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The map label for this gene is gmhA

Identifier: 187734921

GI number: 187734921

Start: 494569

End: 495138

Strand: Reverse

Name: gmhA

Synonym: Amuc_0414

Alternate gene names: 187734921

Gene position: 495138-494569 (Counterclockwise)

Preceding gene: 187734922

Following gene: 187734920

Centisome position: 18.59

GC content: 57.72

Gene sequence:

>570_bases
ATGAGCGAATACATCAGGAACCAGATTTTAGGGATAGCGGACAATTTCAAAGCCCTGGCTTCCATGGCCGGGGATATTGA
GCAGGTTGCCCGCATTTGTACGGATACCCTTAAGGCCGGGAATAAGATCATGTTCTGCGGCAACGGAGGCTCCGCTGCGG
ATTCCCAGCACCTGGCCGCCGAATTGGTGGGGCGTTACAAGCTGAACCGCCCCGCCATGAATGCGCTGGCCCTGACGGTG
GATACTTCCATCCTGACCGCCGTGGGCAATGATTACGGTTATGAGACGGTGTTTTCCAGGCAGCTGGAGGGAGTGGGCCG
TCCCGGAGATCTGCTGGTGGGGCTTTCCACGAGTGGCAACAGCCGGAACATCGTTTTGGCGATGGAGCTGGCGCGCCGGA
TGGGCGTCCGGACGGTGGCCTTGACAGGCCGCGGAGGCGGAGAGATGAAAGAAGTTGCGGAGTTTTGCATTGCCGTTCCT
TCCGATGCCACGAACAACATTCAGGAGATGCACATTGCAGTGGGGCATCTGGTTTGCGAACTGGTTGAACGGGAGATATA
TGGCGGGTAA

Upstream 100 bases:

>100_bases
GACAGTTCGTGAAATCTTATGGAGGGCAGGCTCTTGAACTGCCCCGCCTGGAGGGCTTTTCCTCCACCAATATCATCAAC
CGCATGAAAAGCAGCCCGGA

Downstream 100 bases:

>100_bases
GGCTTTGTTTCTGGACAGGGACGGCGTGGTTAATGTGGATGGCGGGTATGTGCACCGCATAGAGGACTTCCGGCTGGTTC
CCGGAATTCTGAATCTTTGC

Product: phosphoheptose isomerase

Products: NA

Alternate protein names: Sedoheptulose 7-phosphate isomerase

Number of amino acids: Translated: 189; Mature: 188

Protein sequence:

>189_residues
MSEYIRNQILGIADNFKALASMAGDIEQVARICTDTLKAGNKIMFCGNGGSAADSQHLAAELVGRYKLNRPAMNALALTV
DTSILTAVGNDYGYETVFSRQLEGVGRPGDLLVGLSTSGNSRNIVLAMELARRMGVRTVALTGRGGGEMKEVAEFCIAVP
SDATNNIQEMHIAVGHLVCELVEREIYGG

Sequences:

>Translated_189_residues
MSEYIRNQILGIADNFKALASMAGDIEQVARICTDTLKAGNKIMFCGNGGSAADSQHLAAELVGRYKLNRPAMNALALTV
DTSILTAVGNDYGYETVFSRQLEGVGRPGDLLVGLSTSGNSRNIVLAMELARRMGVRTVALTGRGGGEMKEVAEFCIAVP
SDATNNIQEMHIAVGHLVCELVEREIYGG
>Mature_188_residues
SEYIRNQILGIADNFKALASMAGDIEQVARICTDTLKAGNKIMFCGNGGSAADSQHLAAELVGRYKLNRPAMNALALTVD
TSILTAVGNDYGYETVFSRQLEGVGRPGDLLVGLSTSGNSRNIVLAMELARRMGVRTVALTGRGGGEMKEVAEFCIAVPS
DATNNIQEMHIAVGHLVCELVEREIYGG

Specific function: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate

COG id: COG0279

COG function: function code G; Phosphoheptose isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1786416, Length=189, Percent_Identity=42.8571428571429, Blast_Score=156, Evalue=8e-40,
Organism=Escherichia coli, GI1789539, Length=190, Percent_Identity=36.8421052631579, Blast_Score=131, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GMHA_AKKM8 (B2UNE0)

Other databases:

- EMBL:   CP001071
- RefSeq:   YP_001877033.1
- ProteinModelPortal:   B2UNE0
- SMR:   B2UNE0
- GeneID:   6274832
- GenomeReviews:   CP001071_GR
- KEGG:   amu:Amuc_0414
- HOGENOM:   HBG671955
- OMA:   ECHICIG
- GO:   GO:0005737
- HAMAP:   MF_00067
- InterPro:   IPR004515
- InterPro:   IPR020620
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00441

Pfam domain/function: PF01380 SIS

EC number: =5.3.1.28

Molecular weight: Translated: 20109; Mature: 19978

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS51464 SIS

Important sites: BINDING 61-61 BINDING 121-121 BINDING 168-168

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEYIRNQILGIADNFKALASMAGDIEQVARICTDTLKAGNKIMFCGNGGSAADSQHLAA
CCHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHH
ELVGRYKLNRPAMNALALTVDTSILTAVGNDYGYETVFSRQLEGVGRPGDLLVGLSTSGN
HHHHHHHCCCCCHHHEEEEEHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCC
SRNIVLAMELARRMGVRTVALTGRGGGEMKEVAEFCIAVPSDATNNIQEMHIAVGHLVCE
CCEEEEHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LVEREIYGG
HHHHHHCCC
>Mature Secondary Structure 
SEYIRNQILGIADNFKALASMAGDIEQVARICTDTLKAGNKIMFCGNGGSAADSQHLAA
CHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHH
ELVGRYKLNRPAMNALALTVDTSILTAVGNDYGYETVFSRQLEGVGRPGDLLVGLSTSGN
HHHHHHHCCCCCHHHEEEEEHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCC
SRNIVLAMELARRMGVRTVALTGRGGGEMKEVAEFCIAVPSDATNNIQEMHIAVGHLVCE
CCEEEEHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LVEREIYGG
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA