Click here to switch to the map view.

The map label for this gene is hisG [H]

Identifier: 186477508

GI number: 186477508

Start: 3111287

End: 3111985

Strand: Reverse

Name: hisG [H]

Synonym: Bphy_2760

Alternate gene names: 186477508

Gene position: 3111985-3111287 (Counterclockwise)

Preceding gene: 186477509

Following gene: 186477507

Centisome position: 89.45

GC content: 65.24

Gene sequence:

>699_bases
ATGAGCGAATTGCCGCAAACGTCGTCGTCGCCCGCAGCCGGCAAGCCGCTGACGCTCGCGCTGTCGAAGGGCCGCATTTT
CGAGGAAACGGTGCCGCTGCTCGCCGCAGCCGGCATCGAAGTGACGGAAGACCCGGAAACGTCGCGCAAGCTGATCCTGC
CGACCAACGATCCCAACGTGCGAGTCATCATCGTGCGCGCCACCGACGTGCCCACGTACGTCGAATACGGCGCCGCCGAT
TTCGGCGTCGCCGGCAAGGACGTGCTGATCGAGCATGGCGGCGGCGGCCTGTATCAGCCGATCGATCTGGATATCGCGCG
CTGCCGGATGTCAGTGGCCGTGGCGGCCGGTTTCGACTACGCGAACGCGGTGCGCCAGGGTGCGCGGCTGCGCATCGCGA
CCAAGTACGTCGAAACCGCGCGCGAGCACTTTGCATCGAAGGGCGTGCACGTCGATCTGATCAAGCTGTATGGATCGATG
GAACTCGCGCCATTGGTTGGGCTCGCCGACGCGATCGTCGACCTGGTCAGCTCGGGCGGCACGCTGCGCGCCAACAATCT
TGTCGAGGTCGAAGAGATCATGCAGATTTCGTCGCGCCTCGTCGTGAACCAGGCGGCGCTGAAGTTGAAGCGCGCCGCGC
TGGCACCCATTCTCGACGCGTTTCAGCGCGCGTCGCAACGCACTGGCGCAACGGCCTGA

Upstream 100 bases:

>100_bases
TGATCGACCGCATCTATCATCTCGATCGCGGCTACGACCGGATGGAATCGAAACTCACCGCAGTCGGCGCGAAGGTGCGC
CGCATCAAGGGTAATCAGGC

Downstream 100 bases:

>100_bases
CGAACGGGAACACTGCGCGGCGCGACGCGCGCGCCTTACCGAAACGGATACCAGCATGTCTATCAAGATTCGCACACTCG
ATTCCAGCACTGAAGCTTTC

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MSELPQTSSSPAAGKPLTLALSKGRIFEETVPLLAAAGIEVTEDPETSRKLILPTNDPNVRVIIVRATDVPTYVEYGAAD
FGVAGKDVLIEHGGGGLYQPIDLDIARCRMSVAVAAGFDYANAVRQGARLRIATKYVETAREHFASKGVHVDLIKLYGSM
ELAPLVGLADAIVDLVSSGGTLRANNLVEVEEIMQISSRLVVNQAALKLKRAALAPILDAFQRASQRTGATA

Sequences:

>Translated_232_residues
MSELPQTSSSPAAGKPLTLALSKGRIFEETVPLLAAAGIEVTEDPETSRKLILPTNDPNVRVIIVRATDVPTYVEYGAAD
FGVAGKDVLIEHGGGGLYQPIDLDIARCRMSVAVAAGFDYANAVRQGARLRIATKYVETAREHFASKGVHVDLIKLYGSM
ELAPLVGLADAIVDLVSSGGTLRANNLVEVEEIMQISSRLVVNQAALKLKRAALAPILDAFQRASQRTGATA
>Mature_231_residues
SELPQTSSSPAAGKPLTLALSKGRIFEETVPLLAAAGIEVTEDPETSRKLILPTNDPNVRVIIVRATDVPTYVEYGAADF
GVAGKDVLIEHGGGGLYQPIDLDIARCRMSVAVAAGFDYANAVRQGARLRIATKYVETAREHFASKGVHVDLIKLYGSME
LAPLVGLADAIVDLVSSGGTLRANNLVEVEEIMQISSRLVVNQAALKLKRAALAPILDAFQRASQRTGATA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=207, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320896, Length=185, Percent_Identity=30.8108108108108, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 24608; Mature: 24476

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELPQTSSSPAAGKPLTLALSKGRIFEETVPLLAAAGIEVTEDPETSRKLILPTNDPNV
CCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCEECCCCCCCCEEEEECCCCCE
RVIIVRATDVPTYVEYGAADFGVAGKDVLIEHGGGGLYQPIDLDIARCRMSVAVAAGFDY
EEEEEEECCCCHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHEECCCHH
ANAVRQGARLRIATKYVETAREHFASKGVHVDLIKLYGSMELAPLVGLADAIVDLVSSGG
HHHHHCCCEEEEHHHHHHHHHHHHHHCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHCCC
TLRANNLVEVEEIMQISSRLVVNQAALKLKRAALAPILDAFQRASQRTGATA
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SELPQTSSSPAAGKPLTLALSKGRIFEETVPLLAAAGIEVTEDPETSRKLILPTNDPNV
CCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCEECCCCCCCCEEEEECCCCCE
RVIIVRATDVPTYVEYGAADFGVAGKDVLIEHGGGGLYQPIDLDIARCRMSVAVAAGFDY
EEEEEEECCCCHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHEECCCHH
ANAVRQGARLRIATKYVETAREHFASKGVHVDLIKLYGSMELAPLVGLADAIVDLVSSGG
HHHHHCCCEEEEHHHHHHHHHHHHHHCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHCCC
TLRANNLVEVEEIMQISSRLVVNQAALKLKRAALAPILDAFQRASQRTGATA
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA