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The map label for this gene is cysG1 [H]

Identifier: 186476981

GI number: 186476981

Start: 2502694

End: 2503461

Strand: Reverse

Name: cysG1 [H]

Synonym: Bphy_2230

Alternate gene names: 186476981

Gene position: 2503461-2502694 (Counterclockwise)

Preceding gene: 186476982

Following gene: 186476980

Centisome position: 71.96

GC content: 67.84

Gene sequence:

>768_bases
ATGGGTAAGGTGTATCTGATCGGCGCGGGGCCGGGTGCGGCGGACCTGATCACGGTTCGCGGTGCGCGGCTGCTGGAACG
CGCCGATGTCGTGCTGCACGATGCGCTCGTCGAGCCGGCCATGCTCGACTATGCGCTGCATGCGCGCAAGATCGCGGTAG
GCAAGCGCTGCGGCAAGCGCTCGACGGCGCAGCACTTTATCAACAAGCAGATCGTCGATGCCGCGCGCGAGCATGATGTC
GTCGTGCGGTTGAAGGGTGGCGATCCGATGCTGTTCGGCCGCGCCGACGAGGAAATGCGCGCGCTCGAGGCGGCGGGTAT
CGACTACGAAGTCGTGCCGGGCATCACGGCGGCGCTGGCGAGCGCGGCTTCGTTGCGCCGCTCGCTGACGCTGCGCGGCG
TGTCGCGCAGCGTCGCGTTCGCCACTCACAGCCGCGCGCCGGATTCCGCTCAGATTCGCGAGCAGGTGAACGCCGATTCG
CTCGTGTTCTACATGGGCCGCGACAGCGCGCCCGAGATCGCACAGCAGTTGATCGACGCGGGCCGCGCCGGTTCGACGCC
TGTGGCGATCGTCGAAGCGTGTTCGACGCCGCGTGAGCGCATGCTGACGCTGACGCTCGATGGTCTTGCAGCGGGCGATG
CGCAACTGTGGCTCGATGCGTCGCAACCTTCGCTGCTGATGATCGGCGAGGCGTTCGCAGAGCGTGTGGCGGCTGTGCAG
TCGCGCGGCGACGCCGAACAGGACGCGGCTGCGTTACGAGTCGCCTGA

Upstream 100 bases:

>100_bases
TGCTGATCGACGAAGCGACCCATCACACGGTTGCGGCGGGCATGATCCGTTCGGTTTTCGCCTGAAGCATTTGAAGTTCG
CAGTGGAACGGAGCCAGCAA

Downstream 100 bases:

>100_bases
GCGTCGCATTGTCTCTTTGACCGGCCGCATTCGCGCGAGTGAATGCGGCCGATTGTCTTTACTCGATCGTCGCGGGCGGG
CATGTGCATTGCGATAATGC

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MGKVYLIGAGPGAADLITVRGARLLERADVVLHDALVEPAMLDYALHARKIAVGKRCGKRSTAQHFINKQIVDAAREHDV
VVRLKGGDPMLFGRADEEMRALEAAGIDYEVVPGITAALASAASLRRSLTLRGVSRSVAFATHSRAPDSAQIREQVNADS
LVFYMGRDSAPEIAQQLIDAGRAGSTPVAIVEACSTPRERMLTLTLDGLAAGDAQLWLDASQPSLLMIGEAFAERVAAVQ
SRGDAEQDAAALRVA

Sequences:

>Translated_255_residues
MGKVYLIGAGPGAADLITVRGARLLERADVVLHDALVEPAMLDYALHARKIAVGKRCGKRSTAQHFINKQIVDAAREHDV
VVRLKGGDPMLFGRADEEMRALEAAGIDYEVVPGITAALASAASLRRSLTLRGVSRSVAFATHSRAPDSAQIREQVNADS
LVFYMGRDSAPEIAQQLIDAGRAGSTPVAIVEACSTPRERMLTLTLDGLAAGDAQLWLDASQPSLLMIGEAFAERVAAVQ
SRGDAEQDAAALRVA
>Mature_254_residues
GKVYLIGAGPGAADLITVRGARLLERADVVLHDALVEPAMLDYALHARKIAVGKRCGKRSTAQHFINKQIVDAAREHDVV
VRLKGGDPMLFGRADEEMRALEAAGIDYEVVPGITAALASAASLRRSLTLRGVSRSVAFATHSRAPDSAQIREQVNADSL
VFYMGRDSAPEIAQQLIDAGRAGSTPVAIVEACSTPRERMLTLTLDGLAAGDAQLWLDASQPSLLMIGEAFAERVAAVQS
RGDAEQDAAALRVA

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=237, Percent_Identity=39.662447257384, Blast_Score=146, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6322922, Length=233, Percent_Identity=29.6137339055794, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 27036; Mature: 26905

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKVYLIGAGPGAADLITVRGARLLERADVVLHDALVEPAMLDYALHARKIAVGKRCGKR
CCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
STAQHFINKQIVDAAREHDVVVRLKGGDPMLFGRADEEMRALEAAGIDYEVVPGITAALA
HHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHCCCCEEECCCHHHHHH
SAASLRRSLTLRGVSRSVAFATHSRAPDSAQIREQVNADSLVFYMGRDSAPEIAQQLIDA
HHHHHHHHHHHHCCCHHHEEEECCCCCCHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHC
GRAGSTPVAIVEACSTPRERMLTLTLDGLAAGDAQLWLDASQPSLLMIGEAFAERVAAVQ
CCCCCCCCHHHHHCCCCCHHEEEEEECCCCCCCCEEEEECCCCCEEEHHHHHHHHHHHHH
SRGDAEQDAAALRVA
HCCCCCHHHHHEECC
>Mature Secondary Structure 
GKVYLIGAGPGAADLITVRGARLLERADVVLHDALVEPAMLDYALHARKIAVGKRCGKR
CEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
STAQHFINKQIVDAAREHDVVVRLKGGDPMLFGRADEEMRALEAAGIDYEVVPGITAALA
HHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHCCCCEEECCCHHHHHH
SAASLRRSLTLRGVSRSVAFATHSRAPDSAQIREQVNADSLVFYMGRDSAPEIAQQLIDA
HHHHHHHHHHHHCCCHHHEEEECCCCCCHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHC
GRAGSTPVAIVEACSTPRERMLTLTLDGLAAGDAQLWLDASQPSLLMIGEAFAERVAAVQ
CCCCCCCCHHHHHCCCCCHHEEEEEECCCCCCCCEEEEECCCCCEEEHHHHHHHHHHHHH
SRGDAEQDAAALRVA
HCCCCCHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA