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The map label for this gene is nuoD [H]

Identifier: 186476761

GI number: 186476761

Start: 2257542

End: 2258795

Strand: Reverse

Name: nuoD [H]

Synonym: Bphy_2006

Alternate gene names: 186476761

Gene position: 2258795-2257542 (Counterclockwise)

Preceding gene: 186476762

Following gene: 186476760

Centisome position: 64.92

GC content: 59.65

Gene sequence:

>1254_bases
ATGGCAGAGATCAAGAACTACACGCTCAACTTCGGTCCGCAGCACCCGGCAGCGCACGGCGTGTTGCGCCTCGTGCTGGA
ACTCGACGGCGAAGTGATCCAGCGCGCCGATCCGCACATCGGCCTCCTGCACCGCGCTACTGAAAAGCTCGCGGAAAGCA
AGACCTTCATCCAGTCGGTGCCGTACATGGACCGTCTCGACTACGTGTCGATGATGGTCAACGAGCACGGCTATGTGCTG
GCGATCGAAAAGCTGCTCGGCATCGACGTCCCGATTCGCGCGAAATACATTCGCGTGCTGTTCGACGAAGTCACGCGCGT
GCTGAACCACTTGATGTGGATCGGCGCACACGCGCTCGACGTCGGCGCGATGGCCGTGTTCCTGTACGCATTCCGCGAAC
GCGAAGACCTGATGGACGTGTACGAGGCGGTATCCGGCGCACGTATGCATGCCGCGTACTATCGTCCGGGTGGCGTCTAT
CGCGATCTGCCGGATGCGATGCCGCAATACAAGGCATCGAAGATTCGCAATACGAAGGCTCTGTCGAAGCTAAACGAGAA
CCGTCAGGGCTCGCTGCTCGATTTCATCGAAGATTTCTTCAACCGCTTTCCGAAGTGCGTCGACGAGTACGAAACGCTGC
TCACCGACAACCGCATCTGGAAGCAGCGTCTGGTCGGCATTGGCGTCGTGAGTCCGGAGCGCGCGCTGCAGATGGGCCTG
ACGGGTGCGATGCTGCGCGGCTCTGGTATCGAGTGGGATCTCCGCAAGAAGCAGCCCTATGAAGTGTATGACCAGATGGA
TTTCGATATCCCCGTGGGCGTGAATGGCGATTGTTACGACCGCTATCTGGTGCGCGTCGAAGAAATGCGTCAATCCACGC
GCATCGCGAAACAGTGCATTGAGTGGCTGCGTAAGAATCCCGGCCCCGTGATGACGGACAATCACAAGGTCGCGCCGCCA
TCGCGCGTGGGCATGAAGTCGAACATGGAAGAGCTGATTCACCACTTCAAGCTCTTCACGGAAGGCTTCCACGTGCCGGA
AGGCGAAGCGTATGCCGCCGTCGAGCACCCGAAGGGCGAGTTCGGTATTTATCTCGTGTCGGACGGCGCGAATAAGCCGT
ACCGCCTCAAGATCCGTGCGCCGGGTTATGCGCATCTGTCCGCGCTCGACGAAATGGCGCGCGGCCACATGATCGCCGAC
GCCGTGACGATCATCGGCACGCAAGACATCGTGTTCGGTGAAGTGGACCGTTAG

Upstream 100 bases:

>100_bases
GCGCGTCGTCTATCAGCCGGTGACGATCGAGCCTCGGGAAATCACGCCGCGCGTGATCCGCGAGGATCGCTATGGCGGCC
TGAAACACTAAGAGAACGTC

Downstream 100 bases:

>100_bases
CCCGTCGACACAAAGCGGTTTTCATCAAGGCACGCGCTCCCGCAGCCGATAAAGCATGAGAAGCGGAGCGCGCGTCAAGC
AAAGGAACGCCGGGTCTGTC

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MAEIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAESKTFIQSVPYMDRLDYVSMMVNEHGYVL
AIEKLLGIDVPIRAKYIRVLFDEVTRVLNHLMWIGAHALDVGAMAVFLYAFREREDLMDVYEAVSGARMHAAYYRPGGVY
RDLPDAMPQYKASKIRNTKALSKLNENRQGSLLDFIEDFFNRFPKCVDEYETLLTDNRIWKQRLVGIGVVSPERALQMGL
TGAMLRGSGIEWDLRKKQPYEVYDQMDFDIPVGVNGDCYDRYLVRVEEMRQSTRIAKQCIEWLRKNPGPVMTDNHKVAPP
SRVGMKSNMEELIHHFKLFTEGFHVPEGEAYAAVEHPKGEFGIYLVSDGANKPYRLKIRAPGYAHLSALDEMARGHMIAD
AVTIIGTQDIVFGEVDR

Sequences:

>Translated_417_residues
MAEIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAESKTFIQSVPYMDRLDYVSMMVNEHGYVL
AIEKLLGIDVPIRAKYIRVLFDEVTRVLNHLMWIGAHALDVGAMAVFLYAFREREDLMDVYEAVSGARMHAAYYRPGGVY
RDLPDAMPQYKASKIRNTKALSKLNENRQGSLLDFIEDFFNRFPKCVDEYETLLTDNRIWKQRLVGIGVVSPERALQMGL
TGAMLRGSGIEWDLRKKQPYEVYDQMDFDIPVGVNGDCYDRYLVRVEEMRQSTRIAKQCIEWLRKNPGPVMTDNHKVAPP
SRVGMKSNMEELIHHFKLFTEGFHVPEGEAYAAVEHPKGEFGIYLVSDGANKPYRLKIRAPGYAHLSALDEMARGHMIAD
AVTIIGTQDIVFGEVDR
>Mature_416_residues
AEIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAESKTFIQSVPYMDRLDYVSMMVNEHGYVLA
IEKLLGIDVPIRAKYIRVLFDEVTRVLNHLMWIGAHALDVGAMAVFLYAFREREDLMDVYEAVSGARMHAAYYRPGGVYR
DLPDAMPQYKASKIRNTKALSKLNENRQGSLLDFIEDFFNRFPKCVDEYETLLTDNRIWKQRLVGIGVVSPERALQMGLT
GAMLRGSGIEWDLRKKQPYEVYDQMDFDIPVGVNGDCYDRYLVRVEEMRQSTRIAKQCIEWLRKNPGPVMTDNHKVAPPS
RVGMKSNMEELIHHFKLFTEGFHVPEGEAYAAVEHPKGEFGIYLVSDGANKPYRLKIRAPGYAHLSALDEMARGHMIADA
VTIIGTQDIVFGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=414, Percent_Identity=60.8695652173913, Blast_Score=519, Evalue=1e-147,
Organism=Homo sapiens, GI260898743, Length=408, Percent_Identity=59.8039215686275, Blast_Score=501, Evalue=1e-142,
Organism=Escherichia coli, GI145693162, Length=410, Percent_Identity=39.0243902439024, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI1789076, Length=420, Percent_Identity=27.8571428571429, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1788832, Length=408, Percent_Identity=26.7156862745098, Blast_Score=115, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17555284, Length=415, Percent_Identity=59.7590361445783, Blast_Score=496, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17568379, Length=415, Percent_Identity=58.5542168674699, Blast_Score=492, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24638644, Length=415, Percent_Identity=60.2409638554217, Blast_Score=529, Evalue=1e-150,
Organism=Drosophila melanogaster, GI221459469, Length=412, Percent_Identity=54.6116504854369, Blast_Score=468, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47503; Mature: 47372

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAESKTFIQSV
CCCCCCCEEECCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
PYMDRLDYVSMMVNEHGYVLAIEKLLGIDVPIRAKYIRVLFDEVTRVLNHLMWIGAHALD
CCHHHHHHHHHHHCCCCCEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAMAVFLYAFREREDLMDVYEAVSGARMHAAYYRPGGVYRDLPDAMPQYKASKIRNTKA
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
LSKLNENRQGSLLDFIEDFFNRFPKCVDEYETLLTDNRIWKQRLVGIGVVSPERALQMGL
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHCC
TGAMLRGSGIEWDLRKKQPYEVYDQMDFDIPVGVNGDCYDRYLVRVEEMRQSTRIAKQCI
CHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EWLRKNPGPVMTDNHKVAPPSRVGMKSNMEELIHHFKLFTEGFHVPEGEAYAAVEHPKGE
HHHHCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
FGIYLVSDGANKPYRLKIRAPGYAHLSALDEMARGHMIADAVTIIGTQDIVFGEVDR
EEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHCCCCCEEECCCCC
>Mature Secondary Structure 
AEIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAESKTFIQSV
CCCCCCEEECCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
PYMDRLDYVSMMVNEHGYVLAIEKLLGIDVPIRAKYIRVLFDEVTRVLNHLMWIGAHALD
CCHHHHHHHHHHHCCCCCEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAMAVFLYAFREREDLMDVYEAVSGARMHAAYYRPGGVYRDLPDAMPQYKASKIRNTKA
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
LSKLNENRQGSLLDFIEDFFNRFPKCVDEYETLLTDNRIWKQRLVGIGVVSPERALQMGL
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHCC
TGAMLRGSGIEWDLRKKQPYEVYDQMDFDIPVGVNGDCYDRYLVRVEEMRQSTRIAKQCI
CHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EWLRKNPGPVMTDNHKVAPPSRVGMKSNMEELIHHFKLFTEGFHVPEGEAYAAVEHPKGE
HHHHCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
FGIYLVSDGANKPYRLKIRAPGYAHLSALDEMARGHMIADAVTIIGTQDIVFGEVDR
EEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA