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The map label for this gene is livM [H]

Identifier: 186477004

GI number: 186477004

Start: 2527262

End: 2528458

Strand: Direct

Name: livM [H]

Synonym: Bphy_2253

Alternate gene names: 186477004

Gene position: 2527262-2528458 (Clockwise)

Preceding gene: 186477003

Following gene: 186477005

Centisome position: 72.64

GC content: 63.49

Gene sequence:

>1197_bases
ATGACATCGGCGACATCTCATGCTTCGCCCTCCGCTTCGGGAAGCACACGCGGTATCGCGCCCGCGGGCGAACGCGAACG
CCTCGAAGGTTTCGCGCTCGGCCTGCCGCCGCGCCCCGCGCTGCTGTCGCGGCGCGCGTGGCAATGTTTGATCGCACTGA
TCGTCGCAGTGGGACTCGGCGTGCCGTTCACGGCGCTGGTTTTGCCGCAGACGAGCGCGTTCCATCTGTCGGCGTATGCA
ATGACGCTCGCGGGCAAGCTGATGTGCTACGCAATCGCCGCGCTCGCGCTCGATCTCGTGTGGGGCTACTGCGGCATCCT
GAGCCTCGGGCATGGTCTGTTCTTCGCGCTCGGCGGCTACGCGATCGGCATGTACCTGATGCGCGCGATCGGCCACGACG
GCAAATACGGCAGCGACCTGCCCGACTTCATGGTGTTTCTCGACTGGCATCGGTTGCCGTGGTACTGGGAAGGCACGCAG
CATCTCGCGTATGCGCTGTTGCTCGTCGTGCTGGTGCCGGCCGCGATCGCGTGGGTATTCGGCTTCTTCACATTTCGCTC
GCGGGTGAAGGGCGTGTATCTGTCGATCATCACGCAAGCGATGACCTTTGCCGCGATGCTGCTGTTCTATCGCAACGAGA
CGGGGTTCGGCGGCAACAACGGCTTCACCGATTTCAAGCGCATCGCCGGCTTCCCGATCACGCACCCGGGCACGCGCACC
ACGCTCTTTCTGATGACGTTCGGGGTGCTGGTGCTCGCCTTCATCGGCGCACGGGCGATCGTGACGTCGAAGCTCGGGCG
CGTCGTGACAGCCGTGCGCGATGGCGAGACGCGTCTGATGTTCCTCGGCTACAACCCGCTCGCCTACAAGCTGTTCGTAT
GGACGGTGTCCGCGGTGTTGTGCGGCATTGCGGGCGCGCTGTATGTGCCGCAGGTCGGCATCATCAATCCGGGCGAGATG
TCGCCGGGCAACTCGATCGAAATGGCGATCTGGGTGGCTGTCGGCGGACGCGGCACGCTGATCGGACCGATCATCGGCGC
GTTTGCGGTAAATGGCGCGAAGAGTTTTTTCACCGCGTACTTCGCGGAGTACTGGCTGTTCTTCCTGGGGCTGATCTTCG
TGCTGGTGCCGTTGCTGTTGCCGAACGGGATCATGGGATTGCTCGAACTCGTCGCACGCAAGAGGAACCGCAAATGA

Upstream 100 bases:

>100_bases
GTGCTCGCGAAGATCGCGGTGCTCGTGCTGATCGTCCTGTTCATCCAGAAGCGTCCGCAGGGCATGTTCGCCCTCAAGGG
CCGCAGCGCGGAGGCGTGAC

Downstream 100 bases:

>100_bases
ACGAAAACCCGATGGTTCCCGATCTTGCTTTACCCGAAGAGCACGATGGCCGCGCGCTGTCCGGCGTCGCAACGATGGGC
CGCGTCGTCACGCCTGGCGA

Product: urea ABC transporter permease UrtC

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTSATSHASPSASGSTRGIAPAGERERLEGFALGLPPRPALLSRRAWQCLIALIVAVGLGVPFTALVLPQTSAFHLSAYA
MTLAGKLMCYAIAALALDLVWGYCGILSLGHGLFFALGGYAIGMYLMRAIGHDGKYGSDLPDFMVFLDWHRLPWYWEGTQ
HLAYALLLVVLVPAAIAWVFGFFTFRSRVKGVYLSIITQAMTFAAMLLFYRNETGFGGNNGFTDFKRIAGFPITHPGTRT
TLFLMTFGVLVLAFIGARAIVTSKLGRVVTAVRDGETRLMFLGYNPLAYKLFVWTVSAVLCGIAGALYVPQVGIINPGEM
SPGNSIEMAIWVAVGGRGTLIGPIIGAFAVNGAKSFFTAYFAEYWLFFLGLIFVLVPLLLPNGIMGLLELVARKRNRK

Sequences:

>Translated_398_residues
MTSATSHASPSASGSTRGIAPAGERERLEGFALGLPPRPALLSRRAWQCLIALIVAVGLGVPFTALVLPQTSAFHLSAYA
MTLAGKLMCYAIAALALDLVWGYCGILSLGHGLFFALGGYAIGMYLMRAIGHDGKYGSDLPDFMVFLDWHRLPWYWEGTQ
HLAYALLLVVLVPAAIAWVFGFFTFRSRVKGVYLSIITQAMTFAAMLLFYRNETGFGGNNGFTDFKRIAGFPITHPGTRT
TLFLMTFGVLVLAFIGARAIVTSKLGRVVTAVRDGETRLMFLGYNPLAYKLFVWTVSAVLCGIAGALYVPQVGIINPGEM
SPGNSIEMAIWVAVGGRGTLIGPIIGAFAVNGAKSFFTAYFAEYWLFFLGLIFVLVPLLLPNGIMGLLELVARKRNRK
>Mature_397_residues
TSATSHASPSASGSTRGIAPAGERERLEGFALGLPPRPALLSRRAWQCLIALIVAVGLGVPFTALVLPQTSAFHLSAYAM
TLAGKLMCYAIAALALDLVWGYCGILSLGHGLFFALGGYAIGMYLMRAIGHDGKYGSDLPDFMVFLDWHRLPWYWEGTQH
LAYALLLVVLVPAAIAWVFGFFTFRSRVKGVYLSIITQAMTFAAMLLFYRNETGFGGNNGFTDFKRIAGFPITHPGTRTT
LFLMTFGVLVLAFIGARAIVTSKLGRVVTAVRDGETRLMFLGYNPLAYKLFVWTVSAVLCGIAGALYVPQVGIINPGEMS
PGNSIEMAIWVAVGGRGTLIGPIIGAFAVNGAKSFFTAYFAEYWLFFLGLIFVLVPLLLPNGIMGLLELVARKRNRK

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=345, Percent_Identity=25.7971014492754, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 43091; Mature: 42959

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSATSHASPSASGSTRGIAPAGERERLEGFALGLPPRPALLSRRAWQCLIALIVAVGLG
CCCCCCCCCCCCCCCCCCCCCCCCHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCC
VPFTALVLPQTSAFHLSAYAMTLAGKLMCYAIAALALDLVWGYCGILSLGHGLFFALGGY
CCHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIGMYLMRAIGHDGKYGSDLPDFMVFLDWHRLPWYWEGTQHLAYALLLVVLVPAAIAWVF
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHH
GFFTFRSRVKGVYLSIITQAMTFAAMLLFYRNETGFGGNNGFTDFKRIAGFPITHPGTRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCCHH
TLFLMTFGVLVLAFIGARAIVTSKLGRVVTAVRDGETRLMFLGYNPLAYKLFVWTVSAVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEEECCHHHHHHHHHHHHHHH
CGIAGALYVPQVGIINPGEMSPGNSIEMAIWVAVGGRGTLIGPIIGAFAVNGAKSFFTAY
HHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHH
FAEYWLFFLGLIFVLVPLLLPNGIMGLLELVARKRNRK
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSATSHASPSASGSTRGIAPAGERERLEGFALGLPPRPALLSRRAWQCLIALIVAVGLG
CCCCCCCCCCCCCCCCCCCCCCCHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCC
VPFTALVLPQTSAFHLSAYAMTLAGKLMCYAIAALALDLVWGYCGILSLGHGLFFALGGY
CCHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIGMYLMRAIGHDGKYGSDLPDFMVFLDWHRLPWYWEGTQHLAYALLLVVLVPAAIAWVF
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHH
GFFTFRSRVKGVYLSIITQAMTFAAMLLFYRNETGFGGNNGFTDFKRIAGFPITHPGTRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCCHH
TLFLMTFGVLVLAFIGARAIVTSKLGRVVTAVRDGETRLMFLGYNPLAYKLFVWTVSAVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEEECCHHHHHHHHHHHHHHH
CGIAGALYVPQVGIINPGEMSPGNSIEMAIWVAVGGRGTLIGPIIGAFAVNGAKSFFTAY
HHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHH
FAEYWLFFLGLIFVLVPLLLPNGIMGLLELVARKRNRK
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]