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The map label for this gene is pyrC [H]

Identifier: 187734625

GI number: 187734625

Start: 139030

End: 140304

Strand: Reverse

Name: pyrC [H]

Synonym: Amuc_0111

Alternate gene names: 187734625

Gene position: 140304-139030 (Counterclockwise)

Preceding gene: 187734626

Following gene: 187734624

Centisome position: 5.27

GC content: 62.27

Gene sequence:

>1275_bases
ATGAAAACTTCCGTACTTATTCGCAACGCCCGGCTGACGGACGGTTCCGCCCCGGCGGACCTTCTGGTTTCCGGGGGGGT
GATTACAGCGAAAGCTCCTGCCGGAACGCTTTTGGAGAGCGCCGCGGAAAAGGCGCTGGATGCTTCCGGGAAGCTTGTTC
TGCCCGGCCTGTTCGACATCCATGCCCATTTGTGCCAGCCCGGCCGGGAGGACAAGGAACGTGTGGCTACGGCTACCGCC
GCCGCCCTGCATGGAGGAGTGACCGGACTGATGGCGATGCCGGATACCGAACCCGTGATGGACAATGCCGCCCAGATTAC
CACGTTCATGGAAATATGCCGGACGGATGCTCTGGTGGAGGTTATCCCCTCCGGGTGCCTGACCAAGGGGGACGGCGGGG
AAGAGCAGGCCTCCTACGACTCCCTGCGCGCCAAGGGCGTCCGTTTCATCACGGACGGGGACCGTGCGCCGGACAACATG
CTGCTGCTGTACCGCGCCATGCAGTACGCCAGCAATTTGAACCTTACTTTCGCCCTGCGCGGAGACGTGCCGTCCCTGAC
GGCCAGGGCGGCCATGCACCCGGGCACTACTTCCTACCGTCTGGGGTTGATGGGCTCCCCCTCCTGTGCGGAGGAAATAG
GGCTGGAAACCATCATCCGCCTTTCCGTGGATACGGGCAACTCCCTGCATGTGCAGACCGTCTCTACGGCCGGCAGCGTG
GATATCCTGCGCCGCTGCAAGCAGAAAACCGCCGGGTTGAGCGCGGAAGCGGCGCTTCACCATCTCCTGTTCACGCATGA
GGACGTGGGCCGGTACGATACCTGCTACAAGACGCTGCCGCCCCTGCGCGACCAGTCGGATGTGGATGCCCTGATTGCCG
CCGTGAATGACGGCACCATTGACTGCATTGTTTCCGATCACACGCCCTGCACGCCGTTTTCCAAACTTCAGGATTTCGTT
GTCGCCCCGCAGGGCATGATTGCGCTGGATACGTTCCTGCCCGCTATTTACCAGTATCTGGTGGAACCTGGAAAAATGTC
CTGGCAGACGGTGGTGCGCGCCTGCAGCGATGCTCCCCGCAGGCTGATGGGGCTGGCCCCCGTCTCCCTGGAAGAAGGGG
CTCCGGCCAATCTGGTGGTGTTTGACCCGGAAGGAGAAACGCCCGTCACGGATGAAACGCTCCGCAGCCGCGCCCGCAAC
ACTCCATTCCTGGGCAAGACCTTGAAGGGAAAAGTGGATGCCGTGGTGTTCGGAGAACAGCTCCACCGCTTCTGA

Upstream 100 bases:

>100_bases
CTATGAGCGCTGCCTGATCAACCGCCAGGTGGAAAACGGCATCGCCTGCCGCATGTCCATCCTTTACCATCTCACTCCGC
AAACCCAGCACTGATTGTTC

Downstream 100 bases:

>100_bases
TGAAAGCGTCACGGAGAAAGGCCGGCAGCTATTAATTATTAACTATCAGTCTCCGCTTGCAGCCCGTCGCCCGCGTCAGC
ACGTGTTATCCGGACAAATT

Product: dihydroorotase, multifunctional complex type

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MKTSVLIRNARLTDGSAPADLLVSGGVITAKAPAGTLLESAAEKALDASGKLVLPGLFDIHAHLCQPGREDKERVATATA
AALHGGVTGLMAMPDTEPVMDNAAQITTFMEICRTDALVEVIPSGCLTKGDGGEEQASYDSLRAKGVRFITDGDRAPDNM
LLLYRAMQYASNLNLTFALRGDVPSLTARAAMHPGTTSYRLGLMGSPSCAEEIGLETIIRLSVDTGNSLHVQTVSTAGSV
DILRRCKQKTAGLSAEAALHHLLFTHEDVGRYDTCYKTLPPLRDQSDVDALIAAVNDGTIDCIVSDHTPCTPFSKLQDFV
VAPQGMIALDTFLPAIYQYLVEPGKMSWQTVVRACSDAPRRLMGLAPVSLEEGAPANLVVFDPEGETPVTDETLRSRARN
TPFLGKTLKGKVDAVVFGEQLHRF

Sequences:

>Translated_424_residues
MKTSVLIRNARLTDGSAPADLLVSGGVITAKAPAGTLLESAAEKALDASGKLVLPGLFDIHAHLCQPGREDKERVATATA
AALHGGVTGLMAMPDTEPVMDNAAQITTFMEICRTDALVEVIPSGCLTKGDGGEEQASYDSLRAKGVRFITDGDRAPDNM
LLLYRAMQYASNLNLTFALRGDVPSLTARAAMHPGTTSYRLGLMGSPSCAEEIGLETIIRLSVDTGNSLHVQTVSTAGSV
DILRRCKQKTAGLSAEAALHHLLFTHEDVGRYDTCYKTLPPLRDQSDVDALIAAVNDGTIDCIVSDHTPCTPFSKLQDFV
VAPQGMIALDTFLPAIYQYLVEPGKMSWQTVVRACSDAPRRLMGLAPVSLEEGAPANLVVFDPEGETPVTDETLRSRARN
TPFLGKTLKGKVDAVVFGEQLHRF
>Mature_424_residues
MKTSVLIRNARLTDGSAPADLLVSGGVITAKAPAGTLLESAAEKALDASGKLVLPGLFDIHAHLCQPGREDKERVATATA
AALHGGVTGLMAMPDTEPVMDNAAQITTFMEICRTDALVEVIPSGCLTKGDGGEEQASYDSLRAKGVRFITDGDRAPDNM
LLLYRAMQYASNLNLTFALRGDVPSLTARAAMHPGTTSYRLGLMGSPSCAEEIGLETIIRLSVDTGNSLHVQTVSTAGSV
DILRRCKQKTAGLSAEAALHHLLFTHEDVGRYDTCYKTLPPLRDQSDVDALIAAVNDGTIDCIVSDHTPCTPFSKLQDFV
VAPQGMIALDTFLPAIYQYLVEPGKMSWQTVVRACSDAPRRLMGLAPVSLEEGAPANLVVFDPEGETPVTDETLRSRARN
TPFLGKTLKGKVDAVVFGEQLHRF

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=372, Percent_Identity=29.0322580645161, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI19923821, Length=417, Percent_Identity=25.6594724220624, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1786722, Length=432, Percent_Identity=24.537037037037, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI87082175, Length=437, Percent_Identity=24.2562929061785, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI193204318, Length=375, Percent_Identity=27.4666666666667, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6322218, Length=386, Percent_Identity=23.8341968911917, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI18859883, Length=457, Percent_Identity=25.8205689277899, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45263; Mature: 45263

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTSVLIRNARLTDGSAPADLLVSGGVITAKAPAGTLLESAAEKALDASGKLVLPGLFDI
CCCCEEEEECCCCCCCCCHHHEEECCEEEECCCCHHHHHHHHHHHHCCCCCEECCCHHHH
HAHLCQPGREDKERVATATAAALHGGVTGLMAMPDTEPVMDNAAQITTFMEICRTDALVE
HHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
VIPSGCLTKGDGGEEQASYDSLRAKGVRFITDGDRAPDNMLLLYRAMQYASNLNLTFALR
HHCCCCEECCCCCCHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEC
GDVPSLTARAAMHPGTTSYRLGLMGSPSCAEEIGLETIIRLSVDTGNSLHVQTVSTAGSV
CCCCCHHHHHHCCCCCCCEEEECCCCCHHHHHHCCEEEEEEEECCCCEEEEEEECCCCCH
DILRRCKQKTAGLSAEAALHHLLFTHEDVGRYDTCYKTLPPLRDQSDVDALIAAVNDGTI
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHEECCCEE
DCIVSDHTPCTPFSKLQDFVVAPQGMIALDTFLPAIYQYLVEPGKMSWQTVVRACSDAPR
EEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
RLMGLAPVSLEEGAPANLVVFDPEGETPVTDETLRSRARNTPFLGKTLKGKVDAVVFGEQ
HHHCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEECHH
LHRF
HHCC
>Mature Secondary Structure
MKTSVLIRNARLTDGSAPADLLVSGGVITAKAPAGTLLESAAEKALDASGKLVLPGLFDI
CCCCEEEEECCCCCCCCCHHHEEECCEEEECCCCHHHHHHHHHHHHCCCCCEECCCHHHH
HAHLCQPGREDKERVATATAAALHGGVTGLMAMPDTEPVMDNAAQITTFMEICRTDALVE
HHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
VIPSGCLTKGDGGEEQASYDSLRAKGVRFITDGDRAPDNMLLLYRAMQYASNLNLTFALR
HHCCCCEECCCCCCHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEC
GDVPSLTARAAMHPGTTSYRLGLMGSPSCAEEIGLETIIRLSVDTGNSLHVQTVSTAGSV
CCCCCHHHHHHCCCCCCCEEEECCCCCHHHHHHCCEEEEEEEECCCCEEEEEEECCCCCH
DILRRCKQKTAGLSAEAALHHLLFTHEDVGRYDTCYKTLPPLRDQSDVDALIAAVNDGTI
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHEECCCEE
DCIVSDHTPCTPFSKLQDFVVAPQGMIALDTFLPAIYQYLVEPGKMSWQTVVRACSDAPR
EEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
RLMGLAPVSLEEGAPANLVVFDPEGETPVTDETLRSRARNTPFLGKTLKGKVDAVVFGEQ
HHHCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEECHH
LHRF
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA