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The map label for this gene is hisI [H]

Identifier: 186477500

GI number: 186477500

Start: 3104419

End: 3104826

Strand: Reverse

Name: hisI [H]

Synonym: Bphy_2752

Alternate gene names: 186477500

Gene position: 3104826-3104419 (Counterclockwise)

Preceding gene: 186477501

Following gene: 186477499

Centisome position: 89.24

GC content: 59.07

Gene sequence:

>408_bases
ATGAATCCGTCTGAAGTCGGCTGGCTCGACAAGGTGCAGTGGGACGCGAACGGCCTCGTGCCCGTGATCGCGCAGGAAGC
GTCGACGAACGACGTGCTGATGTTCGCGTGGATGAACCGCGAAGCGCTGTCGAAGACGATCGAAACGGGGCGCGCGGTCT
ATTTCTCGCGCTCGCGTCAACGGCTCTGGTTCAAGGGTGAGGAATCTGGCCACGTACAGCACGTGCATGAAGTGCGGCTC
GATTGTGACGAAGACGTCGTGCTGCTCAAGGTCGACCAGGTTTCCGGCATCGCGTGCCATACCGGCCGGCATTCGTGCTT
TTTCCAAAAATTCGAAGGCTCGGTCGATTCCGGCAACTGGGTTGCCGTCGATCCCGTGCTGAAAGACCCCGAACACATCT
ACAAATGA

Upstream 100 bases:

>100_bases
GCGGTGCTGGCCGCGAGCATCTTCCACTATGGCGAGCACACGGTTGGCGAGTGCAAGCGCTTCATGGCCGATCAGGGCAT
TTCGGTGAGGTTGTAACGTG

Downstream 100 bases:

>100_bases
CGCAAGATACCCAATCGACGGGCGACACGCTGTTGCGCCTCGCCGCCGTCATCGACAGCCGCAAGGGCGGCGATCCCGAT
GTTTCGTACGTCTCGCGTCT

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 135; Mature: 135

Protein sequence:

>135_residues
MNPSEVGWLDKVQWDANGLVPVIAQEASTNDVLMFAWMNREALSKTIETGRAVYFSRSRQRLWFKGEESGHVQHVHEVRL
DCDEDVVLLKVDQVSGIACHTGRHSCFFQKFEGSVDSGNWVAVDPVLKDPEHIYK

Sequences:

>Translated_135_residues
MNPSEVGWLDKVQWDANGLVPVIAQEASTNDVLMFAWMNREALSKTIETGRAVYFSRSRQRLWFKGEESGHVQHVHEVRL
DCDEDVVLLKVDQVSGIACHTGRHSCFFQKFEGSVDSGNWVAVDPVLKDPEHIYK
>Mature_135_residues
MNPSEVGWLDKVQWDANGLVPVIAQEASTNDVLMFAWMNREALSKTIETGRAVYFSRSRQRLWFKGEESGHVQHVHEVRL
DCDEDVVLLKVDQVSGIACHTGRHSCFFQKFEGSVDSGNWVAVDPVLKDPEHIYK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=98, Percent_Identity=45.9183673469388, Blast_Score=98, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319819, Length=75, Percent_Identity=38.6666666666667, Blast_Score=68, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 15358; Mature: 15358

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPSEVGWLDKVQWDANGLVPVIAQEASTNDVLMFAWMNREALSKTIETGRAVYFSRSRQ
CCCCCCCCCEEEEECCCCCEEEEEECCCCCCEEEEEECCHHHHHHHHHCCCEEEEECCCC
RLWFKGEESGHVQHVHEVRLDCDEDVVLLKVDQVSGIACHTGRHSCFFQKFEGSVDSGNW
EEEEECCCCCCEEEEEEEECCCCCCEEEEEECCCCCEEEECCCCCEEEEECCCCCCCCCE
VAVDPVLKDPEHIYK
EEECCCCCCHHHHCC
>Mature Secondary Structure
MNPSEVGWLDKVQWDANGLVPVIAQEASTNDVLMFAWMNREALSKTIETGRAVYFSRSRQ
CCCCCCCCCEEEEECCCCCEEEEEECCCCCCEEEEEECCHHHHHHHHHCCCEEEEECCCC
RLWFKGEESGHVQHVHEVRLDCDEDVVLLKVDQVSGIACHTGRHSCFFQKFEGSVDSGNW
EEEEECCCCCCEEEEEEEECCCCCCEEEEEECCCCCEEEECCCCCEEEEECCCCCCCCCE
VAVDPVLKDPEHIYK
EEECCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA