BacMap

Definition	Akkermansia muciniphila ATCC BAA-835, complete genome.
Accession	NC_010655
Length	2,664,102

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The map label for this gene is ucpA [C]

Identifier: 187734871

GI number: 187734871

Start: 428590

End: 429435

Strand: Direct

Name: ucpA [C]

Synonym: Amuc_0363

Alternate gene names: 187734871

Gene position: 428590-429435 (Clockwise)

Preceding gene: 187734870

Following gene: 187734872

Centisome position: 16.09

GC content: 61.23

Gene sequence:

>846_bases
ATGCACACCGCACGCCTCCAATACGACAGGATTATCATTACGGGCGCATCATCCGGCTTCGGGGAAGCGTTTGCCGGAAC
GCTGGCCCCCCATACGGCGGAATTGGTGCTCATCGCCCGGAATGAAGCCGCCCTGCGCCAGCTTGCCGCCGCCCTGGAAA
AACACCATTCAGGCCTTCATGCCTCCGTCCTTCCCTGCGACCTGGCGGACGAAGCCTCCCTGAATATGCTCATTTCCCGC
CTGGACAGCCTTCCTCCGGGAAGAACCCTTCTGATTAACAACGCCGGTGCCGGTGATTACGGAGATTTCTCGGACGGCCG
CTGGGAAAAAATTCGTTTTCTACTGCGCCTGAACGTGGAAAGCCTCACCCGCCTGTGCCATGCGCTGGTCCCCTCCATGA
AGAGGAACGGAGGAGATATCATCAACCTCAGCTCCCTGGGAGCCCTCCTGCCCATTCCGGATTTTGCCGTTTATGCGGCC
ACCAAGGCTTATGTTTCCAGCCTGTCGGAAGCGCTGCGGCTGGAACTGCGCGAACACGGCATACGCGTGCTGGTCGTCTG
CCCGGGCCCGGTTTCCACGGGTTTCGGAAAAGCGGCGCGCCGCCCCGGCTTTACCGGAAACATGATGCCGGGGCGCAACG
CTTTTGACACGTCCGTTGAAACCGTCGTGAAAGACAGCCTCCGTGCCCTGGCCCGCGGACGCGCCCGGGTCTTTCCCGGC
ATGAAAATACGACTGGCCGCCATACTGCTGGCCGCCGCCCCTCTGGGGCTGATACGCCTTTTCATGGGCAGGCGCCCCCG
GAAAGTCCTGCCGGCATCCAATGATTCTCCTTCTTCAGCATCATGA

Upstream 100 bases:

>100_bases
CGGCCTAAAAAAGGGAGACCGGCTTTTTGCGTCCTCCTTCCCCCTTTTTCATTGCGGTTCCGCACCGGATTGACCATGAT
ACGGGCTGCTCCAACCCGCC

Downstream 100 bases:

>100_bases
AAGCGCACCGCCGCAGAATACCCCGCCTCACCTGGTTCAAGCTCGCAGTCTGCATCTGCCTGGCAGCCATGGCAGCCTCC
CTGTTCACGCCGTACCCCGC

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MHTARLQYDRIIITGASSGFGEAFAGTLAPHTAELVLIARNEAALRQLAAALEKHHSGLHASVLPCDLADEASLNMLISR
LDSLPPGRTLLINNAGAGDYGDFSDGRWEKIRFLLRLNVESLTRLCHALVPSMKRNGGDIINLSSLGALLPIPDFAVYAA
TKAYVSSLSEALRLELREHGIRVLVVCPGPVSTGFGKAARRPGFTGNMMPGRNAFDTSVETVVKDSLRALARGRARVFPG
MKIRLAAILLAAAPLGLIRLFMGRRPRKVLPASNDSPSSAS

Sequences:

>Translated_281_residues
MHTARLQYDRIIITGASSGFGEAFAGTLAPHTAELVLIARNEAALRQLAAALEKHHSGLHASVLPCDLADEASLNMLISR
LDSLPPGRTLLINNAGAGDYGDFSDGRWEKIRFLLRLNVESLTRLCHALVPSMKRNGGDIINLSSLGALLPIPDFAVYAA
TKAYVSSLSEALRLELREHGIRVLVVCPGPVSTGFGKAARRPGFTGNMMPGRNAFDTSVETVVKDSLRALARGRARVFPG
MKIRLAAILLAAAPLGLIRLFMGRRPRKVLPASNDSPSSAS
>Mature_281_residues
MHTARLQYDRIIITGASSGFGEAFAGTLAPHTAELVLIARNEAALRQLAAALEKHHSGLHASVLPCDLADEASLNMLISR
LDSLPPGRTLLINNAGAGDYGDFSDGRWEKIRFLLRLNVESLTRLCHALVPSMKRNGGDIINLSSLGALLPIPDFAVYAA
TKAYVSSLSEALRLELREHGIRVLVVCPGPVSTGFGKAARRPGFTGNMMPGRNAFDTSVETVVKDSLRALARGRARVFPG
MKIRLAAILLAAAPLGLIRLFMGRRPRKVLPASNDSPSSAS

Specific function: Unknown

COG id: COG0300

COG function: function code R; Short-chain dehydrogenases of various substrate specificities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4507185, Length=215, Percent_Identity=38.1395348837209, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI7705855, Length=200, Percent_Identity=29.5, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI20149619, Length=278, Percent_Identity=29.4964028776978, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI31542939, Length=208, Percent_Identity=29.8076923076923, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI109715829, Length=197, Percent_Identity=33.502538071066, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4557649, Length=229, Percent_Identity=27.0742358078603, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI33667109, Length=207, Percent_Identity=30.9178743961353, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI32483357, Length=191, Percent_Identity=29.3193717277487, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI5031737, Length=206, Percent_Identity=30.0970873786408, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4503817, Length=196, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI126723191, Length=177, Percent_Identity=29.3785310734463, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI210032110, Length=193, Percent_Identity=29.5336787564767, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI224922801, Length=155, Percent_Identity=32.258064516129, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI66933014, Length=213, Percent_Identity=29.5774647887324, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI40254992, Length=210, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI7706318, Length=211, Percent_Identity=28.9099526066351, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI87082100, Length=192, Percent_Identity=32.2916666666667, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789378, Length=194, Percent_Identity=30.4123711340206, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788459, Length=190, Percent_Identity=30, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787820, Length=188, Percent_Identity=27.6595744680851, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1786701, Length=278, Percent_Identity=27.3381294964029, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1790717, Length=194, Percent_Identity=25.2577319587629, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787335, Length=208, Percent_Identity=29.3269230769231, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI2367175, Length=202, Percent_Identity=31.6831683168317, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787905, Length=210, Percent_Identity=31.4285714285714, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=196, Percent_Identity=33.1632653061224, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994600, Length=197, Percent_Identity=32.48730964467, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17538486, Length=207, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25152911, Length=201, Percent_Identity=30.3482587064677, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17559104, Length=201, Percent_Identity=30.8457711442786, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562906, Length=209, Percent_Identity=30.622009569378, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193204405, Length=211, Percent_Identity=31.2796208530806, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17559552, Length=211, Percent_Identity=26.5402843601896, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=206, Percent_Identity=30.5825242718447, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17565030, Length=203, Percent_Identity=32.512315270936, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=202, Percent_Identity=28.7128712871287, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=209, Percent_Identity=29.1866028708134, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=206, Percent_Identity=32.0388349514563, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560676, Length=195, Percent_Identity=28.7179487179487, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=202, Percent_Identity=29.2079207920792, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=192, Percent_Identity=30.7291666666667, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=203, Percent_Identity=29.5566502463054, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=198, Percent_Identity=29.7979797979798, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71997402, Length=196, Percent_Identity=28.0612244897959, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI212646214, Length=189, Percent_Identity=26.4550264550265, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17557668, Length=214, Percent_Identity=26.1682242990654, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532725, Length=198, Percent_Identity=28.7878787878788, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=198, Percent_Identity=30.3030303030303, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=197, Percent_Identity=28.9340101522843, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=199, Percent_Identity=28.643216080402, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=220, Percent_Identity=29.0909090909091, Blast_Score=83, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319635, Length=233, Percent_Identity=27.8969957081545, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24584752, Length=221, Percent_Identity=28.5067873303167, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24584744, Length=259, Percent_Identity=29.3436293436293, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574402, Length=259, Percent_Identity=30.5019305019305, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28571526, Length=187, Percent_Identity=32.0855614973262, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24640442, Length=228, Percent_Identity=30.2631578947368, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI161076933, Length=243, Percent_Identity=29.6296296296296, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24584748, Length=207, Percent_Identity=29.4685990338164, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24651139, Length=242, Percent_Identity=29.3388429752066, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21357041, Length=194, Percent_Identity=29.8969072164948, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI23397609, Length=184, Percent_Identity=32.0652173913043, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24644339, Length=185, Percent_Identity=30.2702702702703, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI281364494, Length=204, Percent_Identity=29.4117647058824, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21358495, Length=186, Percent_Identity=30.6451612903226, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24580925, Length=208, Percent_Identity=31.25, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24643142, Length=186, Percent_Identity=29.5698924731183, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21356301, Length=228, Percent_Identity=26.7543859649123, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.51 [H]

Molecular weight: Translated: 30067; Mature: 30067

Theoretical pI: Translated: 10.68; Mature: 10.68

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTARLQYDRIIITGASSGFGEAFAGTLAPHTAELVLIARNEAALRQLAAALEKHHSGLH
CCCCCEEECEEEEEECCCCCCHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCC
ASVLPCDLADEASLNMLISRLDSLPPGRTLLINNAGAGDYGDFSDGRWEKIRFLLRLNVE
CEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCHH
SLTRLCHALVPSMKRNGGDIINLSSLGALLPIPDFAVYAATKAYVSSLSEALRLELREHG
HHHHHHHHHHHHHHCCCCCEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
IRVLVVCPGPVSTGFGKAARRPGFTGNMMPGRNAFDTSVETVVKDSLRALARGRARVFPG
CEEEEECCCCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCC
MKIRLAAILLAAAPLGLIRLFMGRRPRKVLPASNDSPSSAS
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHTARLQYDRIIITGASSGFGEAFAGTLAPHTAELVLIARNEAALRQLAAALEKHHSGLH
CCCCCEEECEEEEEECCCCCCHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCC
ASVLPCDLADEASLNMLISRLDSLPPGRTLLINNAGAGDYGDFSDGRWEKIRFLLRLNVE
CEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCHH
SLTRLCHALVPSMKRNGGDIINLSSLGALLPIPDFAVYAATKAYVSSLSEALRLELREHG
HHHHHHHHHHHHHHCCCCCEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
IRVLVVCPGPVSTGFGKAARRPGFTGNMMPGRNAFDTSVETVVKDSLRALARGRARVFPG
CEEEEECCCCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCC
MKIRLAAILLAAAPLGLIRLFMGRRPRKVLPASNDSPSSAS
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8382516; 2026158; 8617258 [H]