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The map label for this gene is thiL [H]

Identifier: 186477353

GI number: 186477353

Start: 2944654

End: 2945649

Strand: Direct

Name: thiL [H]

Synonym: Bphy_2605

Alternate gene names: 186477353

Gene position: 2944654-2945649 (Clockwise)

Preceding gene: 186477349

Following gene: 186477354

Centisome position: 84.64

GC content: 67.77

Gene sequence:

>996_bases
ATGCTTTCAGAGTTTTCGCTGATCGACCGTTTCTTTGCGCGCCGCGCGGCGGGGTCGACCTATCCGCAGCGCGCCGCGCT
CGGCATCGGTGACGACTGCGCGCTGCTCGCCCCGCCCGCAGGCGAGATGCTCGCGATTTCGACGGACATGCTTGTCGCAG
GCCGCCATTTCTTTCCGGATGTCGATCCCAAAGCGCTCGGCCACAAGGCGCTCGCCGTGAATCTGTCGGACCTCGCGGCG
ATGGGCGCCAAGCCGCAAGCCTTCACGCTGGCCTTCGCGCTGCCGGAAGCCGACGCGGACTGGCTCGCCGCGTTCAGCGA
CGGTCTGTTCGAACTCGCCGAGCGCCACGGGTGCGAACTCGTCGGTGGTGACACCACGAGCGGCCCGCTCAATCTGTGCC
TCACGGTGTTCGGCTCGGTGCCGCCGCAAACGGCGCTGCGCCGCGACGCCGCGCAACCCGGCGACGATATCTGGATTTCA
GGAACGCTCGGCGACGCGCGTGCAAGCCTCGGCGTGCAACGCAACGAGTGGTCCGTCGATGCCAGCGATGCTGCGACATT
GCGCCGCGCCATGAATCTGCCCGAACCGCGGGTCGCGCTGGGCCTTGCGTTGCGTGGGGTCGCGCGCGCCGCGCTCGATA
TTTCGGACGGCCTTGCGGGCGACCTGATGCACATCCTCGAACGATCTCAGTTGAATGCGACCGTCGACGCCGACGCTTTG
CCGCGCTCGGACGCGCTGCGCCGCCTTCCCGCCGATATCCAGCGGCGCTGCACGATCGCGGGCGGCGACGACTACGAGTT
GTGCTTCACCGCGCCGCCTTCCTCACGCGACGCAGTCGTTGCGGCAGGTCAACAGGCGCGTGTGCCCGTGACGCGCGTCG
GTACAATAACGACGCTCGATGCGGCGGGCGCCGCGCCCGCGATCTCGTGGCGCGACGCGTCCGGCGCTCCCCTCACTCTG
ACATTGCAAGGCTTCGATCATTTCCATGCAGAATGA

Upstream 100 bases:

>100_bases
TGCGAGGCGCGCCTTTGACGTCGTGTTAGCTTCCATTGGCGCTTCTTGAGCGCATCCATCCACCCGCTTCGGCGGCCTTT
CGCAGTCACATGCCTTGTTT

Downstream 100 bases:

>100_bases
ATCCTCGCTTGGCCCGGCGGGCAGTTTCTCCGACGCGCCAACGGGCGAACCGCCCCGCCCCGCGGGCGCGTCGCCTTCCG
GCGTGCCGGACGGCGCAGGT

Product: thiamine monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MLSEFSLIDRFFARRAAGSTYPQRAALGIGDDCALLAPPAGEMLAISTDMLVAGRHFFPDVDPKALGHKALAVNLSDLAA
MGAKPQAFTLAFALPEADADWLAAFSDGLFELAERHGCELVGGDTTSGPLNLCLTVFGSVPPQTALRRDAAQPGDDIWIS
GTLGDARASLGVQRNEWSVDASDAATLRRAMNLPEPRVALGLALRGVARAALDISDGLAGDLMHILERSQLNATVDADAL
PRSDALRRLPADIQRRCTIAGGDDYELCFTAPPSSRDAVVAAGQQARVPVTRVGTITTLDAAGAAPAISWRDASGAPLTL
TLQGFDHFHAE

Sequences:

>Translated_331_residues
MLSEFSLIDRFFARRAAGSTYPQRAALGIGDDCALLAPPAGEMLAISTDMLVAGRHFFPDVDPKALGHKALAVNLSDLAA
MGAKPQAFTLAFALPEADADWLAAFSDGLFELAERHGCELVGGDTTSGPLNLCLTVFGSVPPQTALRRDAAQPGDDIWIS
GTLGDARASLGVQRNEWSVDASDAATLRRAMNLPEPRVALGLALRGVARAALDISDGLAGDLMHILERSQLNATVDADAL
PRSDALRRLPADIQRRCTIAGGDDYELCFTAPPSSRDAVVAAGQQARVPVTRVGTITTLDAAGAAPAISWRDASGAPLTL
TLQGFDHFHAE
>Mature_331_residues
MLSEFSLIDRFFARRAAGSTYPQRAALGIGDDCALLAPPAGEMLAISTDMLVAGRHFFPDVDPKALGHKALAVNLSDLAA
MGAKPQAFTLAFALPEADADWLAAFSDGLFELAERHGCELVGGDTTSGPLNLCLTVFGSVPPQTALRRDAAQPGDDIWIS
GTLGDARASLGVQRNEWSVDASDAATLRRAMNLPEPRVALGLALRGVARAALDISDGLAGDLMHILERSQLNATVDADAL
PRSDALRRLPADIQRRCTIAGGDDYELCFTAPPSSRDAVVAAGQQARVPVTRVGTITTLDAAGAAPAISWRDASGAPLTL
TLQGFDHFHAE

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=327, Percent_Identity=48.6238532110092, Blast_Score=266, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 34750; Mature: 34750

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSEFSLIDRFFARRAAGSTYPQRAALGIGDDCALLAPPAGEMLAISTDMLVAGRHFFPD
CCCHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCEEECCCCCCEEEEECCCEEECCCCCCC
VDPKALGHKALAVNLSDLAAMGAKPQAFTLAFALPEADADWLAAFSDGLFELAERHGCEL
CCHHHHCCEEEEEEHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEE
VGGDTTSGPLNLCLTVFGSVPPQTALRRDAAQPGDDIWISGTLGDARASLGVQRNEWSVD
ECCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEECCCCHHHHCCCCCCCCCCC
ASDAATLRRAMNLPEPRVALGLALRGVARAALDISDGLAGDLMHILERSQLNATVDADAL
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEECCCCC
PRSDALRRLPADIQRRCTIAGGDDYELCFTAPPSSRDAVVAAGQQARVPVTRVGTITTLD
CCHHHHHHCCHHHHHEEEEECCCCCEEEEECCCCCCCEEEECCCCCCCCEEECCEEEEEC
AAGAAPAISWRDASGAPLTLTLQGFDHFHAE
CCCCCCEEEECCCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MLSEFSLIDRFFARRAAGSTYPQRAALGIGDDCALLAPPAGEMLAISTDMLVAGRHFFPD
CCCHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCEEECCCCCCEEEEECCCEEECCCCCCC
VDPKALGHKALAVNLSDLAAMGAKPQAFTLAFALPEADADWLAAFSDGLFELAERHGCEL
CCHHHHCCEEEEEEHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEE
VGGDTTSGPLNLCLTVFGSVPPQTALRRDAAQPGDDIWISGTLGDARASLGVQRNEWSVD
ECCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEECCCCHHHHCCCCCCCCCCC
ASDAATLRRAMNLPEPRVALGLALRGVARAALDISDGLAGDLMHILERSQLNATVDADAL
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEECCCCC
PRSDALRRLPADIQRRCTIAGGDDYELCFTAPPSSRDAVVAAGQQARVPVTRVGTITTLD
CCHHHHHHCCHHHHHEEEEECCCCCEEEEECCCCCCCEEEECCCCCCCCEEECCEEEEEC
AAGAAPAISWRDASGAPLTLTLQGFDHFHAE
CCCCCCEEEECCCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]