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The map label for this gene is lysA [H]

Identifier: 186477550

GI number: 186477550

Start: 3154639

End: 3155901

Strand: Direct

Name: lysA [H]

Synonym: Bphy_2802

Alternate gene names: 186477550

Gene position: 3154639-3155901 (Clockwise)

Preceding gene: 186477549

Following gene: 186477556

Centisome position: 90.67

GC content: 65.16

Gene sequence:

>1263_bases
ATGACTCAATCCGCTTTTGCTTACGTCGACGGCGTGCTGCACGCCGAAGGCGTGTCCGCCGTGTCGCTTGCCGAGCAATT
CGGCACGCCGCTTTACGTCTACTCGCGCGACGCGCTGACCAAAGCGTGGCACGCCTACGCCGACGCATGCGCCGGCCGCC
GCGCCACGGTGCACGTCGCCGTCAAGGCAAACAGCAACCTGGCCGTGCTGAACCTGTTCGCGCGCATGGGCGCCGGGTTC
GACATCGTGTCGGGCGGCGAACTCGCGCGCGTGCTCGCAGCGGGCGGCAAAGCGGAAAACACGGTGTTCTCCGGTGTGGG
CAAGAGCGTCGCGGAAATGCGCGACGCGCTCGCGGCAGGCGTGAAGTGCTTCAACGTCGAATCGATTCCCGAACTGGATC
GCCTGAACGCCGTCGCGGGCGAAATGGGTAAAAAGGCGCCCGTGTCGCTGCGCGTGAATCCCGACGTCGACGCGAAGACG
CATCCGTATATCTCGACGGGCCTGAAGTCGAACAAATTCGGTGTCGCATTCGACGACGCCCGCGCCACCTATCGCGCCGC
CGCAGCGATGAAGCATCTCGACGTGGTGGGCATCGACTGCCACATCGGTTCGCAAATCACGGAAGTCGCGCCGTATCTCG
ACGCCGTCGACAAACTACTCGAACTCGTCGCGCAGATCGAAGCGGACGGCGTGACGATCAAGCACGTCGACGTCGGCGGC
GGCCTCGGCATCACGTACGACGACGAGACGCCGCCGGACATCGGCGACTTCGTGCGCACGCTGCTCGACCGCATCGAAGC
GCGCGGCCACGGTCATCGCGAAGTGTATTTCGAACCGGGCCGCTCGCTCGTCGGCAACGCGGGCATGCTGCTCACGCGCG
TCGAATTCCTGAAGACGGGCGCCGAGAAGAACTTCGCCATCGTCGACGCCGCGATGAACGATCTCGCGCGCCCCGCAATG
TACGAGGCGTATCACGCAATCGAACCCGTCGTGCAGCGTGACGGCGCGAGGCATGTCTACGACATCGTGGGCCCCGTGTG
CGAAAGCGGTGACTGGCTCGGCCGCGAACGCCGGCTCGCCGTGGAACCCGGCGATCTGCTCGCGATCCGATCGGCAGGCG
CCTACGGTTTCGCGATGAGCTCGAACTACAACACGCGTGCACGCGCGGCCGAAGTGATGGTCGACGGCGACAAGGCATAC
GTCGTGCGCAAGCGCGAGGAAGTGAAAGACCTGTTCGCCGGCGAGTCGGTGCTTCCGTCATAA

Upstream 100 bases:

>100_bases
GCTGTCCCTGTCGCCCGATTCCGAACTGCGCACCGCGCCGAATTCGAACATGCCCGCCCAACCGGCGTCCGGTGCGTCCC
AAGCTGAGTAAGACTGTCGC

Downstream 100 bases:

>100_bases
AGCCGGCCGTTCCGGACGCTCACAGTCAAAAGGCGATGCGCTCATCACGCATCGCCTTTTTGTTTCCGGTTCGGCTTGGT
GCGTCTCACCCTCGCGCCCG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MTQSAFAYVDGVLHAEGVSAVSLAEQFGTPLYVYSRDALTKAWHAYADACAGRRATVHVAVKANSNLAVLNLFARMGAGF
DIVSGGELARVLAAGGKAENTVFSGVGKSVAEMRDALAAGVKCFNVESIPELDRLNAVAGEMGKKAPVSLRVNPDVDAKT
HPYISTGLKSNKFGVAFDDARATYRAAAAMKHLDVVGIDCHIGSQITEVAPYLDAVDKLLELVAQIEADGVTIKHVDVGG
GLGITYDDETPPDIGDFVRTLLDRIEARGHGHREVYFEPGRSLVGNAGMLLTRVEFLKTGAEKNFAIVDAAMNDLARPAM
YEAYHAIEPVVQRDGARHVYDIVGPVCESGDWLGRERRLAVEPGDLLAIRSAGAYGFAMSSNYNTRARAAEVMVDGDKAY
VVRKREEVKDLFAGESVLPS

Sequences:

>Translated_420_residues
MTQSAFAYVDGVLHAEGVSAVSLAEQFGTPLYVYSRDALTKAWHAYADACAGRRATVHVAVKANSNLAVLNLFARMGAGF
DIVSGGELARVLAAGGKAENTVFSGVGKSVAEMRDALAAGVKCFNVESIPELDRLNAVAGEMGKKAPVSLRVNPDVDAKT
HPYISTGLKSNKFGVAFDDARATYRAAAAMKHLDVVGIDCHIGSQITEVAPYLDAVDKLLELVAQIEADGVTIKHVDVGG
GLGITYDDETPPDIGDFVRTLLDRIEARGHGHREVYFEPGRSLVGNAGMLLTRVEFLKTGAEKNFAIVDAAMNDLARPAM
YEAYHAIEPVVQRDGARHVYDIVGPVCESGDWLGRERRLAVEPGDLLAIRSAGAYGFAMSSNYNTRARAAEVMVDGDKAY
VVRKREEVKDLFAGESVLPS
>Mature_419_residues
TQSAFAYVDGVLHAEGVSAVSLAEQFGTPLYVYSRDALTKAWHAYADACAGRRATVHVAVKANSNLAVLNLFARMGAGFD
IVSGGELARVLAAGGKAENTVFSGVGKSVAEMRDALAAGVKCFNVESIPELDRLNAVAGEMGKKAPVSLRVNPDVDAKTH
PYISTGLKSNKFGVAFDDARATYRAAAAMKHLDVVGIDCHIGSQITEVAPYLDAVDKLLELVAQIEADGVTIKHVDVGGG
LGITYDDETPPDIGDFVRTLLDRIEARGHGHREVYFEPGRSLVGNAGMLLTRVEFLKTGAEKNFAIVDAAMNDLARPAMY
EAYHAIEPVVQRDGARHVYDIVGPVCESGDWLGRERRLAVEPGDLLAIRSAGAYGFAMSSNYNTRARAAEVMVDGDKAYV
VRKREEVKDLFAGESVLPS

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=380, Percent_Identity=24.2105263157895, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1789203, Length=435, Percent_Identity=32.183908045977, Blast_Score=158, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17562780, Length=361, Percent_Identity=23.2686980609418, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322664, Length=363, Percent_Identity=23.1404958677686, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24586474, Length=356, Percent_Identity=28.0898876404494, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24586472, Length=344, Percent_Identity=27.3255813953488, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44918; Mature: 44787

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSAFAYVDGVLHAEGVSAVSLAEQFGTPLYVYSRDALTKAWHAYADACAGRRATVHVA
CCCCHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHCCCCEEEEEE
VKANSNLAVLNLFARMGAGFDIVSGGELARVLAAGGKAENTVFSGVGKSVAEMRDALAAG
EECCCCCHHHHHHHHHCCCCEEECCCHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHC
VKCFNVESIPELDRLNAVAGEMGKKAPVSLRVNPDVDAKTHPYISTGLKSNKFGVAFDDA
CEEECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHCCCCCCCCCEEECCH
RATYRAAAAMKHLDVVGIDCHIGSQITEVAPYLDAVDKLLELVAQIEADGVTIKHVDVGG
HHHHHHHHHHHHCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
GLGITYDDETPPDIGDFVRTLLDRIEARGHGHREVYFEPGRSLVGNAGMLLTRVEFLKTG
CEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHCCCHHHHHHHHHHHCC
AEKNFAIVDAAMNDLARPAMYEAYHAIEPVVQRDGARHVYDIVGPVCESGDWLGRERRLA
CCCCEEEEHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEE
VEPGDLLAIRSAGAYGFAMSSNYNTRARAAEVMVDGDKAYVVRKREEVKDLFAGESVLPS
ECCCCEEEEECCCCEEEEECCCCCCHHHEEEEEECCCCEEEEECHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TQSAFAYVDGVLHAEGVSAVSLAEQFGTPLYVYSRDALTKAWHAYADACAGRRATVHVA
CCCHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHCCCCEEEEEE
VKANSNLAVLNLFARMGAGFDIVSGGELARVLAAGGKAENTVFSGVGKSVAEMRDALAAG
EECCCCCHHHHHHHHHCCCCEEECCCHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHC
VKCFNVESIPELDRLNAVAGEMGKKAPVSLRVNPDVDAKTHPYISTGLKSNKFGVAFDDA
CEEECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHCCCCCCCCCEEECCH
RATYRAAAAMKHLDVVGIDCHIGSQITEVAPYLDAVDKLLELVAQIEADGVTIKHVDVGG
HHHHHHHHHHHHCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
GLGITYDDETPPDIGDFVRTLLDRIEARGHGHREVYFEPGRSLVGNAGMLLTRVEFLKTG
CEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHCCCHHHHHHHHHHHCC
AEKNFAIVDAAMNDLARPAMYEAYHAIEPVVQRDGARHVYDIVGPVCESGDWLGRERRLA
CCCCEEEEHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEE
VEPGDLLAIRSAGAYGFAMSSNYNTRARAAEVMVDGDKAYVVRKREEVKDLFAGESVLPS
ECCCCEEEEECCCCEEEEECCCCCCHHHEEEEEECCCCEEEEECHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]