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The map label for this gene is hutC [H]

Identifier: 186476571

GI number: 186476571

Start: 2073014

End: 2073718

Strand: Reverse

Name: hutC [H]

Synonym: Bphy_1813

Alternate gene names: 186476571

Gene position: 2073718-2073014 (Counterclockwise)

Preceding gene: 186476572

Following gene: 186476570

Centisome position: 59.6

GC content: 65.11

Gene sequence:

>705_bases
ATGCCCAGCATGAACGCACCGGCTTATCAGGGAATCAAGGACTTCATCCTCGCCCGCATTCACGCGGGCGAATGGAGCGA
AGGCCATCAGGTTCCATCGGAAAACGAGCTTGCGCGCGAATTCAACGTCGCGCGCATGACGGTCAACCGGGCGCTGCGCG
AGCTGACGGCCGAGCAGGTGCTGACGCGCGTTCAGGGCTCGGGCACGTTCGTCGCGCGACCGAAGTACGAGTCGACGCTA
GTCGCGATCCGCAGCATTTCCGACGAGATCGTCGCGCGCGGTCATTGCTATCACGCGAACGTGCTGCACGTGGGCGCCGC
GATCGCCGACGAAGAACTCGCCGCCGAAATGCAGGTGAGCGCGGGCAGTCCCGTCTTCCATTCGCGCGTGCTGCACTTCG
AGAACGACGAGCCCGTCCAGCTCGAAGAGCGCTGGGTGAATCCCGTCGTCGCCCCCGACTATGCGCTGCAGGACTTCACG
AACACGACACCTAACCAGTATCTCGTGCGCGTCGCGCCGCTGCAGCGCGTTGAGTACCGCATCGAAGCCTCCGCGCCGGA
CGCCGACAACCGCCGGCTTCTGACGATGGACGACGCCGAACCTTGCCTCGTGCTGCACCGGCGCACGTGGTCGCAAGGGG
TGGTCGCGTCCGTGGCCAATCTCTGGCACCCCGGCAACCGTTACCGGTTCACCGGCCACTTCTGA

Upstream 100 bases:

>100_bases
CACCAAGCTCGTGCAGGACGGCACGATCGCGAAGCACAGCCCGTTCTCGTTCATTTCCGAGCAACGCTAACTCCATCTGC
TCAACGGCAGCGCGCCAGAG

Downstream 100 bases:

>100_bases
TTCCGTTTTCGTTTCCGTTCAATCTTCGACTCATCACCGAGTTATCTGCGATTCCGAGGGCATCATGAACAACCCGAAGC
ACATCGACCCGCGTCTCGAC

Product: histidine utilization repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MPSMNAPAYQGIKDFILARIHAGEWSEGHQVPSENELAREFNVARMTVNRALRELTAEQVLTRVQGSGTFVARPKYESTL
VAIRSISDEIVARGHCYHANVLHVGAAIADEELAAEMQVSAGSPVFHSRVLHFENDEPVQLEERWVNPVVAPDYALQDFT
NTTPNQYLVRVAPLQRVEYRIEASAPDADNRRLLTMDDAEPCLVLHRRTWSQGVVASVANLWHPGNRYRFTGHF

Sequences:

>Translated_234_residues
MPSMNAPAYQGIKDFILARIHAGEWSEGHQVPSENELAREFNVARMTVNRALRELTAEQVLTRVQGSGTFVARPKYESTL
VAIRSISDEIVARGHCYHANVLHVGAAIADEELAAEMQVSAGSPVFHSRVLHFENDEPVQLEERWVNPVVAPDYALQDFT
NTTPNQYLVRVAPLQRVEYRIEASAPDADNRRLLTMDDAEPCLVLHRRTWSQGVVASVANLWHPGNRYRFTGHF
>Mature_233_residues
PSMNAPAYQGIKDFILARIHAGEWSEGHQVPSENELAREFNVARMTVNRALRELTAEQVLTRVQGSGTFVARPKYESTLV
AIRSISDEIVARGHCYHANVLHVGAAIADEELAAEMQVSAGSPVFHSRVLHFENDEPVQLEERWVNPVVAPDYALQDFTN
TTPNQYLVRVAPLQRVEYRIEASAPDADNRRLLTMDDAEPCLVLHRRTWSQGVVASVANLWHPGNRYRFTGHF

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=201, Percent_Identity=29.8507462686567, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI87082252, Length=147, Percent_Identity=30.6122448979592, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788418, Length=215, Percent_Identity=28.8372093023256, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1790118, Length=149, Percent_Identity=23.489932885906, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 26326; Mature: 26195

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSMNAPAYQGIKDFILARIHAGEWSEGHQVPSENELAREFNVARMTVNRALRELTAEQV
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTRVQGSGTFVARPKYESTLVAIRSISDEIVARGHCYHANVLHVGAAIADEELAAEMQVS
HHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHCCC
AGSPVFHSRVLHFENDEPVQLEERWVNPVVAPDYALQDFTNTTPNQYLVRVAPLQRVEYR
CCCCHHHHEEEEECCCCCCCHHHHHCCCCCCCCHHHHHHCCCCCCCEEEEECCHHHEEEE
IEASAPDADNRRLLTMDDAEPCLVLHRRTWSQGVVASVANLWHPGNRYRFTGHF
EECCCCCCCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCCCEEEECCC
>Mature Secondary Structure 
PSMNAPAYQGIKDFILARIHAGEWSEGHQVPSENELAREFNVARMTVNRALRELTAEQV
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTRVQGSGTFVARPKYESTLVAIRSISDEIVARGHCYHANVLHVGAAIADEELAAEMQVS
HHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHCCC
AGSPVFHSRVLHFENDEPVQLEERWVNPVVAPDYALQDFTNTTPNQYLVRVAPLQRVEYR
CCCCHHHHEEEEECCCCCCCHHHHHCCCCCCCCHHHHHHCCCCCCCEEEEECCHHHEEEE
IEASAPDADNRRLLTMDDAEPCLVLHRRTWSQGVVASVANLWHPGNRYRFTGHF
EECCCCCCCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]