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The map label for this gene is rmlA2 [H]

Identifier: 187734721

GI number: 187734721

Start: 258184

End: 259047

Strand: Reverse

Name: rmlA2 [H]

Synonym: Amuc_0208

Alternate gene names: 187734721

Gene position: 259047-258184 (Counterclockwise)

Preceding gene: 187734722

Following gene: 187734712

Centisome position: 9.72

GC content: 55.44

Gene sequence:

>864_bases
ATGAAGGGTATTGTTCTGGCCGGGGGAAGCGGCACGCGTCTGCATCCCGTTACGCTTTCCGTCAGCAAGCAATTGCTGCC
CGTTTACGATAAGCCGATGGTTTATTATCCCATCTCCGTGCTGATGCTGGCCGGAATACGGGAAATCCTTGTTATTTCCA
CGCCCCGGGATCTGCCCCTGTACCGGGATTTGCTGGGGGACGGCAGCAGGTTCGGCGTTTCCTTTGAATACAGGGAACAA
CCCAGGCCGGAGGGGCTGGCTCAGGCCTTTATTATTGGAGAGGAGTTCATAGGAAAGGATTCCGTTGCCCTGGTGCTGGG
GGACAATATTTTTTACGGGCGCGGCCTGACGGAGAAGCTGAGGAGGGCCGCCGAACTGACGAGCGGAGCGACCATTTTCG
GTTACCAGGTGCATGACCCGCAGCGTTTCGGGGTAGTGGAATTCAATGAGGAGGGGAAGGCGGTTTCCATTGAGGAAAAA
CCGCTCAGGCCCAAATCGGATATTGCGGTGACGGGCCTCTATTTTTACGACAACCGGGTGGTGGAGATAGCCAAACGGAT
TCCCAAGTCTTCCCGCGGCGAGTTGGAAATCACCTCTGTGAATCAGGAATACCTGAAGCAGGGCCTGTTGCGCGTGGAAA
AACTGGCGCGCGGCTATACGTGGCTGGATACGGGCACGCACGATACCCTTCTGGAGGCTTCCATGTTCGTTCGTACTCTG
GAGCATCACCAGGGGTTCAAGGTAGCCTGCCTGGAGGAGATAGCCTTTAATAACGGCTGGATTTCCCAGGAAACGCTGCG
CTCCCAGGCCGGAGCCATGAATAATAACGGTTATGGCCGTTATCTGGATGAATTGGTGAAATAG

Upstream 100 bases:

>100_bases
GACCATTCAGTGGTATCTGGACCATGAGGAATGGTGGCGGGGCATCCTGTCCGGGGAATACCGCCTGGAACGTCTTGGAA
CCAATGGCTAGGAATTTGAT

Downstream 100 bases:

>100_bases
GGCTGTATGCCGCCGGCAGGGAAACGGGAGGGGTGTCCCTGCGACTCCGCGACTTTCCGGGGGTGGGGCGGGTTGCTTTC
CGGCAATGCTTTCCATACGG

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 2; dTDP-glucose pyrophosphorylase 2; dTDP-glucose synthase 2 [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MKGIVLAGGSGTRLHPVTLSVSKQLLPVYDKPMVYYPISVLMLAGIREILVISTPRDLPLYRDLLGDGSRFGVSFEYREQ
PRPEGLAQAFIIGEEFIGKDSVALVLGDNIFYGRGLTEKLRRAAELTSGATIFGYQVHDPQRFGVVEFNEEGKAVSIEEK
PLRPKSDIAVTGLYFYDNRVVEIAKRIPKSSRGELEITSVNQEYLKQGLLRVEKLARGYTWLDTGTHDTLLEASMFVRTL
EHHQGFKVACLEEIAFNNGWISQETLRSQAGAMNNNGYGRYLDELVK

Sequences:

>Translated_287_residues
MKGIVLAGGSGTRLHPVTLSVSKQLLPVYDKPMVYYPISVLMLAGIREILVISTPRDLPLYRDLLGDGSRFGVSFEYREQ
PRPEGLAQAFIIGEEFIGKDSVALVLGDNIFYGRGLTEKLRRAAELTSGATIFGYQVHDPQRFGVVEFNEEGKAVSIEEK
PLRPKSDIAVTGLYFYDNRVVEIAKRIPKSSRGELEITSVNQEYLKQGLLRVEKLARGYTWLDTGTHDTLLEASMFVRTL
EHHQGFKVACLEEIAFNNGWISQETLRSQAGAMNNNGYGRYLDELVK
>Mature_287_residues
MKGIVLAGGSGTRLHPVTLSVSKQLLPVYDKPMVYYPISVLMLAGIREILVISTPRDLPLYRDLLGDGSRFGVSFEYREQ
PRPEGLAQAFIIGEEFIGKDSVALVLGDNIFYGRGLTEKLRRAAELTSGATIFGYQVHDPQRFGVVEFNEEGKAVSIEEK
PLRPKSDIAVTGLYFYDNRVVEIAKRIPKSSRGELEITSVNQEYLKQGLLRVEKLARGYTWLDTGTHDTLLEASMFVRTL
EHHQGFKVACLEEIAFNNGWISQETLRSQAGAMNNNGYGRYLDELVK

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=251, Percent_Identity=23.9043824701195, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI11761621, Length=251, Percent_Identity=23.9043824701195, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1790224, Length=287, Percent_Identity=64.808362369338, Blast_Score=398, Evalue=1e-112,
Organism=Escherichia coli, GI1788351, Length=286, Percent_Identity=62.2377622377622, Blast_Score=381, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI133931050, Length=243, Percent_Identity=25.1028806584362, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=261, Percent_Identity=25.6704980842912, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21355443, Length=251, Percent_Identity=24.3027888446215, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24644084, Length=251, Percent_Identity=24.3027888446215, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32135; Mature: 32135

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIVLAGGSGTRLHPVTLSVSKQLLPVYDKPMVYYPISVLMLAGIREILVISTPRDLPL
CCCEEEECCCCCEEEEEEEECCCCCCCCCCCCEEEHHHHHHHHHCCCEEEEEECCCCCHH
YRDLLGDGSRFGVSFEYREQPRPEGLAQAFIIGEEFIGKDSVALVLGDNIFYGRGLTEKL
HHHHHCCCCEECEEEECCCCCCCCHHHHHEEECHHHCCCCCEEEEEECCEEECCCHHHHH
RRAAELTSGATIFGYQVHDPQRFGVVEFNEEGKAVSIEEKPLRPKSDIAVTGLYFYDNRV
HHHHHHCCCCEEEEEEECCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEEECCHH
VEIAKRIPKSSRGELEITSVNQEYLKQGLLRVEKLARGYTWLDTGTHDTLLEASMFVRTL
HHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHH
EHHQGFKVACLEEIAFNNGWISQETLRSQAGAMNNNGYGRYLDELVK
HHCCCCEEEHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MKGIVLAGGSGTRLHPVTLSVSKQLLPVYDKPMVYYPISVLMLAGIREILVISTPRDLPL
CCCEEEECCCCCEEEEEEEECCCCCCCCCCCCEEEHHHHHHHHHCCCEEEEEECCCCCHH
YRDLLGDGSRFGVSFEYREQPRPEGLAQAFIIGEEFIGKDSVALVLGDNIFYGRGLTEKL
HHHHHCCCCEECEEEECCCCCCCCHHHHHEEECHHHCCCCCEEEEEECCEEECCCHHHHH
RRAAELTSGATIFGYQVHDPQRFGVVEFNEEGKAVSIEEKPLRPKSDIAVTGLYFYDNRV
HHHHHHCCCCEEEEEEECCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEEECCHH
VEIAKRIPKSSRGELEITSVNQEYLKQGLLRVEKLARGYTWLDTGTHDTLLEASMFVRTL
HHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHH
EHHQGFKVACLEEIAFNNGWISQETLRSQAGAMNNNGYGRYLDELVK
HHCCCCEEEHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503; 7559340 [H]