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The map label for this gene is sir1 [H]

Identifier: 186476986

GI number: 186476986

Start: 2507220

End: 2508899

Strand: Reverse

Name: sir1 [H]

Synonym: Bphy_2235

Alternate gene names: 186476986

Gene position: 2508899-2507220 (Counterclockwise)

Preceding gene: 186476989

Following gene: 186476985

Centisome position: 72.11

GC content: 62.98

Gene sequence:

>1680_bases
ATGTACCAATACGATCAGTACGACCAGACCATCGTCGATGAACGCGTCGCGCAGTACGCCGACCAGGTTCGTCGCCGCCT
GTCGGGCGAATTGAGCGAAGAAGAGTTCCGTCCGCTGCGTCTGCAGAATGGCCTGTACATGCAGCGCCACGCGTACATGC
ACCGCATCGCGATTCCGTACGGCAACCTGCGCAGCGATCAACTGCGCATGCTTGCGACCATTGCGCGCGAGCACGACCGT
GGCTACGGCCATTTCTCGACGCGCTCCAATATCCAGTACAACTGGATCCAGCTCGAGGACACGCCTGAAATCCTGCGCAA
GCTCGCGTCCGTCCAGATGCACGGCATCCAGACGTCGGGTAACTGCATCCGCAACATCACGGCCGATCAGTTCGCGGGCG
TCGCGCCCGACGAAATCGTCGATCCGCGTCCGTGGGCGGAAATCTTGCGCCAATGGTCGACGTTCCACCCCGAGTTCGCA
TGGCTGCCGCGCAAGTTCAAGATTGCCGTGTCCGGCACGAAGGAAGACCGCGCGGCCGTGCAGATCCACGACCTCGGCGT
CTATCTGAAGAAGAACGCAGCGGGCGAAGTCGTCGCGAGCATTCTGGCGGGCGGCGGTCTCGGCCGTACGCCGATCATCG
GCGCGATCATCAAGCAAGACCTGCCGTGGCAGCATCTGCTGACCTATTGCGAAGCCGTGCTGCGCGTGTACAACCGCTAT
GGCCGCCGCGACAACCTGTACAAGGCGCGCATCAAGATTCTCGTGAAGGCGCTGTCGCCCGAGAAGTTCGCGCAGCAGGT
CGAAGAGGAATGGCAGCATCTGAAGGACGGCCCGTCGACGCTGACGGAAGCCGAAGTTGCGCGCGTGGAGCAATACTTTG
CGCCGCCCGTGTATGAAAAGCTGCCGGACACGGATGCTTCGTTCGAAAAGCATCTGCTCGAAAGCAGGCCGTTCGCGCGC
TGGGTCGAGCGCAATGTGCGCCCGCATCGCGTGTCGGGCTATGCGTCGGTGACGATCTCGCTGAAGCCGCGCGACATCGC
GCCGGGCGATGCAACGGACACGCAGATGGAAGCCGTCGCCGACTGGGCGGACCAGTATTCGCTCGGCGAGATCCGCGTGT
CGCACGAACAGAATCTGATTCTCGCGAACGTCAAGAAGCGCGACCTGTACGCGCTGTGGGAGCAGGCGAAGGCGCAGGGT
TTCGCAACGCCCAACATCGGCCTGTTGACCGACATCATCGCGTGCCCGGGCGGCGATTTCTGCTCGCTCGCGAATGCGAA
GTCGATCCCCATTGCGCAAGCCATCCAGGAGCGCTTCGACAACGCGGACTTCGTGCACGACCTTGGCGACCTGTCGCTGA
ACATCTCGGGCTGCATGAACTCGTGCGGCCACCACCACGTCGGCAACATCGGCGTGCTGGGCGTCGACAAGGACGGCTCC
GAGTGGTATCAGGTGTCGCTCGGCGGCGAGCAGGGCACGGGCGTGGACGGCGCGAAGCTCGGCCGTGTGATCGGCCCGTC
GTTCTCGGCGGAAGAAATGCCGGACGTGGTGTCGAAGGTGATCGACACGTTCGTCGAGCACCGCATCGACGGCGAACGCT
TCATCGACACGTACAACCGCATCGGCATCGCACCGTTCAAGGAACGCGTGTACGCATCGCGTCAACCGGCTCACGCGTAA

Upstream 100 bases:

>100_bases
CTGCCAGCGCACTCAAAGCTGACTGGCTAGAAGAATCCGAGGCGTGGCGTAACCGGAACGCCACGTCGTGTGAGACGAAC
ACAAACCCTGGGGTCACCGA

Downstream 100 bases:

>100_bases
CGGCAAGGGATCAAACAGATGGCATCGATTATCAAGGACCGCGCAATCGTCAACGACGACTTCACGGTTGTGCGCGCAGC
CGCAGACGGCGCGCTGCCCG

Product: sulfite reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MYQYDQYDQTIVDERVAQYADQVRRRLSGELSEEEFRPLRLQNGLYMQRHAYMHRIAIPYGNLRSDQLRMLATIAREHDR
GYGHFSTRSNIQYNWIQLEDTPEILRKLASVQMHGIQTSGNCIRNITADQFAGVAPDEIVDPRPWAEILRQWSTFHPEFA
WLPRKFKIAVSGTKEDRAAVQIHDLGVYLKKNAAGEVVASILAGGGLGRTPIIGAIIKQDLPWQHLLTYCEAVLRVYNRY
GRRDNLYKARIKILVKALSPEKFAQQVEEEWQHLKDGPSTLTEAEVARVEQYFAPPVYEKLPDTDASFEKHLLESRPFAR
WVERNVRPHRVSGYASVTISLKPRDIAPGDATDTQMEAVADWADQYSLGEIRVSHEQNLILANVKKRDLYALWEQAKAQG
FATPNIGLLTDIIACPGGDFCSLANAKSIPIAQAIQERFDNADFVHDLGDLSLNISGCMNSCGHHHVGNIGVLGVDKDGS
EWYQVSLGGEQGTGVDGAKLGRVIGPSFSAEEMPDVVSKVIDTFVEHRIDGERFIDTYNRIGIAPFKERVYASRQPAHA

Sequences:

>Translated_559_residues
MYQYDQYDQTIVDERVAQYADQVRRRLSGELSEEEFRPLRLQNGLYMQRHAYMHRIAIPYGNLRSDQLRMLATIAREHDR
GYGHFSTRSNIQYNWIQLEDTPEILRKLASVQMHGIQTSGNCIRNITADQFAGVAPDEIVDPRPWAEILRQWSTFHPEFA
WLPRKFKIAVSGTKEDRAAVQIHDLGVYLKKNAAGEVVASILAGGGLGRTPIIGAIIKQDLPWQHLLTYCEAVLRVYNRY
GRRDNLYKARIKILVKALSPEKFAQQVEEEWQHLKDGPSTLTEAEVARVEQYFAPPVYEKLPDTDASFEKHLLESRPFAR
WVERNVRPHRVSGYASVTISLKPRDIAPGDATDTQMEAVADWADQYSLGEIRVSHEQNLILANVKKRDLYALWEQAKAQG
FATPNIGLLTDIIACPGGDFCSLANAKSIPIAQAIQERFDNADFVHDLGDLSLNISGCMNSCGHHHVGNIGVLGVDKDGS
EWYQVSLGGEQGTGVDGAKLGRVIGPSFSAEEMPDVVSKVIDTFVEHRIDGERFIDTYNRIGIAPFKERVYASRQPAHA
>Mature_559_residues
MYQYDQYDQTIVDERVAQYADQVRRRLSGELSEEEFRPLRLQNGLYMQRHAYMHRIAIPYGNLRSDQLRMLATIAREHDR
GYGHFSTRSNIQYNWIQLEDTPEILRKLASVQMHGIQTSGNCIRNITADQFAGVAPDEIVDPRPWAEILRQWSTFHPEFA
WLPRKFKIAVSGTKEDRAAVQIHDLGVYLKKNAAGEVVASILAGGGLGRTPIIGAIIKQDLPWQHLLTYCEAVLRVYNRY
GRRDNLYKARIKILVKALSPEKFAQQVEEEWQHLKDGPSTLTEAEVARVEQYFAPPVYEKLPDTDASFEKHLLESRPFAR
WVERNVRPHRVSGYASVTISLKPRDIAPGDATDTQMEAVADWADQYSLGEIRVSHEQNLILANVKKRDLYALWEQAKAQG
FATPNIGLLTDIIACPGGDFCSLANAKSIPIAQAIQERFDNADFVHDLGDLSLNISGCMNSCGHHHVGNIGVLGVDKDGS
EWYQVSLGGEQGTGVDGAKLGRVIGPSFSAEEMPDVVSKVIDTFVEHRIDGERFIDTYNRIGIAPFKERVYASRQPAHA

Specific function: This Enzyme Catalyzes The 6-Electron Reduction Of Sulfite To Sulfide. This Is One Of Several Activities Required For The Biosynthesis Of L-Cysteine From Sulfate. [C]

COG id: COG0155

COG function: function code P; Sulfite reductase, beta subunit (hemoprotein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family [H]

Homologues:

None

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005117
- InterPro:   IPR006067
- InterPro:   IPR006066 [H]

Pfam domain/function: PF01077 NIR_SIR; PF03460 NIR_SIR_ferr [H]

EC number: =1.8.7.1 [H]

Molecular weight: Translated: 63025; Mature: 63025

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQYDQYDQTIVDERVAQYADQVRRRLSGELSEEEFRPLRLQNGLYMQRHAYMHRIAIPY
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHCCCCHHHHHHHHHHHCCCC
GNLRSDQLRMLATIAREHDRGYGHFSTRSNIQYNWIQLEDTPEILRKLASVQMHGIQTSG
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCC
NCIRNITADQFAGVAPDEIVDPRPWAEILRQWSTFHPEFAWLPRKFKIAVSGTKEDRAAV
CHHHCCCHHHHCCCCCHHCCCCCHHHHHHHHHHCCCCCHHCCCCEEEEEECCCCCCCCEE
QIHDLGVYLKKNAAGEVVASILAGGGLGRTPIIGAIIKQDLPWQHLLTYCEAVLRVYNRY
EEEECCEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
GRRDNLYKARIKILVKALSPEKFAQQVEEEWQHLKDGPSTLTEAEVARVEQYFAPPVYEK
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHH
LPDTDASFEKHLLESRPFARWVERNVRPHRVSGYASVTISLKPRDIAPGDATDTQMEAVA
CCCCCHHHHHHHHHCCHHHHHHHCCCCCCEECCEEEEEEEECCCCCCCCCCCHHHHHHHH
DWADQYSLGEIRVSHEQNLILANVKKRDLYALWEQAKAQGFATPNIGLLTDIIACPGGDF
HHHHCCCCCCEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCH
CSLANAKSIPIAQAIQERFDNADFVHDLGDLSLNISGCMNSCGHHHVGNIGVLGVDKDGS
HCCCCCCCCCHHHHHHHHCCCCHHHHHHCCCEEEHHHHHHCCCCCCCCCEEEEEECCCCC
EWYQVSLGGEQGTGVDGAKLGRVIGPSFSAEEMPDVVSKVIDTFVEHRIDGERFIDTYNR
CEEEEEECCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IGIAPFKERVYASRQPAHA
CCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MYQYDQYDQTIVDERVAQYADQVRRRLSGELSEEEFRPLRLQNGLYMQRHAYMHRIAIPY
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHCCCCHHHHHHHHHHHCCCC
GNLRSDQLRMLATIAREHDRGYGHFSTRSNIQYNWIQLEDTPEILRKLASVQMHGIQTSG
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCC
NCIRNITADQFAGVAPDEIVDPRPWAEILRQWSTFHPEFAWLPRKFKIAVSGTKEDRAAV
CHHHCCCHHHHCCCCCHHCCCCCHHHHHHHHHHCCCCCHHCCCCEEEEEECCCCCCCCEE
QIHDLGVYLKKNAAGEVVASILAGGGLGRTPIIGAIIKQDLPWQHLLTYCEAVLRVYNRY
EEEECCEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
GRRDNLYKARIKILVKALSPEKFAQQVEEEWQHLKDGPSTLTEAEVARVEQYFAPPVYEK
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHH
LPDTDASFEKHLLESRPFARWVERNVRPHRVSGYASVTISLKPRDIAPGDATDTQMEAVA
CCCCCHHHHHHHHHCCHHHHHHHCCCCCCEECCEEEEEEEECCCCCCCCCCCHHHHHHHH
DWADQYSLGEIRVSHEQNLILANVKKRDLYALWEQAKAQGFATPNIGLLTDIIACPGGDF
HHHHCCCCCCEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCH
CSLANAKSIPIAQAIQERFDNADFVHDLGDLSLNISGCMNSCGHHHVGNIGVLGVDKDGS
HCCCCCCCCCHHHHHHHHCCCCHHHHHHCCCEEEHHHHHHCCCCCCCCCEEEEEECCCCC
EWYQVSLGGEQGTGVDGAKLGRVIGPSFSAEEMPDVVSKVIDTFVEHRIDGERFIDTYNR
CEEEEEECCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IGIAPFKERVYASRQPAHA
CCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA