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The map label for this gene is adiA [H]

Identifier: 186476937

GI number: 186476937

Start: 2453172

End: 2455454

Strand: Reverse

Name: adiA [H]

Synonym: Bphy_2186

Alternate gene names: 186476937

Gene position: 2455454-2453172 (Counterclockwise)

Preceding gene: 186476938

Following gene: 186476936

Centisome position: 70.58

GC content: 62.37

Gene sequence:

>2283_bases
ATGAAGTTCCGTTTTCCCGTCGTCATCATCGACGAAGATTTCCGCTCCGAGAACATCTCGGGCTCAGGCATCCGCGCGCT
TGCCGAGGCCATCGAAAAAGAAGGCGCGGAAGTGCTGGGTCTCACGAGCTATGGCGATCTGACGTCGTTTGCGCAGCAGT
CGAGCCGCGCGTCGTGCTTCATCCTGTCGATCGACGATGACGAACTGCTGCCCTACGTCGAGAACAACGACGGCGAGGCG
CCCGACGTCGCGCCCGCGATCGTCGATCTGCGCGCGTTCGTCGAGGCGGTGCGCAAGCGCAACGCGGACATCCCGATCTT
CCTGTACGGCGAAACGCGCACCTCGCGTCACCTGCCGAACGACATCCTGCGCGAACTGCACGGCTTCATTCACATGTTCG
AGGACACGCCGGAGTTCGTCGCGCGGCACATCATCCGCGAAGCGAAGGTATATCTGGATTCGCTCGCGCCGCCGTTCTTC
AAGGAGCTGGTGCAGTATGCGGACGAAGGCTCGTACTCGTGGCACTGTCCGGGCCACTCGGGCGGCGTCGCGTTCCTGAA
AAATCCGCTTGGCCAGATGTTCCATCAGTTCTTCGGTGAGAACATGCTGCGCGCGGACGTCTGCAATGCCGTCGACGAAC
TCGGCCAGCTGCTCGATCATACGGGCCCGGTGGCGGCATCCGAGCGCAACGCCGCACGCATCTTCAGCGCCGATCACCTG
TTCTTCGTCACCAACGGCACGTCCACGTCCAACAAAATCGTCTGGCACGCGACGGTCGCGCCGGGCGACATCGTGCTGGT
GGACCGCAACTGCCACAAGTCGATCCTGCACGCGATCACGATGACGCATGCGATCCCCGTGTTCCTCACGCCGACGCGCA
ATCACTTCGGCATCATCGGGCCGATCCCGCGCGACGAGTTCAAGCCGGAAAACATCCGCAAGAAGATCGAGGCGAATCCG
TTCGCACGCGAAGCGCTCGCGAAGAACCCGAATCTCAAGCCGCGCATTCTGACGATCACGCAAAGCACCTATGACGGCGT
GATCTACAACGTCGAGATGATCAAGGACCTGCTCGGCGATCTGCTCGACACGCTGCATTTCGACGAAGCGTGGCTGCCGC
ACGCCGAGTTCCACGAGTTCTATCAGGACATGCACGCGATCGGCGCGGGCCGTCCGCGCACGGGCGCGCTGGTGTTCGCG
ACGCACTCGACGCACAAGCTGCTGGCAGGCATTTCGCAGGCTTCGCAGATCGTCGTGCAGGATTCGGAGAACAGCACGTT
CGACCGCCATCGGTTCAATGAGGCTTATCTGATGCACACGTCGACGAGCCCGCAGTACGCGATTATCGCGTCGTGCGACG
TGGCCGCCGCGATGATGGAGCCGCCGGGCGGCACGGCGCTGGTGGAAGAATCGATCGCCGAGGCGCTCGATTTCCGCCGC
GCGATGCGCAAGGTCGACGCCGAATACGGCGACGACTGGTTCTTCAAGGTCTGGGGTCCCGAAGAGCTGGCGGAAGAGGG
CATCGGCTCGCGCGACGACTGGATGCTGCGTCCGAACGACCGCTGGCACGGCTTCGGCCCGCTCGCGGACGGCTTCAACA
TGCTGGACCCGATCAAGGCGACGATCATTACGCCGGGCCTCGACGTCGACGGCGAATTCGGCGAGACGGGCATTCCCGCT
GCGATCGTCACGAAGTATCTGGCCGAGCACGGCATCATCGTCGAGAAGACGGGTCTGTATTCGTTCTTCATCATGTTCAC
GATCGGCATTACGAAGGGCCGCTGGAACTCGATGGTCACGGAACTCCAGCAGTTCAAGGACGACTACGACAATAACCAGC
CGCTGTGGCGCGTGCTGCCCGAGTTCGTCGCGCAACATCCCGCATACGAGCGCATCGGCCTGCGCGATCTGTGCGAGCAG
ATCCACAGCGTCTATCGTGCGAACGACATCGCGCGTCTCACGACGGAGATGTACCTGTCGAGCATGGAGCCGGCCATGAA
GCCGTCCGACGCGTTCGCGAAGCTCGCGCACCGCGAGATCGACCGCGTGCCCATCGACGAACTGGAAGGCCGAGTCACGT
CGATCCTGCTGACGCCGTATCCGCCGGGCATTCCGCTGCTGATTCCGGGCGAGCGCTTCAACAGGACCATCGTCAATTAC
CTGCGCTTCGCACGCGAGTTCAACGAGCGCTTCCCTGGCTTCCATACGGATATTCACGGGCTGGTCGGCGAAACGATCAA
CGGGCGCATCGAGTATTTCGTCGATTGCGTGCGCGATTCGTGA

Upstream 100 bases:

>100_bases
GTTGCCTAAGACGTAACGAAAACGCGCATTGAATCACCAGCTATCCGGGTGACCGCTGCGCTTAACCAGCCCAGCGGTCG
TTCTTTTTGGAGAATCGCCC

Downstream 100 bases:

>100_bases
TCATGAAGACGGCACTGCGCATGAAGGCGTGGCGTCGTGCGCTCGCAGGCGCGGCGCTGCTCGCTGCGTGGCTCGCCGCG
CCCGGCGCGGCACAGGCGGA

Product: lysine decarboxylase

Products: NA

Alternate protein names: ADC [H]

Number of amino acids: Translated: 760; Mature: 760

Protein sequence:

>760_residues
MKFRFPVVIIDEDFRSENISGSGIRALAEAIEKEGAEVLGLTSYGDLTSFAQQSSRASCFILSIDDDELLPYVENNDGEA
PDVAPAIVDLRAFVEAVRKRNADIPIFLYGETRTSRHLPNDILRELHGFIHMFEDTPEFVARHIIREAKVYLDSLAPPFF
KELVQYADEGSYSWHCPGHSGGVAFLKNPLGQMFHQFFGENMLRADVCNAVDELGQLLDHTGPVAASERNAARIFSADHL
FFVTNGTSTSNKIVWHATVAPGDIVLVDRNCHKSILHAITMTHAIPVFLTPTRNHFGIIGPIPRDEFKPENIRKKIEANP
FAREALAKNPNLKPRILTITQSTYDGVIYNVEMIKDLLGDLLDTLHFDEAWLPHAEFHEFYQDMHAIGAGRPRTGALVFA
THSTHKLLAGISQASQIVVQDSENSTFDRHRFNEAYLMHTSTSPQYAIIASCDVAAAMMEPPGGTALVEESIAEALDFRR
AMRKVDAEYGDDWFFKVWGPEELAEEGIGSRDDWMLRPNDRWHGFGPLADGFNMLDPIKATIITPGLDVDGEFGETGIPA
AIVTKYLAEHGIIVEKTGLYSFFIMFTIGITKGRWNSMVTELQQFKDDYDNNQPLWRVLPEFVAQHPAYERIGLRDLCEQ
IHSVYRANDIARLTTEMYLSSMEPAMKPSDAFAKLAHREIDRVPIDELEGRVTSILLTPYPPGIPLLIPGERFNRTIVNY
LRFAREFNERFPGFHTDIHGLVGETINGRIEYFVDCVRDS

Sequences:

>Translated_760_residues
MKFRFPVVIIDEDFRSENISGSGIRALAEAIEKEGAEVLGLTSYGDLTSFAQQSSRASCFILSIDDDELLPYVENNDGEA
PDVAPAIVDLRAFVEAVRKRNADIPIFLYGETRTSRHLPNDILRELHGFIHMFEDTPEFVARHIIREAKVYLDSLAPPFF
KELVQYADEGSYSWHCPGHSGGVAFLKNPLGQMFHQFFGENMLRADVCNAVDELGQLLDHTGPVAASERNAARIFSADHL
FFVTNGTSTSNKIVWHATVAPGDIVLVDRNCHKSILHAITMTHAIPVFLTPTRNHFGIIGPIPRDEFKPENIRKKIEANP
FAREALAKNPNLKPRILTITQSTYDGVIYNVEMIKDLLGDLLDTLHFDEAWLPHAEFHEFYQDMHAIGAGRPRTGALVFA
THSTHKLLAGISQASQIVVQDSENSTFDRHRFNEAYLMHTSTSPQYAIIASCDVAAAMMEPPGGTALVEESIAEALDFRR
AMRKVDAEYGDDWFFKVWGPEELAEEGIGSRDDWMLRPNDRWHGFGPLADGFNMLDPIKATIITPGLDVDGEFGETGIPA
AIVTKYLAEHGIIVEKTGLYSFFIMFTIGITKGRWNSMVTELQQFKDDYDNNQPLWRVLPEFVAQHPAYERIGLRDLCEQ
IHSVYRANDIARLTTEMYLSSMEPAMKPSDAFAKLAHREIDRVPIDELEGRVTSILLTPYPPGIPLLIPGERFNRTIVNY
LRFAREFNERFPGFHTDIHGLVGETINGRIEYFVDCVRDS
>Mature_760_residues
MKFRFPVVIIDEDFRSENISGSGIRALAEAIEKEGAEVLGLTSYGDLTSFAQQSSRASCFILSIDDDELLPYVENNDGEA
PDVAPAIVDLRAFVEAVRKRNADIPIFLYGETRTSRHLPNDILRELHGFIHMFEDTPEFVARHIIREAKVYLDSLAPPFF
KELVQYADEGSYSWHCPGHSGGVAFLKNPLGQMFHQFFGENMLRADVCNAVDELGQLLDHTGPVAASERNAARIFSADHL
FFVTNGTSTSNKIVWHATVAPGDIVLVDRNCHKSILHAITMTHAIPVFLTPTRNHFGIIGPIPRDEFKPENIRKKIEANP
FAREALAKNPNLKPRILTITQSTYDGVIYNVEMIKDLLGDLLDTLHFDEAWLPHAEFHEFYQDMHAIGAGRPRTGALVFA
THSTHKLLAGISQASQIVVQDSENSTFDRHRFNEAYLMHTSTSPQYAIIASCDVAAAMMEPPGGTALVEESIAEALDFRR
AMRKVDAEYGDDWFFKVWGPEELAEEGIGSRDDWMLRPNDRWHGFGPLADGFNMLDPIKATIITPGLDVDGEFGETGIPA
AIVTKYLAEHGIIVEKTGLYSFFIMFTIGITKGRWNSMVTELQQFKDDYDNNQPLWRVLPEFVAQHPAYERIGLRDLCEQ
IHSVYRANDIARLTTEMYLSSMEPAMKPSDAFAKLAHREIDRVPIDELEGRVTSILLTPYPPGIPLLIPGERFNRTIVNY
LRFAREFNERFPGFHTDIHGLVGETINGRIEYFVDCVRDS

Specific function: ADC can be found in two forms:biodegradative and biosynthetic. The biodegradative form may play a role in regulating pH by consuming proteins [H]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI221142684, Length=777, Percent_Identity=37.5804375804376, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI1790573, Length=684, Percent_Identity=38.4502923976608, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI1786384, Length=681, Percent_Identity=38.4728340675477, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI1786909, Length=704, Percent_Identity=31.9602272727273, Blast_Score=364, Evalue=1e-101,
Organism=Escherichia coli, GI87082193, Length=691, Percent_Identity=33.5745296671491, Blast_Score=361, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005308
- InterPro:   IPR011193
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; PF03709 OKR_DC_1_N [H]

EC number: =4.1.1.19 [H]

Molecular weight: Translated: 85531; Mature: 85531

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00703 OKR_DC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFRFPVVIIDEDFRSENISGSGIRALAEAIEKEGAEVLGLTSYGDLTSFAQQSSRASCF
CCEECCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCEEE
ILSIDDDELLPYVENNDGEAPDVAPAIVDLRAFVEAVRKRNADIPIFLYGETRTSRHLPN
EEEECCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCH
DILRELHGFIHMFEDTPEFVARHIIREAKVYLDSLAPPFFKELVQYADEGSYSWHCPGHS
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECCCCC
GGVAFLKNPLGQMFHQFFGENMLRADVCNAVDELGQLLDHTGPVAASERNAARIFSADHL
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCEE
FFVTNGTSTSNKIVWHATVAPGDIVLVDRNCHKSILHAITMTHAIPVFLTPTRNHFGIIG
EEEECCCCCCCEEEEEEEECCCCEEEECCCHHHHHHHHHHHHHCCEEEEECCCCCCEEEC
PIPRDEFKPENIRKKIEANPFAREALAKNPNLKPRILTITQSTYDGVIYNVEMIKDLLGD
CCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEHHHHHHHHHH
LLDTLHFDEAWLPHAEFHEFYQDMHAIGAGRPRTGALVFATHSTHKLLAGISQASQIVVQ
HHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHCEEEEE
DSENSTFDRHRFNEAYLMHTSTSPQYAIIASCDVAAAMMEPPGGTALVEESIAEALDFRR
CCCCCCHHHHCCCCEEEEEECCCCCEEEEEECHHHHHHCCCCCCHHHHHHHHHHHHHHHH
AMRKVDAEYGDDWFFKVWGPEELAEEGIGSRDDWMLRPNDRWHGFGPLADGFNMLDPIKA
HHHHHHHCCCCCEEEEECCHHHHHHCCCCCCCCCEECCCCCCCCCCCHHCCCCHHCCCCC
TIITPGLDVDGEFGETGIPAAIVTKYLAEHGIIVEKTGLYSFFIMFTIGITKGRWNSMVT
EEECCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCCCHHHHHHH
ELQQFKDDYDNNQPLWRVLPEFVAQHPAYERIGLRDLCEQIHSVYRANDIARLTTEMYLS
HHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMEPAMKPSDAFAKLAHREIDRVPIDELEGRVTSILLTPYPPGIPLLIPGERFNRTIVNY
HCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCEEEEEECCCCCCCCEEECCHHHHHHHHHH
LRFAREFNERFPGFHTDIHGLVGETINGRIEYFVDCVRDS
HHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MKFRFPVVIIDEDFRSENISGSGIRALAEAIEKEGAEVLGLTSYGDLTSFAQQSSRASCF
CCEECCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCEEE
ILSIDDDELLPYVENNDGEAPDVAPAIVDLRAFVEAVRKRNADIPIFLYGETRTSRHLPN
EEEECCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCH
DILRELHGFIHMFEDTPEFVARHIIREAKVYLDSLAPPFFKELVQYADEGSYSWHCPGHS
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECCCCC
GGVAFLKNPLGQMFHQFFGENMLRADVCNAVDELGQLLDHTGPVAASERNAARIFSADHL
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCEE
FFVTNGTSTSNKIVWHATVAPGDIVLVDRNCHKSILHAITMTHAIPVFLTPTRNHFGIIG
EEEECCCCCCCEEEEEEEECCCCEEEECCCHHHHHHHHHHHHHCCEEEEECCCCCCEEEC
PIPRDEFKPENIRKKIEANPFAREALAKNPNLKPRILTITQSTYDGVIYNVEMIKDLLGD
CCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEHHHHHHHHHH
LLDTLHFDEAWLPHAEFHEFYQDMHAIGAGRPRTGALVFATHSTHKLLAGISQASQIVVQ
HHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHCEEEEE
DSENSTFDRHRFNEAYLMHTSTSPQYAIIASCDVAAAMMEPPGGTALVEESIAEALDFRR
CCCCCCHHHHCCCCEEEEEECCCCCEEEEEECHHHHHHCCCCCCHHHHHHHHHHHHHHHH
AMRKVDAEYGDDWFFKVWGPEELAEEGIGSRDDWMLRPNDRWHGFGPLADGFNMLDPIKA
HHHHHHHCCCCCEEEEECCHHHHHHCCCCCCCCCEECCCCCCCCCCCHHCCCCHHCCCCC
TIITPGLDVDGEFGETGIPAAIVTKYLAEHGIIVEKTGLYSFFIMFTIGITKGRWNSMVT
EEECCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCCCHHHHHHH
ELQQFKDDYDNNQPLWRVLPEFVAQHPAYERIGLRDLCEQIHSVYRANDIARLTTEMYLS
HHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMEPAMKPSDAFAKLAHREIDRVPIDELEGRVTSILLTPYPPGIPLLIPGERFNRTIVNY
HCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCEEEEEECCCCCCCCEEECCHHHHHHHHHH
LRFAREFNERFPGFHTDIHGLVGETINGRIEYFVDCVRDS
HHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8383109; 7610040; 9278503; 2830169; 4204273 [H]