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The map label for this gene is pcaR [H]

Identifier: 186477121

GI number: 186477121

Start: 2662139

End: 2662945

Strand: Direct

Name: pcaR [H]

Synonym: Bphy_2370

Alternate gene names: 186477121

Gene position: 2662139-2662945 (Clockwise)

Preceding gene: 186477116

Following gene: 186477124

Centisome position: 76.52

GC content: 61.83

Gene sequence:

>807_bases
ATGGATATTTCGCCTGCAGACGACGGCGCCCAGAGCGGCTCCGACCTGCTTTTCAACCAGTCGCTGGAAAAAGGTCTGAA
CGTGTTGCGCGCGTTCAGCGCAAAGCGCCGCACGATGACGCTGGCAGAAGTTGCGGAGGCAGCGTCGATGTCGAAGAGTT
CGGCGCAGCGGATGGTCTACACGCTCGAAAAGCTCGGCTATATCCGCAAGCATCCGTTGACACGCCGCTATCAACTCACG
CCGCGCGTGATGCAGATCGGCTTCAACTATCTCGCCGCGGACACGCTGATTGACGTTGCCAATCCGTTCCTGTCGGAACT
GACGAACAACACGGGCGAGACGACGAATCTGACCGAACCGGACGACGATGAGATGGTGTACGTGTCGCGCTTCGTATCGA
CCAAGTTCGTGCCGATCCACATGCCGATCGGCAGCCGCATCCCGATGTATTGCACCGGCAGCGGGCGTGCGTATCTGAGC
GCACTGCCCGTCGACGAGGCACTCACGCGCCTGGAACGGATGAACCGGGTGGCGTTCACGGCGAACACCATGACGGATCT
CGCGACGCTCGGCGAAAGGCTGGCTGAGGCGCGTCAGCAAGGCTATGCGACGAACCGCGAAGAGCTGTTCATCGGCGATA
TGTCGATCGCCGCACCCGTGATCGGCAGCCAGGGGCGTCCCGTGGCTGCCGTCCATGTCGTGGCGCCCACAAGCAGATGG
ACGTTCGAGGATGCGCGGCAGAAGCTCGCCCCCGCCGTTATCGATTGCGCGAGAGGTATCACCAACTCGATCCGGACGCT
GGAGTAG

Upstream 100 bases:

>100_bases
CGGACCATCATAATCGAATCAAAAAAATCGCCACGAGATTTTTGCGTATCGATATTCGATACGATAAGATGCGATATCGC
GTTCGGGATTTGAGACGACC

Downstream 100 bases:

>100_bases
CAGTCGGCTGGCGACGGTGCTGACTGCAGCGTCCTCTTGCAAGACGAGCGGCCCACTCGTCGTCAAAGGACGATCGTAGG
CAGTTAAAACCAAGCCATCT

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MDISPADDGAQSGSDLLFNQSLEKGLNVLRAFSAKRRTMTLAEVAEAASMSKSSAQRMVYTLEKLGYIRKHPLTRRYQLT
PRVMQIGFNYLAADTLIDVANPFLSELTNNTGETTNLTEPDDDEMVYVSRFVSTKFVPIHMPIGSRIPMYCTGSGRAYLS
ALPVDEALTRLERMNRVAFTANTMTDLATLGERLAEARQQGYATNREELFIGDMSIAAPVIGSQGRPVAAVHVVAPTSRW
TFEDARQKLAPAVIDCARGITNSIRTLE

Sequences:

>Translated_268_residues
MDISPADDGAQSGSDLLFNQSLEKGLNVLRAFSAKRRTMTLAEVAEAASMSKSSAQRMVYTLEKLGYIRKHPLTRRYQLT
PRVMQIGFNYLAADTLIDVANPFLSELTNNTGETTNLTEPDDDEMVYVSRFVSTKFVPIHMPIGSRIPMYCTGSGRAYLS
ALPVDEALTRLERMNRVAFTANTMTDLATLGERLAEARQQGYATNREELFIGDMSIAAPVIGSQGRPVAAVHVVAPTSRW
TFEDARQKLAPAVIDCARGITNSIRTLE
>Mature_268_residues
MDISPADDGAQSGSDLLFNQSLEKGLNVLRAFSAKRRTMTLAEVAEAASMSKSSAQRMVYTLEKLGYIRKHPLTRRYQLT
PRVMQIGFNYLAADTLIDVANPFLSELTNNTGETTNLTEPDDDEMVYVSRFVSTKFVPIHMPIGSRIPMYCTGSGRAYLS
ALPVDEALTRLERMNRVAFTANTMTDLATLGERLAEARQQGYATNREELFIGDMSIAAPVIGSQGRPVAAVHVVAPTSRW
TFEDARQKLAPAVIDCARGITNSIRTLE

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=244, Percent_Identity=27.8688524590164, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1789999, Length=249, Percent_Identity=29.718875502008, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1786715, Length=255, Percent_Identity=26.6666666666667, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1786468, Length=246, Percent_Identity=28.4552845528455, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788131, Length=241, Percent_Identity=29.8755186721992, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI145693096, Length=236, Percent_Identity=27.5423728813559, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788581, Length=185, Percent_Identity=27.027027027027, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29530; Mature: 29530

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDISPADDGAQSGSDLLFNQSLEKGLNVLRAFSAKRRTMTLAEVAEAASMSKSSAQRMVY
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLEKLGYIRKHPLTRRYQLTPRVMQIGFNYLAADTLIDVANPFLSELTNNTGETTNLTEP
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DDDEMVYVSRFVSTKFVPIHMPIGSRIPMYCTGSGRAYLSALPVDEALTRLERMNRVAFT
CCCCEEHHHHHHHHCEEEEECCCCCCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHEE
ANTMTDLATLGERLAEARQQGYATNREELFIGDMSIAAPVIGSQGRPVAAVHVVAPTSRW
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHCCCCCCCEEEEEEEECCCCC
TFEDARQKLAPAVIDCARGITNSIRTLE
CHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDISPADDGAQSGSDLLFNQSLEKGLNVLRAFSAKRRTMTLAEVAEAASMSKSSAQRMVY
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLEKLGYIRKHPLTRRYQLTPRVMQIGFNYLAADTLIDVANPFLSELTNNTGETTNLTEP
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DDDEMVYVSRFVSTKFVPIHMPIGSRIPMYCTGSGRAYLSALPVDEALTRLERMNRVAFT
CCCCEEHHHHHHHHCEEEEECCCCCCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHEE
ANTMTDLATLGERLAEARQQGYATNREELFIGDMSIAAPVIGSQGRPVAAVHVVAPTSRW
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHCCCCCCCEEEEEEEECCCCC
TFEDARQKLAPAVIDCARGITNSIRTLE
CHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]