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The map label for this gene is hisD [H]

Identifier: 186477507

GI number: 186477507

Start: 3109909

End: 3111231

Strand: Reverse

Name: hisD [H]

Synonym: Bphy_2759

Alternate gene names: 186477507

Gene position: 3111231-3109909 (Counterclockwise)

Preceding gene: 186477508

Following gene: 186477506

Centisome position: 89.42

GC content: 66.14

Gene sequence:

>1323_bases
ATGTCTATCAAGATTCGCACACTCGATTCCAGCACTGAAGCTTTCCAGAAGTCGCTGCATGCGGTGCTCGCGTTCGAAGC
GAGCGAAGACGAAGCGATCGAGCGCTCGGTCGCGCAGATTCTGGCCGACGTGAAGGCGCGCGGCGACGCCGCCGTGCTCG
ACTACACGAACCGTTTCGATCGTCTGAACGCGCAGGACGTGGCGGCGCTCGAGTTGCCGATGTCGGAGCTCGAAGCCGCG
CTCGAAGGGCTGGAGCCGAAGCGCCGCGCGGCGCTCGAGGCGGCGGCGGCGCGAGTTCGTGCGTATCACGAGAAGCAGAA
GATCGAATGCGGCAGCCATAGCTGGCAGTACACGGAAGCCGACGGCACGGTGCTCGGGCAAAAGGTGACGCCGCTCGACC
GCGCGGGCATTTATGTGCCAGGCGGCAAGGCGGCGTATCCGTCGTCGGTGCTGATGAACGCCGTCCCGGCGCGCGTCGCG
GGGGTGCGCGAGATCGTCATGGTCGTGCCGACGCCGGACGGCGTGAAGAACCCGCTCGTGCTGGCGGCGGCGCTGCTCGG
CGGGGTCGATCGCGTGTTCACGATCGGCGGCGCGCAGGCCGTCGGCGCGCTCGCGTACGGCACGCAAACCATTCCCGCCG
TCGACAAGATCTGCGGTCCGGGCAACGCGTATGTCGCATCGGCGAAGCGCCGCGTGTTCGGCGTGGTCGGCATCGACATG
ATCGCGGGCCCGTCGGAAATTCTCGTGCTGTGCGACGGCACGACCGACCCGCGCTGGGTCGCGATGGATCTGTTCTCGCA
GGCCGAGCACGACGAACTCGCGCAATCCATCCTGCTGTGCCCGGACGATGGCTTCATCGCCCGCGTGGAAGAAGCGATCA
ACGAACTGCTGCCGACAATGCCGCGCCGCGATGTAATCCAGGCGTCGCTCGAAGGCCGCGGCGCGCTGGTCAAGGTGCGC
GATATGGCGGAAGCCTGCGCGATCGCCAACGACATCGCGCCTGAACACCTCGAAATCTCCGCGCTGGAGCCGCAGCAGTG
GGCGCAGCAGATCCGCCACGCGGGCGCGATCTTCCTTGGCCGCTACACGAGCGAAAGCCTCGGCGATTACTGCGCGGGCC
CGAATCATGTGCTGCCTACGTCGCGTACCGCACGTTTCTCGTCGCCGCTCGGCGTCTATGATTTCTTCAAGCGCTCGAGC
CTGATCGAGGTGAGCGCGGAAGGCGCGCAGACGCTCGGTGAAATTGCCGCCGAACTCGCTTATGGCGAAGGTCTGCAAGC
ACATGCGCGCAGCGCCGAGTACCGGATGAAGAACAACGGCTGA

Upstream 100 bases:

>100_bases
GACGCGTTTCAGCGCGCGTCGCAACGCACTGGCGCAACGGCCTGACGAACGGGAACACTGCGCGGCGCGACGCGCGCGCC
TTACCGAAACGGATACCAGC

Downstream 100 bases:

>100_bases
GCTTCGACCGATGGCAGTTTCGGACGCGCTTGATGCGCGTTGAATTCGAGACAGCCTGCGTTTTCGCGAGTTTTCGCGAG
AGACAGAGAATCCAACCCGG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MSIKIRTLDSSTEAFQKSLHAVLAFEASEDEAIERSVAQILADVKARGDAAVLDYTNRFDRLNAQDVAALELPMSELEAA
LEGLEPKRRAALEAAAARVRAYHEKQKIECGSHSWQYTEADGTVLGQKVTPLDRAGIYVPGGKAAYPSSVLMNAVPARVA
GVREIVMVVPTPDGVKNPLVLAAALLGGVDRVFTIGGAQAVGALAYGTQTIPAVDKICGPGNAYVASAKRRVFGVVGIDM
IAGPSEILVLCDGTTDPRWVAMDLFSQAEHDELAQSILLCPDDGFIARVEEAINELLPTMPRRDVIQASLEGRGALVKVR
DMAEACAIANDIAPEHLEISALEPQQWAQQIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSS
LIEVSAEGAQTLGEIAAELAYGEGLQAHARSAEYRMKNNG

Sequences:

>Translated_440_residues
MSIKIRTLDSSTEAFQKSLHAVLAFEASEDEAIERSVAQILADVKARGDAAVLDYTNRFDRLNAQDVAALELPMSELEAA
LEGLEPKRRAALEAAAARVRAYHEKQKIECGSHSWQYTEADGTVLGQKVTPLDRAGIYVPGGKAAYPSSVLMNAVPARVA
GVREIVMVVPTPDGVKNPLVLAAALLGGVDRVFTIGGAQAVGALAYGTQTIPAVDKICGPGNAYVASAKRRVFGVVGIDM
IAGPSEILVLCDGTTDPRWVAMDLFSQAEHDELAQSILLCPDDGFIARVEEAINELLPTMPRRDVIQASLEGRGALVKVR
DMAEACAIANDIAPEHLEISALEPQQWAQQIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSS
LIEVSAEGAQTLGEIAAELAYGEGLQAHARSAEYRMKNNG
>Mature_439_residues
SIKIRTLDSSTEAFQKSLHAVLAFEASEDEAIERSVAQILADVKARGDAAVLDYTNRFDRLNAQDVAALELPMSELEAAL
EGLEPKRRAALEAAAARVRAYHEKQKIECGSHSWQYTEADGTVLGQKVTPLDRAGIYVPGGKAAYPSSVLMNAVPARVAG
VREIVMVVPTPDGVKNPLVLAAALLGGVDRVFTIGGAQAVGALAYGTQTIPAVDKICGPGNAYVASAKRRVFGVVGIDMI
AGPSEILVLCDGTTDPRWVAMDLFSQAEHDELAQSILLCPDDGFIARVEEAINELLPTMPRRDVIQASLEGRGALVKVRD
MAEACAIANDIAPEHLEISALEPQQWAQQIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSSL
IEVSAEGAQTLGEIAAELAYGEGLQAHARSAEYRMKNNG

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=433, Percent_Identity=40.1847575057737, Blast_Score=278, Evalue=4e-76,
Organism=Saccharomyces cerevisiae, GI6319819, Length=412, Percent_Identity=35.4368932038835, Blast_Score=236, Evalue=5e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47054; Mature: 46923

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKIRTLDSSTEAFQKSLHAVLAFEASEDEAIERSVAQILADVKARGDAAVLDYTNRFD
CEEEEEECCCHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHC
RLNAQDVAALELPMSELEAALEGLEPKRRAALEAAAARVRAYHEKQKIECGSHSWQYTEA
CCCCCCHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECC
DGTVLGQKVTPLDRAGIYVPGGKAAYPSSVLMNAVPARVAGVREIVMVVPTPDGVKNPLV
CCCEECCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHH
LAAALLGGVDRVFTIGGAQAVGALAYGTQTIPAVDKICGPGNAYVASAKRRVFGVVGIDM
HHHHHHCCCHHEEEECCHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHEEEEEEHHH
IAGPSEILVLCDGTTDPRWVAMDLFSQAEHDELAQSILLCPDDGFIARVEEAINELLPTM
CCCCCEEEEEECCCCCCCEEHHHHHHCCCHHHHHHHEEECCCCCHHHHHHHHHHHHHCCC
PRRDVIQASLEGRGALVKVRDMAEACAIANDIAPEHLEISALEPQQWAQQIRHAGAIFLG
CCHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCEEEE
RYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSSLIEVSAEGAQTLGEIAAELA
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECHHHHHHHHHHHHHH
YGEGLQAHARSAEYRMKNNG
HCCCHHHHHCCCCCEECCCC
>Mature Secondary Structure 
SIKIRTLDSSTEAFQKSLHAVLAFEASEDEAIERSVAQILADVKARGDAAVLDYTNRFD
EEEEEECCCHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHC
RLNAQDVAALELPMSELEAALEGLEPKRRAALEAAAARVRAYHEKQKIECGSHSWQYTEA
CCCCCCHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECC
DGTVLGQKVTPLDRAGIYVPGGKAAYPSSVLMNAVPARVAGVREIVMVVPTPDGVKNPLV
CCCEECCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHH
LAAALLGGVDRVFTIGGAQAVGALAYGTQTIPAVDKICGPGNAYVASAKRRVFGVVGIDM
HHHHHHCCCHHEEEECCHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHEEEEEEHHH
IAGPSEILVLCDGTTDPRWVAMDLFSQAEHDELAQSILLCPDDGFIARVEEAINELLPTM
CCCCCEEEEEECCCCCCCEEHHHHHHCCCHHHHHHHEEECCCCCHHHHHHHHHHHHHCCC
PRRDVIQASLEGRGALVKVRDMAEACAIANDIAPEHLEISALEPQQWAQQIRHAGAIFLG
CCHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCEEEE
RYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSSLIEVSAEGAQTLGEIAAELA
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECHHHHHHHHHHHHHH
YGEGLQAHARSAEYRMKNNG
HCCCHHHHHCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA