPEFRDTEGVECTTGPLGQGIANAVGFALSARRAAARFNRPGMDIFTQH
VFCLTGDGCLQEGVARESLALAAVLKLDNLILIYDSNDITLDAPAERTQLTDPRAVYEALGWDVRQIDGHDIRAIESAVE
AAKNAKNGKPQLIIAKTVIGKGIPGIEGTTKGHGEGGAKLQEEAHANWGIPAGERYYVSEDVRTAFANLKAQREKDFNAW
NAMYEQWRRAYPELAEELDAGINACSCGVNPADSDKAIPPFPQDYGDATRSAGAVAINAIAKANPCFLTTSADLYSSNKN
YLSGAGDFSAETPEGRNFWFGIREHAMAAICNGIAYDGLFRVSAATFCVFVDYMRASIRVAALSGLPVTYILTHDSVAVG
EDGPTHQPVETISGLRVIPNLDVIRPADPEETAGAWMAAMQRADGPTALILTRQKVATLNGIPVETRREGVLKGAYIARK
EQGALKAIILASGSELELALKAAEKTGEGIRVVSMPSFCRFDAQPAEYRESVLPSSCMRRVSVEAGVTDLWWKYLGCQGE
AVGINRFGFSAPGTQVLEELGMNVDNVVAAVHKVLAK

Sequences:

>Translated_677_residues
MKLIRSYCPGMNLDLLQKAANQARGLAMDAVHDCASGHLGLPLGCAEIGAVLFGDLLNICPSQPRWLNRDRFILSAGHGS
MFLYGWLHLSGFNIGIEDIKNFRRKGSITPGHPEFRDTEGVECTTGPLGQGIANAVGFALSARRAAARFNRPGMDIFTQH
VFCLTGDGCLQEGVARESLALAAVLKLDNLILIYDSNDITLDAPAERTQLTDPRAVYEALGWDVRQIDGHDIRAIESAVE
AAKNAKNGKPQLIIAKTVIGKGIPGIEGTTKGHGEGGAKLQEEAHANWGIPAGERYYVSEDVRTAFANLKAQREKDFNAW
NAMYEQWRRAYPELAEELDAGINACSCGVNPADSDKAIPPFPQDYGDATRSAGAVAINAIAKANPCFLTTSADLYSSNKN
YLSGAGDFSAETPEGRNFWFGIREHAMAAICNGIAYDGLFRVSAATFCVFVDYMRASIRVAALSGLPVTYILTHDSVAVG
EDGPTHQPVETISGLRVIPNLDVIRPADPEETAGAWMAAMQRADGPTALILTRQKVATLNGIPVETRREGVLKGAYIARK
EQGALKAIILASGSELELALKAAEKTGEGIRVVSMPSFCRFDAQPAEYRESVLPSSCMRRVSVEAGVTDLWWKYLGCQGE
AVGINRFGFSAPGTQVLEELGMNVDNVVAAVHKVLAK
>Mature_677_residues
MKLIRSYCPGMNLDLLQKAANQARGLAMDAVHDCASGHLGLPLGCAEIGAVLFGDLLNICPSQPRWLNRDRFILSAGHGS
MFLYGWLHLSGFNIGIEDIKNFRRKGSITPGHPEFRDTEGVECTTGPLGQGIANAVGFALSARRAAARFNRPGMDIFTQH
VFCLTGDGCLQEGVARESLALAAVLKLDNLILIYDSNDITLDAPAERTQLTDPRAVYEALGWDVRQIDGHDIRAIESAVE
AAKNAKNGKPQLIIAKTVIGKGIPGIEGTTKGHGEGGAKLQEEAHANWGIPAGERYYVSEDVRTAFANLKAQREKDFNAW
NAMYEQWRRAYPELAEELDAGINACSCGVNPADSDKAIPPFPQDYGDATRSAGAVAINAIAKANPCFLTTSADLYSSNKN
YLSGAGDFSAETPEGRNFWFGIREHAMAAICNGIAYDGLFRVSAATFCVFVDYMRASIRVAALSGLPVTYILTHDSVAVG
EDGPTHQPVETISGLRVIPNLDVIRPADPEETAGAWMAAMQRADGPTALILTRQKVATLNGIPVETRREGVLKGAYIARK
EQGALKAIILASGSELELALKAAEKTGEGIRVVSMPSFCRFDAQPAEYRESVLPSSCMRRVSVEAGVTDLWWKYLGCQGE
AVGINRFGFSAPGTQVLEELGMNVDNVVAAVHKVLAK

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI133778974, Length=600, Percent_Identity=27.6666666666667, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI205277463, Length=688, Percent_Identity=26.1627906976744, Blast_Score=153, Evalue=6e-37,
Organism=Homo sapiens, GI4507521, Length=688, Percent_Identity=26.1627906976744, Blast_Score=153, Evalue=6e-37,
Organism=Homo sapiens, GI225637459, Length=593, Percent_Identity=25.2951096121417, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI225637463, Length=484, Percent_Identity=26.8595041322314, Blast_Score=110, Evalue=6e-24,
Organism=Homo sapiens, GI225637461, Length=484, Percent_Identity=26.8595041322314, Blast_Score=109, Evalue=1e-23,
Organism=Escherichia coli, GI48994911, Length=670, Percent_Identity=44.0298507462687, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI1788808, Length=671, Percent_Identity=43.070044709389, Blast_Score=504, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17539652, Length=587, Percent_Identity=26.4054514480409, Blast_Score=145, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6319593, Length=677, Percent_Identity=37.8138847858198, Blast_Score=425, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6325331, Length=681, Percent_Identity=38.0323054331865, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI45551847, Length=510, Percent_Identity=28.2352941176471, Blast_Score=142, Evalue=8e-34,
Organism=Drosophila melanogaster, GI45550715, Length=510, Percent_Identity=28.2352941176471, Blast_Score=142, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24645119, Length=473, Percent_Identity=27.906976744186, Blast_Score=132, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24666278, Length=518, Percent_Identity=27.027027027027, Blast_Score=130, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72857; Mature: 72857

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIRSYCPGMNLDLLQKAANQARGLAMDAVHDCASGHLGLPLGCAEIGAVLFGDLLNIC
CCCHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHC
PSQPRWLNRDRFILSAGHGSMFLYGWLHLSGFNIGIEDIKNFRRKGSITPGHPEFRDTEG
CCCCCCCCCCEEEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
VECTTGPLGQGIANAVGFALSARRAAARFNRPGMDIFTQHVFCLTGDGCLQEGVARESLA
CEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCEEEEEECCHHHHHHHHHHHHH
LAAVLKLDNLILIYDSNDITLDAPAERTQLTDPRAVYEALGWDVRQIDGHDIRAIESAVE
HHHHHHHCCEEEEECCCCEEECCCCCCCCCCCHHHHHHHHCCCEEECCCCHHHHHHHHHH
AAKNAKNGKPQLIIAKTVIGKGIPGIEGTTKGHGEGGAKLQEEAHANWGIPAGERYYVSE
HHHCCCCCCCCEEEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCEEEEHH
DVRTAFANLKAQREKDFNAWNAMYEQWRRAYPELAEELDAGINACSCGVNPADSDKAIPP
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCC
FPQDYGDATRSAGAVAINAIAKANPCFLTTSADLYSSNKNYLSGAGDFSAETPEGRNFWF
CCCHHCHHHHCCCCEEEEHHHCCCCEEEEECHHHHCCCCCCCCCCCCCCCCCCCCCCEEE
GIREHAMAAICNGIAYDGLFRVSAATFCVFVDYMRASIRVAALSGLPVTYILTHDSVAVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEEECCCEEEC
EDGPTHQPVETISGLRVIPNLDVIRPADPEETAGAWMAAMQRADGPTALILTRQKVATLN
CCCCCCCHHHHHCCCEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHCC
GIPVETRREGVLKGAYIARKEQGALKAIILASGSELELALKAAEKTGEGIRVVSMPSFCR
CCCCCHHHCCCHHHHHHHCCCCCCEEEEEEECCCCEEEHHHHHHHCCCCEEEEECCHHHC
FDAQPAEYRESVLPSSCMRRVSVEAGVTDLWWKYLGCQGEAVGINRFGFSAPGTQVLEEL
CCCCHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHH
GMNVDNVVAAVHKVLAK
CCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLIRSYCPGMNLDLLQKAANQARGLAMDAVHDCASGHLGLPLGCAEIGAVLFGDLLNIC
CCCHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHC
PSQPRWLNRDRFILSAGHGSMFLYGWLHLSGFNIGIEDIKNFRRKGSITPGHPEFRDTEG
CCCCCCCCCCEEEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
VECTTGPLGQGIANAVGFALSARRAAARFNRPGMDIFTQHVFCLTGDGCLQEGVARESLA
CEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCEEEEEECCHHHHHHHHHHHHH
LAAVLKLDNLILIYDSNDITLDAPAERTQLTDPRAVYEALGWDVRQIDGHDIRAIESAVE
HHHHHHHCCEEEEECCCCEEECCCCCCCCCCCHHHHHHHHCCCEEECCCCHHHHHHHHHH
AAKNAKNGKPQLIIAKTVIGKGIPGIEGTTKGHGEGGAKLQEEAHANWGIPAGERYYVSE
HHHCCCCCCCCEEEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCEEEEHH
DVRTAFANLKAQREKDFNAWNAMYEQWRRAYPELAEELDAGINACSCGVNPADSDKAIPP
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCC
FPQDYGDATRSAGAVAINAIAKANPCFLTTSADLYSSNKNYLSGAGDFSAETPEGRNFWF
CCCHHCHHHHCCCCEEEEHHHCCCCEEEEECHHHHCCCCCCCCCCCCCCCCCCCCCCEEE
GIREHAMAAICNGIAYDGLFRVSAATFCVFVDYMRASIRVAALSGLPVTYILTHDSVAVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEEECCCEEEC
EDGPTHQPVETISGLRVIPNLDVIRPADPEETAGAWMAAMQRADGPTALILTRQKVATLN
CCCCCCCHHHHHCCCEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHCC
GIPVETRREGVLKGAYIARKEQGALKAIILASGSELELALKAAEKTGEGIRVVSMPSFCR
CCCCCHHHCCCHHHHHHHCCCCCCEEEEEEECCCCEEEHHHHHHHCCCCEEEEECCHHHC
FDAQPAEYRESVLPSSCMRRVSVEAGVTDLWWKYLGCQGEAVGINRFGFSAPGTQVLEEL
CCCCHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHH
GMNVDNVVAAVHKVLAK
CCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9384377; 9068642 [H]