Click here to switch to the map view.

The map label for this gene is livH [H]

Identifier: 186477003

GI number: 186477003

Start: 2525629

End: 2527260

Strand: Direct

Name: livH [H]

Synonym: Bphy_2252

Alternate gene names: 186477003

Gene position: 2525629-2527260 (Clockwise)

Preceding gene: 186477002

Following gene: 186477004

Centisome position: 72.59

GC content: 66.05

Gene sequence:

>1632_bases
ATGGCGTATTCATTTTCCACGCTCGCGGCTCGCGTCGCGCTCATTGCGGCGCTGGCCACCGTCCTGCCCGCGAGTGCCTA
CGCACTGACGACGGGCGAAGTCGCGCCGCTTGCCGGCGACGATTTCGATGCGAAGTCGGCCGCCATCGACAAGCTGATCG
CGAACCACGATGCGCCATCGCTTGCGCTGCTCAAAGCGCTCTCCGAAGACAGCGCGCTCGCCACGGATAGCGGCGAAGTG
CTGATCCAGCTCGGTGATTCCTCCGGCGACACCGCACGCGACGCCGTCACGGGCAAGACCGTTGCCGCAGGCGGCGCACA
ACCGATAACACTGAACAACCTGTTGCGCTCGAAAGTTGCGGGCGCGCTGTCGGGCCTGCAACTCGACTCGCCCGATTCGG
CGAAACGCGCCGCCGCCATCGCCGCGCTGCTGCAAAGCCCCGATCCTTCGATGAAGCCGCAGATCGACGCCGCGCGTGCA
AAAGAGACCGACCCGGCGCTGAAGAAGCGCCTCGACACGCTCTGGGCGATGACGGCGCTGCACGACAGCGATGCGGCGAA
ACGCCTCGAAGCCGTCAAGCTCGTCGCCGCCCGGCACGATCTCGACATGTACGAACTGCTGCGCCCGCTCGTCGCAAAGA
AGCCGGACGGCACATTCGTCGAAAGCGACGCTCAGGTGCGCGAGAGTGCGCAGCAAGGCATCGATGCGCTCGACTCCATT
CAACGCCGCAGCGAGATTGCGGGGACGCTGTTCGCGGGACTGTCGCTCGGCAGCGTGCTGCTGCTCGCGGCGCTCGGCCT
CGCCATCACCTACGGCCTGATCGGCGTGATCAACATGGCGCACGGCGAGTTTCTGATGATCGGCGCGTATGCGACGTACG
TGGTGCAGAACCTCGTGCAACGATATCTTCCGGGCGCGTTCGACTGGTATCCGCTCTTCGCCGTGCCCGCTGCATTCGCG
GTCGCGGCGCTCGTCGGCATCGTGCTCGAACGGCTGGTGCTGAAGCATCTGTACGGACGTCCGCTCGAAACGCTGCTCAC
CACCTTCGGCATCAGCCTGATCCTGATTCAGGCGACGCGCATGCTGTTCGGCGCGCAGAACGTACAGGTCGTGAATCCTT
CGTGGATGAGCGGCGGCGTCACCGTGATGCAGAATCTGATCCTGCCGTACAACCGGCTCGCGATTCTCGCGTTTTCGCTG
ATCGTCGTCGCGACCGCGTGGGCCGTGCTGACGAAGACGCGCCTCGGGCTGTTCGTGCGAGCCGTCACGCAGAACCGCCG
CATGGCGGCGTGCGTCGGCGTGAAGACCGCCTACGTCGACTCCTGTGCGTTCGCATTCGGCGCGGGCATCGCGGGGCTCG
GCGGCTGCGCGCTGTCGCAGATCGGCAATGTCGGGCCGGACCTCGGGCAGAGCTATATCATCGATTCGTTCATGGCCGTC
GTGCTGGGCGGCGTGGGCCAGCTGGCGGGCACGGTGATCGGCGGCTTCGGGCTCGGTCTCGTGAGCAAGGCCATCGAGCC
GTTCTGGGGCGCCGTGCTCGCGAAGATCGCGGTGCTCGTGCTGATCGTCCTGTTCATCCAGAAGCGTCCGCAGGGCATGT
TCGCCCTCAAGGGCCGCAGCGCGGAGGCGTGA

Upstream 100 bases:

>100_bases
GACTCAACGCGGCCGAGGTCATGCAACGAGCGGTGCGCCATGTGCGGGCGGCGCACCGCGCCGGCCTGCTGGTCTTGCCG
ATCCATTTCTCGAGCACATC

Downstream 100 bases:

>100_bases
CATGACATCGGCGACATCTCATGCTTCGCCCTCCGCTTCGGGAAGCACACGCGGTATCGCGCCCGCGGGCGAACGCGAAC
GCCTCGAAGGTTTCGCGCTC

Product: urea ABC transporter permease UrtB

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MAYSFSTLAARVALIAALATVLPASAYALTTGEVAPLAGDDFDAKSAAIDKLIANHDAPSLALLKALSEDSALATDSGEV
LIQLGDSSGDTARDAVTGKTVAAGGAQPITLNNLLRSKVAGALSGLQLDSPDSAKRAAAIAALLQSPDPSMKPQIDAARA
KETDPALKKRLDTLWAMTALHDSDAAKRLEAVKLVAARHDLDMYELLRPLVAKKPDGTFVESDAQVRESAQQGIDALDSI
QRRSEIAGTLFAGLSLGSVLLLAALGLAITYGLIGVINMAHGEFLMIGAYATYVVQNLVQRYLPGAFDWYPLFAVPAAFA
VAALVGIVLERLVLKHLYGRPLETLLTTFGISLILIQATRMLFGAQNVQVVNPSWMSGGVTVMQNLILPYNRLAILAFSL
IVVATAWAVLTKTRLGLFVRAVTQNRRMAACVGVKTAYVDSCAFAFGAGIAGLGGCALSQIGNVGPDLGQSYIIDSFMAV
VLGGVGQLAGTVIGGFGLGLVSKAIEPFWGAVLAKIAVLVLIVLFIQKRPQGMFALKGRSAEA

Sequences:

>Translated_543_residues
MAYSFSTLAARVALIAALATVLPASAYALTTGEVAPLAGDDFDAKSAAIDKLIANHDAPSLALLKALSEDSALATDSGEV
LIQLGDSSGDTARDAVTGKTVAAGGAQPITLNNLLRSKVAGALSGLQLDSPDSAKRAAAIAALLQSPDPSMKPQIDAARA
KETDPALKKRLDTLWAMTALHDSDAAKRLEAVKLVAARHDLDMYELLRPLVAKKPDGTFVESDAQVRESAQQGIDALDSI
QRRSEIAGTLFAGLSLGSVLLLAALGLAITYGLIGVINMAHGEFLMIGAYATYVVQNLVQRYLPGAFDWYPLFAVPAAFA
VAALVGIVLERLVLKHLYGRPLETLLTTFGISLILIQATRMLFGAQNVQVVNPSWMSGGVTVMQNLILPYNRLAILAFSL
IVVATAWAVLTKTRLGLFVRAVTQNRRMAACVGVKTAYVDSCAFAFGAGIAGLGGCALSQIGNVGPDLGQSYIIDSFMAV
VLGGVGQLAGTVIGGFGLGLVSKAIEPFWGAVLAKIAVLVLIVLFIQKRPQGMFALKGRSAEA
>Mature_542_residues
AYSFSTLAARVALIAALATVLPASAYALTTGEVAPLAGDDFDAKSAAIDKLIANHDAPSLALLKALSEDSALATDSGEVL
IQLGDSSGDTARDAVTGKTVAAGGAQPITLNNLLRSKVAGALSGLQLDSPDSAKRAAAIAALLQSPDPSMKPQIDAARAK
ETDPALKKRLDTLWAMTALHDSDAAKRLEAVKLVAARHDLDMYELLRPLVAKKPDGTFVESDAQVRESAQQGIDALDSIQ
RRSEIAGTLFAGLSLGSVLLLAALGLAITYGLIGVINMAHGEFLMIGAYATYVVQNLVQRYLPGAFDWYPLFAVPAAFAV
AALVGIVLERLVLKHLYGRPLETLLTTFGISLILIQATRMLFGAQNVQVVNPSWMSGGVTVMQNLILPYNRLAILAFSLI
VVATAWAVLTKTRLGLFVRAVTQNRRMAACVGVKTAYVDSCAFAFGAGIAGLGGCALSQIGNVGPDLGQSYIIDSFMAVV
LGGVGQLAGTVIGGFGLGLVSKAIEPFWGAVLAKIAVLVLIVLFIQKRPQGMFALKGRSAEA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=298, Percent_Identity=28.1879194630872, Blast_Score=88, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 56713; Mature: 56582

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYSFSTLAARVALIAALATVLPASAYALTTGEVAPLAGDDFDAKSAAIDKLIANHDAPS
CCCCHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCH
LALLKALSEDSALATDSGEVLIQLGDSSGDTARDAVTGKTVAAGGAQPITLNNLLRSKVA
HHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHCCCCEECCCCCCCHHHHHHHHHHH
GALSGLQLDSPDSAKRAAAIAALLQSPDPSMKPQIDAARAKETDPALKKRLDTLWAMTAL
HHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHH
HDSDAAKRLEAVKLVAARHDLDMYELLRPLVAKKPDGTFVESDAQVRESAQQGIDALDSI
HCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHH
QRRSEIAGTLFAGLSLGSVLLLAALGLAITYGLIGVINMAHGEFLMIGAYATYVVQNLVQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHH
RYLPGAFDWYPLFAVPAAFAVAALVGIVLERLVLKHLYGRPLETLLTTFGISLILIQATR
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
MLFGAQNVQVVNPSWMSGGVTVMQNLILPYNRLAILAFSLIVVATAWAVLTKTRLGLFVR
HHHCCCCCEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVTQNRRMAACVGVKTAYVDSCAFAFGAGIAGLGGCALSQIGNVGPDLGQSYIIDSFMAV
HHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
VLGGVGQLAGTVIGGFGLGLVSKAIEPFWGAVLAKIAVLVLIVLFIQKRPQGMFALKGRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCC
AEA
CCC
>Mature Secondary Structure 
AYSFSTLAARVALIAALATVLPASAYALTTGEVAPLAGDDFDAKSAAIDKLIANHDAPS
CCCHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCH
LALLKALSEDSALATDSGEVLIQLGDSSGDTARDAVTGKTVAAGGAQPITLNNLLRSKVA
HHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHCCCCEECCCCCCCHHHHHHHHHHH
GALSGLQLDSPDSAKRAAAIAALLQSPDPSMKPQIDAARAKETDPALKKRLDTLWAMTAL
HHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHH
HDSDAAKRLEAVKLVAARHDLDMYELLRPLVAKKPDGTFVESDAQVRESAQQGIDALDSI
HCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHH
QRRSEIAGTLFAGLSLGSVLLLAALGLAITYGLIGVINMAHGEFLMIGAYATYVVQNLVQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHH
RYLPGAFDWYPLFAVPAAFAVAALVGIVLERLVLKHLYGRPLETLLTTFGISLILIQATR
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
MLFGAQNVQVVNPSWMSGGVTVMQNLILPYNRLAILAFSLIVVATAWAVLTKTRLGLFVR
HHHCCCCCEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVTQNRRMAACVGVKTAYVDSCAFAFGAGIAGLGGCALSQIGNVGPDLGQSYIIDSFMAV
HHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
VLGGVGQLAGTVIGGFGLGLVSKAIEPFWGAVLAKIAVLVLIVLFIQKRPQGMFALKGRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCC
AEA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]