Click here to switch to the map view.

The map label for this gene is norM [H]

Identifier: 187734564

GI number: 187734564

Start: 64665

End: 66170

Strand: Direct

Name: norM [H]

Synonym: Amuc_0048

Alternate gene names: 187734564

Gene position: 64665-66170 (Clockwise)

Preceding gene: 187734563

Following gene: 187734568

Centisome position: 2.43

GC content: 58.57

Gene sequence:

>1506_bases
ATGAGTGCGGGGGACGCAAGAGAAGGCATCATACGCGGCAAGGCGGCACGCGCCCGCCTGGGCGGAAAACTTGCCGGACT
ATCCCTGCCCCGGCAAATCGCCGTGATTGCTTTCTGGCCATTCCTGGAACAGCTGCTGAGCTTTTTCGTCACCTCGTCCG
ACCTTTTCATCGCCACTAAAATAGGGGTGGACGCCCAGGACACCATCAACATCTCTGACGGCATGGGCGCCGTCGTCTTC
ATCATGTGGTTCGGCTTCGTCATCCAGGGGTCTATCATGATGGGAGCCACAGCCATCGTTTCCCGCATGACGGGCGCCAG
GGACTATCCCCAGGCCCAGCATGGCCTGCACCAGGCCGCCATGCTGGGGCTCCTGGCAGGAACCATCTCCTGCGGACTTC
TCTTCACATGCAGCGATTTCCTGGTCACGCACGTACTGACCATGAATGAAACCGCCCGGGCCTACGCCCTGCAATACGTT
TATATGGCCGCATTTGCGGCCCCGTTCAGCGGCGTGGTCTTTGCCATCAATGCCGCCCTGCGAGGCTCCGGAGACACGCG
GCTTCCCTTCTGGATCATGATGAGCGTAGGCATCCTCAATGTCATCTTCAGCGTCATCTTCGTCTTTGCGGACGCTCCTC
TGGGCGGCTGGCGCATCGGAGGAATTGCGGCAGGAACGGTCTGCGGCTACGGCATCAGCATGTGCATCCTGCTGTTCATC
ATGCTGCGGCGCAGAAAAAAAATCTTCACGGGCAGGAAAAATGAATCCCTGGAAGAACTTGTCCGGGAACGGGGAGAACA
CTATGCCCCGCCCCTGTACCTCAGCTTTTCCCATCTGCGGCCGGACATGGGCATGCAGAAGCGCATCCTGAAAATCGGGC
TGCCGCAGGCCGTGGAAGTCTTCGGCATGTGGGGCATCCAGATGTTCTGCCTTTCCATCATCAGTGAACTGCCTGTTAAA
GGCGTGCTGGGCGTCCACAATATTGCCGTCCGCATTGAATCGCTCAGTTTCCTGCCCGGCTTCGCCATCGGCATGGCCGC
TTCCACGCTCGTGGGGCAATACCTGGGCGCCCGGAACGCGCTTATGGCCCGCATCACCATCTGGAAATGCATGCGGTACG
CCGTCATCTTCATGACAGGCCTGGGAGTGCTCTTCAGCGCCTTTCCCGCCCTGTTCATGGAGATATTTTCCAACGGCAGC
ACGACCCTCATTGATACCGGAATCCCCGTGTTGCGCACCATGTTGGTGGTGGAACCCTTCTTCGCCGCCTGCATCGTGAT
GAAAATGTCCCTGCGCGGCGCGGGAGACACCCGGAGAGTCATGCTTATTTCCTACGGCATTATGGGCTTTTTCCGGGTCG
TCTGCACCTGGGTATGGTTCAGGCTGGCACCGGAAACCATGACTTTGTGGGGCATCTGGCTGGTTTTCGCCTTTGAAATG
GCCGTTCAATCCGCCATCCTCTATAAAATCGTCAAGGGGCGGAGCTGGACGAAGCTGCAAGTCTGA

Upstream 100 bases:

>100_bases
GCGGGCAGGCCATGAAGACTCTGCTGCGGGAATGCGGCTACAGCAACATCACGGCGGAAGCTCTGAACGGGGGAATTGCC
AGCATTTACACAGCCCAGCG

Downstream 100 bases:

>100_bases
ACCTTTCTCCGGCCTCTCCCGCCTCCCGGCCCATTCGCAAATCCAAAACGTTTACTGCAGGATAAAAACTTTGCTTTCCT
CCTCCAATTCTGCTAGCATC

Product: MATE efflux family protein

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MSAGDAREGIIRGKAARARLGGKLAGLSLPRQIAVIAFWPFLEQLLSFFVTSSDLFIATKIGVDAQDTINISDGMGAVVF
IMWFGFVIQGSIMMGATAIVSRMTGARDYPQAQHGLHQAAMLGLLAGTISCGLLFTCSDFLVTHVLTMNETARAYALQYV
YMAAFAAPFSGVVFAINAALRGSGDTRLPFWIMMSVGILNVIFSVIFVFADAPLGGWRIGGIAAGTVCGYGISMCILLFI
MLRRRKKIFTGRKNESLEELVRERGEHYAPPLYLSFSHLRPDMGMQKRILKIGLPQAVEVFGMWGIQMFCLSIISELPVK
GVLGVHNIAVRIESLSFLPGFAIGMAASTLVGQYLGARNALMARITIWKCMRYAVIFMTGLGVLFSAFPALFMEIFSNGS
TTLIDTGIPVLRTMLVVEPFFAACIVMKMSLRGAGDTRRVMLISYGIMGFFRVVCTWVWFRLAPETMTLWGIWLVFAFEM
AVQSAILYKIVKGRSWTKLQV

Sequences:

>Translated_501_residues
MSAGDAREGIIRGKAARARLGGKLAGLSLPRQIAVIAFWPFLEQLLSFFVTSSDLFIATKIGVDAQDTINISDGMGAVVF
IMWFGFVIQGSIMMGATAIVSRMTGARDYPQAQHGLHQAAMLGLLAGTISCGLLFTCSDFLVTHVLTMNETARAYALQYV
YMAAFAAPFSGVVFAINAALRGSGDTRLPFWIMMSVGILNVIFSVIFVFADAPLGGWRIGGIAAGTVCGYGISMCILLFI
MLRRRKKIFTGRKNESLEELVRERGEHYAPPLYLSFSHLRPDMGMQKRILKIGLPQAVEVFGMWGIQMFCLSIISELPVK
GVLGVHNIAVRIESLSFLPGFAIGMAASTLVGQYLGARNALMARITIWKCMRYAVIFMTGLGVLFSAFPALFMEIFSNGS
TTLIDTGIPVLRTMLVVEPFFAACIVMKMSLRGAGDTRRVMLISYGIMGFFRVVCTWVWFRLAPETMTLWGIWLVFAFEM
AVQSAILYKIVKGRSWTKLQV
>Mature_500_residues
SAGDAREGIIRGKAARARLGGKLAGLSLPRQIAVIAFWPFLEQLLSFFVTSSDLFIATKIGVDAQDTINISDGMGAVVFI
MWFGFVIQGSIMMGATAIVSRMTGARDYPQAQHGLHQAAMLGLLAGTISCGLLFTCSDFLVTHVLTMNETARAYALQYVY
MAAFAAPFSGVVFAINAALRGSGDTRLPFWIMMSVGILNVIFSVIFVFADAPLGGWRIGGIAAGTVCGYGISMCILLFIM
LRRRKKIFTGRKNESLEELVRERGEHYAPPLYLSFSHLRPDMGMQKRILKIGLPQAVEVFGMWGIQMFCLSIISELPVKG
VLGVHNIAVRIESLSFLPGFAIGMAASTLVGQYLGARNALMARITIWKCMRYAVIFMTGLGVLFSAFPALFMEIFSNGST
TLIDTGIPVLRTMLVVEPFFAACIVMKMSLRGAGDTRRVMLISYGIMGFFRVVCTWVWFRLAPETMTLWGIWLVFAFEMA
VQSAILYKIVKGRSWTKLQV

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=476, Percent_Identity=23.5294117647059, Blast_Score=79, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 55019; Mature: 54887

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAGDAREGIIRGKAARARLGGKLAGLSLPRQIAVIAFWPFLEQLLSFFVTSSDLFIATK
CCCCCCHHHHHCCHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
IGVDAQDTINISDGMGAVVFIMWFGFVIQGSIMMGATAIVSRMTGARDYPQAQHGLHQAA
ECCCCCCCEECCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
MLGLLAGTISCGLLFTCSDFLVTHVLTMNETARAYALQYVYMAAFAAPFSGVVFAINAAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHEEEHHH
RGSGDTRLPFWIMMSVGILNVIFSVIFVFADAPLGGWRIGGIAAGTVCGYGISMCILLFI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHH
MLRRRKKIFTGRKNESLEELVRERGEHYAPPLYLSFSHLRPDMGMQKRILKIGLPQAVEV
HHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEEHHHCCCCCCHHHHHHHHCCCHHHHH
FGMWGIQMFCLSIISELPVKGVLGVHNIAVRIESLSFLPGFAIGMAASTLVGQYLGARNA
HHHHHHHHHHHHHHHHCCCCHHCCHHHHHEEEEHHHCCCCHHHHHHHHHHHHHHHCHHHH
LMARITIWKCMRYAVIFMTGLGVLFSAFPALFMEIFSNGSTTLIDTGIPVLRTMLVVEPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHH
FAACIVMKMSLRGAGDTRRVMLISYGIMGFFRVVCTWVWFRLAPETMTLWGIWLVFAFEM
HHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AVQSAILYKIVKGRSWTKLQV
HHHHHHHHHHHCCCCCEEECC
>Mature Secondary Structure 
SAGDAREGIIRGKAARARLGGKLAGLSLPRQIAVIAFWPFLEQLLSFFVTSSDLFIATK
CCCCCHHHHHCCHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
IGVDAQDTINISDGMGAVVFIMWFGFVIQGSIMMGATAIVSRMTGARDYPQAQHGLHQAA
ECCCCCCCEECCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
MLGLLAGTISCGLLFTCSDFLVTHVLTMNETARAYALQYVYMAAFAAPFSGVVFAINAAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHEEEHHH
RGSGDTRLPFWIMMSVGILNVIFSVIFVFADAPLGGWRIGGIAAGTVCGYGISMCILLFI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHH
MLRRRKKIFTGRKNESLEELVRERGEHYAPPLYLSFSHLRPDMGMQKRILKIGLPQAVEV
HHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEEHHHCCCCCCHHHHHHHHCCCHHHHH
FGMWGIQMFCLSIISELPVKGVLGVHNIAVRIESLSFLPGFAIGMAASTLVGQYLGARNA
HHHHHHHHHHHHHHHHCCCCHHCCHHHHHEEEEHHHCCCCHHHHHHHHHHHHHHHCHHHH
LMARITIWKCMRYAVIFMTGLGVLFSAFPALFMEIFSNGSTTLIDTGIPVLRTMLVVEPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHH
FAACIVMKMSLRGAGDTRRVMLISYGIMGFFRVVCTWVWFRLAPETMTLWGIWLVFAFEM
HHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AVQSAILYKIVKGRSWTKLQV
HHHHHHHHHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]