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The map label for this gene is ung [H]

Identifier: 186477451

GI number: 186477451

Start: 3056086

End: 3056898

Strand: Direct

Name: ung [H]

Synonym: Bphy_2703

Alternate gene names: 186477451

Gene position: 3056086-3056898 (Clockwise)

Preceding gene: 186477450

Following gene: 186477456

Centisome position: 87.84

GC content: 65.44

Gene sequence:

>813_bases
ATGAATTCCGCAAAACACTCCCGAACTCCGCCGACGCAGCCGTCGCTTTTCACCGACGACGACACCAGCCGCGCACCCGC
CCCCGCTGTCGACACCCGAACGCTCGAATCGCAATTCGAAGCATTGCCGCCAGCATGGCGCGCACATCTGAAGCCCTTCA
TCGATAGCGATAGTTACGCGCCGCTGTGCCGTTTCGTCGACGGCGAGCGAGCCGCCGGCAAGACCGTGTATCCCGCCGAC
GTGTTCCGCGCACTGCGTCTGACCAGTCCCGACGACGTCAAGGTCGTGATTCTCGGCCAGGACCCGTATCACGGCGAAGA
CCGCGGCACACCGCAAGCTCACGGACTCGCGTTTTCGGTTCCGCCTTCGGTGCGGCCGCCGCCGTCGCTGCGCAACATCT
TCAAGGAGATCGCGGCGAGCCTCGGCTATGAGACGCCCCAGCACGGTTGCCTCGATGCGTGGGCGCGCCAGGGCGTGCTC
CTGCTCAACACGGTGCTGACCGTCGAACGCGACCGTGCAGCGAGTCACGCAAAGCGCGGCTGGGAAAAATGCACCGACAC
GCTGATCCATGAACTCGCGATGCGCCACGACGGGCTCGTTTTCATGCTGTGGGGCGCGCATGCGCAGGCCAAGCGTGCGT
TGCTCGAAGGCAAGTCGCATTGCGTGCTGGAGGCGCCTCACCCCTCGCCGCTGTCCGCGCATCGCGGCTTTCTCGGCTGC
CGGCATTTCGCGCTCGCGAACGAATTTCTCGAAGCGCACGGCCGACCGGGCATCGACTGGCGCTTGCCGGAAACGGGCGA
AGTGTTCGCCTGA

Upstream 100 bases:

>100_bases
CGAGAAGTAGCCGGCGACGCGGGGCGAAAGCGGCGGCGAGCGTGCACGCGAACGCGAGGAACCTTGAGCGCGTTCGCGTT
TGCTGCCACACTAGCCCGCC

Downstream 100 bases:

>100_bases
AGCGCGGTTTACCTCGCTTCCTGCGACCGATCAGAAAATCCAAAGAAGAACGCCACGGAATCGTGTTCCGTGGCGTTGTA
TTTTGCCGTCGCGATTCAGC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MNSAKHSRTPPTQPSLFTDDDTSRAPAPAVDTRTLESQFEALPPAWRAHLKPFIDSDSYAPLCRFVDGERAAGKTVYPAD
VFRALRLTSPDDVKVVILGQDPYHGEDRGTPQAHGLAFSVPPSVRPPPSLRNIFKEIAASLGYETPQHGCLDAWARQGVL
LLNTVLTVERDRAASHAKRGWEKCTDTLIHELAMRHDGLVFMLWGAHAQAKRALLEGKSHCVLEAPHPSPLSAHRGFLGC
RHFALANEFLEAHGRPGIDWRLPETGEVFA

Sequences:

>Translated_270_residues
MNSAKHSRTPPTQPSLFTDDDTSRAPAPAVDTRTLESQFEALPPAWRAHLKPFIDSDSYAPLCRFVDGERAAGKTVYPAD
VFRALRLTSPDDVKVVILGQDPYHGEDRGTPQAHGLAFSVPPSVRPPPSLRNIFKEIAASLGYETPQHGCLDAWARQGVL
LLNTVLTVERDRAASHAKRGWEKCTDTLIHELAMRHDGLVFMLWGAHAQAKRALLEGKSHCVLEAPHPSPLSAHRGFLGC
RHFALANEFLEAHGRPGIDWRLPETGEVFA
>Mature_270_residues
MNSAKHSRTPPTQPSLFTDDDTSRAPAPAVDTRTLESQFEALPPAWRAHLKPFIDSDSYAPLCRFVDGERAAGKTVYPAD
VFRALRLTSPDDVKVVILGQDPYHGEDRGTPQAHGLAFSVPPSVRPPPSLRNIFKEIAASLGYETPQHGCLDAWARQGVL
LLNTVLTVERDRAASHAKRGWEKCTDTLIHELAMRHDGLVFMLWGAHAQAKRALLEGKSHCVLEAPHPSPLSAHRGFLGC
RHFALANEFLEAHGRPGIDWRLPETGEVFA

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=220, Percent_Identity=49.0909090909091, Blast_Score=205, Evalue=3e-53,
Organism=Homo sapiens, GI6224979, Length=220, Percent_Identity=49.0909090909091, Blast_Score=204, Evalue=1e-52,
Organism=Escherichia coli, GI1788934, Length=198, Percent_Identity=57.5757575757576, Blast_Score=227, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI17556304, Length=220, Percent_Identity=42.2727272727273, Blast_Score=183, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6323620, Length=252, Percent_Identity=40.8730158730159, Blast_Score=162, Evalue=6e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 29754; Mature: 29754

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSAKHSRTPPTQPSLFTDDDTSRAPAPAVDTRTLESQFEALPPAWRAHLKPFIDSDSYA
CCCCCCCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCCC
PLCRFVDGERAAGKTVYPADVFRALRLTSPDDVKVVILGQDPYHGEDRGTPQAHGLAFSV
HHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHCCEEEEC
PPSVRPPPSLRNIFKEIAASLGYETPQHGCLDAWARQGVLLLNTVLTVERDRAASHAKRG
CCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHH
WEKCTDTLIHELAMRHDGLVFMLWGAHAQAKRALLEGKSHCVLEAPHPSPLSAHRGFLGC
HHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHH
RHFALANEFLEAHGRPGIDWRLPETGEVFA
HHHHHHHHHHHHCCCCCCCEECCCCCCCCC
>Mature Secondary Structure
MNSAKHSRTPPTQPSLFTDDDTSRAPAPAVDTRTLESQFEALPPAWRAHLKPFIDSDSYA
CCCCCCCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCCC
PLCRFVDGERAAGKTVYPADVFRALRLTSPDDVKVVILGQDPYHGEDRGTPQAHGLAFSV
HHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHCCEEEEC
PPSVRPPPSLRNIFKEIAASLGYETPQHGCLDAWARQGVLLLNTVLTVERDRAASHAKRG
CCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHH
WEKCTDTLIHELAMRHDGLVFMLWGAHAQAKRALLEGKSHCVLEAPHPSPLSAHRGFLGC
HHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHH
RHFALANEFLEAHGRPGIDWRLPETGEVFA
HHHHHHHHHHHHCCCCCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA