| Definition | Akkermansia muciniphila ATCC BAA-835, complete genome. |
|---|---|
| Accession | NC_010655 |
| Length | 2,664,102 |
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The map label for this gene is fabG [C]
Identifier: 187734742
GI number: 187734742
Start: 288487
End: 289272
Strand: Reverse
Name: fabG [C]
Synonym: Amuc_0230
Alternate gene names: 187734742
Gene position: 289272-288487 (Counterclockwise)
Preceding gene: 187734743
Following gene: 187734740
Centisome position: 10.86
GC content: 56.62
Gene sequence:
>786_bases ATGAAGGATGTTGATTTTTCCGGCAGTACCGTGGTGGTGACGGGAGGAGCCTGCGGCATTGGCCGCGCCATTGCGGAAGC TTTCGCTGCGGCGGGAGCCCGGGTGGCGGTTTTGGATGTGAAGCATGAGGAAACGGCCTCCCTGCTGGAGGAATTGCCGG GAGAGGGGCATCTTTGCGTGACGGGCAACGCGGGTGTGGAAGAGGACGTGCGGTCTTTTGCGGAAAAGGTGTTGGAATGT TTTGGCCGTGTGGATGTGCTGGTAAATAATGCGTGCATCACGCGTCGCGGCATTCTTTCCGGCTGTTCCTTCGAGGAATT CAATGAAGTTTTGCGCGTGGGAGTTTCCGCGCCCTATCTGCTGAGCCTTTTATTTCGCGACCATTTTTCCCGCGGCGCTT CCATTGTGAATATTGCTTCCACCCGCGCTTCCATGTCCCAGAAGGATACGGAAAGCTATAGTGCGGCCAAGGGCGCCCTC ACTTCTTTAACTCACGCTCTCGCCATGAGCCTTTCCCCTTTCGGCGTTCGTGTGAACAGTATCAGTCCAGGCTGGATTGA CACGGGGGTGTTCGGCGTCCTGTCTCCGGAAGATGCTTTTCAGCATCCTTCCGGGCGCGTCGGTTTGCCGGAAGATATCG TGAAGGCCGTTTTCTTTCTATGCGGCTCCAGCTTTGTCAATGCGGAGAATCTGGTCATTGACGGCGGCATGTCCCGTATG ATGGTGTACCACGGAGATGAGGGGTGGTCATTCCATCCGGAACAGTCGGACAGCGTTCCCTCCTGA
Upstream 100 bases:
>100_bases AGAGCCATGGGGCTTTACCGCGATGTAATGTATGCACGTTAAGTACCGTATGCCGGAAGGCGATGATTGACTTTCTTGAG TGGAATATGACAATCAGCCT
Downstream 100 bases:
>100_bases CGGGCTTGCGCTTCCGGCATGCTTTCCATTGCAGCTGTTTCAAACAGGTCCCGTGCCGTCCGGACGCTTGTTCCGCCTGG AACTGGAATAACAGCGGCAG
Product: short-chain dehydrogenase/reductase SDR
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: NA
Number of amino acids: Translated: 261; Mature: 261
Protein sequence:
>261_residues MKDVDFSGSTVVVTGGACGIGRAIAEAFAAAGARVAVLDVKHEETASLLEELPGEGHLCVTGNAGVEEDVRSFAEKVLEC FGRVDVLVNNACITRRGILSGCSFEEFNEVLRVGVSAPYLLSLLFRDHFSRGASIVNIASTRASMSQKDTESYSAAKGAL TSLTHALAMSLSPFGVRVNSISPGWIDTGVFGVLSPEDAFQHPSGRVGLPEDIVKAVFFLCGSSFVNAENLVIDGGMSRM MVYHGDEGWSFHPEQSDSVPS
Sequences:
>Translated_261_residues MKDVDFSGSTVVVTGGACGIGRAIAEAFAAAGARVAVLDVKHEETASLLEELPGEGHLCVTGNAGVEEDVRSFAEKVLEC FGRVDVLVNNACITRRGILSGCSFEEFNEVLRVGVSAPYLLSLLFRDHFSRGASIVNIASTRASMSQKDTESYSAAKGAL TSLTHALAMSLSPFGVRVNSISPGWIDTGVFGVLSPEDAFQHPSGRVGLPEDIVKAVFFLCGSSFVNAENLVIDGGMSRM MVYHGDEGWSFHPEQSDSVPS >Mature_261_residues MKDVDFSGSTVVVTGGACGIGRAIAEAFAAAGARVAVLDVKHEETASLLEELPGEGHLCVTGNAGVEEDVRSFAEKVLEC FGRVDVLVNNACITRRGILSGCSFEEFNEVLRVGVSAPYLLSLLFRDHFSRGASIVNIASTRASMSQKDTESYSAAKGAL TSLTHALAMSLSPFGVRVNSISPGWIDTGVFGVLSPEDAFQHPSGRVGLPEDIVKAVFFLCGSSFVNAENLVIDGGMSRM MVYHGDEGWSFHPEQSDSVPS
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI40254992, Length=232, Percent_Identity=32.3275862068966, Blast_Score=103, Evalue=2e-22, Organism=Homo sapiens, GI59889578, Length=226, Percent_Identity=31.858407079646, Blast_Score=100, Evalue=2e-21, Organism=Homo sapiens, GI5031737, Length=248, Percent_Identity=33.0645161290323, Blast_Score=98, Evalue=7e-21, Organism=Homo sapiens, GI32483357, Length=245, Percent_Identity=31.0204081632653, Blast_Score=93, Evalue=2e-19, Organism=Homo sapiens, GI31542939, Length=200, Percent_Identity=32.5, Blast_Score=91, Evalue=1e-18, Organism=Homo sapiens, GI19923817, Length=258, Percent_Identity=29.4573643410853, Blast_Score=90, Evalue=2e-18, Organism=Homo sapiens, GI7705925, Length=243, Percent_Identity=30.4526748971193, Blast_Score=88, Evalue=7e-18, Organism=Homo sapiens, GI4758504, Length=258, Percent_Identity=31.3953488372093, Blast_Score=86, Evalue=5e-17, Organism=Homo sapiens, GI15277342, Length=247, Percent_Identity=29.5546558704453, Blast_Score=82, Evalue=5e-16, Organism=Homo sapiens, GI10190704, Length=241, Percent_Identity=29.4605809128631, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI20149619, Length=192, Percent_Identity=30.2083333333333, Blast_Score=78, Evalue=1e-14, Organism=Homo sapiens, GI33667109, Length=182, Percent_Identity=35.7142857142857, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI4504505, Length=230, Percent_Identity=28.695652173913, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI224922801, Length=188, Percent_Identity=30.8510638297872, Blast_Score=71, Evalue=9e-13, Organism=Homo sapiens, GI126723750, Length=248, Percent_Identity=27.0161290322581, Blast_Score=70, Evalue=3e-12, Organism=Homo sapiens, GI83715985, Length=252, Percent_Identity=29.3650793650794, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI66933014, Length=250, Percent_Identity=28.4, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI126723191, Length=182, Percent_Identity=30.2197802197802, Blast_Score=66, Evalue=4e-11, Organism=Escherichia coli, GI1787335, Length=245, Percent_Identity=34.2857142857143, Blast_Score=120, Evalue=8e-29, Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=30.4, Blast_Score=120, Evalue=1e-28, Organism=Escherichia coli, GI1786812, Length=251, Percent_Identity=30.6772908366534, Blast_Score=100, Evalue=2e-22, Organism=Escherichia coli, GI1789208, Length=243, Percent_Identity=28.3950617283951, Blast_Score=96, Evalue=2e-21, Organism=Escherichia coli, GI87082100, Length=250, Percent_Identity=30, Blast_Score=90, Evalue=2e-19, Organism=Escherichia coli, GI1788459, Length=171, Percent_Identity=31.5789473684211, Blast_Score=90, Evalue=2e-19, Organism=Escherichia coli, GI87082160, Length=243, Percent_Identity=29.6296296296296, Blast_Score=89, Evalue=4e-19, Organism=Escherichia coli, GI1787905, Length=246, Percent_Identity=30.4878048780488, Blast_Score=86, Evalue=4e-18, Organism=Escherichia coli, GI1789057, Length=217, Percent_Identity=29.9539170506912, Blast_Score=84, Evalue=1e-17, Organism=Escherichia coli, GI1789378, Length=235, Percent_Identity=28.0851063829787, Blast_Score=79, Evalue=2e-16, Organism=Escherichia coli, GI2367365, Length=238, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=4e-16, Organism=Escherichia coli, GI2367175, Length=254, Percent_Identity=27.5590551181102, Blast_Score=64, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17555706, Length=245, Percent_Identity=32.2448979591837, Blast_Score=109, Evalue=1e-24, Organism=Caenorhabditis elegans, GI72000259, Length=263, Percent_Identity=33.0798479087452, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17551412, Length=274, Percent_Identity=31.7518248175182, Blast_Score=102, Evalue=1e-22, Organism=Caenorhabditis elegans, GI17562904, Length=266, Percent_Identity=31.5789473684211, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17561402, Length=250, Percent_Identity=31.6, Blast_Score=102, Evalue=3e-22, Organism=Caenorhabditis elegans, GI17560332, Length=269, Percent_Identity=31.2267657992565, Blast_Score=102, Evalue=3e-22, Organism=Caenorhabditis elegans, GI17562908, Length=281, Percent_Identity=30.2491103202847, Blast_Score=102, Evalue=3e-22, Organism=Caenorhabditis elegans, GI193204405, Length=265, Percent_Identity=30.188679245283, Blast_Score=100, Evalue=6e-22, Organism=Caenorhabditis elegans, GI17538480, Length=269, Percent_Identity=30.1115241635688, Blast_Score=100, Evalue=7e-22, Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=30.4182509505703, Blast_Score=100, Evalue=9e-22, Organism=Caenorhabditis elegans, GI17562990, Length=265, Percent_Identity=30.9433962264151, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17538182, Length=255, Percent_Identity=30.9803921568627, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=29.6992481203008, Blast_Score=98, Evalue=4e-21, Organism=Caenorhabditis elegans, GI17560220, Length=273, Percent_Identity=29.3040293040293, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI25147288, Length=244, Percent_Identity=30.327868852459, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17562910, Length=264, Percent_Identity=29.9242424242424, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17559104, Length=270, Percent_Identity=30, Blast_Score=95, Evalue=4e-20, Organism=Caenorhabditis elegans, GI17560150, Length=261, Percent_Identity=29.5019157088123, Blast_Score=94, Evalue=5e-20, Organism=Caenorhabditis elegans, GI17563726, Length=267, Percent_Identity=30.3370786516854, Blast_Score=93, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17560676, Length=243, Percent_Identity=30.4526748971193, Blast_Score=87, Evalue=7e-18, Organism=Caenorhabditis elegans, GI71994604, Length=251, Percent_Identity=27.0916334661355, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=26.2745098039216, Blast_Score=84, Evalue=6e-17, Organism=Caenorhabditis elegans, GI17536651, Length=260, Percent_Identity=28.8461538461538, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17538486, Length=267, Percent_Identity=25.4681647940075, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI115534694, Length=250, Percent_Identity=28.8, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17565030, Length=265, Percent_Identity=27.1698113207547, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17544670, Length=274, Percent_Identity=27.007299270073, Blast_Score=74, Evalue=5e-14, Organism=Caenorhabditis elegans, GI17508895, Length=203, Percent_Identity=27.5862068965517, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17564282, Length=196, Percent_Identity=29.0816326530612, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI193203117, Length=208, Percent_Identity=28.3653846153846, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI193203115, Length=210, Percent_Identity=28.0952380952381, Blast_Score=66, Evalue=2e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=273, Percent_Identity=29.3040293040293, Blast_Score=90, Evalue=4e-19, Organism=Saccharomyces cerevisiae, GI6324126, Length=264, Percent_Identity=26.5151515151515, Blast_Score=70, Evalue=2e-13, Organism=Drosophila melanogaster, GI23397609, Length=245, Percent_Identity=34.6938775510204, Blast_Score=112, Evalue=2e-25, Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=28.9795918367347, Blast_Score=102, Evalue=3e-22, Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=31.7460317460317, Blast_Score=100, Evalue=2e-21, Organism=Drosophila melanogaster, GI24644339, Length=253, Percent_Identity=28.0632411067194, Blast_Score=96, Evalue=2e-20, Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=29.0836653386454, Blast_Score=95, Evalue=5e-20, Organism=Drosophila melanogaster, GI24644337, Length=253, Percent_Identity=32.4110671936759, Blast_Score=91, Evalue=8e-19, Organism=Drosophila melanogaster, GI24643142, Length=250, Percent_Identity=30.8, Blast_Score=91, Evalue=9e-19, Organism=Drosophila melanogaster, GI21355319, Length=250, Percent_Identity=31.2, Blast_Score=91, Evalue=9e-19, Organism=Drosophila melanogaster, GI17737361, Length=253, Percent_Identity=28.8537549407115, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI221331218, Length=204, Percent_Identity=25.9803921568627, Blast_Score=65, Evalue=6e-11, Organism=Drosophila melanogaster, GI24665243, Length=203, Percent_Identity=25.615763546798, Blast_Score=64, Evalue=7e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 27610; Mature: 27610
Theoretical pI: Translated: 4.66; Mature: 4.66
Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.3 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 4.6 %Cys+Met (Translated Protein) 2.3 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 4.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKDVDFSGSTVVVTGGACGIGRAIAEAFAAAGARVAVLDVKHEETASLLEELPGEGHLCV CCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCEEE TGNAGVEEDVRSFAEKVLECFGRVDVLVNNACITRRGILSGCSFEEFNEVLRVGVSAPYL ECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCCCHHHH LSLLFRDHFSRGASIVNIASTRASMSQKDTESYSAAKGALTSLTHALAMSLSPFGVRVNS HHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECC ISPGWIDTGVFGVLSPEDAFQHPSGRVGLPEDIVKAVFFLCGSSFVNAENLVIDGGMSRM CCCCCCCCCEEEEECCHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCEE MVYHGDEGWSFHPEQSDSVPS EEEECCCCCCCCCCCCCCCCC >Mature Secondary Structure MKDVDFSGSTVVVTGGACGIGRAIAEAFAAAGARVAVLDVKHEETASLLEELPGEGHLCV CCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCEEE TGNAGVEEDVRSFAEKVLECFGRVDVLVNNACITRRGILSGCSFEEFNEVLRVGVSAPYL ECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCCCHHHH LSLLFRDHFSRGASIVNIASTRASMSQKDTESYSAAKGALTSLTHALAMSLSPFGVRVNS HHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECC ISPGWIDTGVFGVLSPEDAFQHPSGRVGLPEDIVKAVFFLCGSSFVNAENLVIDGGMSRM CCCCCCCCCEEEEECCHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCEE MVYHGDEGWSFHPEQSDSVPS EEEECCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 8550425; 10360571 [H]