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The map label for this gene is galE [C]

Identifier: 186477048

GI number: 186477048

Start: 2578005

End: 2578937

Strand: Direct

Name: galE [C]

Synonym: Bphy_2297

Alternate gene names: 186477048

Gene position: 2578005-2578937 (Clockwise)

Preceding gene: 186477047

Following gene: 186477049

Centisome position: 74.1

GC content: 57.45

Gene sequence:

>933_bases
ATGAAAATTACCGTCTTCGGTGGCGGCGGGTTCATCGGATCGACCATCGTCGATCGACTGCTGCGCGACAACCACGAGAT
CTGCGTTTTCGAGCGTCCGCGTGTCGACCCCTATCGTCAGTTCAATGACGGCGAGAAGGTGCACTGGATGACGGGCGATC
TCACCAGCGTGCACGACGTCACGGAAGCCATCGACGGCTCCGACATCGTCGTGCATCTGGTGTCGACGACGCTGCCGAAA
AGCTCAAACGACGATCCCATCTACGACGTCCAGAGCAATCTCGTCGCGACGCTGCAGTTGCTGAACGCGATGGTCGCAAA
AAACGTGAAGAAGATCGTGTTCATTTCGTCGGGCGGGACCGTGTATGGCGACCCCGTCTATCTGCCCATCGACGAAAAGC
ACCCGACCAATCCGAAGGTGTCGTACGGCATCACGAAACTGGCGATCGAGAAGTACCTGCTGCTCTACCAGTATCAGCAC
GGGATCAAGGCAAACATCCTGCGCGTCGCGAATCCTTATGGAGAACGGCAACGCGTCGAAACAGCGCAAGGCGCGATCGC
CGTCTTTCTTGACAAGGCGCTCAGAAAGCAGCCATTCGAGATCTGGGGCGACGGTACTGTTACGCGCGACTACCTGTACA
TCGGCGACGTCGCCGAGGCGTTCGCCCGCGCGGTTCAATACGACGGCAACGAGTCCGTGTTCAACATCAGTTCGGGCTAT
GGCACGAGCCTGAACGAAATCATCGGCAAGATCGAAACGATACTCGGACATCCTGTGGAACGGACATATCGTCCGGGGCG
TCCTTTCGACGTTCCCGCCAGCGTGCTCGATAACACACTCGCGAAAAGAGAACTCGGCTGGGAACCGAAGGTCGCTTTGG
ACGCTGGAATTAAACTGACGGCCACATGGCTGCGCTCGCAGATCCATGAATAA

Upstream 100 bases:

>100_bases
CGAACCTGGCGTTGGACCGTACCGACTTCTCGCTCGCGTGGCCGCCCCGGATCGAACCGCTGCCACGCCATGCCGCGCCG
CTCGACAATAAGGAAATGGC

Downstream 100 bases:

>100_bases
GGTCTGAAGCCTACGCGGGGACGGGCCGCCTCGCGCACGCATCAGCGTAACGGGCACTGCGCACGCGGTGCAGACCCGGT
GAGACAGGCATCCGGCCGCT

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MKITVFGGGGFIGSTIVDRLLRDNHEICVFERPRVDPYRQFNDGEKVHWMTGDLTSVHDVTEAIDGSDIVVHLVSTTLPK
SSNDDPIYDVQSNLVATLQLLNAMVAKNVKKIVFISSGGTVYGDPVYLPIDEKHPTNPKVSYGITKLAIEKYLLLYQYQH
GIKANILRVANPYGERQRVETAQGAIAVFLDKALRKQPFEIWGDGTVTRDYLYIGDVAEAFARAVQYDGNESVFNISSGY
GTSLNEIIGKIETILGHPVERTYRPGRPFDVPASVLDNTLAKRELGWEPKVALDAGIKLTATWLRSQIHE

Sequences:

>Translated_310_residues
MKITVFGGGGFIGSTIVDRLLRDNHEICVFERPRVDPYRQFNDGEKVHWMTGDLTSVHDVTEAIDGSDIVVHLVSTTLPK
SSNDDPIYDVQSNLVATLQLLNAMVAKNVKKIVFISSGGTVYGDPVYLPIDEKHPTNPKVSYGITKLAIEKYLLLYQYQH
GIKANILRVANPYGERQRVETAQGAIAVFLDKALRKQPFEIWGDGTVTRDYLYIGDVAEAFARAVQYDGNESVFNISSGY
GTSLNEIIGKIETILGHPVERTYRPGRPFDVPASVLDNTLAKRELGWEPKVALDAGIKLTATWLRSQIHE
>Mature_310_residues
MKITVFGGGGFIGSTIVDRLLRDNHEICVFERPRVDPYRQFNDGEKVHWMTGDLTSVHDVTEAIDGSDIVVHLVSTTLPK
SSNDDPIYDVQSNLVATLQLLNAMVAKNVKKIVFISSGGTVYGDPVYLPIDEKHPTNPKVSYGITKLAIEKYLLLYQYQH
GIKANILRVANPYGERQRVETAQGAIAVFLDKALRKQPFEIWGDGTVTRDYLYIGDVAEAFARAVQYDGNESVFNISSGY
GTSLNEIIGKIETILGHPVERTYRPGRPFDVPASVLDNTLAKRELGWEPKVALDAGIKLTATWLRSQIHE

Specific function: Galactose metabolism; third step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=315, Percent_Identity=26.984126984127, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI56237023, Length=329, Percent_Identity=28.8753799392097, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI56118217, Length=329, Percent_Identity=28.8753799392097, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI189083684, Length=329, Percent_Identity=28.8753799392097, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI7657641, Length=325, Percent_Identity=26.4615384615385, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1786974, Length=329, Percent_Identity=29.483282674772, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1788353, Length=346, Percent_Identity=24.5664739884393, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1788589, Length=333, Percent_Identity=23.7237237237237, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788365, Length=276, Percent_Identity=23.1884057971014, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17539532, Length=320, Percent_Identity=26.5625, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71982035, Length=334, Percent_Identity=28.7425149700599, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71982038, Length=336, Percent_Identity=27.9761904761905, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17568069, Length=323, Percent_Identity=24.7678018575851, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI115532424, Length=340, Percent_Identity=22.3529411764706, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319493, Length=335, Percent_Identity=27.1641791044776, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI21356223, Length=315, Percent_Identity=26.3492063492064, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI19923002, Length=340, Percent_Identity=29.1176470588235, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 34478; Mature: 34478

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITVFGGGGFIGSTIVDRLLRDNHEICVFERPRVDPYRQFNDGEKVHWMTGDLTSVHDV
CEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHCCCCCEEEEEECCCHHHHHH
TEAIDGSDIVVHLVSTTLPKSSNDDPIYDVQSNLVATLQLLNAMVAKNVKKIVFISSGGT
HHHCCCCCEEEEEEHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCE
VYGDPVYLPIDEKHPTNPKVSYGITKLAIEKYLLLYQYQHGIKANILRVANPYGERQRVE
EECCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
TAQGAIAVFLDKALRKQPFEIWGDGTVTRDYLYIGDVAEAFARAVQYDGNESVFNISSGY
HHHHHHHHHHHHHHHCCCCEEECCCCEEEEEEEECHHHHHHHHHHHCCCCCCEEEECCCC
GTSLNEIIGKIETILGHPVERTYRPGRPFDVPASVLDNTLAKRELGWEPKVALDAGIKLT
CCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCEEH
ATWLRSQIHE
HHHHHHHHCC
>Mature Secondary Structure
MKITVFGGGGFIGSTIVDRLLRDNHEICVFERPRVDPYRQFNDGEKVHWMTGDLTSVHDV
CEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHCCCCCEEEEEECCCHHHHHH
TEAIDGSDIVVHLVSTTLPKSSNDDPIYDVQSNLVATLQLLNAMVAKNVKKIVFISSGGT
HHHCCCCCEEEEEEHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCE
VYGDPVYLPIDEKHPTNPKVSYGITKLAIEKYLLLYQYQHGIKANILRVANPYGERQRVE
EECCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
TAQGAIAVFLDKALRKQPFEIWGDGTVTRDYLYIGDVAEAFARAVQYDGNESVFNISSGY
HHHHHHHHHHHHHHHCCCCEEECCCCEEEEEEEECHHHHHHHHHHHCCCCCCEEEECCCC
GTSLNEIIGKIETILGHPVERTYRPGRPFDVPASVLDNTLAKRELGWEPKVALDAGIKLT
CCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCEEH
ATWLRSQIHE
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]