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The map label for this gene is envZ [H]

Identifier: 186477154

GI number: 186477154

Start: 2703258

End: 2704655

Strand: Reverse

Name: envZ [H]

Synonym: Bphy_2403

Alternate gene names: 186477154

Gene position: 2704655-2703258 (Counterclockwise)

Preceding gene: 186477155

Following gene: 186477153

Centisome position: 77.74

GC content: 66.95

Gene sequence:

>1398_bases
ATGAGCGCGCGCGCGCTGCGGTATCTGTTGCCGCGCAGTGTGCTCGGGCGCAACATCGCGCTGCTGATCGTTCTGGTGGC
GCTTAGCCAGGTCTGTGCATTGAGCGTGCTCGTTCACTATGTGCAGAAGCCGCGCGTCGAACGCGCGGCCGCCGTGTTCG
GCGCGTACATCAGGACGCTGGACAATGCGCTGACGGCCTCGCCCGAGGGCGAGCGCGCGACGCTCGTCGCACGGCTCGAT
GCGCGCAGCGAGCCGCCCGCCGAAGCCGTTTCCGAGCCGCGAGTTCGCTTGCTGGCGTTTTATCGCACGTCTCAATTGGT
GACGTTTCTGGAGACGCTGCATCGTTATCTGCCGCCGGGGACGGAAGTGCGCTGGCAAGGCGAGCCGCATCCGCGCATGT
GGATACGCATGCACGTGGCCGCGACGCCTTACTGGATCGGCCTGCAGGTACCGGAGGAAGCGCAGGGCGGCGGCATGTTG
ACAGCGGTGCTGCTGTCGATCGGCCTTGGCCTGCTCGCCGCGCTGACGGGTTTCGTGTTGCAGGCGTACCTGGATCGTCC
GCTGCGCGAACTGGCGCAGGCGGCGCGGCGCGTGAGCGCGGGCGAGACGCCGCCGCCGCTGCCCGTCGACGGCCCGACGG
AAATTGCGCAGGTGAGCAGCGCATTCAATCAGATGACGCAGGCGCTGCAGCAGGCGGAAGCAACGCGCGCGCTGATGCTC
GCGGGCATTTCGCACGACATCCGCACGCCGCTCACGAAGCTGCGTCTCGCGATGGCGATGGCCAACGATACCAACGGCGA
CGAAGCGTTTGTCGGTGCGGCGGAATCCTATCTCGATCAGATCGATATCATTCTCCAGCAGTTCATGGACTACGCGGGCA
GCGGTGAACGCGAGGCGCCACAACGTGGCGATCTGAACGCGCTGATCAGCCAGCTGGCCGCGGACTTTGCGGGGCTCGGG
CACGAGTTCGACTTGCAGCTGGGCGAATTGCCCGAGCACGCGTTCAGGCCGATCACGATGATGCGGCTCGTGATGAACCT
CATGCAGAACGCCGTCGTGTATGGGCAAACGGGACTCGCCGTCAGGACATGGGCCGATGCGCGAGCGATCTACGTGGCCG
TCGCCGATCGCGGCAAGGGCTTGAGCGCGGAAGAACTCGAACGGCTCAAGGCGCCGTTCCAGCGCGGCAAGAACGCGCAT
GGGAAAACGGGCGGCACGGGGCTGGGGCTCGCCATCGTCGAACGTATTGCGCGCCTGCATGGCGGCACGTTGGCGTTCCA
TGCACGCGAAGGCGGCGGTCTCGAAGTGTGGGCGGTGCTGCCGATCCGGCTCGGCGCACACGCGGCGGGTGAGCCGTCGG
TTTCGGGTGAGCCGTCCGCCGCGCAGCCTGCCGCCTGA

Upstream 100 bases:

>100_bases
TTCTGCGGCTGCGGCAAGCGATCGAACACGATCCGTCGAAGCCGCGTTTCATCAAGACCGTGTGGGGCGTCGGCTATATG
CTCGTCGCCGACGTCGAAGC

Downstream 100 bases:

>100_bases
GCGACGTGGGCCACTGGAGCTACTGGAGCCACGGAAGCCACTTCAGCTGCTGGAGTGGCTCAAGCGCGCAAGACAATTCG
GTTGCGAGCCGCTAATCTGT

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSARALRYLLPRSVLGRNIALLIVLVALSQVCALSVLVHYVQKPRVERAAAVFGAYIRTLDNALTASPEGERATLVARLD
ARSEPPAEAVSEPRVRLLAFYRTSQLVTFLETLHRYLPPGTEVRWQGEPHPRMWIRMHVAATPYWIGLQVPEEAQGGGML
TAVLLSIGLGLLAALTGFVLQAYLDRPLRELAQAARRVSAGETPPPLPVDGPTEIAQVSSAFNQMTQALQQAEATRALML
AGISHDIRTPLTKLRLAMAMANDTNGDEAFVGAAESYLDQIDIILQQFMDYAGSGEREAPQRGDLNALISQLAADFAGLG
HEFDLQLGELPEHAFRPITMMRLVMNLMQNAVVYGQTGLAVRTWADARAIYVAVADRGKGLSAEELERLKAPFQRGKNAH
GKTGGTGLGLAIVERIARLHGGTLAFHAREGGGLEVWAVLPIRLGAHAAGEPSVSGEPSAAQPAA

Sequences:

>Translated_465_residues
MSARALRYLLPRSVLGRNIALLIVLVALSQVCALSVLVHYVQKPRVERAAAVFGAYIRTLDNALTASPEGERATLVARLD
ARSEPPAEAVSEPRVRLLAFYRTSQLVTFLETLHRYLPPGTEVRWQGEPHPRMWIRMHVAATPYWIGLQVPEEAQGGGML
TAVLLSIGLGLLAALTGFVLQAYLDRPLRELAQAARRVSAGETPPPLPVDGPTEIAQVSSAFNQMTQALQQAEATRALML
AGISHDIRTPLTKLRLAMAMANDTNGDEAFVGAAESYLDQIDIILQQFMDYAGSGEREAPQRGDLNALISQLAADFAGLG
HEFDLQLGELPEHAFRPITMMRLVMNLMQNAVVYGQTGLAVRTWADARAIYVAVADRGKGLSAEELERLKAPFQRGKNAH
GKTGGTGLGLAIVERIARLHGGTLAFHAREGGGLEVWAVLPIRLGAHAAGEPSVSGEPSAAQPAA
>Mature_464_residues
SARALRYLLPRSVLGRNIALLIVLVALSQVCALSVLVHYVQKPRVERAAAVFGAYIRTLDNALTASPEGERATLVARLDA
RSEPPAEAVSEPRVRLLAFYRTSQLVTFLETLHRYLPPGTEVRWQGEPHPRMWIRMHVAATPYWIGLQVPEEAQGGGMLT
AVLLSIGLGLLAALTGFVLQAYLDRPLRELAQAARRVSAGETPPPLPVDGPTEIAQVSSAFNQMTQALQQAEATRALMLA
GISHDIRTPLTKLRLAMAMANDTNGDEAFVGAAESYLDQIDIILQQFMDYAGSGEREAPQRGDLNALISQLAADFAGLGH
EFDLQLGELPEHAFRPITMMRLVMNLMQNAVVYGQTGLAVRTWADARAIYVAVADRGKGLSAEELERLKAPFQRGKNAHG
KTGGTGLGLAIVERIARLHGGTLAFHAREGGGLEVWAVLPIRLGAHAAGEPSVSGEPSAAQPAA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=453, Percent_Identity=30.4635761589404, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1790346, Length=268, Percent_Identity=29.4776119402985, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787894, Length=254, Percent_Identity=27.1653543307087, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI145693157, Length=255, Percent_Identity=25.0980392156863, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788393, Length=272, Percent_Identity=25, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=31.651376146789, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786783, Length=323, Percent_Identity=24.1486068111455, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789149, Length=231, Percent_Identity=25.5411255411255, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788549, Length=240, Percent_Identity=25, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI48994928, Length=227, Percent_Identity=27.3127753303965, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788279, Length=279, Percent_Identity=21.505376344086, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50065; Mature: 49934

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS50885 HAMP ; PS01109 RIBOSOMAL_L10 ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARALRYLLPRSVLGRNIALLIVLVALSQVCALSVLVHYVQKPRVERAAAVFGAYIRTL
CCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
DNALTASPEGERATLVARLDARSEPPAEAVSEPRVRLLAFYRTSQLVTFLETLHRYLPPG
HHHHCCCCCCCCEEEEEEECCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
TEVRWQGEPHPRMWIRMHVAATPYWIGLQVPEEAQGGGMLTAVLLSIGLGLLAALTGFVL
CCEEECCCCCCCEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QAYLDRPLRELAQAARRVSAGETPPPLPVDGPTEIAQVSSAFNQMTQALQQAEATRALML
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGISHDIRTPLTKLRLAMAMANDTNGDEAFVGAAESYLDQIDIILQQFMDYAGSGEREAP
HHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
QRGDLNALISQLAADFAGLGHEFDLQLGELPEHAFRPITMMRLVMNLMQNAVVYGQTGLA
CCCCHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCE
VRTWADARAIYVAVADRGKGLSAEELERLKAPFQRGKNAHGKTGGTGLGLAIVERIARLH
EEEECCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHC
GGTLAFHAREGGGLEVWAVLPIRLGAHAAGEPSVSGEPSAAQPAA
CCEEEEEECCCCCEEEEEEEEHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SARALRYLLPRSVLGRNIALLIVLVALSQVCALSVLVHYVQKPRVERAAAVFGAYIRTL
CCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
DNALTASPEGERATLVARLDARSEPPAEAVSEPRVRLLAFYRTSQLVTFLETLHRYLPPG
HHHHCCCCCCCCEEEEEEECCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
TEVRWQGEPHPRMWIRMHVAATPYWIGLQVPEEAQGGGMLTAVLLSIGLGLLAALTGFVL
CCEEECCCCCCCEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QAYLDRPLRELAQAARRVSAGETPPPLPVDGPTEIAQVSSAFNQMTQALQQAEATRALML
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGISHDIRTPLTKLRLAMAMANDTNGDEAFVGAAESYLDQIDIILQQFMDYAGSGEREAP
HHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
QRGDLNALISQLAADFAGLGHEFDLQLGELPEHAFRPITMMRLVMNLMQNAVVYGQTGLA
CCCCHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCE
VRTWADARAIYVAVADRGKGLSAEELERLKAPFQRGKNAHGKTGGTGLGLAIVERIARLH
EEEECCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHC
GGTLAFHAREGGGLEVWAVLPIRLGAHAAGEPSVSGEPSAAQPAA
CCEEEEEECCCCCEEEEEEEEHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]