Click here to switch to the map view.

The map label for this gene is hemA

Identifier: 187734605

GI number: 187734605

Start: 118946

End: 119968

Strand: Reverse

Name: hemA

Synonym: Amuc_0091

Alternate gene names: 187734605

Gene position: 119968-118946 (Counterclockwise)

Preceding gene: 187734606

Following gene: 187734604

Centisome position: 4.5

GC content: 56.3

Gene sequence:

>1023_bases
ATGAGAATGGTTTGTTTAGGCTTGAATCACCGGACCGCTCCCGTGGAAATACGGGAGCGGTTTGCCGTGCCGTCCCATAA
ACTCCGGGAGGAAGGACAGCGCATCCGTTCCCTTCCTGGAGTGGACCAGTGCGTTGTGCTTTCCACCTGCAACCGCATGG
AAATTTATTATTGGTCCAACGCTCCGGAAAATGCGCAGGAGCACATTTTATCCCATTTTCTGGGTGATGGGCGTGGGGAA
CTGGATATGGCTTCTTATTTTTACAGCCATCAGGGAGAAGATGCTCTAGGCCATCTGTGCCGCGTGCTGAGCGGCCTGGA
TTCCATGGTGCTGGGGGAAACGGAAATCTTCGGACAGGTAAAAACGGCTTACCAGACGGCCCTGGATGCCGGAGTAACTG
CGGCCTGCGCCAACAAAACCTTTCAGAAAGCCTTTACTATCGGTAAAAAAGTGCGGACGGAAAGCCAGATTCATGCCGGG
GCAACCTCCGTGGGATCCGTGGCAGTAGAGCTGGCGGAACAAATTTTCGGGGATCTTTCCGGCACCCGCGTCCTTATTCT
GGGGGCGGGCGAGATGAGCCGCGTTACGGGGCGCGCCCTTCATGCCCGGGGTGCTGAGGGCATTTATGTGGCCAACCGCT
CCTTTGACCGTGCGGTAGAGCTGGCGGGCATGATCGGCGGCCAGGCCATCCGGTATGACGTGTGGGGGAACTATCTCAGG
GATATTGACGTGGTGGTGGCCGCCACCGCTGCTCCCCACTGCATCATCACCCGGGAAACGCTTCTGCCTTTGCGTGCCTC
CCGTAAATACCGCTCCCTCTTTTTGATTGATATTTCCGTGCCGCGCAACATTTCTCCAGACGTGGCGGATATTGACGAAG
TGTATCTCTACGATATTGATACCCTCACCCAGCTGGCGGATGAAGCCAAGCGCAGCCGGAAGCAGGAGGTTTCCCGGTGC
GAGGCCATCATCCGGGACAGCATCTCCAGATATTTTCCGGATTCCGCTCTTTATGACCAGTAA

Upstream 100 bases:

>100_bases
TGCTGTGGTTCATCTACCGCCGCGGCATTCCGGGAAGGATGTTGGCCTGCTGCTGCGTGGCCCTCTTTATTGCATCCATG
AGCATTTTCCTGGTAAGTTG

Downstream 100 bases:

>100_bases
AAATACCCTCATCATCGGCACCCGCGGGAGCGCCCTGGCCCTGGCCCAGGCGGATATGGTCCGTGCTGCCCTTTCCCTCC
GTTATCCGGAACTGGACGTG

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MRMVCLGLNHRTAPVEIRERFAVPSHKLREEGQRIRSLPGVDQCVVLSTCNRMEIYYWSNAPENAQEHILSHFLGDGRGE
LDMASYFYSHQGEDALGHLCRVLSGLDSMVLGETEIFGQVKTAYQTALDAGVTAACANKTFQKAFTIGKKVRTESQIHAG
ATSVGSVAVELAEQIFGDLSGTRVLILGAGEMSRVTGRALHARGAEGIYVANRSFDRAVELAGMIGGQAIRYDVWGNYLR
DIDVVVAATAAPHCIITRETLLPLRASRKYRSLFLIDISVPRNISPDVADIDEVYLYDIDTLTQLADEAKRSRKQEVSRC
EAIIRDSISRYFPDSALYDQ

Sequences:

>Translated_340_residues
MRMVCLGLNHRTAPVEIRERFAVPSHKLREEGQRIRSLPGVDQCVVLSTCNRMEIYYWSNAPENAQEHILSHFLGDGRGE
LDMASYFYSHQGEDALGHLCRVLSGLDSMVLGETEIFGQVKTAYQTALDAGVTAACANKTFQKAFTIGKKVRTESQIHAG
ATSVGSVAVELAEQIFGDLSGTRVLILGAGEMSRVTGRALHARGAEGIYVANRSFDRAVELAGMIGGQAIRYDVWGNYLR
DIDVVVAATAAPHCIITRETLLPLRASRKYRSLFLIDISVPRNISPDVADIDEVYLYDIDTLTQLADEAKRSRKQEVSRC
EAIIRDSISRYFPDSALYDQ
>Mature_340_residues
MRMVCLGLNHRTAPVEIRERFAVPSHKLREEGQRIRSLPGVDQCVVLSTCNRMEIYYWSNAPENAQEHILSHFLGDGRGE
LDMASYFYSHQGEDALGHLCRVLSGLDSMVLGETEIFGQVKTAYQTALDAGVTAACANKTFQKAFTIGKKVRTESQIHAG
ATSVGSVAVELAEQIFGDLSGTRVLILGAGEMSRVTGRALHARGAEGIYVANRSFDRAVELAGMIGGQAIRYDVWGNYLR
DIDVVVAATAAPHCIITRETLLPLRASRKYRSLFLIDISVPRNISPDVADIDEVYLYDIDTLTQLADEAKRSRKQEVSRC
EAIIRDSISRYFPDSALYDQ

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=334, Percent_Identity=37.4251497005988, Blast_Score=214, Evalue=5e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_AKKM8 (B2ULP2)

Other databases:

- EMBL:   CP001071
- RefSeq:   YP_001876717.1
- ProteinModelPortal:   B2ULP2
- SMR:   B2ULP2
- GeneID:   6274993
- GenomeReviews:   CP001071_GR
- KEGG:   amu:Amuc_0091
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 37606; Mature: 37606

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 108-108 BINDING 119-119

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMVCLGLNHRTAPVEIRERFAVPSHKLREEGQRIRSLPGVDQCVVLSTCNRMEIYYWSN
CEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEECC
APENAQEHILSHFLGDGRGELDMASYFYSHQGEDALGHLCRVLSGLDSMVLGETEIFGQV
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHCCCHHHHHHH
KTAYQTALDAGVTAACANKTFQKAFTIGKKVRTESQIHAGATSVGSVAVELAEQIFGDLS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
GTRVLILGAGEMSRVTGRALHARGAEGIYVANRSFDRAVELAGMIGGQAIRYDVWGNYLR
CCEEEEEECCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCEEEEHHHHHHHH
DIDVVVAATAAPHCIITRETLLPLRASRKYRSLFLIDISVPRNISPDVADIDEVYLYDID
HHHHEEEECCCCEEEEEHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCEEEEEHH
TLTQLADEAKRSRKQEVSRCEAIIRDSISRYFPDSALYDQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRMVCLGLNHRTAPVEIRERFAVPSHKLREEGQRIRSLPGVDQCVVLSTCNRMEIYYWSN
CEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEECC
APENAQEHILSHFLGDGRGELDMASYFYSHQGEDALGHLCRVLSGLDSMVLGETEIFGQV
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHCCCHHHHHHH
KTAYQTALDAGVTAACANKTFQKAFTIGKKVRTESQIHAGATSVGSVAVELAEQIFGDLS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
GTRVLILGAGEMSRVTGRALHARGAEGIYVANRSFDRAVELAGMIGGQAIRYDVWGNYLR
CCEEEEEECCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCEEEEHHHHHHHH
DIDVVVAATAAPHCIITRETLLPLRASRKYRSLFLIDISVPRNISPDVADIDEVYLYDID
HHHHEEEECCCCEEEEEHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCEEEEEHH
TLTQLADEAKRSRKQEVSRCEAIIRDSISRYFPDSALYDQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA