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The map label for this gene is gcvT [H]

Identifier: 187734953

GI number: 187734953

Start: 529944

End: 531029

Strand: Direct

Name: gcvT [H]

Synonym: Amuc_0446

Alternate gene names: 187734953

Gene position: 529944-531029 (Clockwise)

Preceding gene: 187734952

Following gene: 187734954

Centisome position: 19.89

GC content: 56.91

Gene sequence:

>1086_bases
ATGACTGATACAGACGTCAAATCCACCCCCCTGGCAACTAAACACGTTGAACTGGGAGCCAGAATGGTTCCTTTCGCCGG
CTGGAATATGCCGGTGCAGTACACCGGCATTCTGGACGAACACAAAGCAGTGCGCGAAACCTGCGGCATTTTTGACATCT
CCCACATGGGGCAGTTCACGGTAGCCGGCGGTTCCGCTGCAGCATGGCTGAACTCCATGCTGACCAATGACATCAACAAA
CTGAATGTAGGGCAGGGGCAATACTCCGTCATGCTCAATGACAGGGCCGGAGTCATTGACGACCTCATCCTGTACCGGAT
GGAACCGGAAACCTTCTTCGTAGTGGTGAACGCCTCCAAGATTGATGAAGACTTCGCATGGCTTTCCGCCCATCAACCTG
CAGGCGTAACTCTGGAAAACCACTCCGACGAATACGTGGGGCTGGCTGTTCAAGGTCCCGAATGCGGAGAAGTATTCTCC
CGCGTCATCCCCGGCGTGGAACTTCCCCCCCGCAATGGAATCTCCCGCATCACGGCGGAAGGGACGGATCTCATTATCTG
CCGCACCGGCTATACCGGGGAAGATGGTTTTGAATTCTTCTGCCCGGCTAAGGAAGGCGTCAAATGGTTTGAAGCCTTTC
TTGGAGCAGGAGCCAAACCCTGCGGCCTGGGCGCCCGCGACAGCCTGCGTCTGGAAATGTGCTATCCTCTGAACGGCTCC
GACCTCTCTCCGGACAAAACGCCTCTGGAAGCCGGGCTCGGATTCTTCTGCGCGCTGGATACGGACTTCATCGGTTCCGA
TATTCTCCGGGAACAAAAAGCCAACGGCCTCAGCCGTCGGCTGGCCGCTATTGAATACACCGGCAAGGGAGCTCCTCCCC
GCGCCCACTATGCCGTGCACGTCCCCGGCGGAGAAGCCATCGGAGAACTTACCAGCGGCGTGCTCTCTCCTTCGCTGATG
AAGGGCATTGCCCTGGCCTACCTGCCTGCCGCCTATGCCAAGGTCGGCACGGAGCTGGAAATTGACGTAAGGGGAAGGAA
ATTCCCAGCCGTGGTCGTAAAAAAACCCTTTTATAAAAAAGGCTGA

Upstream 100 bases:

>100_bases
CATCGAATTCCGCTTCAATGTCTAGACGGAAGCGTTACCGGAATTCCATTGACTTTTACTGATATAAGGGGCAGATTGCT
CATAACCTTCACATCGCCTC

Downstream 100 bases:

>100_bases
CACTACGGCGCAAAAATAAACTGACAAACACCTCATTTTACTACACTCTCACTTCAAACAATTACATCTTATGCACGACG
TACCAGAAAATCTGCTGTAT

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MTDTDVKSTPLATKHVELGARMVPFAGWNMPVQYTGILDEHKAVRETCGIFDISHMGQFTVAGGSAAAWLNSMLTNDINK
LNVGQGQYSVMLNDRAGVIDDLILYRMEPETFFVVVNASKIDEDFAWLSAHQPAGVTLENHSDEYVGLAVQGPECGEVFS
RVIPGVELPPRNGISRITAEGTDLIICRTGYTGEDGFEFFCPAKEGVKWFEAFLGAGAKPCGLGARDSLRLEMCYPLNGS
DLSPDKTPLEAGLGFFCALDTDFIGSDILREQKANGLSRRLAAIEYTGKGAPPRAHYAVHVPGGEAIGELTSGVLSPSLM
KGIALAYLPAAYAKVGTELEIDVRGRKFPAVVVKKPFYKKG

Sequences:

>Translated_361_residues
MTDTDVKSTPLATKHVELGARMVPFAGWNMPVQYTGILDEHKAVRETCGIFDISHMGQFTVAGGSAAAWLNSMLTNDINK
LNVGQGQYSVMLNDRAGVIDDLILYRMEPETFFVVVNASKIDEDFAWLSAHQPAGVTLENHSDEYVGLAVQGPECGEVFS
RVIPGVELPPRNGISRITAEGTDLIICRTGYTGEDGFEFFCPAKEGVKWFEAFLGAGAKPCGLGARDSLRLEMCYPLNGS
DLSPDKTPLEAGLGFFCALDTDFIGSDILREQKANGLSRRLAAIEYTGKGAPPRAHYAVHVPGGEAIGELTSGVLSPSLM
KGIALAYLPAAYAKVGTELEIDVRGRKFPAVVVKKPFYKKG
>Mature_360_residues
TDTDVKSTPLATKHVELGARMVPFAGWNMPVQYTGILDEHKAVRETCGIFDISHMGQFTVAGGSAAAWLNSMLTNDINKL
NVGQGQYSVMLNDRAGVIDDLILYRMEPETFFVVVNASKIDEDFAWLSAHQPAGVTLENHSDEYVGLAVQGPECGEVFSR
VIPGVELPPRNGISRITAEGTDLIICRTGYTGEDGFEFFCPAKEGVKWFEAFLGAGAKPCGLGARDSLRLEMCYPLNGSD
LSPDKTPLEAGLGFFCALDTDFIGSDILREQKANGLSRRLAAIEYTGKGAPPRAHYAVHVPGGEAIGELTSGVLSPSLMK
GIALAYLPAAYAKVGTELEIDVRGRKFPAVVVKKPFYKKG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=366, Percent_Identity=34.4262295081967, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI257796258, Length=352, Percent_Identity=33.5227272727273, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI257796254, Length=360, Percent_Identity=31.9444444444444, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI24797151, Length=330, Percent_Identity=28.1818181818182, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI257796256, Length=314, Percent_Identity=32.484076433121, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI197927446, Length=324, Percent_Identity=26.2345679012346, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI21361378, Length=324, Percent_Identity=26.2345679012346, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI194306651, Length=350, Percent_Identity=25.7142857142857, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1789272, Length=366, Percent_Identity=36.8852459016393, Blast_Score=217, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17560118, Length=380, Percent_Identity=33.4210526315789, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI71994045, Length=357, Percent_Identity=25.4901960784314, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71994052, Length=357, Percent_Identity=25.4901960784314, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI32563613, Length=339, Percent_Identity=23.0088495575221, Blast_Score=92, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320222, Length=380, Percent_Identity=33.4210526315789, Blast_Score=177, Evalue=2e-45,
Organism=Drosophila melanogaster, GI20129441, Length=372, Percent_Identity=34.1397849462366, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI20130091, Length=358, Percent_Identity=26.8156424581006, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28571104, Length=287, Percent_Identity=24.390243902439, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 38914; Mature: 38783

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTDVKSTPLATKHVELGARMVPFAGWNMPVQYTGILDEHKAVRETCGIFDISHMGQFT
CCCCCCCCCCCCCHHHHCCCEECCCCCCCCCEEEECCHHHHHHHHHHCCEEECCCCCEEE
VAGGSAAAWLNSMLTNDINKLNVGQGQYSVMLNDRAGVIDDLILYRMEPETFFVVVNASK
ECCCHHHHHHHHHHHCCCCEEECCCCEEEEEECCCCCHHHHEEEEEECCCEEEEEEECCC
IDEDFAWLSAHQPAGVTLENHSDEYVGLAVQGPECGEVFSRVIPGVELPPRNGISRITAE
CCCCHHHHCCCCCCCCEEECCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCEEEEC
GTDLIICRTGYTGEDGFEFFCPAKEGVKWFEAFLGAGAKPCGLGARDSLRLEMCYPLNGS
CCEEEEECCCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCC
DLSPDKTPLEAGLGFFCALDTDFIGSDILREQKANGLSRRLAAIEYTGKGAPPRAHYAVH
CCCCCCCCHHHCCEEEEEECCCHHHHHHHHHHHHCCHHHHEEEEEECCCCCCCCCEEEEE
VPGGEAIGELTSGVLSPSLMKGIALAYLPAAYAKVGTELEIDVRGRKFPAVVVKKPFYKK
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCC
G
C
>Mature Secondary Structure 
TDTDVKSTPLATKHVELGARMVPFAGWNMPVQYTGILDEHKAVRETCGIFDISHMGQFT
CCCCCCCCCCCCHHHHCCCEECCCCCCCCCEEEECCHHHHHHHHHHCCEEECCCCCEEE
VAGGSAAAWLNSMLTNDINKLNVGQGQYSVMLNDRAGVIDDLILYRMEPETFFVVVNASK
ECCCHHHHHHHHHHHCCCCEEECCCCEEEEEECCCCCHHHHEEEEEECCCEEEEEEECCC
IDEDFAWLSAHQPAGVTLENHSDEYVGLAVQGPECGEVFSRVIPGVELPPRNGISRITAE
CCCCHHHHCCCCCCCCEEECCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCEEEEC
GTDLIICRTGYTGEDGFEFFCPAKEGVKWFEAFLGAGAKPCGLGARDSLRLEMCYPLNGS
CCEEEEECCCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCC
DLSPDKTPLEAGLGFFCALDTDFIGSDILREQKANGLSRRLAAIEYTGKGAPPRAHYAVH
CCCCCCCCHHHCCEEEEEECCCHHHHHHHHHHHHCCHHHHEEEEEECCCCCCCCCEEEEE
VPGGEAIGELTSGVLSPSLMKGIALAYLPAAYAKVGTELEIDVRGRKFPAVVVKKPFYKK
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA