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The map label for this gene is glk [H]

Identifier: 186477329

GI number: 186477329

Start: 2903074

End: 2903910

Strand: Direct

Name: glk [H]

Synonym: Bphy_2581

Alternate gene names: 186477329

Gene position: 2903074-2903910 (Clockwise)

Preceding gene: 186477324

Following gene: 186477331

Centisome position: 83.44

GC content: 64.99

Gene sequence:

>837_bases
ATGCTGTCTCAGGTGGAAGCGATGCGCGACCAGATGCGCCCTTCGGAACGCAAGCTCGCCGACTACGTGATGGAAGCGCC
GCGCGAGGTGCTCGACCTGTCGATGACGGAGGTGGCCGCACGCGCGGGCGTGAGCCAGCCGACCATTGCGCGCTTCTGCC
ACGCGCTCGGTTTTTCCGGCTTCCGCGAGTTCAAGATCCGGCTCGCCCAAGGTATAGCAACGCAGGTGCCCGCCGTTTAT
CGCGACGTGCGGCCCGACGAACCCGCGCCGGGCGTCGCGGCGAAGGTGCTGGACCGGACGATCGGCGCGCTCATCCAGGT
GCGCAACAATCTGTCGTCCGATAGCGTCGCGGCGGCGATCGAGCTTCTGGCGAACGCAAAACGCGTCGAGTTCTATGGCG
CGGGCGGCTCGGGCATTGCCGCGCTCGATATGCAGCACAAGTTCTTCCGGCTGGGCATGCCGAGCGTCGCGTATTCGGAT
CCGCACACGTTTCTTATGTCGGCGGCATTGCTCGGCGAAGGCGATGTCGTCGTGGCCATTTCGAACACAGGCCGCACGCG
CGACATCATCGACGCCGCCCGGTCAGCGATGAAGGCGGGCGCGAAGGTGATTGCCGTGACACACGGGAATTCGCCGCTCG
CGCGGGTTGCGTCGATTGGACTCTTCGCGAATGTCGACGAAGACACCGACATCTTTTCGCCGATGACGTCGCGCACATCG
CATCTGGCGATCGGCGATATCCTGGCGGTCGGCGTCGCGTTGCATCGCGGGCCGGACTTGGCGGAGAAGCTGGCTGGGGC
AAAAGATCTGATTGCGCAGCGCAGGGTTGGCGGGTAA

Upstream 100 bases:

>100_bases
CGTCAGGGTAATCACCTACGGCACACATGTAGTTTTTGTACTTGATTCGTCTATGAGCTATAGTCCACGCATTCTTCAGC
ATAGTGCGAGATTCCCGATG

Downstream 100 bases:

>100_bases
CGAGACGACCTTGTGGGTCGGCCTCGCGCGGCATGGCTGCATAAATGCAAAACGGGCTCCGTCGGAGCCCGTTTCGTTTT
GAAGCGTACTGCTGTTGCTG

Product: RpiR family transcriptional regulator

Products: NA

Alternate protein names: Glucokinase; Glucose kinase; Putative HTH-type transcriptional regulator [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MLSQVEAMRDQMRPSERKLADYVMEAPREVLDLSMTEVAARAGVSQPTIARFCHALGFSGFREFKIRLAQGIATQVPAVY
RDVRPDEPAPGVAAKVLDRTIGALIQVRNNLSSDSVAAAIELLANAKRVEFYGAGGSGIAALDMQHKFFRLGMPSVAYSD
PHTFLMSAALLGEGDVVVAISNTGRTRDIIDAARSAMKAGAKVIAVTHGNSPLARVASIGLFANVDEDTDIFSPMTSRTS
HLAIGDILAVGVALHRGPDLAEKLAGAKDLIAQRRVGG

Sequences:

>Translated_278_residues
MLSQVEAMRDQMRPSERKLADYVMEAPREVLDLSMTEVAARAGVSQPTIARFCHALGFSGFREFKIRLAQGIATQVPAVY
RDVRPDEPAPGVAAKVLDRTIGALIQVRNNLSSDSVAAAIELLANAKRVEFYGAGGSGIAALDMQHKFFRLGMPSVAYSD
PHTFLMSAALLGEGDVVVAISNTGRTRDIIDAARSAMKAGAKVIAVTHGNSPLARVASIGLFANVDEDTDIFSPMTSRTS
HLAIGDILAVGVALHRGPDLAEKLAGAKDLIAQRRVGG
>Mature_278_residues
MLSQVEAMRDQMRPSERKLADYVMEAPREVLDLSMTEVAARAGVSQPTIARFCHALGFSGFREFKIRLAQGIATQVPAVY
RDVRPDEPAPGVAAKVLDRTIGALIQVRNNLSSDSVAAAIELLANAKRVEFYGAGGSGIAALDMQHKFFRLGMPSVAYSD
PHTFLMSAALLGEGDVVVAISNTGRTRDIIDAARSAMKAGAKVIAVTHGNSPLARVASIGLFANVDEDTDIFSPMTSRTS
HLAIGDILAVGVALHRGPDLAEKLAGAKDLIAQRRVGG

Specific function: Represses The Expression Of The Hex Regulon (Zwf, Eda, Glp And Gap) (By Similarity). [C]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=276, Percent_Identity=36.9565217391304, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI87082369, Length=246, Percent_Identity=30.4878048780488, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI87082130, Length=245, Percent_Identity=28.9795918367347, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1788767, Length=281, Percent_Identity=27.4021352313167, Blast_Score=101, Evalue=6e-23,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003836
- InterPro:   IPR000843
- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02685 Glucokinase; PF01418 HTH_6; PF01380 SIS [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 29507; Mature: 29507

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS00356 HTH_LACI_1 ; PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSQVEAMRDQMRPSERKLADYVMEAPREVLDLSMTEVAARAGVSQPTIARFCHALGFSG
CCCHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCH
FREFKIRLAQGIATQVPAVYRDVRPDEPAPGVAAKVLDRTIGALIQVRNNLSSDSVAAAI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ELLANAKRVEFYGAGGSGIAALDMQHKFFRLGMPSVAYSDPHTFLMSAALLGEGDVVVAI
HHHHCCCEEEEEECCCCCEEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEEE
SNTGRTRDIIDAARSAMKAGAKVIAVTHGNSPLARVASIGLFANVDEDTDIFSPMTSRTS
CCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHCCHHCCCC
HLAIGDILAVGVALHRGPDLAEKLAGAKDLIAQRRVGG
HHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHCCCC
>Mature Secondary Structure
MLSQVEAMRDQMRPSERKLADYVMEAPREVLDLSMTEVAARAGVSQPTIARFCHALGFSG
CCCHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCH
FREFKIRLAQGIATQVPAVYRDVRPDEPAPGVAAKVLDRTIGALIQVRNNLSSDSVAAAI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ELLANAKRVEFYGAGGSGIAALDMQHKFFRLGMPSVAYSDPHTFLMSAALLGEGDVVVAI
HHHHCCCEEEEEECCCCCEEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEEE
SNTGRTRDIIDAARSAMKAGAKVIAVTHGNSPLARVASIGLFANVDEDTDIFSPMTSRTS
CCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHCCHHCCCC
HLAIGDILAVGVALHRGPDLAEKLAGAKDLIAQRRVGG
HHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA