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The map label for this gene is purM

Identifier: 186477236

GI number: 186477236

Start: 2797651

End: 2798718

Strand: Reverse

Name: purM

Synonym: Bphy_2487

Alternate gene names: 186477236

Gene position: 2798718-2797651 (Counterclockwise)

Preceding gene: 186477244

Following gene: 186477233

Centisome position: 80.44

GC content: 64.42

Gene sequence:

>1068_bases
ATGAATCAACCGAAATCCGCTCCGAATTCACCTGATTCGGCCCAAGGTTTGTCGTATCGGGACGCAGGCGTGGACATCGA
CGCGGGCGACGCCCTGGTCGACGCGATCAAGCCCTTTGCCAGGAAGACGCTGCGCGACGGCGTGCTGGGTGGCATCGGCG
GTTTCGGCGCGCTGTTCGAGGTGCCGAAGAAGTACAAGGAGCCTGTGCTCGTGTCGGGCACGGACGGCGTCGGCACGAAG
CTGAAGCTCGCGTTCACGCTGAACCGTCACGATACCGTTGGCCAGGATCTCGTCGCGATGAGCGTCAACGACATTCTGGT
GCAAGGCGCCGAGCCGCTGTTCTTCCTCGACTATTTCGCGTGCGGCAAGCTGGACGTCGGCACGGCGGCGACGGTCGTCA
AGGGGATCGCGCAGGGCTGCGAGCTGGCCGGCTGCGCCCTGATCGGCGGCGAGACGGCTGAAATGCCGGGCATGTACCCG
GACGGCGAGTACGATCTGGCGGGCTTCGCAGTCGGCGCGGTGGAGAAGAGCAAGATCATCGACGGCAGCAAGATTGTGCC
GGGCGATGTCGTGCTGGGTCTTGCGTCGAGCGGCATCCATTCGAACGGTTACTCGCTGGTGCGCAAGATCATCGAGCGCG
CGCAGCCCGATCTGGACGCCGACTTCGACGGCCGCACGCTAGCCGAGGCGCTGATGGCGCCGACGCACATCTACGTGAAG
CCCTTGCTGGCACTGATGCAGCAACTCGAGGTGAAGGGCATGGCGCACATTACGGGCGGCGGCCTGGTCGAGAACATTCC
GCGCGTGCTGCGGGAAGGCTTGACGGCCGAGCTGGATCATCGCGCATGGCCGCTGCCGCCGCTGTTCGCATGGCTGCAGA
AGCATGGCGGTGTGGCCGATGCTGAGATGCATCGCGTGTTCAATTGCGGTATCGGGATGGTTGTGATTGTGTCGGCTGCC
GATGCCGACGCCGCGACCGGGCTTTTGGCCGCCGCCGGCGAGCAGGTTTGGAAGATCGGTACGGTGCGGCAGAGTAAGGA
AGGTGAGGCGCAGACCGTAGTGGTTTGA

Upstream 100 bases:

>100_bases
CAAAGCGGATTTCCCAGGTGTCGTGTCGGCGTCTCAAATTCCAGCCACGCGGCCGGCATCGGGTAAAATCGCATTTTACC
GACCTTCGAGCACTCCCCCC

Downstream 100 bases:

>100_bases
TTGCCGCTGGCGGTTGGTTTTGCCTGTTGTGGTGCTGTTGCTGTTGTCGGCATCCGCGGTTGCGACTTGCGCTCTTGCAG
GCATCTGCGTGATGCCTTCG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MNQPKSAPNSPDSAQGLSYRDAGVDIDAGDALVDAIKPFARKTLRDGVLGGIGGFGALFEVPKKYKEPVLVSGTDGVGTK
LKLAFTLNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVGTAATVVKGIAQGCELAGCALIGGETAEMPGMYP
DGEYDLAGFAVGAVEKSKIIDGSKIVPGDVVLGLASSGIHSNGYSLVRKIIERAQPDLDADFDGRTLAEALMAPTHIYVK
PLLALMQQLEVKGMAHITGGGLVENIPRVLREGLTAELDHRAWPLPPLFAWLQKHGGVADAEMHRVFNCGIGMVVIVSAA
DADAATGLLAAAGEQVWKIGTVRQSKEGEAQTVVV

Sequences:

>Translated_355_residues
MNQPKSAPNSPDSAQGLSYRDAGVDIDAGDALVDAIKPFARKTLRDGVLGGIGGFGALFEVPKKYKEPVLVSGTDGVGTK
LKLAFTLNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVGTAATVVKGIAQGCELAGCALIGGETAEMPGMYP
DGEYDLAGFAVGAVEKSKIIDGSKIVPGDVVLGLASSGIHSNGYSLVRKIIERAQPDLDADFDGRTLAEALMAPTHIYVK
PLLALMQQLEVKGMAHITGGGLVENIPRVLREGLTAELDHRAWPLPPLFAWLQKHGGVADAEMHRVFNCGIGMVVIVSAA
DADAATGLLAAAGEQVWKIGTVRQSKEGEAQTVVV
>Mature_355_residues
MNQPKSAPNSPDSAQGLSYRDAGVDIDAGDALVDAIKPFARKTLRDGVLGGIGGFGALFEVPKKYKEPVLVSGTDGVGTK
LKLAFTLNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVGTAATVVKGIAQGCELAGCALIGGETAEMPGMYP
DGEYDLAGFAVGAVEKSKIIDGSKIVPGDVVLGLASSGIHSNGYSLVRKIIERAQPDLDADFDGRTLAEALMAPTHIYVK
PLLALMQQLEVKGMAHITGGGLVENIPRVLREGLTAELDHRAWPLPPLFAWLQKHGGVADAEMHRVFNCGIGMVVIVSAA
DADAATGLLAAAGEQVWKIGTVRQSKEGEAQTVVV

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=363, Percent_Identity=51.5151515151515, Blast_Score=360, Evalue=1e-100,
Organism=Homo sapiens, GI209869995, Length=363, Percent_Identity=51.5151515151515, Blast_Score=360, Evalue=1e-100,
Organism=Homo sapiens, GI209869993, Length=363, Percent_Identity=51.5151515151515, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI1788845, Length=339, Percent_Identity=59.5870206489675, Blast_Score=409, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17567511, Length=343, Percent_Identity=44.8979591836735, Blast_Score=261, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6321203, Length=344, Percent_Identity=49.1279069767442, Blast_Score=324, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24582400, Length=314, Percent_Identity=48.4076433121019, Blast_Score=258, Evalue=3e-69,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_BURP8 (B2JGD2)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001858706.1
- GeneID:   6243971
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_2487
- HOGENOM:   HBG531222
- OMA:   GIDMIAM
- ProtClustDB:   PRK05385
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 37173; Mature: 37173

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQPKSAPNSPDSAQGLSYRDAGVDIDAGDALVDAIKPFARKTLRDGVLGGIGGFGALFE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
VPKKYKEPVLVSGTDGVGTKLKLAFTLNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFA
HHHHHCCCEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHH
CGKLDVGTAATVVKGIAQGCELAGCALIGGETAEMPGMYPDGEYDLAGFAVGAVEKSKII
CCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCHHHHCC
DGSKIVPGDVVLGLASSGIHSNGYSLVRKIIERAQPDLDADFDGRTLAEALMAPTHIYVK
CCCCCCCCHHEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHH
PLLALMQQLEVKGMAHITGGGLVENIPRVLREGLTAELDHRAWPLPPLFAWLQKHGGVAD
HHHHHHHHHHHCCEEEECCCHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHCCCCH
AEMHRVFNCGIGMVVIVSAADADAATGLLAAAGEQVWKIGTVRQSKEGEAQTVVV
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCHHHHHHCCCCCCCCCCCEEEEC
>Mature Secondary Structure
MNQPKSAPNSPDSAQGLSYRDAGVDIDAGDALVDAIKPFARKTLRDGVLGGIGGFGALFE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
VPKKYKEPVLVSGTDGVGTKLKLAFTLNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFA
HHHHHCCCEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHH
CGKLDVGTAATVVKGIAQGCELAGCALIGGETAEMPGMYPDGEYDLAGFAVGAVEKSKII
CCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCHHHHCC
DGSKIVPGDVVLGLASSGIHSNGYSLVRKIIERAQPDLDADFDGRTLAEALMAPTHIYVK
CCCCCCCCHHEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHH
PLLALMQQLEVKGMAHITGGGLVENIPRVLREGLTAELDHRAWPLPPLFAWLQKHGGVAD
HHHHHHHHHHHCCEEEECCCHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHCCCCH
AEMHRVFNCGIGMVVIVSAADADAATGLLAAAGEQVWKIGTVRQSKEGEAQTVVV
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCHHHHHHCCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA