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The map label for this gene is pabB [H]

Identifier: 186477244

GI number: 186477244

Start: 2805305

End: 2807170

Strand: Reverse

Name: pabB [H]

Synonym: Bphy_2495

Alternate gene names: 186477244

Gene position: 2807170-2805305 (Counterclockwise)

Preceding gene: 186477245

Following gene: 186477236

Centisome position: 80.68

GC content: 64.2

Gene sequence:

>1866_bases
ATGACGGCTCAAGCGACAGGCAGCGTGTTCGCGTTGCTGGACGACTGCGACTCGACCGCGAGTCGCCGGTCGAGCCGGTT
ATACACGGGCTTCCGGCACGAACACGTCTGCGCTGACCCCGCTCAGCTGGATGCGGTGTGCGACGCGGCGTCGGCCGATG
TCGACAGCGGTCTTTTCGCTGTCGTGCTCGCCGATTACGAGTTTGGACAGGCTTTGCAACAGGAAACGCAGCGTGCCAGT
GGCTCGCTGCGTTTTTTATTGTTCGAGCACTGTCAGAAAATGTCGCGCGACGAGGTCGACCGCTGGCTCGCGCTCTACGA
CAGCGCAGCCGTCGAACCGTCGGTGGCGGGCATCGGCGGCGTCCAGGCGAGCGTCGACGAAACGGCATTCACGCAGGCCA
TCGATGCCGTCCACGAAGCTTTGCGTGCGGGCGACTCCTATCAGATCAACTACACCTATCGGCTGTACTTCGACGTGTTC
GGCACGCCGGCCGCACTTTTCCGGCGGCTGCGCGCGCGGCAATCGGTTCATTACGGCGCACTGATCGCACTGCCTGGCGA
CCGCTGGGTCGTGTCGTGTTCGCCGGAACTGTTCGTCGAGAAGAAAGGGATGTCGTTGCGCACGCGTCCAATGAAAGGGA
CGGCGCCCCGCTCATCGAACCCTGAACAGGACAACGCTGCGGCCGAGTTCCTCGCTCACGATCCGAAGAATCGCGCGGAA
AATGTGATGATCGTCGATCTGCTGCGCAACGACCTCTCGCGGATCGCCGAAACGGGTACGGTGAAAACACCGGCGCTGTT
CTCCGTCGAACCGTATCAGTCGGTGTGGCAGATGACATCGACAGTGACGGCGATGCTGCGCCCACGCACGTCGTTCGCCG
ACGTTCTGCGCGCGCTTTTCCCCTGCGGCTCAATCACGGGCGCGCCGAAGCACAAGACGATGCAATTGATCGAGCAGATA
GAATCCACGCCGCGCGGCCTGTACACGGGTGCAATCGGCTGGCTCGATGCGCAGCCCGATTTCGGCGAAACCGTCGGCAA
GCAGTGCGAGGACTTCTGTCTGTCGGTGGCGATTCGTACGCTGACGCTCGGCGCTGCGACGCCGCTCGCAGCGCGCCGGG
GGGAAATGGGTATCGGCGCGGGCATCGTGCTCGACAGCGTGGCGCAAGACGAATACGCGGAGTGCAAATTGAAAGCACGT
TTCCTGACGGAAGCCGACCCCGGCTTCCAGCTATTCGAAACGATGTATGCGACGCACGAGGGCGGCGTGCGGCATCTCGA
ACGCCATCTTGCGCGGCTTGGTCACAGCGCGCGCTGGCTGGGCTTTCCATTCGACGAGGACAGCGTGCGCGCGCAACTCT
GCGCGCAATGCGCGACGTTGCGCAACGCGACGCCGCACCGGATGCGGCTCACGCTGGACAAGGCCGGCGCGACGGAAATC
ACGTTTGCCCCGCTCGTGCCGCTGACGGACGAAGTGGTCGGCGTGCTGCTCGGCCCCGATCACGGCTTTGCGTCGATGCA
GGCGGCCGATCCGCTGCTGCTGCACAAAACGACGCGTCGCGCGGAATACGATCGCGGCTGGCGTGAAGCCGAATCACACG
ATGCGTTCGACACGCTCTTTTTCAACGAGCGCGGCGAGTTGACCGAGGGCGGGCGGTCCAATGTTTTCGTGAAGCTGGAG
GGACGCTGGTGGACGCCGCCGTTGTCGTCGGGCGTGTTGCCGGGCGTGATGCGTGGCGTTCTGCTCGAGGATCCCGACAT
GCAGGCGGGCGAGCGCGTGTTGACGCGGGGCGACGTGTCGAATGCGCAAGCGCTGATGCTCTGCAATGCGCTGCGTGGCG
CGTTGCCGGCGCGCGTTGTCGTTTGA

Upstream 100 bases:

>100_bases
GCTGGTCGAAGGCGGCGCGCGTCATAGCCCGCAGAGCAAGAGCTGGTTCGACCGCGTCAAGAGCTTTTTCGACTAACGCG
TTCTGAAGTTGGCGGTATGC

Downstream 100 bases:

>100_bases
AGGATTGAGCCGGCAGCGGGGAAAGGCTCGCATCAACCGTGATGCCGCTGAAGCAGGCGCCCGGTCCTGAAAAGCGGCGC
TCGAAAGCGCCGCCCGGCTT

Product: para-aminobenzoate synthase subunit I

Products: NA

Alternate protein names: ADC synthase; Para-aminobenzoate synthase component I [H]

Number of amino acids: Translated: 621; Mature: 620

Protein sequence:

>621_residues
MTAQATGSVFALLDDCDSTASRRSSRLYTGFRHEHVCADPAQLDAVCDAASADVDSGLFAVVLADYEFGQALQQETQRAS
GSLRFLLFEHCQKMSRDEVDRWLALYDSAAVEPSVAGIGGVQASVDETAFTQAIDAVHEALRAGDSYQINYTYRLYFDVF
GTPAALFRRLRARQSVHYGALIALPGDRWVVSCSPELFVEKKGMSLRTRPMKGTAPRSSNPEQDNAAAEFLAHDPKNRAE
NVMIVDLLRNDLSRIAETGTVKTPALFSVEPYQSVWQMTSTVTAMLRPRTSFADVLRALFPCGSITGAPKHKTMQLIEQI
ESTPRGLYTGAIGWLDAQPDFGETVGKQCEDFCLSVAIRTLTLGAATPLAARRGEMGIGAGIVLDSVAQDEYAECKLKAR
FLTEADPGFQLFETMYATHEGGVRHLERHLARLGHSARWLGFPFDEDSVRAQLCAQCATLRNATPHRMRLTLDKAGATEI
TFAPLVPLTDEVVGVLLGPDHGFASMQAADPLLLHKTTRRAEYDRGWREAESHDAFDTLFFNERGELTEGGRSNVFVKLE
GRWWTPPLSSGVLPGVMRGVLLEDPDMQAGERVLTRGDVSNAQALMLCNALRGALPARVVV

Sequences:

>Translated_621_residues
MTAQATGSVFALLDDCDSTASRRSSRLYTGFRHEHVCADPAQLDAVCDAASADVDSGLFAVVLADYEFGQALQQETQRAS
GSLRFLLFEHCQKMSRDEVDRWLALYDSAAVEPSVAGIGGVQASVDETAFTQAIDAVHEALRAGDSYQINYTYRLYFDVF
GTPAALFRRLRARQSVHYGALIALPGDRWVVSCSPELFVEKKGMSLRTRPMKGTAPRSSNPEQDNAAAEFLAHDPKNRAE
NVMIVDLLRNDLSRIAETGTVKTPALFSVEPYQSVWQMTSTVTAMLRPRTSFADVLRALFPCGSITGAPKHKTMQLIEQI
ESTPRGLYTGAIGWLDAQPDFGETVGKQCEDFCLSVAIRTLTLGAATPLAARRGEMGIGAGIVLDSVAQDEYAECKLKAR
FLTEADPGFQLFETMYATHEGGVRHLERHLARLGHSARWLGFPFDEDSVRAQLCAQCATLRNATPHRMRLTLDKAGATEI
TFAPLVPLTDEVVGVLLGPDHGFASMQAADPLLLHKTTRRAEYDRGWREAESHDAFDTLFFNERGELTEGGRSNVFVKLE
GRWWTPPLSSGVLPGVMRGVLLEDPDMQAGERVLTRGDVSNAQALMLCNALRGALPARVVV
>Mature_620_residues
TAQATGSVFALLDDCDSTASRRSSRLYTGFRHEHVCADPAQLDAVCDAASADVDSGLFAVVLADYEFGQALQQETQRASG
SLRFLLFEHCQKMSRDEVDRWLALYDSAAVEPSVAGIGGVQASVDETAFTQAIDAVHEALRAGDSYQINYTYRLYFDVFG
TPAALFRRLRARQSVHYGALIALPGDRWVVSCSPELFVEKKGMSLRTRPMKGTAPRSSNPEQDNAAAEFLAHDPKNRAEN
VMIVDLLRNDLSRIAETGTVKTPALFSVEPYQSVWQMTSTVTAMLRPRTSFADVLRALFPCGSITGAPKHKTMQLIEQIE
STPRGLYTGAIGWLDAQPDFGETVGKQCEDFCLSVAIRTLTLGAATPLAARRGEMGIGAGIVLDSVAQDEYAECKLKARF
LTEADPGFQLFETMYATHEGGVRHLERHLARLGHSARWLGFPFDEDSVRAQLCAQCATLRNATPHRMRLTLDKAGATEIT
FAPLVPLTDEVVGVLLGPDHGFASMQAADPLLLHKTTRRAEYDRGWREAESHDAFDTLFFNERGELTEGGRSNVFVKLEG
RWWTPPLSSGVLPGVMRGVLLEDPDMQAGERVLTRGDVSNAQALMLCNALRGALPARVVV

Specific function: Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine [H]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=275, Percent_Identity=37.4545454545455, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1787518, Length=284, Percent_Identity=30.2816901408451, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI1786809, Length=282, Percent_Identity=24.113475177305, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI87082077, Length=226, Percent_Identity=24.7787610619469, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320935, Length=288, Percent_Identity=29.8611111111111, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6324361, Length=251, Percent_Identity=28.6852589641434, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =2.6.1.85 [H]

Molecular weight: Translated: 68040; Mature: 67909

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQATGSVFALLDDCDSTASRRSSRLYTGFRHEHVCADPAQLDAVCDAASADVDSGLFA
CCCCCCCCEEEEEHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEE
VVLADYEFGQALQQETQRASGSLRFLLFEHCQKMSRDEVDRWLALYDSAAVEPSVAGIGG
EEEECCHHHHHHHHHHHHHCCCEEHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCC
VQASVDETAFTQAIDAVHEALRAGDSYQINYTYRLYFDVFGTPAALFRRLRARQSVHYGA
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEECCCHHHHHHHHHHHHCCCCCE
LIALPGDRWVVSCSPELFVEKKGMSLRTRPMKGTAPRSSNPEQDNAAAEFLAHDPKNRAE
EEEECCCCEEEEECHHHEEECCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHC
NVMIVDLLRNDLSRIAETGTVKTPALFSVEPYQSVWQMTSTVTAMLRPRTSFADVLRALF
CEEEHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHC
PCGSITGAPKHKTMQLIEQIESTPRGLYTGAIGWLDAQPDFGETVGKQCEDFCLSVAIRT
CCCCCCCCCCHHHHHHHHHHHCCCCCEEECCEEEECCCCCHHHHHHHHHHHHHHHHHHHH
LTLGAATPLAARRGEMGIGAGIVLDSVAQDEYAECKLKARFLTEADPGFQLFETMYATHE
HHHCCCCCHHHCCCCCCCCCHHHHHHHHCCHHHHHEEEEEEECCCCCCHHHHHHHHHHCC
GGVRHLERHLARLGHSARWLGFPFDEDSVRAQLCAQCATLRNATPHRMRLTLDKAGATEI
CHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEE
TFAPLVPLTDEVVGVLLGPDHGFASMQAADPLLLHKTTRRAEYDRGWREAESHDAFDTLF
EEECCCCCCCHHEEEEECCCCCCCCHHCCCCCEEEHHHHHHHHHCCHHHHCCCCCHHHEE
FNERGELTEGGRSNVFVKLEGRWWTPPLSSGVLPGVMRGVLLEDPDMQAGERVLTRGDVS
ECCCCCCCCCCCCCEEEEECCEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCC
NAQALMLCNALRGALPARVVV
CHHHHHHHHHHHCCCCCEECC
>Mature Secondary Structure 
TAQATGSVFALLDDCDSTASRRSSRLYTGFRHEHVCADPAQLDAVCDAASADVDSGLFA
CCCCCCCEEEEEHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEE
VVLADYEFGQALQQETQRASGSLRFLLFEHCQKMSRDEVDRWLALYDSAAVEPSVAGIGG
EEEECCHHHHHHHHHHHHHCCCEEHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCC
VQASVDETAFTQAIDAVHEALRAGDSYQINYTYRLYFDVFGTPAALFRRLRARQSVHYGA
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEECCCHHHHHHHHHHHHCCCCCE
LIALPGDRWVVSCSPELFVEKKGMSLRTRPMKGTAPRSSNPEQDNAAAEFLAHDPKNRAE
EEEECCCCEEEEECHHHEEECCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHC
NVMIVDLLRNDLSRIAETGTVKTPALFSVEPYQSVWQMTSTVTAMLRPRTSFADVLRALF
CEEEHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHC
PCGSITGAPKHKTMQLIEQIESTPRGLYTGAIGWLDAQPDFGETVGKQCEDFCLSVAIRT
CCCCCCCCCCHHHHHHHHHHHCCCCCEEECCEEEECCCCCHHHHHHHHHHHHHHHHHHHH
LTLGAATPLAARRGEMGIGAGIVLDSVAQDEYAECKLKARFLTEADPGFQLFETMYATHE
HHHCCCCCHHHCCCCCCCCCHHHHHHHHCCHHHHHEEEEEEECCCCCCHHHHHHHHHHCC
GGVRHLERHLARLGHSARWLGFPFDEDSVRAQLCAQCATLRNATPHRMRLTLDKAGATEI
CHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEE
TFAPLVPLTDEVVGVLLGPDHGFASMQAADPLLLHKTTRRAEYDRGWREAESHDAFDTLF
EEECCCCCCCHHEEEEECCCCCCCCHHCCCCCEEEHHHHHHHHHCCHHHHCCCCCHHHEE
FNERGELTEGGRSNVFVKLEGRWWTPPLSSGVLPGVMRGVLLEDPDMQAGERVLTRGDVS
ECCCCCCCCCCCCCEEEEECCEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCC
NAQALMLCNALRGALPARVVV
CHHHHHHHHHHHCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]